Nucleic acid-sensing toll-like receptors 3, 7 and 8 in esophageal epithelium, barrett’s esophagus, dysplasia and adenocarcinoma

References

• Takeda K, Kaisho T, Akira S. Toll-like receptors. Annu Rev Immunol 2003; 21:335–76; PMID:12524386; http://dx.doi.org/10.1146/annurev.immunol.21.120601.141126
   PubMed Web of Science ®Google Scholar
• Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell 2011; 144:646–74; PMID:21376230; http://dx.doi.org/10.1016/j.cell.2011.02.013
   PubMed Web of Science ®Google Scholar
• Wells JM, Rossi O, Meijerink M, van Baarlen P. Epithelial crosstalk at the microbiota-mucosal interface. Proc Natl Acad Sci U S A 2011; 108 Suppl 1:4607–14; PMID:20826446; http://dx.doi.org/10.1073/pnas.1000092107
   PubMed Web of Science ®Google Scholar
• Coste I, Le Corf K, Kfoury A, Hmitou I, Druillennec S, Hainaut P, Eychene A, Lebecque S, Renno T. Dual function of MyD88 in RAS signaling and inflammation, leading to mouse and human cell transformation. J Clin Invest 2010; 120:3663–7; PMID:20941850; http://dx.doi.org/10.1172/JCI42771
   PubMed Web of Science ®Google Scholar
• Takala H, Kauppila JH, Soini Y, Selander KS, Vuopala KS, Lehenkari PP, Saarnio J, Karttunen TJ. Toll-like receptor 9 is a novel biomarker for esophageal squamous cell dysplasia and squamous cell carcinoma progression. J Innate Immun 2011; 3:631–8; PMID:21876325; http://dx.doi.org/10.1159/000329115
   PubMed Web of Science ®Google Scholar
• Kauppila JH, Takala H, Selander KS, Lehenkari PP, Saarnio J, Karttunen TJ. Increased Toll-like receptor 9 expression indicates adverse prognosis in oesophageal adenocarcinoma. Histopathology 2011; 59:643–9; PMID:22014045; http://dx.doi.org/10.1111/j.1365-2559.2011.03991.x
   PubMed Web of Science ®Google Scholar
• Huhta H, Helminen O, Kauppila JH, Takala H, Metsikko K, Lehenkari P, Saarnio J, Karttunen T. Toll-like receptor 9 expression in the natural history of Barrett mucosa. Virchows Arch 2015; 467:9–18; PMID:25838081; http://dx.doi.org/10.1007/s00428-015-1770-3
   PubMed Web of Science ®Google Scholar
• Kauppila JH, Karttunen TJ, Saarnio J, Nyberg P, Salo T, Graves DE, Lehenkari PP, Selander KS. Short DNA sequences and bacterial DNA induce esophageal, gastric, and colorectal cancer cell invasion. APMIS 2013; 121:511–22; PMID:23082743; http://dx.doi.org/10.1111/apm.12016
   PubMed Web of Science ®Google Scholar
• Sheyhidin I, Nabi G, Hasim A, Zhang RP, Ainiwaer J, Ma H, Wang H. Overexpression of TLR3, TLR4, TLR7 and TLR9 in esophageal squamous cell carcinoma. World J Gastroenterol 2011; 17:3745–51; PMID:21990957; http://dx.doi.org/10.3748/wjg.v17.i32.3745
   PubMed Web of Science ®Google Scholar
• Kauppila JH, Selander KS. Toll-like receptors in esophageal cancer. Front Immunol 2014; 5:200; PMID:24847326; http://dx.doi.org/10.3389/fimmu.2014.00200
   PubMed Web of Science ®Google Scholar
• Helminen O, Huhta H, Takala H, Lehenkari PP, Saarnio J, Kauppila JH, Karttunen TJ. Increased Toll-like receptor 5 expression indicates esophageal columnar dysplasia. Virchows Arch 2014; 464:11–8; PMID:24221343; http://dx.doi.org/10.1007/s00428-013-1505-2
   PubMed Web of Science ®Google Scholar
• Cavassani KA, Ishii M, Wen H, Schaller MA, Lincoln PM, Lukacs NW, Hogaboam CM, Kunkel SL. TLR3 is an endogenous sensor of tissue necrosis during acute inflammatory events. J Exp Med 2008; 205:2609–21; PMID:18838547; http://dx.doi.org/10.1084/jem.20081370
   PubMed Web of Science ®Google Scholar
• Uehara A, Fujimoto Y, Fukase K, Takada H. Various human epithelial cells express functional Toll-like receptors, NOD1 and NOD2 to produce anti-microbial peptides, but not proinflammatory cytokines. Mol Immunol 2007; 44:3100–11; PMID:17403538; http://dx.doi.org/10.1016/j.molimm.2007.02.007
   PubMed Web of Science ®Google Scholar
• Lim DM, Wang ML. Toll-like receptor 3 signaling enables human esophageal epithelial cells to sense endogenous danger signals released by necrotic cells. Am J Physiol Gastrointest Liver Physiol 2011; 301:G91–9; PMID:21474651; http://dx.doi.org/10.1152/ajpgi.00471.2010
   PubMedGoogle Scholar
• Verbeek RE, Siersema PD, Ten Kate FJ, Fluiter K, Souza RF, Vleggaar FP, Bus P, van Baal JW. Toll-like receptor 4 activation in Barrett's esophagus results in a strong increase in COX-2 expression. J Gastroenterol 2014; 49:1121–34; PMID:23955118; http://dx.doi.org/10.1007/s00535-013-0862-6
   PubMed Web of Science ®Google Scholar
• Fernandez-Garcia B, Eiro N, Gonzalez-Reyes S, Gonzalez L, Aguirre A, Gonzalez LO, Del Casar JM, García-Muñiz JL, Vizoso FJ. Clinical significance of toll-like receptor 3, 4, and 9 in gastric cancer. J Immunother 2014; 37:77–83; PMID:24509170; http://dx.doi.org/10.1097/CJI.0000000000000016
   PubMed Web of Science ®Google Scholar
• Diebold SS, Kaisho T, Hemmi H, Akira S, Reis e Sousa C. Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA. Science 2004; 303:1529–31; PMID:14976261; http://dx.doi.org/10.1126/science.1093616
   PubMed Web of Science ®Google Scholar
• Li L, Cheng FW, Wang F, Jia B, Luo X, Zhang SQ. The activation of TLR7 regulates the expression of VEGF, TIMP1, MMP2, IL-6, and IL-15 in Hela cells. Mol Cell Biochem 2014; 389:43–9; PMID:24347177; http://dx.doi.org/10.1007/s11010-013-1925-y
   PubMed Web of Science ®Google Scholar
• Kawai T, Akira S. Antiviral signaling through pattern recognition receptors. J Biochem 2007; 141:137–45; PMID:17190786; http://dx.doi.org/10.1093/jb/mvm032
   PubMed Web of Science ®Google Scholar
• Yu H, Wang Z, Sun G, Yu Y. Recognition of nucleic acid ligands by toll-like receptors 7/8: importance of chemical modification. Curr Med Chem 2012; 19:1365–77; PMID:22204348; http://dx.doi.org/10.2174/092986712799462603
   PubMed Web of Science ®Google Scholar
• Brameier M, Krings A, MacCallum RM. NucPred–predicting nuclear localization of proteins. Bioinformatics 2007; 23:1159–60; PMID:17332022; http://dx.doi.org/10.1093/bioinformatics/btm066
   PubMed Web of Science ®Google Scholar
• Lee BL, Barton GM. Trafficking of endosomal Toll-like receptors. Trends Cell Biol 2014; 24:360–9; PMID:24439965; http://dx.doi.org/10.1016/j.tcb.2013.12.002
   PubMed Web of Science ®Google Scholar
• Fabbri M, Paone A, Calore F, Galli R, Gaudio E, Santhanam R, Lovat F, Fadda P, Mao C, Nuovo GJ et al. MicroRNAs bind to Toll-like receptors to induce prometastatic inflammatory response. Proc Natl Acad Sci U S A 2012; 109:E2110–6; PMID:22753494; http://dx.doi.org/10.1073/pnas.1209414109
   PubMed Web of Science ®Google Scholar
• Roberts TC. The MicroRNA biology of the mammalian nucleus. Mol Ther Nucleic Acids 2014; 3:e188; PMID:25137140; http://dx.doi.org/10.1038/mtna.2014.40
   PubMedGoogle Scholar