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Original Research

Prognostic implications of tumor-infiltrating macrophages, M2 macrophages, regulatory T-cells, and indoleamine 2,3-dioxygenase-positive cells in primary diffuse large B-cell lymphoma of the central nervous system

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Article: e1442164 | Received 24 Oct 2017, Accepted 14 Feb 2018, Published online: 13 Mar 2018

References

  • Rubenstein J, Ferreri AJ, Pittaluga S. Primary lymphoma of the central nervous system: epidemiology, pathology and current approaches to diagnosis, prognosis and treatment. Leuk Lymphoma. 2008;49(Suppl 1):43–51. doi:10.1080/10428190802311441. PMID:18821432.
  • Tun HW, Personett D, Baskerville KA, Menke DM, Jaeckle KA, Kreinest P, Edenfield B, Zubair AC, O'Neill BP, Lai WR, et al. Pathway analysis of primary central nervous system lymphoma. Blood. 2008;111:3200–10. doi:10.1182/blood-2007-10-119099. PMID:18184868.
  • Rubenstein JL, Fridlyand J, Shen A, Aldape K, Ginzinger D, Batchelor T, Treseler P, Berger M, McDermott M, Prados M, et al. Gene expression and angiotropism in primary CNS lymphoma. Blood. 2006;107:3716–23. doi:10.1182/blood-2005-03-0897. PMID:16418334.
  • Sung CO, Kim SC, Karnan S, Karube K, Shin HJ, Nam DH, Suh YL, Kim SH, Kim JY, Kim SJ, et al. Genomic profiling combined with gene expression profiling in primary central nervous system lymphoma. Blood. 2011;117:1291–300. doi:10.1182/blood-2010-07-297861. PMID:21088137.
  • Soussain C, Hoang-Xuan K. Primary central nervous system lymphoma: an update. Curr Opin Oncol. 2009;21:550–8. doi:10.1097/CCO.0b013e3283310eb3. PMID:19684518.
  • Chapuy B, Roemer MG, Stewart C, Tan Y, Abo RP, Zhang L, Dunford AJ, Meredith DM, Thorner AR, Jordanova ES, et al. Targetable genetic features of primary testicular and primary central nervous system lymphomas. Blood. 2016; 127:869–81. doi:10.1182/blood-2015-10-673236. PMID:26702065.
  • Langner-Lemercier S, Houillier C, Soussain C, Ghesquieres H, Chinot O, Taillandier L, Soubeyran P, Lamy T, Morschhauser F, Benouaich-Amiel A, et al. Primary CNS lymphoma at first relapse/progression: characteristics, management, and outcome of 256 patients from the French LOC network. Neuro-oncology. 2016;18:1297–303. doi:10.1093/neuonc/now033. PMID:26951382.
  • Goodman A, Patel SP, Kurzrock R. PD-1-PD-L1 immune-checkpoint blockade in B-cell lymphomas. Nat Rev Clin Oncol. 2017;14(4):203–20. doi:10.1038/nrclinonc.2016.168. PMID:27805626.
  • Nayak L, Iwamoto FM, LaCasce A, Mukundan S, Roemer MGM, Chapuy B, Armand P, Rodig SJ, Shipp MA. PD-1 blockade with nivolumab in relapsed/refractory primary central nervous system and testicular lymphoma. Blood. 2017;129:3071–3. doi:10.1182/blood-2017-01-764209. PMID:28356247.
  • Kerkar SP, Restifo NP. Cellular Constituents of Immune Escape within the Tumor Microenvironment. Cancer Res. 2012;72:3125–30. doi:10.1158/0008-5472.CAN-11-4094. PMID:22721837.
  • Burger JA, Ghia P, Rosenwald A, Caligaris-Cappio F. The microenvironment in mature B-cell malignancies: a target for new treatment strategies. Blood. 2009;114:3367–75. doi:10.1182/blood-2009-06-225326. PMID:19636060.
  • Coutinho R, Clear AJ, Mazzola E, Owen A, Greaves P, Wilson A, Matthews J, Lee A, Alvarez R, da Silva MG, et al. Revisiting the immune microenvironment of diffuse large B-cell lymphoma using a tissue microarray and immunohistochemistry: robust semi- automated analysis reveals CD3 and FoxP3 as potential predictors of response to R-CHOP. Haematologica. 2015;100:363–9. doi:10.3324/haematol.2014.110189. PMID:25425693.
  • Pollard JW. Tumour-educated macrophages promote tumour progression and metastasis. Nat Rev Cancer. 2004;4:71–8. doi:10.1038/nrc1256. PMID:14708027.
  • Solinas G, Germano G, Mantovani A, Allavena P. Tumor-associated macrophages (TAM) as major players of the cancer-related inflammation. J Leukoc Biol. 2009;86:1065–73. doi:10.1189/jlb.0609385. PMID:19741157.
  • Sakaguchi S, Miyara M, Costantino CM, Hafler DA. FOXP3(+) regulatory T cells in the human immune system. Nat Rev Immunol. 2010;10:490–500. doi:10.1038/nri2785. PMID:20559327.
  • Wahlin BE, Aggarwal M, Montes-Moreno S, Gonzalez LF, Roncador G, Sanchez-Verde L, Christensson B, Sander B, Kimby E. A unifying microenvironment model in follicular lymphoma: outcome is predicted by programmed Death-1-Positive, regulatory, cytotoxic, and helper T cells and macrophages. Clin Cancer Res. 2010;16:637–50. doi:10.1158/1078-0432.CCR-09-2487. PMID:20068089.
  • Kim WY, Jeon YK, Kim TM, Kim JE, Kim YA, Lee SH, Kim DW, Heo DS, Kim CW. Increased quantity of tumor-infiltrating FOXP3-positive regulatory T cells is an independent predictor for improved clinical outcome in extranodal NK/T-cell lymphoma. Ann Oncol. 2009;20:1688–96. doi:10.1093/annonc/mdp056. PMID:19542249.
  • Carreras J, Lopez-Guillermo A, Fox BC, Colomo L, Martinez A, Roncador G, Montserrat E, Campo E, Banham AH. High numbers of tumor-infiltrating FOXP3-positive regulatory T cells are associated with improved overall survival in follicular lymphoma. Blood. 2006;108:2957–64. doi:10.1182/blood-2006-04-018218. PMID:16825494.
  • Ahearne MJ, Bhuller K, Hew R, Ibrahim H, Naresh K, Wagner SD. Expression of PD-1 (CD279) and FoxP3 in diffuse large B-cell lymphoma. Virchows Arch. 2014;465:351–8. doi:10.1007/s00428-014-1615-5. PMID:25011996.
  • Tzankov A, Meier C, Hirschmann P, Went P, Pileri SA, Dirnhofer S. Correlation of high numbers of intratumoral FOXP3+ regulatory T cells with improved survival in germinal center-like diffuse large B-cell lymphoma, follicular lymphoma and classical Hodgkin's lymphoma. Haematologica. 2008;93:193–200. doi:10.3324/haematol.11702. PMID:18223287.
  • Munn DH, Mellor AL. Indoleamine 2,3 dioxygenase and metabolic control of immune responses. Trends Immunol. 2013;34:137–43. doi:10.1016/j.it.2012.10.001. PMID:23103127.
  • Platten M, Wick W, Van den Eynde BJ. Tryptophan Catabolism in Cancer: Beyond IDO and Tryptophan Depletion. Cancer Res. 2012;72:5435–40. doi:10.1158/0008-5472.CAN-12-0569. PMID:23090118.
  • Wilke CM, Zou WP. T lymphocytes to IDO(+) cells: check. Blood. 2011;117:2082–3. doi:10.1182/blood-2010-12-322172. PMID:21330479.
  • Frumento G, Rotondo R, Tonetti M, Damonte G, Benatti U, Ferrara GB. Tryptophan-derived catabolites are responsible for inhibition of T and natural killer cell proliferation induced by indoleamine 2,3-dioxygenase. J Exp Med. 2002;196:459–68. doi:10.1084/jem.20020121. PMID:12186838.
  • Sharma MD, Baban B, Chandler P, Hou DY, Singh N, Yagita H, Azurna M, Blazar BR, Mellor AL, Munn DH. Plasmacytoid dendritic cells from mouse tumor-draining lymph nodes directly activate mature Tregs via indoleamine 2,3-dioxygenase. J Clin Invest. 2007;117:2570–82. doi:10.1172/JCI31911. PMID:17710230.
  • Muldoon LL, Alvarez JI, Begley DJ, Boado RJ, Del Zoppo GJ, Doolittle ND, Engelhardt B, Hallenbeck JM, Lonser RR, Ohlfest JR, et al. Immunologic privilege in the central nervous system and the blood-brain barrier. J Cereb Blood Flow Metab. 2013;33:13–21. doi:10.1038/jcbfm.2012.153. PMID:23072749.
  • Nam SJ, Go H, Paik JH, Kim TM, Heo DS, Kim CW, Jeon YK. An increase of M2 macrophages predicts poor prognosis in patients with diffuse large B-cell lymphoma treated with rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone. Leuk Lymphoma. 2014;55:2466–76. doi:10.3109/10428194.2013.879713. PMID:24397616.
  • Nam SJ, Kim S, Paik JH, Kim TM, Heo DS, Kim CW, Jeon YK. An increase in indoleamine 2,3-dioxygenase-positive cells in the tumor microenvironment predicts favorable prognosis in patients with diffuse large B-cell lymphoma treated with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisolone. Leuk Lymphoma. 2016:1–5.
  • Chang C, Lin CH, Cheng AL, Medeiros LJ, Chang KC. Primary central nervous system diffuse large B-cell lymphoma has poorer immune cell infiltration and prognosis than its peripheral counterpart. Histopathology. 2015;67:625–35. doi:10.1111/his.12706. PMID:25829022.
  • Puente XS, Pinyol M, Quesada V, Conde L, Ordonez GR, Villamor N, Escaramis G, Jares P, Bea S, Gonzalez-Diaz M, et al. Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia. Nature. 2011;475:101–5. doi:10.1038/nature10113. PMID:21642962.
  • Canioni D, Salles G, Mounier N, Brousse N, Keuppens M, Morchhauser F, Lamy T, Sonet A, Rousselet MC, Foussard C, et al. High numbers of tumor-associated macrophages have an adverse prognostic value that can be circumvented by rituximab in patients with follicular lymphoma enrolled onto the GELA-GOELAMS FL-2000 trial. J Clin Oncol. 2008;26:440–6. doi:10.1200/JCO.2007.12.8298. PMID:18086798.
  • Steidl C, Lee T, Shah SP, Farinha P, Han G, Nayar T, Delaney A, Jones SJ, Iqbal J, Weisenburger DD, et al. Tumor-associated macrophages and survival in classic Hodgkin's lymphoma. New Engl J Med. 2010;362:875–85. doi:10.1056/NEJMoa0905680.
  • Kadoch C, Dinca EB, Voicu R, Chen LJ, Nguyen D, Parikh S, Karrim J, Shuman MA, Lowell CA, Treseler PA, et al. Pathologic correlates of primary central nervous system lymphoma defined in an Orthotopic Xenograft Model. Clin Cancer Res. 2009;15:1989–97. doi:10.1158/1078-0432.CCR-08-2054. PMID:19276270.
  • Zheng X, Turkowski K, Mora J, Brune B, Seeger W, Weigert A, Savai R. Redirecting tumor-associated macrophages to become tumoricidal effectors as a novel strategy for cancer therapy. Oncotarget. 2017;18;8(29):48436–52. doi: 10.18632/oncotarget.17061. PMID:28467800.
  • Georgoudaki AM, Prokopec KE, Boura VF, Hellqvist E, Sohn S, Ostling J, Dahan R, Harris RA, Rantalainen M, Klevebring D, et al. Reprogramming tumor-associated macrophages by antibody targeting inhibits cancer progression and metastasis. Cell Rep. 2016;15:2000–11. doi:10.1016/j.celrep.2016.04.084. PMID:27210762.
  • Liu XQ, Lu K, Feng LL, Ding M, Gao JM, Ge XL, Wang X. Up-regulated expression of indoleamine 2,3-dioxygenase 1 in non-Hodgkin lymphoma correlates with increased regulatory T-cell infiltration. Leuk Lymphoma. 2014;55:405–14. doi:10.3109/10428194.2013.804917. PMID:23682557.
  • Godin-Ethier J, Hanafi LA, Piccirillo CA, Lapointe R. Indoleamine 2,3-dioxygenase expression in human cancers: clinical and immunologic perspectives. Clin Cancer Res. 2011;17:6985–91. doi:10.1158/1078-0432.CCR-11-1331. PMID:22068654.
  • Adikari SB, Lian H, Link H, Huang YM, Xiao BG. Interferon-gamma-modified dendritic cells suppress B cell function and ameliorate the development of experimental autoimmune myasthenia gravis. Clin Exp Immunol. 2004;138:230–6. doi:10.1111/j.1365-2249.2004.02585.x. PMID:15498031.
  • Maby-El Hajjami H, Ame-Thomas P, Pangault C, Tribut O, DeVos J, Jean R, Bescher N, Monvoisin C, Dulong J, Lamy T, et al. Functional Alteration of the Lymphoma Stromal Cell Niche by the Cytokine Context: Role of Indoleamine-2,3 Dioxygenase. Cancer Res. 2009;69:3228–37. doi:10.1158/0008-5472.CAN-08-3000. PMID:19276371.
  • Komohara Y, Horlad H, Ohnishi K, Ohta K, Makino K, Hondo H, Yamanaka R, Kajiwara K, Saito T, Kuratsu J, et al. M2 macrophage/microglial cells induce activation of Stat3 in primary central nervous system lymphoma. J Clin Exp Hematop. 2011;51:93–9. doi:10.3960/jslrt.51.93. PMID:22104307.
  • Swerdlow S, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J, Vardiman JW. WHO classifi cation of tumours of haematopoietic and lymphoid tissues. Lyon: IARC Press; 2008.
  • Hans CP, Weisenburger DD, Greiner TC, Gascoyne RD, Delabie J, Ott G, Muller-Hermelink HK, Campo E, Braziel RM, Jaffe ES, et al. Confirmation of the molecular classification of diffuse large B-cell lymphoma by immunohistochemistry using a tissue microarray. Blood. 2004;103:275–82. doi:10.1182/blood-2003-05-1545. PMID:14504078.