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OncoImmunology Volume 5, 2016 - Issue 5
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Harnessing the IL-7/IL-7Rα axis to improve tumor immunotherapy

C. Bryce JohnsonDepartment of Surgery, Medical University of South Carolina, Charleston, SC
,
John WrangleDepartment of Microbiology & Immunology, Medical University of South Carolina, Charleston, SC
,
Shikhar MehrotraDepartment of Surgery, Medical University of South Carolina, Charleston, SC
,
Zihai LiDepartment of Microbiology & Immunology, Medical University of South Carolina, Charleston, SC
,
Chrystal M. PaulosDepartment of Surgery, Medical University of South Carolina, Charleston, SC;Department of Microbiology & Immunology, Medical University of South Carolina, Charleston, SC
,
David J. ColeDepartment of Surgery, Medical University of South Carolina, Charleston, SC
,
Charles D. SurhAcademy of Immunology and Microbiology, Institute for Basic Science, Pohang, South Korea;Department of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology, Pohang, South Korea;Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, CA, USA
&
Mark P. RubinsteinDepartment of Surgery, Medical University of South Carolina, Charleston, SC;Department of Microbiology & Immunology, Medical University of South Carolina, Charleston, SCCorrespondence[email protected]
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Article: e1122865 | Received 16 Nov 2015, Accepted 16 Nov 2015, Published online: 29 Apr 2016

References

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  • Rubinstein MP, Su EW, Suriano S, Cloud CA, Andrijauskaite K, Kesarwani P, Schwartz KM, Williams KM, Johnson CB, Li M et al. Interleukin-12 enhances the function and anti-tumor activity in murine and human CD8(+) T cells. Cancer Immunol Immunother 2015; 64:539-49; PMID:25676709; http://dx.doi.org/10.1007/s00262-015-1655-y
  • Rubinstein MP, Cloud CA, Garrett TE, Moore CJ, Schwartz KM, Johnson CB, Craig DH, Salem ML, Paulos CM, Cole DJ. Ex vivo interleukin-12-priming during CD8(+) T cell activation dramatically improves adoptive T cell transfer antitumor efficacy in a lymphodepleted host. J Am Coll Surg 2012; 214:700-7; discussion 7–8; PMID:22360982; http://dx.doi.org/10.1016/j.jamcollsurg.2011.12.034
  • Johnson CB, Riesenberg BP, May BR, Gilreath SC, Li G, Staveley-O'Carroll KF, Garrett-Mayer E, Mehrotra S, Cole DJ, Rubinstein MP. Effector CD8+ T-cell Engraftment and Antitumor Immunity in Lymphodepleted Hosts Is IL7Ralpha Dependent. Cancer Immunol Res 2015; 3(12):1364-74; http://dx.doi.org/10.1158/2326-6066
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