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Research Paper

Constitutive IFNα/β signaling maintains expression of signaling intermediaries for efficient cytokine responses

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Article: e1173804 | Received 09 Feb 2016, Accepted 29 Mar 2016, Published online: 18 May 2016

REFERENCES

  • Bartee E, Mohamed MR, McFadden G. Tumor necrosis factor and interferon: cytokines in harmony. Curr Opin Microbiol 2008; 11:378-83; PMID:18595771; http://dx.doi.org/10.1016/j.mib.2008.05.015
  • Paludan SR. Synergistic action of pro-inflammatory agents: cellular and molecular aspects. J Leukoc Biol 2000; 67:18-25; PMID:10647993.
  • Bartee E, Mohamed MR, Lopez MC, Baker HV, McFadden G. The addition of tumor necrosis factor plus β interferon induces a novel synergistic antiviral state against poxviruses in primary human fibroblasts. J Virol 2009; 83:498-511; PMID:18971273; http://dx.doi.org/10.1128/JVI.01376-08
  • Yarilina A, Park-Min KH, Antoniv T, Hu X, Ivashkiv LB. TNF activates an IRF1-dependent autocrine loop leading to sustained expression of chemokines and STAT1-dependent type I interferon-response genes. Nat Immunol 2008; 9:378-87; PMID: 18345002; http://dx.doi.org/10.1038/ni1576
  • Pfeffer LM, Kim JG, Pfeffer SR, Carrigan DJ, Baker DP, Wei L, Homayouni R. Role of nuclear factor-kappaB in the antiviral action of interferon and interferon-regulated gene expression. J Biol Chem 2004; 279:31304-11; PMID:15131130; http://dx.doi.org/10.1074/jbc.M308975200
  • Onozaki K, Urawa H, Tamatani T, Iwamura Y, Hashimoto T, Baba T, Suzuki H, Yamada M, Yamamoto S, Oppenheim JJ, et al. Synergistic interactions of interleukin 1, interferon-β, and tumor necrosis factor in terminally differentiating a mouse myeloid leukemic cell line (M1). Evidence that interferon-β is an autocrine differentiating factor. J Immunol 1988; 140:112-9; PMID:3275716.
  • Gao PQ, Sims SH, Chang DC, Deisseroth AB. Interferon-gamma priming effects in the activation and deactivation of ISGF3 in K562 cells. J Biol Chem 1993; 268:12380-7; PMID:8509377.
  • Improta T, Pine R, Pfeffer LM. Interferon-gamma potentiates the antiviral activity and the expression of interferon-stimulated genes induced by interferon-α in U937 cells. J Interferon Res 1992; 12:87-94; PMID:1315834; http://dx.doi.org/10.1089/jir.1992.12.87
  • Sainz B, Jr, Halford WP. Alpha/Beta interferon and gamma interferon synergize to inhibit the replication of herpes simplex virus type 1. J Virol 2002; 76:11541-50; PMID:12388715; http://dx.doi.org/10.1128/JVI.76.22.11541-11550.2002
  • Mossel EC, Sainz B, Jr, Garry RF, Peters CJ. Synergistic inhibition of SARS-coronavirus replication by type I and type II IFN. Adv Exp Med Biol 2006; 581:503-6; PMID:17037585; http://dx.doi.org/10.1007/978-0-387-33012-9_89
  • Durbin JE, Hackenmiller R, Simon MC, Levy DE. Targeted disruption of the mouse Stat1 gene results in compromised innate immunity to viral disease. Cell 1996; 84:443-50; PMID:8608598; http://dx.doi.org/10.1016/S0092-8674(00)81289-1
  • Meraz MA, White JM, Sheehan KC, Bach EA, Rodig SJ, Dighe AS, Kaplan DH, Riley JK, Greenlund AC, Campbell D, et al. Targeted disruption of the Stat1 gene in mice reveals unexpected physiologic specificity in the JAK-STAT signaling pathway. Cell 1996; 84:431-42; PMID:8608597; http://dx.doi.org/10.1016/S0092-8674(00)81288-X
  • Gil MP, Bohn E, O'Guin AK, Ramana CV, Levine B, Stark GR, Virgin HW, Schreiber RD. Biologic consequences of Stat1-independent IFN signaling. Proc Natl Acad Sci U S A 2001; 98:6680-5; PMID:11390995; http://dx.doi.org/10.1073/pnas.111163898
  • Ramana CV, Gil MP, Schreiber RD, Stark GR. Stat1-dependent and -independent pathways in IFN-gamma-dependent signaling. Trends Immunol 2002; 23:96-101; PMID:11929133; http://dx.doi.org/10.1016/S1471-4906(01)02118-4
  • Bach EA, Aguet M, Schreiber RD. The IFN gamma receptor: a paradigm for cytokine receptor signaling. Annu Rev Immunol 1997; 15:563-91; PMID:9143700; http://dx.doi.org/10.1146/annurev.immunol.15.1.563
  • Gough DJ, Levy DE, Johnstone RW, Clarke CJ. IFNgamma signaling-does it mean JAK-STAT? Cytokine Growth Factor Rev 2008; 19:383-94; PMID:18929502; http://dx.doi.org/10.1016/j.cytogfr.2008.08.004
  • Dezfouli S, Hatzinisiriou I, Ralph SJ. Enhancing CTL responses to melanoma cell vaccines in vivo: synergistic increases obtained using IFNgamma primed and IFNbeta treated B7-1+ B16-F10 melanoma cells. Immunol Cell Biol 2003; 81:459-71; PMID:14636243; http://dx.doi.org/10.1046/j.0818-9641.2003.01189.x
  • Robinson CM, Shirey KA, Carlin JM. Synergistic transcriptional activation of indoleamine dioxygenase by IFN-gamma and tumor necrosis factor-α. J Interferon Cytokine Res 2003; 23:413-21; PMID:13678429; http://dx.doi.org/10.1089/107999003322277829
  • Takaoka A, Mitani Y, Suemori H, Sato M, Yokochi T, Noguchi S, Tanaka N, Taniguchi T. Cross talk between interferon-gamma and -α/β signaling components in caveolar membrane domains. Science 2000; 288:2357-60; PMID:10875919; http://dx.doi.org/10.1126/science.288.5475.2357
  • Phipps-Yonas H, Seto J, Sealfon SC, Moran TM, Fernandez-Sesma A. Interferon-β pretreatment of conventional and plasmacytoid human dendritic cells enhances their activation by influenza virus. PLoS Pathog 2008; 4:e1000193; PMID:18974865; http://dx.doi.org/10.1371/journal.ppat.1000193
  • Hamilton JA, Whitty GA, Kola I, Hertzog PJ. Endogenous IFN-α β suppresses colony-stimulating factor (CSF)-1-stimulated macrophage DNA synthesis and mediates inhibitory effects of lipopolysaccharide and TNF-α. J Immunol 1996; 156:2553-7; PMID:8786318.
  • Vogel SN, Fertsch D. Endogenous interferon production by endotoxin-responsive macrophages provides an autostimulatory differentiation signal. Infect Immun 1984; 45:417-23; PMID:6378797.
  • Gough DJ, Messina NL, Hii L, Gould JA, Sabapathy K, Robertson AP, Trapani JA, Levy DE, Hertzog PJ, Clarke CJ, et al. Functional crosstalk between type I and II interferon through the regulated expression of STAT1. PLoS Biol 2010; 8:e1000361; PMID:20436908; http://dx.doi.org/10.1371/journal.pbio.1000361
  • Nickolaus P, Zawatzky R. Inhibition by interleukin-4 of constitutive β interferon synthesis in mouse macrophages. J Virol 1994; 68:6763-6; PMID:8084010.
  • Karaghiosoff M, Neubauer H, Lassnig C, Kovarik P, Schindler H, Pircher H, McCoy B, Bogdan C, Decker T, Brem G, et al. Partial impairment of cytokine responses in Tyk2-deficient mice. Immunity 2000; 13:549-60; PMID:11070173; http://dx.doi.org/10.1016/S1074-7613(00)00054-6
  • Park C, Li S, Cha E, Schindler C. Immune response in Stat2 knockout mice. Immunity 2000; 13:795-804; PMID:11163195; http://dx.doi.org/10.1016/S1074-7613(00)00077-7
  • Mitani Y, Takaoka A, Kim SH, Kato Y, Yokochi T, Tanaka N, Taniguchi T. Cross talk of the interferon-α/β signalling complex with gp130 for effective interleukin-6 signalling. Genes Cells 2001; 6:631-40; PMID:11473581; http://dx.doi.org/10.1046/j.1365-2443.2001.00448.x
  • Bartee E, McFadden G. Cytokine synergy: an underappreciated contributor to innate anti-viral immunity. Cytokine 2013; 63:237-40; PMID:23693158; http://dx.doi.org/10.1016/j.cyto.2013.04.036
  • Rayamajhi M, Humann J, Penheiter K, Andreasen K, Lenz LL. Induction of IFN-alphabeta enables Listeria monocytogenes to suppress macrophage activation by IFN-gamma. J Exp Med 2010; 207:327-37; PMID:20123961; http://dx.doi.org/10.1084/jem.20091746
  • Ruggiero V, Tavernier J, Fiers W, Baglioni C. Induction of the synthesis of tumor necrosis factor receptors by interferon-gamma. J Immunol 1986; 136:2445-50; PMID:3005411.
  • Aggarwal BB, Eessalu TE, Hass PE. Characterization of receptors for human tumour necrosis factor and their regulation by gamma-interferon. Nature 1985; 318:665-7; PMID:3001529; http://dx.doi.org/10.1038/318665a0
  • Clarke DL, Clifford RL, Jindarat S, Proud D, Pang L, Belvisi M, Knox AJ. TNFalpha and IFNgamma synergistically enhance transcriptional activation of CXCL10 in human airway smooth muscle cells via STAT-1, NF-kappaB, and the transcriptional coactivator CREB-binding protein. J Biol Chem 2010; 285:29101-10; PMID:20833730; http://dx.doi.org/10.1074/jbc.M109.099952
  • Qiao Y, Giannopoulou EG, Chan CH, Park SH, Gong S, Chen J, Hu X, Elemento O, Ivashkiv LB. Synergistic activation of inflammatory cytokine genes by interferon-gamma-induced chromatin remodeling and toll-like receptor signaling. Immunity 2013; 39:454-69; PMID:24012417; http://dx.doi.org/10.1016/j.immuni.2013.08.009
  • Klampfer L, Huang J, Kaler P, Sasazuki T, Shirasawa S, Augenlicht L. STAT1-independent inhibition of cyclooxygenase-2 expression by IFNgamma; a common pathway of IFNgamma-mediated gene repression but not gene activation. Oncogene 2007; 26:2071-81; PMID:17016440; http://dx.doi.org/10.1038/sj.onc.1210015
  • Xu Y, Harton JA, Smith BD. CIITA mediates interferon-gamma repression of collagen transcription through phosphorylation-dependent interactions with co-repressor molecules. J Biol Chem 2008; 283:1243-56; PMID:17991736; http://dx.doi.org/10.1074/jbc.M707180200
  • Li P, Zhao Y, Wu X, Xia M, Fang M, Iwasaki Y, Sha J, Chen Q, Xu Y, Shen A. Interferon gamma (IFN-gamma) disrupts energy expenditure and metabolic homeostasis by suppressing SIRT1 transcription. Nucleic Acids Res 2012; 40:1609-20; PMID:22064865; http://dx.doi.org/10.1093/nar/gkr984
  • Weng X, Cheng X, Wu X, Xu H, Fang M, Xu Y. Sin3B mediates collagen type I gene repression by interferon gamma in vascular smooth muscle cells. Biochem Biophys Res Commun 2014; 447:263-70; PMID:24709079; http://dx.doi.org/10.1016/j.bbrc.2014.03.140
  • Der SD, Zhou A, Williams BR, Silverman RH. Identification of genes differentially regulated by interferon α, β, or gamma using oligonucleotide arrays. Proc Natl Acad Sci U S A 1998; 95:15623-8; PMID:9861020; http://dx.doi.org/10.1073/pnas.95.26.15623
  • Hu X, Herrero C, Li WP, Antoniv TT, Falck-Pedersen E, Koch AE, Woods JM, Haines GK, Ivashkiv LB. Sensitization of IFN-gamma Jak-STAT signaling during macrophage activation. Nat Immunol 2002; 3:859-66; PMID:12172544; http://dx.doi.org/10.1038/ni828
  • Wong LH, Hatzinisiriou I, Devenish RJ, Ralph SJ. IFN-gamma priming up-regulates IFN-stimulated gene factor 3 (ISGF3) components, augmenting responsiveness of IFN-resistant melanoma cells to type I IFNs. J Immunol 1998; 160:5475-84; PMID:9605150.
  • Peng T, Zhu J, Hwangbo Y, Corey L, Bumgarner RE. Independent and cooperative antiviral actions of β interferon and gamma interferon against herpes simplex virus replication in primary human fibroblasts. J Virol 2008; 82:1934-45; PMID:18057251; http://dx.doi.org/10.1128/JVI.01649-07
  • Muller M, Laxton C, Briscoe J, Schindler C, Improta T, Darnell JE, Jr, Stark GR, Kerr IM. Complementation of a mutant cell line: central role of the 91 kDa polypeptide of ISGF3 in the interferon-α and -gamma signal transduction pathways. EMBO J 1993; 12:4221-8; PMID:7693454.
  • Brucet M, Marques L, Sebastian C, Lloberas J, Celada A. Regulation of murine Tap1 and Lmp2 genes in macrophages by interferon gamma is mediated by STAT1 and IRF-1. Genes Immun 2004; 5:26-35; PMID:14735146; http://dx.doi.org/10.1038/sj.gene.6364035
  • Rouyez MC, Lestingi M, Charon M, Fichelson S, Buzyn A, Dusanter-Fourt I. IFN regulatory factor-2 cooperates with STAT1 to regulate transporter associated with antigen processing-1 promoter activity. J Immunol 2005; 174:3948-58; PMID:15778351; http://dx.doi.org/10.4049/jimmunol.174.7.3948
  • Min W, Pober JS, Johnson DR. Kinetically coordinated induction of TAP1 and HLA class I by IFN-gamma: the rapid induction of TAP1 by IFN-gamma is mediated by Stat1 α. J Immunol 1996; 156:3174-83; PMID:8617938.
  • Miyagi T, Gil MP, Wang X, Louten J, Chu WM, Biron CA. High basal STAT4 balanced by STAT1 induction to control type 1 interferon effects in natural killer cells. J Exp Med 2007; 204:2383-96; PMID:17846149; http://dx.doi.org/10.1084/jem.20070401
  • Huang Y, Lei Y, Zhang H, Hou L, Zhang M, Dayton AI. MicroRNA regulation of STAT4 protein expression: rapid and sensitive modulation of IL-12 signaling in human natural killer cells. Blood 2011; 118:6793-802; PMID:22077060; http://dx.doi.org/10.1182/blood-2011-05-356162
  • Auphan N, Di Donato JA, Rosette C, Helmberg A, Karin M. Immunosuppression by glucocorticoids: inhibition of NF-kappa B activity through induction of I kappa B synthesis. Science 1995; 270:286-90; PMID:7569976; http://dx.doi.org/10.1126/science.270.5234.286
  • Weihua X, Hu J, Roy SK, Mannino SB, Kalvakolanu DV. Interleukin-6 modulates interferon-regulated gene expression by inducing the ISGF3 gamma gene using CCAAT/enhancer binding protein-β(C/EBP-β). Biochim Biophys Acta 2000; 1492:163-71; PMID:11004486; http://dx.doi.org/10.1016/S0167-4781(00)00111-1
  • Hayes MP, Zoon KC. Priming of human monocytes for enhanced lipopolysaccharide responses: expression of α interferon, interferon regulatory factors, and tumor necrosis factor. Infect Immun 1993; 61:3222-7; PMID:8335353.
  • von Bernuth H, Picard C, Puel A, Casanova JL. Experimental and natural infections in MyD88- and IRAK-4-deficient mice and humans. Eur J Immunol 2012; 42:3126-35; PMID:23255009; http://dx.doi.org/10.1002/eji.201242683
  • Kawai T, Adachi O, Ogawa T, Takeda K, Akira S. Unresponsiveness of MyD88-deficient mice to endotoxin. Immunity 1999; 11:115-22; PMID:10435584; http://dx.doi.org/10.1016/S1074-7613(00)80086-2
  • Gouwy M, Struyf S, Proost P, Van Damme J. Synergy in cytokine and chemokine networks amplifies the inflammatory response. Cytokine Growth Factor Rev 2005; 16:561-80; PMID:16023396; http://dx.doi.org/10.1016/j.cytogfr.2005.03.005
  • Sharif MN, Tassiulas I, Hu Y, Mecklenbrauker I, Tarakhovsky A, Ivashkiv LB. IFN-α priming results in a gain of proinflammatory function by IL-10: implications for systemic lupus erythematosus pathogenesis. J Immunol 2004; 172:6476-81; PMID:15128840; http://dx.doi.org/10.4049/jimmunol.172.10.6476
  • Reis LF, Ho Lee T, Vilcek J. Tumor necrosis factor acts synergistically with autocrine interferon-β and increases interferon-β mRNA levels in human fibroblasts. J Biol Chem 1989; 264:16351-4; PMID:2550437.
  • Hwang SY, Hertzog PJ, Holland KA, Sumarsono SH, Tymms MJ, Hamilton JA, Whitty G, Bertoncello I, Kola I. A null mutation in the gene encoding a type I interferon receptor component eliminates antiproliferative and antiviral responses to interferons α and β and alters macrophage responses. Proc Natl Acad Sci U S A 1995; 92:11284-8; PMID:7479980; http://dx.doi.org/10.1073/pnas.92.24.11284
  • Irizarry RA, Hobbs B, Collin F, Beazer-Barclay YD, Antonellis KJ, Scherf U, Speed TP. Exploration, normalization, and summaries of high density oligonucleotide array probe level data. Biostatistics 2003; 4:249-64; PMID:12925520; http://dx.doi.org/10.1093/biostatistics/4.2.249
  • Smyth GK. Linear models and empirical bayes methods for assessing differential expression in microarray experiments. Stat Appl Genet Mol Biol 2004; 3:1-25; PMID:16646809.
  • de Hoon MJ, Imoto S, Nolan J, Miyano S. Open source clustering software. Bioinformatics 2004; 20:1453-4; PMID:14871861; http://dx.doi.org/10.1093/bioinformatics/bth078
  • Saldanha AJ. Java Treeview–extensible visualization of microarray data. Bioinformatics 2004; 20:3246-8; PMID:15180930; http://dx.doi.org/10.1093/bioinformatics/bth349

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