786
Views
17
CrossRef citations to date
0
Altmetric
Author's View

A novel targeted immunotherapy for CTCL is on its way: Anti-KIR3DL2 mAb IPH4102 is potent and safe in non-clinical studies

, , , , &
Article: e1022306 | Received 13 Jan 2015, Accepted 19 Feb 2015, Published online: 15 Jun 2015

References

  • Willemze R, Jaffe ES, Burg G, Cerroni L, Berti E, Swerdlow SH, Ralfkiaer E, Chimenti S, Diaz-Perez JL, Duncan LM, et al. WHO-EORTC classification for cutaneous lymphomas. Blood 2005; 105:3768–85; PMID:15692063; http://dx.doi.org/10.1182/blood-2004-09-3502
  • Olsen E, Vonderheid E, Pimpinelli N, Willemze R, Kim Y, Knobler R, Zackheim H, Duvic M, Estrach T, Lamberg S, et al. Revisions to the staging and classification of mycosis fungoides and sezary syndrome: a proposal of the international society for cutaneous lymphomas (ISCL) and the cutaneous lymphoma task force of the european organization of research and treatment of cancer (EORTC). Blood 2007; 110:1713–22; PMID:17540844; http://dx.doi.org/10.1182/blood-2007-03-055749
  • Thielens A, Vivier E, Romagne F. NK cell MHC class I specific receptors (KIR): from biology to clinical intervention. Curr Opinion Immunol 2012; 24:239–45; PMID:22264929; http://dx.doi.org/10.1016/j.coi.2012.01.001
  • Chan AT, Kollnberger SD, Wedderburn LR, Bowness P. Expansion and enhanced survival of natural killer cells expressing the killer immunoglobulin-like receptor KIR3DL2 in spondylarthritis. Arthritis Rheumatism 2005; 52:3586–95; PMID:16255049; http://dx.doi.org/10.1002/art.21395
  • Sako N, Schiavon V, Bounfour T, Dessirier V, Ortonne N, Olive D, Ram-Wolff C, Michel L, Sicard H, Marie-Cardine A, et al. Membrane expression of NK receptors CD160 and CD158k contributes to delineate a unique CD4 T-lymphocyte subset in normal and mycosis fungoides skin. Cytometry Part A 2014; 85:869-82; PMID:25044837; http://dx.doi.org/10.1002/cyto.a.22512
  • Bagot M, Moretta A, Sivori S, Biassoni R, Cantoni C, Bottino C, Boumsell L, Bensussan A. CD4(+) cutaneous T-cell lymphoma cells express the p140-killer cell immunoglobulin-like receptor. Blood 2001; 97:1388–91; PMID:11222384; http://dx.doi.org/10.1182/blood.V97.5.1388
  • Marie-Cardine A, Viaud N, Thonnart N, Joly R, Chanteux S, Gauthier L, Bonnafous C, Rossi B, Blery M, Paturel C, et al. IPH4102, a humanized KIR3DL2 antibody with potent activity against cutaneous T-cell lymphoma. Cancer Res 2014; 74:6060–70; PMID:25361998; http://dx.doi.org/10.1158/0008-5472.CAN-14-1456
  • Alinari L, Lapalombella R, Andritsos L, Baiocchi RA, Lin TS, Byrd JC. Alemtuzumab (Campath-1H) in the treatment of chronic lymphocytic leukemia. Oncogene 2007; 26:3644–53; PMID:17530018; http://dx.doi.org/10.1038/sj.onc.1210380
  • Kim EJ, Hess S, Richardson SK, Newton S, Showe LC, Benoit BM, Ubriani R, Vittorio CC, Junkins-Hopkins JM, Wysocka M, et al. Immunopathogenesis and therapy of cutaneous T cell lymphoma. J Clin Invest 2005; 115:798–812; PMID:15841167; http://dx.doi.org/10.1172/JCI200524826
  • Guenova E, Watanabe R, Teague JE, Desimone JA, Jiang Y, Dowlatshahi M, Schlapbach C, Schaekel K, Rook AH, Tawa M, et al. TH2 cytokines from malignant cells suppress TH1 responses and enforce a global TH2 bias in leukemic cutaneous T-cell lymphoma. Clin Cancer Res 2013; 19:3755–63; PMID:23785046; http://dx.doi.org/10.1158/1078-0432.CCR-12-3488

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.