2,602
Views
1
CrossRef citations to date
0
Altmetric
Research Article

Zyflamend, a unique herbal blend, induces cell death and inhibits adipogenesis through the coordinated regulation of PKA and JNK

, , , , , , ORCID Icon, & ORCID Icon show all
Pages 454-471 | Received 17 Oct 2019, Accepted 15 Jul 2020, Published online: 11 Aug 2020

References

  • Bloomgarden ZT. Obesity and diabetes. Diabetes Care. 2000;23(10):1584–1590.
  • Prevention CFDCa. National diabetes and obesity statistic reports. CDC, 2017.
  • Catenacci VA, Pan Z, Ostendorf D, et al. A randomized pilot study comparing zero-calorie alternate-day fasting to daily caloric restriction in adults with obesity. Obesity. 2016;24(9):1874–1883.
  • De J P, Jc V, Sj P-S HH. Obesity and target organ damage: the kidney. Int J Obes Relat Metab Disord. 2002;26:S21–24.
  • Coppell KJ, Miller JC, Gray AR, et al. Obesity and the extent of liver damage among adult New Zealanders: findings from a national survey. Obes Sci Pract. 2015;1(2):67–77.
  • Schunkert H. Obesity and target organ damage: the heart. Int J Obes Relat Metab Disord. 2002;26(S4):S15–S20.
  • Cheung BM, Cheung TT, Samaranayake NR. Safety of antiobesity drugs. Ther Adv Drug Saf. 2013;4:171–181.
  • Hainer V, Hainerova IA. Do we need anti-obesity drugs? Diabetes Metab Res Rev. 2012;28(Suppl 2):8–20.
  • Huang EC, Zhao Y, Chen G, et al. Zyflamend, a polyherbal mixture, down regulates class I and class II histone deacetylases and increases p21 levels in castrate-resistant prostate cancer cells. BMC Complement Altern Med. 2014;14:68.
  • MacDonald AF, Bettaieb A, Donohoe DR, et al. Concurrent regulation of LKB1 and CaMKK2 in the activation of AMPK in castrate-resistant prostate cancer by a well-defined polyherbal mixture with anticancer properties. BMC Complement Altern Med. 2018;18(1):188.
  • Tague ED, Bourdon AK, MacDonald A, et al. Metabolomics approach in the study of the well-defined polyherbal preparation Zyflamend. J Med Food. 2018;21(3):306–316.
  • Souslova T, Averill-Bates DA. Multidrug-resistant hela cells overexpressing MRP1 exhibit sensitivity to cell killing by hyperthermia: interactions with etoposide. Int J Rad Oncol Biol Phys. 2004;60:1538–1551.
  • Duangjai A, Nuengchamnong N, Suphrom N, et al. Potential of coffee fruit extract and quinic acid on adipogenesis and lipolysis in 3T3-L1 adipocytes. Kobe J Med Sci. 2018;64:E84–E92.
  • Matsuo K, Bettaieb A, Nagata N, et al. Regulation of brown fat adipogenesis by protein tyrosine phosphatase 1B. PloS One. 2011;6(1):e16446.
  • Thornberry NA, Lazebnik Y. Caspases: enemies within. Science. 1998;281:1312–1316.
  • Haj FG, Zabolotny JM, Kim YB, et al. Liver-specific protein-tyrosine phosphatase 1B (PTP1B) re-expression alters glucose homeostasis of PTP1B-/-mice. J Biol Chem. 2005;280:15038–15046.
  • Averill-Bates DA, Cherif A, Agostinelli E, et al. Anti-tumoral effect of native and immobilized bovine serum amine oxidase in a mouse melanoma model. Biochem Pharmacol. 2005;69(12):1693–1704.
  • Cui Q, Yu JH, Wu JN, et al. P53-mediated cell cycle arrest and apoptosis through a caspase-3- independent, but caspase-9-dependent pathway in oridonin-treated MCF-7 human breast cancer cells. Acta Pharmacol Sin. 2007;28:1057–1066.
  • Zhao Y, Collier JJ, Huang EC, et al. Turmeric and Chinese goldthread synergistically inhibit prostate cancer cell proliferation and NF-kB signaling. Funct Food Health Dis. 2014;4:312–339.
  • Rosen ED, Walkey CJ, Puigserver P, et al. Transcriptional regulation of adipogenesis. Genes Dev. 2000;14:1293–1307.
  • Rangwala SM, Lazar MA. Transcriptional control of adipogenesis. Annu Rev Nutr. 2000;20:535–559.
  • Koutnikova H, Auwerx J. Regulation of adipocyte differentiation. Ann Med. 2001;33(8):556–561.
  • Camp HS, Ren D, Leff T. Adipogenesis and fat-cell function in obesity and diabetes. Trends Mol Med. 2002;8(9):442–447.
  • Orellana EA, Kasinski AL, Sulforhodamine B. (SRB) assay in cell culture to investigate cell proliferation. Biol Protoc. 2016;6:6–9.
  • Huang EC, McEntee MF, Whelan J. Zyflamend, a combination of herbal extracts, attenuates tumor growth in murine xenograft models of prostate cancer. Nutr Cancer. 2012;64(5):749–760.
  • Ekmekcioglu S, Chattopadhyay C, Akar U, et al. Zyflamend mediates therapeutic induction of autophagy to apoptosis in melanoma cells. Nutr Cancer. 2011;63(6):940–949.
  • Yang P, Cartwright C, Chan D, et al. Zyflamend-mediated inhibition of human prostate cancer PC3 cell proliferation: effects on 12-LOX and Rb protein phosphorylation. Cancer Biol Ther. 2007;6:228–236.
  • Tseng YH, Kriauciunas KM, Kokkotou E, et al. Differential roles of insulin receptor substrates in brown adipocyte differentiation. Mol Cell Biol. 2004;24:1918–1929.
  • Tseng YH, Butte AJ, Kokkotou E, et al. Prediction of preadipocyte differentiation by gene expression reveals role of insulin receptor substrates and necdin. Nat Cell Biol. 2005;7:601–611.
  • Desjardins EM, Steinberg GR. Emerging role of AMPK in brown and beige adipose tissue (BAT): implications for obesity, insulin resistance, and type 2 diabetes. Curr Diab Rep. 2018;18(10):80–89.
  • Bijland S, Mancini SJ, Salt IP. Role of AMP-activated protein kinase in adipose tissue metabolism and inflammation. Clin Sci. 2013;124(8):491–507.
  • Chen ZP, McConell GK, Michell BJ, et al. AMPK signaling in contracting human skeletal muscle: acetyl-CoA carboxylase and NO synthase phosphorylation. Am J Physiol Endocrinol Metab. 2000;279:E1202–6.
  • Holm C. Molecular mechanisms regulating hormone-sensitive lipase and lipolysis. Biochem Soc Trans. 2003;31(6):1120–1124.
  • Engin A. Human protein kinases and obesity. Adv Exp Med Biol. 2017;960:111–134.
  • Kunnumakkara AB, Sung B, Ravindran J, et al. Zyflamend suppresses growth and sensitizes human pancreatic tumors to gemcitabine in an orthotopic mouse model through modulation of multiple targets. Int J Cancer. 2012;131(3):E292–303.
  • Takeno A, Kanazawa I, Notsu M, et al. Phloretin promotes adipogenesis via mitogen-activated protein kinase pathways in mouse marrow stromal ST2 cells. Int J Mol Sci. 2018;19.
  • Li F, Wang D, Zhou Y, et al. Protein kinase A suppresses the differentiation of 3T3-L1 preadipocytes. Cell Res. 2008;18(2):311–323.
  • Yi F, Khan M, Gao H, et al. Increased differentiation capacity of bone marrow-derived mesenchymal stem cells in aquaporin-5 deficiency. Stem Cells Dev. 2012;21(13):2495–2507.
  • Liu Z, Jin L, Yang JK, et al. The dysfunctional MDM2-p53 axis in adipocytes contributes to aging-related metabolic complications by induction of lipodystrophy. Diabetes. 2018;67:2397–2409.
  • Luk CT, Shi SY, Cai EP, et al. FAK signalling controls insulin sensitivity through regulation of adipocyte survival. Nat Commun. 2017;8:14360.
  • Xue Y, Yang L, Li J, et al. Combination chemotherapy with Zyflamend reduced the acquired resistance of bladder cancer cells to cisplatin through inhibiting NFκB signaling pathway. Onco Targets Ther. 2018;11:4413–4429.
  • Subbaramaiah K, Sue E, Bhardwaj P, et al. Dietary polyphenols suppress elevated levels of proinflammatory mediators and aromatase in the mammary gland of obese mice. Cancer Prev Res (Phila). 2013;6(9):886–897.
  • Bemis DL, Capodice JL, Anastasiadis AG, et al. Zyflamend, a unique herbal preparation with nonselective COX inhibitory activity, induces apoptosis of prostate cancer cells that lack COX-2 expression. Nutr Cancer. 2005;52:202–212.
  • Marquez MP, Alencastro F, Madrigal A, et al. The role of cellular proliferation in adipogenic differentiation of human adipose tissue-derived mesenchymal stem cells. Stem Cells Dev. 2017;26:1578–1595.
  • Cho YC, Jefcoate CR. PPARgamma1 synthesis and adipogenesis in C3H10T1/2 cells depends on S-phase progression, but does not require mitotic clonal expansion. J Cell Biochem. 2004;91:336–353.
  • Tang QQ, Otto TC, Lane MD. Mitotic clonal expansion: a synchronous process required for adipogenesis. Proc Natl Acad Sci USA. 2003;100:44–49.
  • Lopez-Mejia IC, Castillo-Armengol J, Lagarrigue S, et al. Role of cell cycle regulators in adipose tissue and whole body energy homeostasis. Cell Mol Life Sci. 2018;75(6):975–987.
  • Aguilar V, Fajas L. Cycling through metabolism. EMBO Mol Med. 2010;2(9):338–348.
  • Rayalam S, Della-Fera MA, Baile CA. Phytochemicals and regulation of the adipocyte life cycle. J Nutr Biochem. 2008;19:717–726.
  • Hu A, Huang JJ, Zhang JF, et al. Curcumin induces G2/M cell cycle arrest and apoptosis of head and neck squamous cell carcinoma in vitro and in vivo through ATM/Chk2/p53-dependent pathway. Oncotarget. 2017;8:50747–50760.
  • Jang YG, Hwang KA, Choi KC. Rosmarinic acid, a component of rosemary tea, induced the cell cycle arrest and apoptosis through modulation of HDAC2 expression in prostate cancer cell lines. Nutrients. 2018;10:1784.
  • Stefanon B, Pomari E, Colitti M. Effects of Rosmarinus officinalis extract on human primary omental preadipocytes and adipocytes. Exp Biol Med. 2015;240(7):884–895.
  • Andersen C, Rayalam S, Della-Fera MA, et al. Phytochemicals and adipogenesis. Biofactors. 2010;36(6):415–422.
  • Park HJ, Yang JY, Ambati S, et al. Combined effects of genistein, quercetin, and resveratrol in human and 3T3-L1 adipocytes. J Med Food. 2008;11:773–783.
  • Cummings DE, Brandon EP, Planas JV, et al. Genetically lean mice result from targeted disruption of the RII beta subunit of protein kinase A. Nature. 1996;382:622–626.
  • Schreyer SA, Cummings DE, McKnight GS, et al. Mutation of the RIIbeta subunit of protein kinase A prevents diet-induced insulin resistance and dyslipidemia in mice. Diabetes. 2001;50:2555–2562.
  • London E, Nesterova M, Sinaii N, et al. Differentially regulated protein kinase A (PKA) activity in adipose tissue and liver is associated with resistance to diet-induced obesity and glucose intolerance in mice that lack PKA regulatory subunit type IIα. Endocrinology. 2014;155(9):3397–3408.
  • London E, Noguchi A, Springer D, et al. The catalytic subunit β of PKA affects energy balance and catecholaminergic activity. J Endocr Soc. 2019;3(5):1062–1078.
  • Mantovani G, Bondioni S, Alberti L, et al. Protein kinase A regulatory subunits in human adipose tissue: decreased R2B expression and activity in adipocytes from obese subjects. Diabetes. 2009;58(3):620–626.
  • Kato Y, Ozaki N, Yamada T, et al. H-89 potentiates adipogenesis in 3T3-L1 cells by activating insulin signaling independently of protein kinase A. Life Sci. 2007;80(5):476–483.
  • Kim NJ, Baek JH, Lee J, et al. A PDE1 inhibitor reduces adipogenesis in mice via regulation of lipolysis and adipogenic cell signaling. Exp Mol Med. 2019;51:5.
  • Fredrikson G, Stralfors P, Nilsson NO, et al. Hormone-sensitive lipase of rat adipose tissue purification and some properties. J Biol Chem. 1981;256:6311–6320.
  • Lampidonis AD, Rogdakis E, Voutsinas GE, et al. The resurgence of hormone-sensitive lipase (HSL) in mammalian lipolysis. Gene. 2011;477(1–2):1–11.
  • Garton AJ, Yeaman SJ. Identification and role of the basal phosphorylation site on hormone-sensitive lipase. Eur J Biochem. 1990;191:245–250.
  • Lu M, Cao Y, Xiao J, et al. Molecular mechanisms of the anti-obesity effect of bioactive ingredients in common spices: a review. Food Funct. 2018;9:4569–4581.
  • Choi JH, Kim SW, Yu R, et al. Monoterpene phenolic compound thymol promotes browning of 3T3-L1 adipocytes. Eur J Nutr. 2017;56(7):2329–2341.
  • Hossain KM, Abdal Dayem A, Han J, et al. Molecular mechanisms of the anti-obesity and anti-diabetic properties of flavonoids. Int J Mol Sci. 2016;17(4):569.
  • Moseti D, Regassa A, Kim WK. Molecular regulation of adipogenesis and potential anti-adipogenic bioactive molecules. Int J Mol Sci. 2016;17:17–24.
  • Fernandez-Galilea M, Perez-Matute P, Prieto-Hontoria PL, et al. Effects of lipoic acid on lipolysis in 3T3-L1 adipocytes. J Lipid Res. 2012;53(11):2296–2306.
  • Kusuyama J, Ohnishi T, Bandow K, et al. Constitutive activation of p46JNK2 is indispensable for C/EBPδ induction in the initial stage of adipogenic differentiation. Biochemical J. 2017;474(20):3421–3437.
  • Rozo AV, Vijayvargia R, Weiss HR, et al. Silencing Jnk1 and Jnk2 accelerates basal lipolysis and promotes fatty acid re-esterification in mouse adipocytes. Diabetologia. 2008;51(8):1493–1504.
  • Aouadi M, Jager J, Laurent K, et al. p38MAP Kinase activity is required for human primary adipocyte differentiation. FEBS Lett. 2007;581(29):5591–5596.
  • Aguirre V, Werner ED, Giraud J, et al. Phosphorylation of Ser307 in insulin receptor substrate-1 blocks interactions with the insulin receptor and inhibits insulin action. J Biol Chem. 2002;277:1531–1537.
  • Lee YH, Giraud J, Davis RJ, et al. c-Jun N-terminal kinase (JNK) mediates feedback inhibition of the insulin signaling cascade. J Biol Chem. 2003;278(5):2896–2902.
  • Solinas G, Naugler W, Galimi F, et al. Saturated fatty acids inhibit induction of insulin gene transcription by JNK-mediated phosphorylation of insulin-receptor substrates. Proc Natl Acad Sci USA. 2006;103(44):16454–16459.
  • Miki H, Yamauchi T, Suzuki R, et al. Essential role of insulin receptor substrate 1 (IRS-1) and IRS-2 in adipocyte differentiation. Mol Cell Biol. 2001;21(7):2521–2532.
  • Groeneveld MP, Brierley GV, Rocha NM, et al. Acute knockdown of the insulin receptor or its substrates Irs1 and 2 in 3T3-L1 adipocytes suppresses adiponectin production. Sci Rep. 2016;6:21105–21106.
  • Fasshauer M, Klein J, Kriauciunas KM, et al. Essential role of insulin receptor substrate 1 in differentiation of brown adipocytes. Mol Cell Biol. 2001;21(1):319–329.