Improved time to disease progression in the brain in patients with melanoma brain metastases treated with concurrent delivery of radiosurgery and ipilimumab

References

• Davies MA, Liu P, McIntyre S, Kim KB, Papadopoulos N, Hwu WJ, Hwu P, Bedikian A. Prognostic factors for survival in melanoma patients with brain metastases. Cancer 2011; 117(8):1687-96; PMID:20960525; http://dx.doi.org/10.1002/cncr.25634
   PubMed Web of Science ®Google Scholar
• Fife KM, Colman MH, Stevens GN, Firth IC, Moon D, Shannon KF, Harman R, Petersen-Schaefer K, Zacest AC, Besser M et al. Determinants of outcome in melanoma patients with cerebral metastases. J Clin Oncol 2004; 22(7):1293-300; PMID:15051777; http://dx.doi.org/10.1200/JCO.2004.08.140
   PubMed Web of Science ®Google Scholar
• Sperduto PW, Chao ST, Sneed PK, Luo X, Suh J, Roberge D, Bhatt A, Jensen AW, Brown PD, Shih H et al. Diagnosis-specific prognostic factors, indexes, and treatment outcomes for patients with newly diagnosed brain metastases: a multi-institutional analysis of 4,259 patients. Int J Radiat Oncol Biol Phys 2010; 77(3):655-61; PMID:19942357; http://dx.doi.org/10.1016/j.ijrobp.2009.08.025
   PubMed Web of Science ®Google Scholar
• Kiess AP, Wolchok JD, Barker CA, Postow MA, Tabar V, Huse JT, Chan TA, Yamada Y, Beal K. Stereotactic radiosurgery for melanoma brain metastases in patients receiving Ipilimumab: safety profile and efficacy of combined treatment. Int J Radiat Oncol Biol Phys 2015; 92(2)368-75; PMID:25754629; http://dx.doi.org/10.1016/j.ijrobp.2015.01.004
   PubMed Web of Science ®Google Scholar
• Manon R, O'Neill A, Knisley J, Werner-Wasik M, Lazarus HM, Wagner H, Gilbert M, Mehta M, Eastern Cooperative Oncology Group. Phase II trial of radiosurgery for one to three newly diagnosed brain metastases from renal cell carcinoma, melanoma, and sarcoma: an ECOG study (E 6397). J Clin Oncol 2005; 23(34):8870-6; PMID:16314647; http://dx.doi.org/10.1200/JCO.2005.01.8747
   PubMed Web of Science ®Google Scholar
• Gibney GT, Forsyth PA, Sondak VK. Melanoma in the brain: biology and therapeutic options. Melanoma Res 2012; 22(3):177-183; PMID:22495668; http://dx.doi.org/10.1097/CMR.0b013e328352dbef
   PubMed Web of Science ®Google Scholar
• Margolin K, Ernstoff MS, Hamid O, Lawrence D, McDermott D, Puzanov I, Wolchok JD, Clark JI, Sznol M, Logan TF et al. Ipilimumab in patients with melanoma and brain metastases: an open-label phase 2 trial. Lancet Oncol 2012; 13(5):459-65; PMID:22456429; http://dx.doi.org/10.1016/S1470-2045(12)70090-6
   PubMed Web of Science ®Google Scholar
• Wilson EH, Weninger W, Hunger CA. Trafficking of immune cells in the central nervous system. J Clin Invest 2010; 120(5):1368-79; PMID:20440079; http://dx.doi.org/10.1172/JCI41911
   PubMed Web of Science ®Google Scholar
• Postow MA, Callahan MK, Barker CA, Barker CA, Yamada Y, Yuan J, Kitano S, Mu Z, Rasalan T, Adamow M et al. Immunologic correlates of the abscopal effect in a patient with melanoma. N Engl J Med 2012; 366(10):925-31; PMID:22397654; http://dx.doi.org/10.1056/NEJMoa1112824
   PubMed Web of Science ®Google Scholar
• Stamell EF, Wolchok JD, Gnjatic S, Lee NY, Brownell I. The abscopal effect associated with a systemic anti-melanoma immune response. Int J Radiat Oncol Biol Phys 2013; 85(2):293-5; PMID:22560555; http://dx.doi.org/10.1016/j.ijrobp.2012.03.017
   PubMed Web of Science ®Google Scholar
• Twyman-Saint\sVictor C, Rech AJ, Maity A, Rengan R, Pauken KE, Stelekati E, Benci JL, Xu B, Dada H, Odorizzi PM et al. Radiation and dual checkpoint blockade activate non-redundant immune mechanisms in cancer. Nature 2015; 520(7547):373-7; PMID:25754329; http://dx.doi.org/10.1038/nature14292
   PubMed Web of Science ®Google Scholar
• Tang C, Wang X, Soh H, Seyedin S, Cortez MA, Krishnan S, Massarelli E, Hong D, Naing A, Diab A et al. Combining radiation and immunotherapy: a new systemic therapy for solid tumors? Cancer Immunol Res 2014; 2(9):831-8; PMID:25187273; http://dx.doi.org/10.1158/2326-6066.CIR-14-0069
   PubMed Web of Science ®Google Scholar
• Apetoh L, Ladoire S, Coukos G, Ghiringhelli F. Combining immunotherapy and anticancer agents: the right path to achieve cancer cure? Ann Oncol 2015; 26:1813-23; http://dx.doi.org/10.1093/annonc/mdv209
   PubMed Web of Science ®Google Scholar
• Wu L, Wu M, De la Maza L, Yun Z, Yu J, Zhao Y, Cho J, de Perrot M. Targeting the inhibitory receptor CTLA-4 on T cells increased abscopal effects in murine mesothelioma model. Oncotarget 2015; 6(14):12468-12480; PMID:25980578; http://dx.doi.org/10.18632/oncotarget.3487
   PubMed Web of Science ®Google Scholar
• Grimaldi AM, Simeone E, Giannarelli D, Muto P, Falivene S, Borzillo V, Giugliano FM, Sandomenico F, Petrillo A, Curvietto M et al. Abscopal effects of radiotherapy on advanced melanoma patients who progressed after ipilimumab immunotherapy. Oncoimmunology 2014; 3:e28780; PMID:25083318; http://dx.doi.org/10.4161/onci.28780
   PubMed Web of Science ®Google Scholar
• Johnson CB, Jagsi R. The promise of the abscopal effect and the future of trials combining immunotherapy and radiation therapy. Int J Radiat Oncol Biol Phys 2016; 95(4):1254-56; PMID:27354132; http://dx.doi.org/10.1016/j.ijrobp.2016.02.067
   PubMed Web of Science ®Google Scholar
• Reynders K, Illidge T, Siva S, Chang JY, De Ruysscher D. The abscopal effect of local radiotherapy: using immunotherapy to make a rare event clinically relevant. Cancer Treat Rev 2015; 41(6):503-10; PMID:25872878; http://dx.doi.org/10.1016/j.ctrv.2015.03.011
   PubMed Web of Science ®Google Scholar
• Abuodeh Y, Venkat P, Kim S. Systematic review of case reports on the abscopal effect. Curr Probl Cancer 2016; 40(1):25-37; PMID:26582738; http://dx.doi.org/10.1016/j.currproblcancer.2015.10.001
   PubMed Web of Science ®Google Scholar
• Chandra RA, Wilhite TJ, Balboni TA, Alexander BM, Spektor A, Ott PA, Ng AK, Hodi FS, Schoenfeld JD. A systematic evaluation of abscopal responses following radiotherapy in patients with metastatic melanoma treated with Ipilimumab. Oncoimmunology 2015; 4(11):e1046028; PMID:26451318; http://dx.doi.org/10.1080/2162402X.2015.1046028
   PubMed Web of Science ®Google Scholar
• Silk AW, Bassetti MF, West BT, Tsien CI, Lao CD. Ipilimumab and radiation therapy for melanoma brain metastases. Cancer Med 2013; 2(6):899-906; PMID:24403263; http://dx.doi.org/10.1002/cam4.140
   PubMed Web of Science ®Google Scholar
• Schoenfeld JD, Mahadevan A, Floyd SR, Dyer MA, Catalano PJ, Alexander BM, McDermott DF, Kaplan ID. Ipilimumab and cranial radiation in metastatic melanoma patients: a case series and review. J Immunother Cancer 2015; 3:50; PMID:26672895; http://dx.doi.org/10.1186/s40425-015-0095-8
   PubMed Web of Science ®Google Scholar
• Patel KR, Shoukat S, Oliver DE, Chowdhary M, Rizzo M, Lawson DH, Khosa F, Liu Y, Khan MK. Ipilimumab and Stereotactic Radiosurgery Versus Stereotactic Radiosurgery Alone for Newly Diagnosed Melanoma Brain Metastases. Am J Clin Oncol. 2015 May 16. [Epub ahead of print]. PMID:26017484; http://dx.doi.org/10.1097/COC.0000000000000199
   Google Scholar
• Knisely JPS, Yu JB, Flanigan J, Sznol M, Kluger HM, Chiang VL. Radiosurgery for melanoma brain metastases in the ipilimumab era and the possibility of longer survival. J Neurosurg 2012; 117(2):227-33; PMID:22702482; http://dx.doi.org/10.3171/2012.5.JNS111929
   PubMed Web of Science ®Google Scholar
• Tazi K, Hathaway A, Chiuzan C, Shirai K. Survival of melanoma patients with brain metastases treated with Ipilimumab and stereotactic radiosurgery. Cancer Med. 2015; 4(1):1-6; PMID:25164960; http://dx.doi.org/10.1002/cam4.315
   PubMed Web of Science ®Google Scholar
• Shoukat S, Marcus D, Rizzo M, Lawson D, Liu Y, Khan M. Outcome with stereotactic radiosurgery (SRS) and ipilimumab (Ipi) for malignant melanoma brain metastases.. J Clin Oncol; ASCO Annual Meeting; 2013. 2013. abstr 3032.
   Google Scholar
• Eisenhauer EA, Therasse P, Bogaerts J, Schwartz LH, Sargent D, Ford R, Dancey J, Arbuck S, Gwyther S, Mooney M et al. New response evaluation criteria in solid tumors: revised RECIST guideline (v1.1). Eur J Cancer 2009; 45(2):228-47; PMID:19097774; http://dx.doi.org/10.1016/j.ejca.2008.10.026
   PubMed Web of Science ®Google Scholar
• Formenti SC, Demaria S. Combining radiotherapy and cancer immunotherapy: a paradigm shift. J Natl Cancer Inst 2013; 105(4):256-65; PMID:23291374; http://dx.doi.org/10.1093/jnci/djs629
   PubMed Web of Science ®Google Scholar
• Levy A, Chargari C, Cheminant M, Simon N, Bourgier C, Deutsch E. Radiation therapy and immunotherapy: implications for a combined cancer treatment. Crit Rev Oncol Hematol 2013; 85(3):278-87; PMID:23036459; http://dx.doi.org/10.1016/j.critrevonc.2012.09.001
   PubMed Web of Science ®Google Scholar
• Shahabi V, Postow MA, Tuck D, Wolchok JD. Immune priming of the tumor microenvironment by radiotherapy. Rationale for combination with immunotherapy to improve anticancer efficacy. Am J Clin Oncol 2015; 38(1):90-7; PMID:25616204; http://dx.doi.org/10.1097/COC.0b013e3182868ec8
   PubMed Web of Science ®Google Scholar
• Demaria S, Ng B, Devitt ML, Babb JS, Kawashima N, Liebes L, Formenti SC. Ionizing radiation inhibition of distant untreated tumors (abscopal effect) is immune mediated. Int J Radiat Oncol Biol Phys 2004; 58(3):862-70; PMID:14967443; http://dx.doi.org/10.1016/j.ijrobp.2003.09.012
   PubMed Web of Science ®Google Scholar
• Dewan MZ, Galloway AE, Kawashima N, Dewyngaert JK, Babb JS, Formenti SC, Demaria S. Fractionated but not single-dose radiotherapy induces an immune-mediated abscopal effect when combined with anti-CTLA-4 antibody. Clin Cancer Res 2009; 15(17):5379-88; PMID:19706802; http://dx.doi.org/10.1158/1078-0432.CCR-09-0265
   PubMed Web of Science ®Google Scholar
• Demaria S, Formenti SC. Role of T lymphocytes in tumor response to radiotherapy. Front Oncol 2012; 2:95; PMID:22937524; http://dx.doi.org/10.3389/fonc.2012.00095
   PubMedGoogle Scholar
• Kim S, Ramakrishnan R, Lavilla-Alonso S, Chinnaiyan P, Rao N, Fowler E, Heine J, Gabrilovich DI. Radiation induced autophagy potentiates immunotherapy of cancer via upregulation of mannose 6-phosphate receptor on tumor cells in mice. Cancer Immunol Immunother 2014; 63:1009-1021; PMID:24943275; http://dx.doi.org/10.1007/s00262-014-1573-4
   PubMed Web of Science ®Google Scholar
• Weber JS, O'Day S, Urba W, Powderly J, Nichol G, Yellin M, Snively J, Hersh E. Phase I/II study of ipilimumab for patients with metastatic melanoma. J Clin Oncol 2008; 26:5950-5956; PMID:19018089; http://dx.doi.org/10.1200/JCO.2008.16.1927
   PubMed Web of Science ®Google Scholar
• Qian JM, Yu JB, Kluger HM, Chiang VL. Timing and type of immune checkpoint therapy affect the early radiographic response of melanoma brain metastases to stereotactic radiosurgery. Cancer 2016. Oct;122(19):3051-8. Epub 2016 Jun 10; PMID:27285122; http://dx.doi.org/10.1002/cncr.30138.
   Google Scholar
• Ahmed KA, Stallworth DG, Kim Y, Johnstone PA, Harrison LB, Caudell JJ, Yu HH, Etame AB, Weber JS, Gibney GT. Clinical outcomes of melanoma brain metastases treated with stereotactic radiation and anti-PD1 therapy. Ann Oncol 2016; 27(3):434-41; PMID:26712903; http://dx.doi.org/10.1093/annonc/mdv622
   PubMed Web of Science ®Google Scholar
• Sneed PK, Mendez J, Fogh SE, Barani IJ, Ma L, McDermott MW et al. Risk factors for radiation necrosis after radiosurgery for brain metastases. Int J Rad Onc Biol Phys 2012; 84(3):118-119; http://dx.doi.org/10.1016/j.ijrobp.2012.07.208
   Google Scholar
• Minniti G, Clarke E, Lanzetta G, Osti MF, Trasimeni G, Bozzao A, Romano A, Enrici RM. Stereotactic radiosurgery for brain metastases: analysis of outcome and risk of brain radionecrosis. Radiat Oncol 2011; 6:48; PMID:21575163; http://dx.doi.org/10.1186/1748-717X-6-48
   PubMed Web of Science ®Google Scholar
• Colaco RJ, Martin P, Kluger HM, Yu JB, Chiang VL. Does immunotherapy increase the rate of radiation necrosis after radiosurgical treatment of brain metastases? J Neurosurg 2015; 125(1):17-23; PMID:26544782; http://dx.doi.org/10.3171/2015.6.JNS142763
   PubMed Web of Science ®Google Scholar
• Kluger HM, Goldberg SB, Sznol M, Choueiri TK, Powderly JD, Smith DC, Brahmer JR, Carvajal RD, Hammers HJ, Puzanov I et al. Safety and activity of Pembrolizumab in melanoma patients with untreated brain metastases. J Clin Oncol 2015; 33(18):2013-20; ( suppl; abstr 9009); PMID:25800770; http://dx.doi.org/10.1200/JCO.2014.58.1041
   PubMed Web of Science ®Google Scholar