Glioma-induced SIRT1-dependent activation of hMOF histone H4 lysine 16 acetyltransferase in microglia promotes a tumor supporting phenotype

References

• Batchelor T. Patient information: High-grade glioma in adults (Beyond the Basics). UpToDate: Wolters Kluwer; 2015; https://www.uptodate.com/contents/high-grade-glioma-inadults-beyond-the-basics#
   Google Scholar
• Hambardzumyan D, Gutmann DH, Kettenmann H. The role of microglia and macrophages in glioma maintenance and progression. Nat Neurosci. 2015;19:20-27. doi:10.1038/nn.4185.
   Web of Science ®Google Scholar
• Markovic DS, Vinnakota K, Chirasani S, Synowitz M, Raguet H, Stock K, Sliwa M, Lehmann S, Kälin R, van Rooijen N, et al. Gliomas induce and exploit microglial MT1-MMP expression for tumor expansion. Proc Natl Acad Sci U S A. 2009; 106:12530-35. doi:10.1073/pnas.0804273106. PMID:19617536.
   PubMed Web of Science ®Google Scholar
• Muller A, Brandenburg S, Turkowski K, Muller S, Vajkoczy P. Resident microglia, and not peripheral macrophages, are the main source of brain tumor mononuclear cells. Int J Cancer. 2015; 137:278-88. doi:10.1002/ijc.29379. PMID:25477239.
   PubMed Web of Science ®Google Scholar
• Saijo K, Glass CK. Microglial cell origin and phenotypes in health and disease. Nat Rev Immunol. 2011;11:775-87. doi:10.1038/nri3086. PMID:22025055.
   PubMed Web of Science ®Google Scholar
• Hambardzumyan D, Gutmann DH, Kettenmann H. The role of microglia and macrophages in glioma maintenance and progression. Nat Neurosci. 2016;19:20-27. doi:10.1038/nn.4185. PMID:26713745.
   PubMed Web of Science ®Google Scholar
• Markovic DS, Glass R, Synowitz M, Rooijen N, Kettenmann H. Microglia stimulate the invasiveness of glioma cells by increasing the activity of metalloprotease-2. Jf Neuropathol Exp Neurol. 2005;64:754-62. doi:10.1097/01.jnen.0000178445.33972.a9. PMID:16141784.
   PubMed Web of Science ®Google Scholar
• Szulzewsky F, Pelz A, Feng X, Synowitz M, Markovic D, Langmann T, Holtman IR, Wang X, Eggen BJ, Boddeke HW, et al. Glioma-associated microglia/macrophages display an expression profile different from M1 and M2 polarization and highly express Gpnmb and Spp1. PloS One. 2015;10:e0116644. doi:10.1371/journal.pone.0116644. PMID:25658639.
   PubMed Web of Science ®Google Scholar
• Garden GA. Epigenetics and the modulation of neuroinflammation. Neurotherapeutics: the journal of the American Society for Experimental NeuroTherapeutics. 2013;10:782-88. doi:10.1007/s13311-013-0207-4. PMID:23963788.
   PubMed Web of Science ®Google Scholar
• Schones DE, Cui K, Cuddapah S, Roh TY, Barski A, Wang Z, Wei G, Zhao K. Dynamic regulation of nucleosome positioning in the human genome. Cell. 2008;132:887-98. doi:10.1016/j.cell.2008.02.022. PMID:18329373.
   PubMed Web of Science ®Google Scholar
• Horikoshi N, Kumar P, Sharma GG, Chen M, Hunt CR, Westover K, Chowdhury S, Pandita TK. Genome-wide distribution of histone H4 Lysine 16 acetylation sites and their relationship to gene expression. Genome Integr. 2013;4:3. doi:10.1186/2041-9414-4-3. PMID:23587301.
   PubMedGoogle Scholar
• Hajji N, Wallenborg K, Vlachos P, Fullgrabe J, Hermanson O, Joseph B. Opposing effects of hMOF and SIRT1 on H4K16 acetylation and the sensitivity to the topoisomerase II inhibitor etoposide. Oncogene. 2010;29:2192-204. doi:10.1038/onc.2009.505. PMID:20118981.
   PubMed Web of Science ®Google Scholar
• Rea S, Xouri G, Akhtar A. Males absent on the first (MOF): from flies to humans. Oncogene. 2007;26:5385-94. doi:10.1038/sj.onc.1210607. PMID:17694080.
   PubMed Web of Science ®Google Scholar
• Donmez G. The neurobiology of sirtuins and their role in neurodegeneration. Trends Pharmacol Sci. 2012;33:494-501. doi:10.1016/j.tips.2012.05.007. PMID:22749331.
   PubMed Web of Science ®Google Scholar
• Mellert HS, McMahon SB. hMOF, a KAT(8) with many lives. Mol Cell. 2009;36:174-5. doi:10.1016/j.molcel.2009.10.005. PMID:19854127.
   PubMed Web of Science ®Google Scholar
• Zhao L, Wang DL, Liu Y, Chen S, Sun FL. Histone acetyltransferase hMOF promotes S phase entry and tumorigenesis in lung cancer. Cell Signal. 2013;25:1689-98. doi:10.1016/j.cellsig.2013.04.006. PMID:23628702.
   PubMed Web of Science ®Google Scholar
• Zhong J, Li X, Cai W, Wang Y, Dong S, Yang J, Zhang J, Wu N, Li Y, Mao F, et al. TET1 modulates H4K16 acetylation by controlling auto-acetylation of hMOF to affect gene regulation and DNA repair function. Nucleic Acids Res. 2017;45:672-84. doi:10.1093/nar/gkw919. PMID:27733505.
   PubMed Web of Science ®Google Scholar
• Lu L, Li L, Lv X, Wu XS, Liu DP, Liang CC. Modulations of hMOF autoacetylation by SIRT1 regulate hMOF recruitment and activities on the chromatin. Cell Res. 2011;21:1182-95. doi:10.1038/cr.2011.71. PMID:21502975.
   PubMed Web of Science ®Google Scholar
• Zhang R, Erler J, Langowski J. Histone Acetylation Regulates Chromatin Accessibility: Role of H4K16 in Inter-nucleosome Interaction. Biophys J. 2017;112:450-9. doi:10.1016/j.bpj.2016.11.015. PMID:27931745.
   PubMed Web of Science ®Google Scholar
• Taylor GC, Eskeland R, Hekimoglu-Balkan B, Pradeepa MM, Bickmore WA. H4K16 acetylation marks active genes and enhancers of embryonic stem cells, but does not alter chromatin compaction. Genome Res. 2013;23:2053-65. doi:10.1101/gr.155028.113. PMID:23990607.
   PubMed Web of Science ®Google Scholar
• Shogren-Knaak M, Ishii H, Sun JM, Pazin MJ, Davie JR, Peterson CL. Histone H4-K16 acetylation controls chromatin structure and protein interactions. Science (New York, NY). 2006;311:844-7. doi:10.1126/science.1124000.
   Google Scholar
• Burguillos MA, Deierborg T, Kavanagh E, Persson A, Hajji N, Garcia-Quintanilla A, Cano J, Brundin P, Englund E, Venero JL, et al. Caspase signalling controls microglia activation and neurotoxicity. Nature. 2011;472:319-24. doi:10.1038/nature09788. PMID:21389984.
   PubMed Web of Science ®Google Scholar
• Shen X, Burguillos MA, Osman AM, Frijhoff J, Carrillo-Jimenez A, Kanatani S, Augsten M, Saidi D, Rodhe J, Kavanagh E, et al. Glioma-induced inhibition of caspase-3 in microglia promotes a tumor-supportive phenotype. Nat Immunol. 2016;17:1282-90. doi:10.1038/ni.3545. PMID:27618552.
   PubMed Web of Science ®Google Scholar
• Maes W, Van Gool SW. Experimental immunotherapy for malignant glioma: lessons from two decades of research in the GL261 model. Cancer immunology, immunotherapy: CII. 2011;60:153-60. doi:10.1007/s00262-010-0946-6. PMID:21120655.
   PubMed Web of Science ®Google Scholar
• Fullgrabe J, Lynch-Day MA, Heldring N, Li W, Struijk RB, Ma Q, Hermanson O, Rosenfeld MG, Klionsky DJ, Joseph B. et al. The histone H4 lysine 16 acetyltransferase hMOF regulates the outcome of autophagy. Nature. 2013;500:468-71.
   PubMed Web of Science ®Google Scholar
• Vaquero A, Sternglanz R, Reinberg D. NAD+-dependent deacetylation of H4 lysine 16 by class III HDACs. Oncogene. 2007;26:5505-20. doi:10.1038/sj.onc.1210617. PMID:17694090.
   PubMed Web of Science ®Google Scholar
• Kapoor-Vazirani P, Kagey JD, Powell DR, Vertino PM. Role of hMOF-dependent histone H4 lysine 16 acetylation in the maintenance of TMS1/ASC gene activity. Cancer Res. 2008;68:6810-21. doi:10.1158/0008-5472.CAN-08-0141. PMID:18701507.
   PubMed Web of Science ®Google Scholar
• Taipale M, Rea S, Richter K, Vilar A, Lichter P, Imhof A, Akhtar A. hMOF histone acetyltransferase is required for histone H4 lysine 16 acetylation in mammalian cells. Mol Cell Biol. 2005;25:6798-10. doi:10.1128/MCB.25.15.6798-6810.2005. PMID:16024812.
   PubMed Web of Science ®Google Scholar
• Tanno M, Sakamoto J, Miura T, Shimamoto K, Horio Y. Nucleocytoplasmic shuttling of the NAD+-dependent histone deacetylase SIRT1. J Biol Chem. 2007;282:6823-32. doi:10.1074/jbc.M609554200. PMID:17197703.
   PubMed Web of Science ®Google Scholar
• Ostrom QT, Gittleman H, Stetson L, Virk SM, Barnholtz-Sloan JS. Epidemiology of gliomas. Cancer Treat Res. 2015;163:1-14. doi:10.1007/978-3-319-12048-5_1. PMID:25468222.
   PubMedGoogle Scholar
• Brandenburg S, Muller A, Turkowski K, Radev YT, Rot S, Schmidt C, Bungert AD, Acker G, Schorr A, Hippe A, et al. Resident microglia rather than peripheral macrophages promote vascularization in brain tumors and are source of alternative pro-angiogenic factors. Acta Neuropathol. 2016;131:365-78. doi:10.1007/s00401-015-1529-6. PMID:26718201.
   PubMed Web of Science ®Google Scholar
• Pyonteck SM, Akkari L, Schuhmacher AJ, Bowman RL, Sevenich L, Quail DF, Olson OC, Quick ML, Huse JT, Teijeiro V, et al. CSF-1R inhibition alters macrophage polarization and blocks glioma progression. Nat Med. 2013;19:1264-72. doi:10.1038/nm.3337. PMID:24056773.
   PubMed Web of Science ®Google Scholar
• Quail DF, Bowman RL, Akkari L, Quick ML, Schuhmacher AJ, Huse JT, Holland EC, Sutton JC, Joyce JA. The tumor microenvironment underlies acquired resistance to CSF-1R inhibition in gliomas. Science. 2016;352:aad3018. doi:10.1126/science.aad3018. PMID:27199435.
   PubMed Web of Science ®Google Scholar
• Dion MF, Altschuler SJ, Wu LF, Rando OJ. Genomic characterization reveals a simple histone H4 acetylation code. Proceedings of the National Academy of Sciences of the United States of America. 2005;102:5501-06. doi:10.1073/pnas.0500136102. PMID:15795371.
   PubMed Web of Science ®Google Scholar
• Oppikofer M, Kueng S, Martino F, Soeroes S, Hancock SM, Chin JW, Fischle W, Gasser SM. A dual role of H4K16 acetylation in the establishment of yeast silent chromatin. EMBO J. 2011;30:2610-21. doi:10.1038/emboj.2011.170. PMID:21666601.
   PubMed Web of Science ®Google Scholar
• Kwon HS, Ott M. The ups and downs of SIRT1. Trends Biochem Sci. 2008;33:517-25. doi:10.1016/j.tibs.2008.08.001. PMID:18805010.
   PubMed Web of Science ®Google Scholar
• Hisahara S, Chiba S, Matsumoto H, Tanno M, Yagi H, Shimohama S, Sato M, Horio Y. Histone deacetylase SIRT1 modulates neuronal differentiation by its nuclear translocation. Proc Natl Acad Sci U S A. 2008;105:15599-604. doi:10.1073/pnas.0800612105. PMID:18829436.
   PubMed Web of Science ®Google Scholar
• Yang Y, Fu W, Chen J, Olashaw N, Zhang X, Nicosia SV, Bhalla K, Bai W. SIRT1 sumoylation regulates its deacetylase activity and cellular response to genotoxic stress. Nat Cell Biol. 2007;9:1253-62. doi:10.1038/ncb1645. PMID:17934453.
   PubMed Web of Science ®Google Scholar
• Nasrin N, Kaushik VK, Fortier E, Wall D, Pearson KJ, de Cabo R, Bordone L. JNK1 phosphorylates SIRT1 and promotes its enzymatic activity. PLoS One. 2009;4:e8414. doi:10.1371/journal.pone.0008414. PMID:20027304.
   PubMed Web of Science ®Google Scholar
• Peng L, Ling H, Yuan Z, Fang B, Bloom G, Fukasawa K, Koomen J, Chen J, Lane WS, Seto E. SIRT1 negatively regulates the activities, functions, and protein levels of hMOF and TIP60. Mol Cell Biol. 2012;32:2823-36. doi:10.1128/MCB.00496-12. PMID:22586264.
   PubMed Web of Science ®Google Scholar
• Yuan H, Rossetto D, Mellert H, Dang W, Srinivasan M, Johnson J, Hodawadekar S, Ding EC, Speicher K, Abshiru N, et al. MYST protein acetyltransferase activity requires active site lysine autoacetylation. The EMBO journal. 2012;31:58-70. doi:10.1038/emboj.2011.382. PMID:22020126.
   PubMed Web of Science ®Google Scholar
• McCullough CE, Song S, Shin MH, Johnson FB, Marmorstein R. Structural and Functional Role of Acetyltransferase hMOF K274 Autoacetylation. J Biol Chem. 2016;291:18190-98. doi:10.1074/jbc.M116.736264. PMID:27382063.
   PubMed Web of Science ®Google Scholar
• Wang H, Lathia JD, Wu Q, Wang J, Li Z, Heddleston JM, Eyler CE, Elderbroom J, Gallagher J, Schuschu J, et al. Targeting interleukin 6 signaling suppresses glioma stem cell survival and tumor growth. Stem Cells. 2009;27:2393-404. doi:10.1002/stem.188. PMID:19658188.
   PubMed Web of Science ®Google Scholar
• Zhang J, Sarkar S, Cua R, Zhou Y, Hader W, Yong VW. A dialog between glioma and microglia that promotes tumor invasiveness through the CCL2/CCR2/interleukin-6 axis. Carcinogenesis. 2012;33:312-9. doi:10.1093/carcin/bgr289. PMID:22159219.
   PubMed Web of Science ®Google Scholar
• Hoffman EA, Frey BL, Smith LM, Auble DT. Formaldehyde crosslinking: a tool for the study of chromatin complexes. J Biol Chem. 2015;290:26404-11. doi:10.1074/jbc.R115.651679. PMID:26354429.
   PubMed Web of Science ®Google Scholar
• Phillips JJ, Huillard E, Robinson AE, Ward A, Lum DH, Polley MY, Rosen SD, Rowitch DH, Werb Z. Heparan sulfate sulfatase SULF2 regulates PDGFRalpha signaling and growth in human and mouse malignant glioma. J Clin Invest. 2012;122:911-22. doi:10.1172/JCI58215. PMID:22293178.
   PubMed Web of Science ®Google Scholar
• Ligon KL, Huillard E, Mehta S, Kesari S, Liu H, Alberta JA, Bachoo RM, Kane M, Louis DN, Depinho RA, et al. Olig2-regulated lineage-restricted pathway controls replication competence in neural stem cells and malignant glioma. Neuron. 2007;53:503-17. doi:10.1016/j.neuron.2007.01.009. PMID:17296553.
   PubMed Web of Science ®Google Scholar