CABLES1 expression is reduced in human subcutaneous adipose tissue in obesity and type 2 diabetes but may not directly impact adipocyte glucose and lipid metabolism

References

• Björntorp P. ’Portal’ adipose tissue as a generator of risk factors for cardiovascular disease and diabetes. J Am Heart Assoc. 1990;10(4):493–14. doi: 10.1161/01.ATV.10.4.493
   Google Scholar
• Kershaw EE, Flier JS. Adipose tissue as an endocrine organ. J Clin Endocrinol Metab. 2004;89:2548–2556. doi: 10.1210/jc.2004-0395
   PubMed Web of Science ®Google Scholar
• Scherer PE. Adipose tissue: from lipid storage compartment to endocrine organ. Diabetes. 2006;55(6):1537–1545. doi: 10.2337/db06-0263
   PubMed Web of Science ®Google Scholar
• Stefan N, Häring HU, Hu FB, et al. Metabolically healthy obesity: epidemiology, mechanisms, and clinical implications. Lancet Diabetes Endocrinol. 2013;1(2):152–162. doi: 10.1016/s2213-8587(13)70062-7
   PubMed Web of Science ®Google Scholar
• Zukerberg LR, Patrick GN, Nikolic M, et al. Cables links Cdk5 and c-Abl and facilitates Cdk5 tyrosine phosphorylation, kinase upregulation, and neurite outgrowth. Neuron. 2000;26(3):633–646. doi: 10.1016/s0896-6273(00)81200-3
   PubMed Web of Science ®Google Scholar
• Wu CL, Kirley SD, Xiao H, et al. Cables enhances cdk2 tyrosine 15 phosphorylation by Wee1, inhibits cell growth, and is lost in many human colon and squamous cancers. Cancer Res. 2001;61(19):7325–7332.
   PubMed Web of Science ®Google Scholar
• Park DY, Sakamoto H, Kirley SD, et al. The cables gene on chromosome 18q is silenced by promoter hypermethylation and allelic loss in human colorectal cancer. Am J Pathol. 2007;171(5):1509–1519. doi: 10.2353/ajpath.2007.070331
   PubMed Web of Science ®Google Scholar
• Zukerberg LR, DeBernardo RL, Kirley SD, et al. Loss of cables, a cyclin-dependent kinase regulatory protein, is associated with the development of endometrial hyperplasia and endometrial cancer. Cancer Res. 2004;64(1):202–208. doi: 10.1158/0008-5472.can-03-2833
   PubMed Web of Science ®Google Scholar
• Sakamoto H, Friel AM, Wood AW, et al. Mechanisms of cables 1 gene inactivation in human ovarian cancer development. Cancer Biol Ther. 2008;7(2):180–188. doi: 10.4161/cbt.7.2.5253
   PubMed Web of Science ®Google Scholar
• Pereira MJ, VRANIC M, KAMBLE PG, et al. CDKN2C expression in adipose tissue is reduced in type II diabetes and central obesity: impact on adipocyte differentiation and lipid storage? Transl Res. 2022;242:105–121. doi: 10.1016/j.trsl.2021.12.003
   PubMed Web of Science ®Google Scholar
• Li X, Kim JW, Grønborg M, et al. Role of cdk2 in the sequential phosphorylation/activation of C/EBPbeta during adipocyte differentiation. Proceedings of the National Academy of Sciences of the United States of America, 2007;104, 11597–11602. doi:10.1073/pnas.0703771104.
   Google Scholar
• Marcon BH, Shigunov P, Spangenberg L, et al. Cell cycle genes are downregulated after adipogenic triggering in human adipose tissue-derived stem cells by regulation of mRNA abundance. Sci Rep. 2019;9(1):5611. doi: 10.1038/s41598-019-42005-3
   PubMedGoogle Scholar
• Choi JH, Banks AS, Estall JL, et al. Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPARγ by Cdk5. Nature. 2010;466(7305):451–456. doi: 10.1038/nature09291
   PubMed Web of Science ®Google Scholar
• Banks AS, McAllister FE, Camporez JPG, et al. An ERK/Cdk5 axis controls the diabetogenic actions of PPARγ. Nature. 2015;517(7534):391–395. doi: 10.1038/nature13887
   PubMed Web of Science ®Google Scholar
• Rask-Andersen M, Karlsson T, Ek WE, et al. Genome-wide association study of body fat distribution identifies adiposity loci and sex-specific genetic effects. Nat Commun. 2019;10(1):339. doi: 10.1038/s41467-018-08000-4
   PubMedGoogle Scholar
• Galván-Femenía I, Obón-Santacana M, Piñeyro D, et al. Multitrait genome association analysis identifies new susceptibility genes for human anthropometric variation in the GCAT cohort. J Med Genet. 2018;55(11):765–778. doi: 10.1136/jmedgenet-2018-105437
   PubMed Web of Science ®Google Scholar
• Zhang X, Li T-Y, Xiao H-M, et al. Epigenomic and transcriptomic prioritization of candidate obesity-risk regulatory GWAS SNPs. Int J Mol Sci. 2022;23(3):1271. doi: 10.3390/ijms23031271
   PubMed Web of Science ®Google Scholar
• Ahmadian M, Suh JM, Hah N, et al. PPARγ signaling and metabolism: the good, the bad and the future. Nature Med. 2013;19(5):557–566. doi: 10.1038/nm.3159
   PubMed Web of Science ®Google Scholar
• Leonardini A, Laviola L, Perrini S, et al. Cross-talk between PPARγ and insulin signaling and modulation of insulin sensitivity. PPAR Res. 2009;2009:818945. doi: 10.1155/2009/818945
   PubMed Web of Science ®Google Scholar
• Lenz M, Arts ICW, Peeters RLM, et al. Adipose tissue in health and disease through the lens of its building blocks. Sci Rep. 2020;10:10433. doi: 10.1038/s41598-020-67177-1
   PubMed Web of Science ®Google Scholar
• Massier L, Jalkanen J, Elmastas M, et al. An integrated single cell and spatial transcriptomic map of human white adipose tissue. Nat Commun. 2023;14(1):1438. doi: 10.1038/s41467-023-36983-2
   PubMed Web of Science ®Google Scholar
• Kamble PG, Hetty S, Vranic M, et al. Proof-of-concept for CRISPR/Cas9 gene editing in human preadipocytes: deletion of FKBP5 and PPARG and effects on adipocyte differentiation and metabolism. Sci Rep. 2020;10(1):10565. doi: 10.1038/s41598-020-67293-y
   PubMed Web of Science ®Google Scholar
• Marquez MP, Alencastro F, Madrigal A, et al. The role of cellular proliferation in adipogenic differentiation of human adipose tissue-derived mesenchymal stem cells. Stem Cells Dev. 2017;26(21):1578–1595. doi: 10.1089/scd.2017.0071
   PubMed Web of Science ®Google Scholar
• Huang JR, Tan GM, Li Y, et al. The emerging role of cables1 in cancer and other diseases. Mol Pharmacol. 2017;92(3):240–245. doi: 10.1124/mol.116.107730
   PubMed Web of Science ®Google Scholar
• Pereira MJ, Skrtic S, Katsogiannos P, et al. Impaired adipose tissue lipid storage, but not altered lipolysis, contributes to elevated levels of NEFA in type 2 diabetes. Degree of hyperglycemia and adiposity are important factors. Metabolism. 2016;65(12):1768–1780. doi: 10.1016/j.metabol.2016.09.008
   PubMed Web of Science ®Google Scholar
• Katsogiannos P, Kamble PG, Boersma GJ, et al. Early changes in adipose tissue morphology, gene expression, and metabolism after RYGB in patients with obesity and T2D. J Clin Endocrinol Metab. 2019;104(7):2601–2613. doi: 10.1210/jc.2018-02165
   PubMed Web of Science ®Google Scholar
• Almby KE, Katsogiannos P, Pereira MJ, et al. Time course of metabolic, neuroendocrine, and adipose effects during 2 years of follow-up after gastric bypass in patients with type 2 diabetes. J Clin Endocrinol Metab. 2021;106(10):e4049–e4061. doi: 10.1210/clinem/dgab398
   PubMed Web of Science ®Google Scholar
• Kamble PG, Pereira MJ, Gustafsson S, et al. Role of peroxisome proliferator-activated receptor gamma Pro12Ala polymorphism in human adipose tissue: assessment of adipogenesis and adipocyte glucose and lipid turnover. Adipocyte. 2018;7(4):285–296. doi: 10.1080/21623945.2018.1503030
   PubMed Web of Science ®Google Scholar
• Ahmed F, Hetty S, Vranic M, et al. ESR2 expression in subcutaneous adipose tissue is related to body fat distribution in women, and knockdown impairs preadipocyte differentiation. Adipocyte. 2022;11(1):434–447. doi: 10.1080/21623945.2022.2102116
   PubMed Web of Science ®Google Scholar