In vivo potential of recombinant granulysin against human tumors

References

• Peña SV, Hanson DA, Carr BA, Goralski TJ, Krensky AM. Processing, subcellular localization, and function of 519 (granulysin), a human late T cell activation molecule with homology to small, lytic, granule proteins. J Immunol 1997; 158:2680-8; PMID:9058801
   PubMed Web of Science ®Google Scholar
• Clayberger C, Finn MW, Wang T, Saini R, Wilson C, Barr VA, Sabatino M, Castiello L, Stroncek D, Krensky AM. 15 kDa Granulysin Causes Differentiation of Monocytes to Dendritic Cells but Lacks Cytotoxic Activity. J Immunol 2012; 188:6119-26; PMID:22586033; http://dx.doi.org/10.4049/jimmunol.1200570
   PubMed Web of Science ®Google Scholar
• Stenger S, Hanson DA, Teitelbaum R, Dewan P, Niazi KR, Froelich CJ, Ganz T, Thoma-Uszynski S, Melián A, Bogdan C et al. An antimicrobial activity of cytolytic T cells mediated by granulysin. Science 1998; 282:121-5; PMID:9756476; http://dx.doi.org/10.1126/science.282.5386.121
   PubMed Web of Science ®Google Scholar
• Ernst WA, Thoma-Uszynski S, Teitelbaum R, Ko C, Hanson DA, Clayberger C, Krensky AM, Leippe M, Bloom BR, Ganz T et al. Granulysin, a T cell product, kills bacteria by altering membrane permeability. J Immunol 2000; 165:7102-8; PMID:11120840; http://dx.doi.org/10.4049/jimmunol.165.12.7102
   PubMed Web of Science ®Google Scholar
• Ma LL, Spurrell JCL, Wang JF, Neely GG, Epelman S, Krensky AM, Mody CH. CD8 T cell-mediated killing of Cryptcoccus neoformans requires granulysin and is dependent on CD4 T cells and IL-15. J Immunol 2002; 169:5787-95; PMID:12421959; http://dx.doi.org/10.4049/jimmunol.169.10.5787
   PubMed Web of Science ®Google Scholar
• Hata A, Zerboni L, Sommer M, Kaspar A, Clayberger C, Krensky A, Arvin AM. Granulysin blocks replication of varicella-zoster virus and triggers apoptosis of infected cells. Viral Immunol 2001; 14:125-33; PMID:11398808; http://dx.doi.org/10.1089/088282401750234501
   PubMed Web of Science ®Google Scholar
• Ochoa MT, Stenger S, Sieling PA, Thoma-Uszynski S, Sabet S, Cho S, Krensky AM, Rollinghoff M, Nunes Sarno E, Burdick AE et al. T-cell relese of granulysin contributes to host defense in leprosy. Nature Med 2001; 7:174-9; PMID:11175847; http://dx.doi.org/10.1038/84620
   PubMed Web of Science ®Google Scholar
• Walch M, Dotiwala F, Mulik S, Thiery J, Kirchhausen T, Clayberger C, Krensky AM, Martinvalet D, Lieberman J. Cytotoxic Cells Kill Intracellular Bacteria through Granulysin-Mediated Delivery of Granzymes. Cell 2014; 157:1309-23; PMID:24906149; http://dx.doi.org/10.1016/j.cell.2014.03.062
   PubMed Web of Science ®Google Scholar
• Aporta A, Catalán E, Galán-Malo P, Ramírez-Labrada A, Pérez M, Azaceta G, Palomera L, Naval J, Marzo I, Pardo J et al. Granulysin induces apoptotic cell death and cleavage of the autophagy regulator Atg5 in human hematological tumors. Biochem Pharmacol 2014; 87:410-23; PMID:24269628; http://dx.doi.org/10.1016/j.bcp.2013.11.004
   PubMed Web of Science ®Google Scholar
• Gamen S, Hanson DA, Kaspar A, Naval J, Krensky AM, Anel A. Granulysin-induced apoptosis. I. Involvement of at least two distinct pathways. J Immunol 1998; 161:1758-64; PMID:9712041
   PubMed Web of Science ®Google Scholar
• Pardo J, Pérez-Galán P, Gamen S, Marzo I, Monleón I, Kaspar AA, Susín SA, Kroemer G, Krensky AM, Naval J et al. A role of the mitochondrial apoptosis-inducing factor (AIF) in granulysin-induced apoptosis. J Immunol 2001; 167:1222-9; PMID:11466337; http://dx.doi.org/10.4049/jimmunol.167.3.1222
   PubMed Web of Science ®Google Scholar
• Tewary P, Yang D, de la Rosa G, Li Y, Krensky AM, Clayberger C, Oppenheim JJ. Granulysin activates antigen-presenting cells through TLR4 and acts as an immune alarmin. Blood 2010; 116:3465-74; PMID:20660289; http://dx.doi.org/10.1182/blood-2010-03-273953
   PubMed Web of Science ®Google Scholar
• Kaspar AA, Okada S, Kumar J, Poulain FR, Drouvalakis KA, Kelekar A, Hanson DA, Kluck RM, Hitoshi Y, Johnson DE et al. A distinct pathway of cell-mediated apoptosis initiated by granulysin. J Immunol 2001; 167:350-6; PMID:11418670; http://dx.doi.org/10.4049/jimmunol.167.1.350
   PubMed Web of Science ®Google Scholar
• Okada S, Li Q, Whitin JC, Clayberger C, Krensky AM. Intracellular mediators of granulysin-induced cell death. J Immunol 2003; 171:2556-62; PMID:12928406; http://dx.doi.org/10.4049/jimmunol.171.5.2556
   PubMed Web of Science ®Google Scholar
• Saini RV, Wilson C, Finn MW, Wang T, Krensky AM, Clayberger C. Granulysin delivered by cytotoxic cells damages endoplasmic reticulum and activates caspase-7 in target cells. J Immunol 2011; 186:4497-3504; PMID:21296981; http://dx.doi.org/10.4049/jimmunol.1003409
   PubMed Web of Science ®Google Scholar
• Dunn GP, Bruce AT, Ikeda H, Old LJ, Schreiber RD. Cancer immunoediting : from immunosurveillance to tumor escape. Nature Immunol 2002; 3:991-8; PMID:12407406; http://dx.doi.org/10.1038/ni1102-991
   PubMed Web of Science ®Google Scholar
• Kishi A, Takamori Y, Ogawa K, Takano S, Tomita S, Tanigawa M, Niman M, Kishida T, Fujita S. Differential expression of granulysin and perforin by NK cells in cancer patients and correlation of impaired granulysin expression with progression of cancer. Cancer Immunol Immunother 2002; 50:604-14; PMID:11807624; http://dx.doi.org/10.1007/s002620100228
   PubMed Web of Science ®Google Scholar
• Pagès F, Berger A, Camus M, Sanchez-Cabo F, Costes A, Molidor R, Mlecnik B, Kirilovsky A, Nilsson M, Damotte D et al. Effector memory T cells, early metastasis, and survival in colorectal Cancer. New Eng J Med 2005; 353:2654-66; PMID:16371631; http://dx.doi.org/10.1056/NEJMoa051424
   PubMed Web of Science ®Google Scholar
• Saigusa S, Ichikura T, Tsujimoto H, Sugasawa H, Majima T, Kawabayashi N, Chochi K, Ono S, Kinoshita M, Seki S et al. Serum granulysin level as a novel prognostic marker in patients with gastric carcinoma. J Gastroenterol Hepatol 2007; 22:1322-7; PMID:17688669; http://dx.doi.org/10.1111/j.1440-1746.2006.04796.x
   PubMed Web of Science ®Google Scholar
• Nagasawa M, Kawamoto H, Tsuji Y, Mizutani S. Transient increase of serum granulysin in a stage IVs neuroblastoma patient during spontaneous regression: case report. Int J Hematol 2005; 82:456-7; PMID:16533752; http://dx.doi.org/10.1532/IJH97.05091
   PubMed Web of Science ®Google Scholar
• Huang LP, Lyu SC, Clayberger C, Krensky AM. Granulysin-mediated tumor rejection in transgenic mice. J Immunol 2007; 178:3688-94; PMID:17182542
   PubMed Web of Science ®Google Scholar
• Ellerby HM, Lee S, Ellerby LM, Chen S, Kiyota T, del Rio G, Sugihara G, Sun Y, Bredesen DE, Arap W et al. An artificially designed pore-forming protein with anti-tumor effects. J Biol Chem 2003; 278:35311-6; PMID:12750379; http://dx.doi.org/10.1074/jbc.M300474200
   PubMed Web of Science ®Google Scholar
• Li Q, Dong C, Deng A, Katsumata M, Nakadai A, Kawada T, Okada S, Clayberger C, Krensky AM. Hemolysis of erythrocytes by granulysin-derived peptides but not by granulysin. Antimicrob Agents Chemother 2005; 49:388-97; PMID:15616319; http://dx.doi.org/10.1128/AAC.49.1.388-397.2005
   PubMed Web of Science ®Google Scholar
• Anel A, Aguiló JI, Catalán E, Garaude J, Rathore MG, Pardo J, Villalba M. Protein kinase C-q (PKC-q) in natural killer cell function and anti-tumor immunity. Front Immunol 2012; 3:187; PMID:22783260; http://dx.doi.org/10.3389/fimmu.2012.00187
   PubMed Web of Science ®Google Scholar
• Chung WH, Hung SI, Yang JY, Su SC, Huang SP, Wei CY, Chin SW, Chiou CC, Chu SC, Ho HC et al. Granulysin is a key mediator for disseminated keratinocyte death in Stevens-Johnson syndrome and toxic epidermal necrolysis. Nature Med 2008; 14:1343-50; PMID:19029983; http://dx.doi.org/10.1038/nm.1884
   PubMed Web of Science ®Google Scholar
• Palumbo A, Anderson K. Multiple myeloma. New Eng J Med 2011; 364:1046-60; PMID:21410373; http://dx.doi.org/10.1056/NEJMra1011442
   PubMed Web of Science ®Google Scholar
• Poltorak A, He X, Smirnova I, Liu M, Van Huffel C, Du X, Birdwell D, Alejos E, Silva M, Galanos C et al. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science 1998; 282:2085-8; PMID:9851930; http://dx.doi.org/10.1126/science.282.5396.2085
   PubMed Web of Science ®Google Scholar
• Takeuchi O, Hoshino K, Kawai T, Sanjo H, Takada H, Ogawa T, Takeda K, Akira S. Differential roles of TLR2 and TLR4 in recognition of gramnegative and gram-positive bacterial cell wall components. Immunity 1999; 11:443-51; PMID:10549626; http://dx.doi.org/10.1016/S1074-7613(00)80119-3
   PubMed Web of Science ®Google Scholar
• Casares N, Pequignot MO, Tesniere A, Ghiringhelli F, Roux S, Chaput N, Schmitt E, Hamai A, Hervas-Stubbs S, Obeid M et al. Caspase-dependent immunogenicity of doxorubicin-induced tumor cell death. J Exp Med 2005; 202:1691-701; PMID:16365148; http://dx.doi.org/10.1084/jem.20050915
   PubMed Web of Science ®Google Scholar
• Vacchelli E, Aranda F, Eggermont A, Galon J, Sautès-Fridman C, Cremer I, Zitvogel L, Kroemer G, Galluzzi L. Trial watch: chemotherapy with immunogenic cell death inducers. OncoImmunol 2014; 3:e27878; PMID:24800173; http://dx.doi.org/10.4161/onci.27878
   PubMed Web of Science ®Google Scholar
• Oganesyan N, Kim SH, Kim R. On-column protein refolding for crystallization. J Struct Func Genomics 2005; 6:177-82; PMID:16211516; http://dx.doi.org/10.1007/s10969-005-2827-3
   PubMedGoogle Scholar