Clinically confirmed DEL-1 as a myokine attenuates lipid-induced inflammation and insulin resistance in 3T3-L1 adipocytes via AMPK/HO-1- pathway

References

• Stefani L, Galanti G. Physical exercise prescription in metabolic chronic disease. Adv Exp Med Biol. 2017;1005:123–141.
   PubMed Web of Science ®Google Scholar
• Pedersen BK, Febbraio MA. Muscles, exercise and obesity: skeletal muscle as a secretory organ. Nat Rev Endocrinol. 2012;8(8):457–465.
   PubMed Web of Science ®Google Scholar
• Jung TW, Hwang HJ, Hong HC, et al. BAIBA attenuates insulin resistance and inflammation induced by palmitate or a high fat diet via an AMPK-PPARdelta-dependent pathway in mice. Diabetologia. 2015;58(9):2096–2105.
   PubMed Web of Science ®Google Scholar
• Jung TW, Lee SH, Kim HC, et al. METRNL attenuates lipid-induced inflammation and insulin resistance via AMPK or PPARdelta-dependent pathways in skeletal muscle of mice. Exp Mol Med. 2018;50(9):122.
   PubMed Web of Science ®Google Scholar
• Gizaw M, Anandakumar P, Debela TA. Review on the role of Irisin in Insulin resistance and Type 2 diabetes mellitus. J Pharmacopuncture. 2017;20(4):235–242.
   PubMed Web of Science ®Google Scholar
• Li H, Wu G, Fang Q, et al. Fibroblast growth factor 21 increases insulin sensitivity through specific expansion of subcutaneous fat. Nat Commun. 2018;9(1):272.
   PubMedGoogle Scholar
• Yan X, Gou Z, Li Y, et al. Fibroblast growth factor 21 inhibits atherosclerosis in apoE-/- mice by ameliorating Fas-mediated apoptosis. Lipids Health Dis. 2018;17(1):203.
   PubMedGoogle Scholar
• Penta K, Varner JA, Liaw L, et al. Del1 induces integrin signaling and angiogenesis by ligation of alphaVbeta3. J Biol Chem. 1999;274(16):11101–11109.
   PubMed Web of Science ®Google Scholar
• Chavakis E, Choi EY, Chavakis T. Novel aspects in the regulation of the leukocyte adhesion cascade. Thromb Haemost. 2009;102(2):191–197.
   PubMed Web of Science ®Google Scholar
• Choi EY, Chavakis E, Czabanka MA, et al. Del-1, an endogenous leukocyte-endothelial adhesion inhibitor, limits inflammatory cell recruitment. Science. 2008;322(5904):1101–1104.
   PubMed Web of Science ®Google Scholar
• Kang YY, Kim DY, Lee SH, et al. Deficiency of developmental endothelial locus-1 (Del-1) aggravates bleomycin-induced pulmonary fibrosis in mice. Biochem Biophys Res Commun. 2014;445(2):369–374.
   PubMed Web of Science ®Google Scholar
• Eskan MA, Jotwani R, Abe T, et al. The leukocyte integrin antagonist Del-1 inhibits IL-17-mediated inflammatory bone loss. Nat Immunol. 2012;13(5):465–473.
   PubMed Web of Science ®Google Scholar
• Choi EY, Lim JH, Neuwirth A, et al. Developmental endothelial locus-1 is a homeostatic factor in the central nervous system limiting neuroinflammation and demyelination. Mol Psychiatry. 2015;20(7):880–888.
   PubMed Web of Science ®Google Scholar
• Sun JL, Park J, Lee T, et al. DEL-1 ameliorates high-fat diet-induced insulin resistance in mouse skeletal muscle through SIRT1/SERCA2-mediated ER stress suppression. Biochem Pharmacol. 2020;171:113730.
   PubMed Web of Science ®Google Scholar
• Weisberg SP, McCann D, Desai M, et al. Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest. 2003;112(12):1796–1808.
   PubMed Web of Science ®Google Scholar
• Lee W, Yun S, Choi GH, et al. Fibronectin Type III domain containing 4 attenuates hyperlipidemia-induced insulin resistance via suppression of inflammation and ER stress through HO-1 expression in adipocytes. Biochem Biophys Res Commun. 2018;502(1):129–136.
   PubMed Web of Science ®Google Scholar
• Begriche K, Massart J, Abbey-Toby A, et al. Beta-aminoisobutyric acid prevents diet-induced obesity in mice with partial leptin deficiency. Obesity (Silver Spring). 2008;16(9):2053–2067.
   PubMed Web of Science ®Google Scholar
• Andersen B, Straarup EM, Heppner KM, et al. FGF21 decreases body weight without reducing food intake or bone mineral density in high-fat fed obese rhesus macaque monkeys. Int J Obes (Lond). 2018;42(6):1151–1160.
   PubMed Web of Science ®Google Scholar
• Rothwell NJ, Saville ME, Stock MJ. Role of insulin in thermogenic responses to refeeding in 3-day-fasted rats. Am J Physiol. 1983;245(2):E160–165.
   PubMedGoogle Scholar
• Monteiro R, Azevedo I. Chronic inflammation in obesity and the metabolic syndrome. Mediators Inflamm. 2010;2010:1–10.
   PubMed Web of Science ®Google Scholar
• Kanda H, Tateya S, Tamori Y, et al. MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity. J Clin Invest. 2006;116(6):1494–1505.
   PubMed Web of Science ®Google Scholar
• Coelho M, Oliveira T, Fernandes R. Biochemistry of adipose tissue: an endocrine organ. Arch Med Sci. 2013;9(2):191–200.
   PubMed Web of Science ®Google Scholar
• Fried SK, Bunkin DA, Greenberg AS. Omental and subcutaneous adipose tissues of obese subjects release interleukin-6: depot difference and regulation by glucocorticoid. J Clin Endocrinol Metab. 1998;83(3):847–850.
   PubMed Web of Science ®Google Scholar
• Starkie R, Ostrowski SR, Jauffred S, et al. Exercise and IL-6 infusion inhibit endotoxin-induced TNF-alpha production in humans. Faseb J. 2003;17(8):884–886.
   PubMedGoogle Scholar
• Kjobsted R, Hingst JR, Fentz J, et al. AMPK in skeletal muscle function and metabolism. Faseb J. 2018;32(4):1741–1777.
   PubMed Web of Science ®Google Scholar
• Herzig S, Shaw RJ. AMPK: guardian of metabolism and mitochondrial homeostasis. Nat Rev Mol Cell Biol. 2018;19(2):121–135.
   PubMed Web of Science ®Google Scholar
• Jensen J, O’Rahilly S. AMPK is required for exercise to enhance insulin sensitivity in skeletal muscles. Mol Metab. 2017;6(4):315–316.
   PubMed Web of Science ®Google Scholar
• Yan J, Wang C, Jin Y, et al. Catalpol ameliorates hepatic insulin resistance in type 2 diabetes through acting on AMPK/NOX4/PI3K/AKT pathway. Pharmacol Res. 2018;130:466–480.
   PubMed Web of Science ®Google Scholar
• Wu L, Zhang L, Li B, et al. AMP-activated protein kinase (AMPK) regulates energy metabolism through modulating thermogenesis in adipose tissue. Front Physiol. 2018;9:122.
   Web of Science ®Google Scholar
• Nishimura S, Manabe I, Nagai R. Adipose tissue inflammation in obesity and metabolic syndrome. Discov Med. 2009;8(41):55–60.
   PubMedGoogle Scholar
• Bai A, Ma AG, Yong M, et al. AMPK agonist downregulates innate and adaptive immune responses in TNBS-induced murine acute and relapsing colitis. Biochem Pharmacol. 2010;80(11):1708–1717.
   PubMed Web of Science ®Google Scholar
• Zhao X, Zmijewski JW, Lorne E, et al. Activation of AMPK attenuates neutrophil proinflammatory activity and decreases the severity of acute lung injury. Am J Physiol Lung Cell Mol Physiol. 2008;295(3):L497–504.
   PubMed Web of Science ®Google Scholar
• Zhu H, Chai Y, Dong D, et al. AICAR-induced AMPK activation inhibits the noncanonical NF-kappaB pathway to attenuate liver injury and fibrosis in BDL rats. Can J Gastroenterol Hepatol. 2018;2018:6181432.
   PubMed Web of Science ®Google Scholar
• Prasad R, Giri S, Nath N, et al. 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside attenuates experimental autoimmune encephalomyelitis via modulation of endothelial-monocyte interaction. J Neurosci Res. 2006;84(3):614–625.
   PubMed Web of Science ®Google Scholar
• Akbar DH. Effect of metformin and sulfonylurea on C-reactive protein level in well-controlled type 2 diabetics with metabolic syndrome. Endocrine. 2003;20(3):215–218.
   PubMed Web of Science ®Google Scholar
• Lee W, Yun S, Choi GH, et al. BAIBA attenuates the expression of inflammatory cytokines and attachment molecules and ER stress in HUVECs and THP-1 cells. Pathobiology. 2018;85(5–6):280–288.
   PubMed Web of Science ®Google Scholar
• Maines MD. The heme oxygenase system: a regulator of second messenger gases. Annu Rev Pharmacol Toxicol. 1997;37:517–554.
   PubMed Web of Science ®Google Scholar
• Trakshel GM, Kutty RK, Maines MD. Purification and characterization of the major constitutive form of testicular heme oxygenase. The noninducible isoform. J Biol Chem. 1986;261(24):11131–11137.
   PubMed Web of Science ®Google Scholar
• Xin G, Du J, Wang YT, et al. Effect of oxidative stress on heme oxygenase-1 expression in patients with gestational diabetes mellitus. Exp Ther Med. 2014;7(2):478–482.
   PubMed Web of Science ®Google Scholar
• Liu XM, Peyton KJ, Ensenat D, et al. Endoplasmic reticulum stress stimulates heme oxygenase-1 gene expression in vascular smooth muscle. Role in cell survival. J Biol Chem. 2005;280(2):872–877.
   PubMed Web of Science ®Google Scholar
• Takahashi T, Shimizu H, Morimatsu H, et al. Heme oxygenase-1: a fundamental guardian against oxidative tissue injuries in acute inflammation. Mini Rev Med Chem. 2007;7(7):745–753.
   PubMed Web of Science ®Google Scholar
• Alcaraz MJ, Fernandez P, Guillen MI. Anti-inflammatory actions of the heme oxygenase-1 pathway. Curr Pharm Des. 2003;9(30):2541–2551.
   PubMed Web of Science ®Google Scholar
• Paine A, Eiz-Vesper B, Blasczyk R, et al. Signaling to heme oxygenase-1 and its anti-inflammatory therapeutic potential. Biochem Pharmacol. 2010;80(12):1895–1903.
   PubMed Web of Science ®Google Scholar
• Lee IT, Luo SF, Lee CW, et al. Overexpression of HO-1 protects against TNF-alpha-mediated airway inflammation by down-regulation of TNFR1-dependent oxidative stress. Am J Pathol. 2009;175(2):519–532.
   PubMed Web of Science ®Google Scholar
• Zampetaki A, Minamino T, Mitsialis SA, et al. Effect of heme oxygenase-1 overexpression in two models of lung inflammation. Exp Biol Med (Maywood). 2003;228(5):442–446.
   PubMed Web of Science ®Google Scholar
• Lee T, Park HS, Jeong JH, et al. Kynurenic acid attenuates pro-inflammatory reactions in lipopolysaccharide-stimulated endothelial cells through the PPARdelta/HO-1-dependent pathway. Mol Cell Endocrinol. 2019;495:110510.
   PubMed Web of Science ®Google Scholar
• Jung TW, Park HS, Jeong JH, et al. Salsalate ameliorates the atherosclerotic response through HO-1- and SIRT1-mediated suppression of ER stress and inflammation. Inflamm Res. 2019;68(8):655–663.
   PubMed Web of Science ®Google Scholar
• Poss KD, Tonegawa S. Reduced stress defense in heme oxygenase 1-deficient cells. Proc Natl Acad Sci U S A. 1997;94(20):10925–10930.
   PubMed Web of Science ®Google Scholar
• Soares MP, Marguti I, Cunha A, et al. Immunoregulatory effects of HO-1: how does it work? Curr Opin Pharmacol. 2009;9(4):482–489.
   PubMed Web of Science ®Google Scholar
• Kapturczak MH, Wasserfall C, Brusko T, et al. Heme oxygenase-1 modulates early inflammatory responses: evidence from the heme oxygenase-1-deficient mouse. Am J Pathol. 2004;165(3):1045–1053.
   PubMed Web of Science ®Google Scholar
• Giri S, Rattan R, Haq E, et al. AICAR inhibits adipocyte differentiation in 3T3L1 and restores metabolic alterations in diet-induced obesity mice model. Nutr Metab (Lond). 2006;3:31.
   Web of Science ®Google Scholar