Mitochondrial STAT3 and reactive oxygen species: A fulcrum of adipogenesis?

REFERENCES

• Li J, Papadopoulos V, Vihma V. Steroid biosynthesis in adipose tissue. Steroids 2015; http://dx.doi.org/10.1016/j.steroids.2015.03.016
   Web of Science ®Google Scholar
• Kershaw EE, Flier JS. Adipose tissue as an endocrine organ. J Clin Endocrinol Metab 2004; 89:2548-56; PMID:15181022; http://dx.doi.org/10.1210/jc.2004-0395
   PubMed Web of Science ®Google Scholar
• Weisberg SP, McCann D, Desai M, Rosenbaum M, Leibel RL, Ferrante AW Jr. Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest 2003; 112:1796-808; PMID:14679176; http://dx.doi.org/10.1172/JCI200319246
   PubMed Web of Science ®Google Scholar
• Hotamisligil GS, Arner P, Caro JF, Atkinson RL, Spiegelman BM. Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance. J Clin Invest 1995; 95:2409-15; PMID:7738205; http://dx.doi.org/10.1172/JCI117936
   PubMed Web of Science ®Google Scholar
• Nishimura S, Manabe I, Nagai R. Adipose tissue inflammation in obesity and metabolic syndrome. Discov Med 2009; 8:55-60; PMID:19788868
   PubMedGoogle Scholar
• Ray PD, Huang B-W, Tsuji Y. Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling. Cell Signal 2012; 24:981-90; PMID:22286106; http://dx.doi.org/10.1016/j.cellsig.2012.01.008
   PubMed Web of Science ®Google Scholar
• D'Autréaux B, Toledano MB. ROS as signalling molecules: mechanisms that generate specificity in ROS homeostasis. Nat Rev Mol Cell Biol 2007; 8:813-24; PMID:17848967; http://dx.doi.org/10.1038/nrm2256
   PubMed Web of Science ®Google Scholar
• Finkel T. Signal transduction by reactive oxygen species. J Cell Biol 2011; 194:7-15; PMID:21746850; http://dx.doi.org/10.1083/jcb.201102095
   PubMed Web of Science ®Google Scholar
• Schieber M, Chandel NS. ROS function in redox signaling and oxidative stress. Curr Biol 2014; 24:R453-62; PMID:24845678; http://dx.doi.org/10.1016/j.cub.2014.03.034
   PubMed Web of Science ®Google Scholar
• Murphy MP. How mitochondria produce reactive oxygen species. Biochem J 2009; 417:1-13; PMID:19061483; http://dx.doi.org/10.1042/BJ20081386
   PubMed Web of Science ®Google Scholar
• Su W-C, Chou HY, Chang CJ, Lee YM, Chen WH, Huang KH, Lee MY, Lee SC. Differential activation of a C/EBP beta isoform by a novel redox switch may confer the lipopolysaccharide-inducible expression of interleukin-6 gene. J Biol Chem 2003; 278:51150-8; PMID:14530280; http://dx.doi.org/10.1074/jbc.M305501200
   PubMed Web of Science ®Google Scholar
• Lee H, Lee YJ, Choi H, Ko EH, Kim J-W. Reactive oxygen species facilitate adipocyte differentiation by accelerating mitotic clonal expansion. J Biol Chem 2009; 284:10601-9; PMID:19237544; http://dx.doi.org/10.1074/jbc.M808742200
   PubMed Web of Science ®Google Scholar
• Stephens JM, Morrison RF, Pilch PF. The expression and regulation of STATs during 3T3-L1 adipocyte differentiation. J Biol Chem 1996; 271:10441-104449; PMID:8631837; http://dx.doi.org/10.1074/jbc.271.18.10441
   PubMed Web of Science ®Google Scholar
• Deng J, Hua K, Lesser SS, Harp JB. Activation of signal transducer and activator of transcription-3 during proliferative phases of 3T3-L1 adipogenesis. Endocrinology 2000; 141:2370-6; PMID:10875236
   PubMed Web of Science ®Google Scholar
• Zhang K, Guo W, Yang Y, Wu J. JAK2/STAT3 pathway is involved in the early stage of adipogenesis through regulating C/EBPβ transcription. J Cell Biochem 2011; 112:488-97; PMID:21268070; http://dx.doi.org/10.1002/jcb.22936
   PubMed Web of Science ®Google Scholar
• Wang D, Zhou Y, Lei W, Zhang K, Shi J, Hu Y, Shu G, Song J. Signal transducer and activator of transcription 3 (STAT3) regulates adipocyte differentiation via peroxisome-proliferator-activated receptor gamma (PPARgamma). Biol Cell 2010; 102:1-12; http://dx.doi.org/10.1042/BC20090070
   Web of Science ®Google Scholar
• Wegrzyn J, Potla R, Chwae YJ, Sepuri NB, Zhang Q, Koeck T, Derecka M, Szczepanek K, Szelag M, Gornicka A, et al. Function of mitochondrial Stat3 in cellular respiration. Science 2009; 323:793-7; PMID:19131594; http://dx.doi.org/10.1126/science.1164551
   PubMed Web of Science ®Google Scholar
• Gough DJ, Corlett A, Schlessinger K, Wegrzyn J, Larner AC, Levy DE. Mitochondrial STAT3 supports Ras-dependent oncogenic transformation. Science 2009; 324:1713-6; PMID:19556508; http://dx.doi.org/10.1126/science.1171721
   PubMed Web of Science ®Google Scholar
• Macias E, Rao D, Carbajal S, Kiguchi K, DiGiovanni J. Stat3 binds to mtDNA and regulates mitochondrial gene expression in keratinocytes. J Invest Dermatol 2014; 134:1971-80; PMID:24496235; http://dx.doi.org/10.1038/jid.2014.68
   PubMed Web of Science ®Google Scholar
• Kramer AH, Edkins AL, Hoppe HC, Prinsloo E. Dynamic Mitochondrial Localisation of STAT3 in the Cellular Adipogenesis Model 3T3-L1. J Cell Biochem 2015; 116:1232-40; PMID:25565605; http://dx.doi.org/10.1002/jcb.25076
   PubMed Web of Science ®Google Scholar
• Zhao P, Stephens JM. Identification of STAT target genes in adipocytes. JAKSTAT 2013; 1-7; PMID:24058802
   PubMedGoogle Scholar
• Gregoire FM, Smas CM, Sul HS. Understanding adipocyte differentiation. Physiol Rev 1998; 78:783-809; PMID:9674695
   PubMed Web of Science ®Google Scholar
• Otto TC, Lane MD. Adipose development: from stem cell to adipocyte. Crit Rev Biochem Mol Biol 2005; 40:229-242; PMID:16126487; http://dx.doi.org/10.1080/10409230591008189
   PubMed Web of Science ®Google Scholar
• Tang Q-Q, Otto TC, Lane MD. Mitotic clonal expansion: a synchronous process required for adipogenesis. Proc Natl Acad Sci 2003; 100:44-49; PMID:12502791; http://dx.doi.org/10.1073/pnas.0137044100
   PubMed Web of Science ®Google Scholar
• Janderová L, McNeil M, Murrell AN, Mynatt RL, Smith SR. Human mesenchymal stem cells as an in vitro model for human adipogenesis. Obes Res 2003; 11:65-74; PMID:12529487; http://dx.doi.org/10.1038/oby.2003.11
   PubMedGoogle Scholar
• Green H, Kehinde O. An established preadipose cell line and its differentiation in culture.II. Factors affecting the adipose conversion. Cell 1975; 5:19-27; PMID:165899; http://dx.doi.org/10.1016/0092-8674(75)90087-2
   PubMed Web of Science ®Google Scholar
• Rubin CS, Hirsch A, Fung C, Rosen OM. Development of hormone receptors and hormonal responsiveness in vitro. Insulin receptors and insulin sensitivity in the preadipocyte and adipocyte forms of 3T3-L1 cells. J Biol Chem 1978; 253:7570-7578; PMID:81205
   PubMed Web of Science ®Google Scholar
• Russell TR, Ho RJ. Conversion of 3T3 fibroblasts into adipose cells: triggering of differentiation by prostaglandin F2alpha and 1-methyl-3-isobutyl xanthine. Proc Natl Acad Sci 1976; 73:4516-4520; PMID:188043; http://dx.doi.org/10.1073/pnas.73.12.4516
   PubMed Web of Science ®Google Scholar
• Zebisch K, Voigt V, Wabitsch M, Brandsch M. Protocol for effective differentiation of 3T3-L1 cells to adipocytes. Anal Biochem 2012; 425:88-90; PMID:22425542; http://dx.doi.org/10.1016/j.ab.2012.03.005
   PubMed Web of Science ®Google Scholar
• Brand MD. The sites and topology of mitochondrial superoxide production. Exp Gerontol 2010; 45, 466-72; PMID:20064600; http://dx.doi.org/10.1016/j.exger.2010.01.003
   PubMed Web of Science ®Google Scholar
• Kobayashi CI, Suda T. Regulation of reactive oxygen species in stem cells and cancer stem cells. J Cell Physiol 2012; 227:421-30; PMID:21448925; http://dx.doi.org/10.1002/jcp.22764
   PubMed Web of Science ®Google Scholar
• Finkel T. Signal transduction by mitochondrial oxidants. J Biol Chem 2012; 287:4434-40; PMID:21832045; http://dx.doi.org/10.1074/jbc.R111.271999
   PubMed Web of Science ®Google Scholar
• Lefterova MI, Haakonsson AK, Lazar MA, Mandrup S. PPARγ and the global map of adipogenesis and beyond. Trends Endocrinol Metab 2014; 25:293-302; PMID:24793638; http://dx.doi.org/10.1016/j.tem.2014.04.001
   PubMed Web of Science ®Google Scholar
• Furukawa S, Fujita T, Shimabukuro M, Iwaki M, Yamada Y, Nakajima Y, Nakayama O, Makishima M, Matsuda M, Shimomura I. Increased oxidative stress in obesity and its impact on metabolic syndrome. J Clin Invest 2004; 114:1752-61; PMID:15599400; http://dx.doi.org/10.1172/JCI21625
   PubMed Web of Science ®Google Scholar
• Tormos KV, Anso E, Hamanaka RB, Eisenbart J, Joseph J, Kalyanaraman B, Chandel NS. Mitochondrial complex III ROS regulate adipocyte differentiation. Cell Metab 2011; 14:537-44; PMID:21982713; http://dx.doi.org/10.1016/j.cmet.2011.08.007
   PubMed Web of Science ®Google Scholar
• Kanda Y, Hinata T, Kang SW, Watanabe Y. Reactive oxygen species mediate adipocyte differentiation in mesenchymal stem cells. Life Sci 2011; 89:250-8; PMID:21722651; http://dx.doi.org/10.1016/j.lfs.2011.06.007
   PubMed Web of Science ®Google Scholar
• Xu D, Yin C, Wang S, Xiao Y. JAK-STAT in lipid metabolism of adipocytes. Jak-Stat 2013; 2:e27203; PMID:24498541; http://dx.doi.org/10.4161/jkst.27203
   PubMedGoogle Scholar
• Meier JA, Larner AC. Toward a new STATe: The role of STATs in mitochondrial function. Semin Immunol 2014; 26:20-28; PMID:24434063; http://dx.doi.org/10.1016/j.smim.2013.12.005
   PubMed Web of Science ®Google Scholar
• Huang Y, Qiu J, Dong S, Redell MS, Poli V, Mancini MA, Tweardy D. J Stat3 isoforms, alpha and beta, demonstrate distinct intracellular dynamics with prolonged nuclear retention of Stat3beta mapping to its unique C-terminal end. J Biol Chem 2007; 282:34958-34967; PMID:17855361; http://dx.doi.org/10.1074/jbc.M704548200
   PubMed Web of Science ®Google Scholar
• Ng IHW, Ng DCH, Jans DA, Bogoyevitch MA. Selective STAT3-α or –β expression reveals spliceform-specific phosphorylation kinetics, nuclear retention and distinct gene expression outcomes. Biochem J 2012; 447:125-36; PMID:22799634; http://dx.doi.org/10.1042/BJ20120941
   PubMed Web of Science ®Google Scholar
• Deng J, Hua K, Caveney EJ, Takahashi N, Harp JB. Protein inhibitor of activated STAT3 inhibits adipogenic gene expression. Biochem Biophys Res Commun 2006; 339:923-31; PMID:16329991; http://dx.doi.org/10.1016/j.bbrc.2005.10.217
   PubMed Web of Science ®Google Scholar
• Andersson CX, Sopasakis VR, Wallerstedt E, Smith U. Insulin antagonizes interleukin-6 signaling and is anti-inflammatory in 3T3-L1 adipocytes. J Biol Chem 2007; 282:9430-5; PMID:17267401; http://dx.doi.org/10.1074/jbc.M609980200
   PubMed Web of Science ®Google Scholar
• Chung J, Uchida E, Grammer TC, Blenis J. STAT3 serine phosphorylation by ERK-dependent and -independent pathways negatively modulates its tyrosine phosphorylation. Mol Cell Biol 1997; 17:6508-16; PMID:9343414
   PubMed Web of Science ®Google Scholar
• Chueh FY, Leong KF, Yu, CL. Mitochondrial translocation of signal transducer and activator of transcription 5 (STAT5) in leukemic T cells and cytokine-stimulated cells. Biochem Biophys Res Commun 2010; 402:778-783; PMID:21036145; http://dx.doi.org/10.1016/j.bbrc.2010.10.112
   PubMed Web of Science ®Google Scholar
• Khan R, Lee JE, Yang Y-M, Liang F-X, Sehgal PB. Live-cell imaging of the association of STAT6-GFP with mitochondria. PLoS One 2013; 8:e55426; PMID:23383189; http://dx.doi.org/10.1371/journal.pone.0055426
   PubMedGoogle Scholar
• Xu F, Mukhopadhyay S, Sehgal PB. Live cell imaging of interleukin-6-induced targeting of ‘transcription factor’ STAT3 to sequestering endosomes in the cytoplasm. Am J Physiol Cell Physiol 2007; 293:C1374-82; PMID:17670892; http://dx.doi.org/10.1152/ajpcell.00220.2007
   PubMedGoogle Scholar
• Timofeeva OA, Chasovskikh S, Lonskaya I, Tarasova NI, Khavrutskii L, Tarasov SG, Zhang X, Korostyshevskiy VR, Cheema A, Zhang L, et al. Mechanisms of unphosphorylated STAT3 transcription factor binding to DNA. J Biol Chem 2012; 287:14192-200; PMID:22378781; http://dx.doi.org/10.1074/jbc.M111.323899
   PubMed Web of Science ®Google Scholar
• Boengler K, Hilfiker-Kleiner D, Heusch G, Schulz R. Inhibition of permeability transition pore opening by mitochondrial STAT3 and its role in myocardial ischemia/reperfusion. Basic Res Cardiol 2010; 105:771-85; PMID:20960209; http://dx.doi.org/10.1007/s00395-010-0124-1
   PubMed Web of Science ®Google Scholar
• Tammineni P, Anugula C, Mohammed F, Anjaneyulu M, Larner AC, Sepuri NB. The import of the transcription factor STAT3 into mitochondria depends on GRIM-19, a component of the electron transport chain. J Biol Chem 2013; 288:4723-32; PMID:23271731; http://dx.doi.org/10.1074/jbc.M112.378984
   PubMed Web of Science ®Google Scholar
• Lufei C, Ma J, Huang G, Zhang T, Novotny-Diermayr V, Ong CT, Cao X. GRIM-19, a death-regulatory gene product, suppresses Stat3 activity via functional interaction. EMBO J 2003; 22:1325-35; PMID:12628925; http://dx.doi.org/10.1093/emboj/cdg135
   PubMed Web of Science ®Google Scholar
• Zhang J, Yang J, Roy SK, Tininini S, Hu J, Bromberg JF, Poli V, Stark GR, Kalvakolanu DV. The cell death regulator GRIM-19 is an inhibitor of signal transducer and activator of transcription 3. Proc Natl Acad Sci U S A 2003; 100:9342-7; PMID:12867595; http://dx.doi.org/10.1073/pnas.1633516100
   PubMed Web of Science ®Google Scholar
• Zhang Q, Raje V, Yakovlev VA, Yacoub A, Szczepanek K, Meier J, Derecka M, Chen Q, Hu Y, Sisler J, et al. Mitochondrial localized Stat3 promotes breast cancer growth via phosphorylation of serine 727. J Biol Chem 2013; 288:31280-8; PMID:24019511; http://dx.doi.org/10.1074/jbc.M113.505057
   PubMed Web of Science ®Google Scholar
• Phillips D, Reilley MJ, Aponte AM, Wang G, Boja E, Gucek M, Balaban RS. Stoichiometry of STAT3 and mitochondrial proteins: Implications for the regulation of oxidative phosphorylation by protein-protein interactions. J Biol Chem 2010; 285:23532-6; PMID:20558729; http://dx.doi.org/10.1074/jbc.C110.152652
   PubMed Web of Science ®Google Scholar
• Sabater D, Arriarán S, Romero Mdel M, Agnelli S, Remesar X, Fernández-López JA, Alemany M. Cultured 3T3L1 adipocytes dispose of excess medium glucose as lactate under abundant oxygen availability. Sci Rep 2014; 4:3663; PMID:24413028; http://dx.doi.org/10.1038/srep03663
   PubMed Web of Science ®Google Scholar
• Demaria M, Giorgi C, Lebiedzinska M, Esposito G, D'Angeli L, Bartoli A, Gough DJ, Turkson J, Levy DE, Watson CJ, et al. A STAT3-mediated metabolic switch is involved in tumour transformation and STAT3 addiction. Aging (Albany. NY) 2010; 2:823-42; PMID:21084727
   PubMedGoogle Scholar
• López-Lázaro M. The warburg effect: why and how do cancer cells activate glycolysis in the presence of oxygen? Anticancer Agents Med Chem 2008; 8:305-12; PMID:18393789; http://dx.doi.org/10.2174/187152008783961932
   PubMed Web of Science ®Google Scholar
• Ruckenstuhl C, Büttner S, Carmona-Gutierrez D, Eisenberg T, Kroemer G, Sigrist SJ, Fröhlich KU, Madeo F. The Warburg effect suppresses oxidative stress induced apoptosis in a yeast model for cancer. PLoS One 2009; 4:e4592; PMID:19240798; http://dx.doi.org/10.1371/journal.pone.0004592
   PubMed Web of Science ®Google Scholar
• Ito K, Suda T. Metabolic requirements for the maintenance of self-renewing stem cells. Nat Rev Mol Cell Biol 2014; 15:243-56; PMID:24651542; http://dx.doi.org/10.1038/nrm3772
   PubMed Web of Science ®Google Scholar
• Baer PC, Geiger H. Adipose-derived mesenchymal stromal/stem cells: tissue localization, characterization, and heterogeneity. Stem Cells Int 2012; 2012:812693; PMID:22577397; http://dx.doi.org/10.1155/2012/812693
   PubMed Web of Science ®Google Scholar
• Feng Y, Dangelmajer S, Lee YM, Wijesekera O, Castellanos CX, Denduluri A, Chaichana KL, Li Q, Zhang H, Levchenko A, et al. Hypoxia-cultured human adipose-derived mesenchymal stem cells are non-oncogenic and have enhanced viability, motility, and tropism to brain cancer. Cell Death Dis 2014; 5:e1567; PMID:25501828; http://dx.doi.org/10.1038/cddis.2014.521
   PubMed Web of Science ®Google Scholar