3,133
Views
80
CrossRef citations to date
0
Altmetric
Original Research

Complex pattern of immune evasion in MSI colorectal cancer

ORCID Icon, , ORCID Icon &
Article: e1445453 | Received 04 Dec 2017, Accepted 21 Feb 2018, Published online: 26 Mar 2018

References

  • Kloor M, Staffa L, Ahadova A, Von Knebel Doeberitz M. Clinical significance of microsatellite instability in colorectal cancer. Langenbeck's Archives of Surgery. 2014;399(1):23–31. doi:10.1007/s00423-013-1112-3. PMID:24048684
  • Jasperson KW, Tuohy TM, Neklason DW, Burt RW. Hereditary and Familial Colon Cancer. Gastroenterology. 2010;138(6):2044–58. doi:10.1053/j.gastro.2010.01.054. PMID:20420945
  • Kloor M, Von Knebel Doeberitz M. The immune biology of microsatellite-unstable cancer. Trends Cancer. 2016;2(3):121–33. doi:10.1016/j.trecan.2016.02.004. PMID:28741532
  • Buckowitz A, Knaebel H-P, Benner A, Bläker H, Gebert J, Kienle P, von Knebel Doeberitz M, Kloor M. Microsatellite instability in colorectal cancer is associated with local lymphocyte infiltration and low frequency of distant metastases. Br J Cancer. 2005;92(9):1746–53. doi:10.1038/sj.bjc.6602534. PMID:15856045
  • Dolcetti R, Viel A, Doglioni C, Russo A, Guidoboni M, Capozzi E, Vecchiato N, Macrì E, Fornasarig M, Boiocchi M. High Prevalence of Activated Intraepithelial Cytotoxic T Lymphocytes and Increased Neoplastic Cell Apoptosis in Colorectal Carcinomas with Microsatellite Instability. Am J Pathol. 1999;154(6):1805–13. doi:10.1016/S0002-9440(10)65436-3. PMID:10362805
  • Lee K, Tosti E, Edelmann W. Mouse models of DNA mismatch repair in cancer research. DNA Repair. 2016;38:140–6. doi:10.1016/j.dnarep.2015.11.015. PMID:26708047
  • Lee V, Murphy A, Le DT, Diaz LA. Mismatch Repair Deficiency and Response to Immune Checkpoint Blockade. The Oncologist. 2016;21(10):1200–11. doi:10.1634/theoncologist.2016-0046. PMID:27412392
  • Le DT, Uram JN, Wang H, Bartlett BR, Kemberling H, Eyring AD, Skora AD, Luber BS, Azad NS, Laheru D, et al. PD-1 Blockade in Tumors with Mismatch-Repair Deficiency. N Engl J Med. 2015;372(26):2509–20. doi:10.1056/NEJMoa1500596. PMID:26028255
  • Teixidó C, González-Cao M, Karachaliou N, Rosell R. Predictive factors for immunotherapy in melanoma. Ann Trans Med. 2015;3(15):208. doi:10.3978/j.issn.2305-5839.2015.05.07 PMID:26488004
  • Kloor M, Michel S, von Knebel Doeberitz M. Immune evasion of microsatellite unstable colorectal cancers. Int J Cancer. 2010;127(5):1001–10. doi:10.1002/ijc.25283. PMID:20198617
  • Bicknell DC, Kaklamanis L, Hampson R, Bodmer WF, Karran P. Selection for beta 2-microglobulin mutation in mismatch repair-defective colorectal carcinomas. Curr Biol. 1996;6(12):1695–7. doi:10.1016/S0960-9822(02)70795-1. PMID:8994836
  • Kloor M, von Knebel Doeberitz M, Gebert JF. Molecular testing for microsatellite instability and its value in tumor characterization. Expert review of molecular diagnostics. 2005;5(4):599–611. doi:10.1586/14737159.5.4.599. PMID:16013977
  • Kloor M, Michel S, Buckowitz B, Rüschoff J, Büttner R, Holinski-Feder E, Dippold W, Wagner R, Tariverdian M, Benner A, et al. Beta2-microglobulin mutations in microsatellite unstable colorectal tumors. Int J Cancer. 2007;121(2):454–8. doi:10.1002/ijc.22691. PMID:17373663
  • Benitez R, Godelaine D, Lopez-Nevot MA, Brasseur F, Jiménez P, Marchand M, Oliva MR, van Baren N, Cabrera T, Andry G, et al. Mutations of the beta2-microglobulin gene result in a lack of HLA class I molecules on melanoma cells of two patients immunized with MAGE peptides. Tissue Antigens. 1998;52(6):520–9. doi:10.1111/j.1399-0039.1998.tb03082.x. PMID:9894850
  • Echterdiek F, Janikovits J, Staffa L, Müller M, Lahrmann B, Frühschütz M, Hartog B, Nelius N, Benner A, Tariverdian M, et al. Low density of FOXP3-positive T cells in normal colonic mucosa is related to the presence of beta2-microglobulin mutations in Lynch syndrome-associated colorectal cancer. OncoImmunology. 2016;5(2):e1075692. doi:10.1080/2162402X.2015.1075692. PMID:27057447
  • Janikovits J, Müller M, Krzykalla J, Körner S, Echterdiek F, Lahrmann B, Grabe N, Schneider M, Benner A, Doeberitz M von K, et al. High numbers of PDCD1 (PD-1)-positive T cells and B2M mutations in microsatellite-unstable colorectal cancer. OncoImmunology. 2018;7(2):e1390640. doi:10.1080/2162402X.2017.1390640. PMID:29308317
  • Le DT, Durham JN, Smith KN, Wang H, Bartlett BR, Aulakh LK, Lu S, Kemberling H, Wilt C, Luber BS, et al. Mismatch repair deficiency predicts response of solid tumors to PD-1 blockade. Science. 2017;357(6349):409–13. doi:10.1126/science.aan6733. PMID:28596308
  • Shin DS, Zaretsky JM, Escuin-Ordinas H, Garcia-Diaz A, Hu-Lieskovan S, Kalbasi A, Grasso CS, Hugo W, Sandoval S, Torrejon DY, et al. Primary resistance to PD-1 blockade mediated by JAK1/2 mutations. Cancer Discovery. 2017;7(2):188–201. doi:10.1158/2159-8290.CD-16-1223. PMID:27903500
  • Rosenberg SA, Yang JC, Robbins PF, Wunderlich JR, Sherry RM, Schwartzentruber DJ, Topalian SL, Nicholas P, Filie A, Chang R, et al. Cell transfer therapy for cancer: lessons from sequential treatments of a patient with metastatic melanoma. J Immunother. 2003;26(5):385–93. doi:10.1097/00002371-200309000-00001. PMID:12973027
  • Zaretsky JM, Garcia-Diaz A, Shin DS, Escuin-Ordinas H, Hugo W, Hu-Lieskovan S, Torrejon DY, Abril-Rodriguez G, Sandoval S, Barthly L, et al. Mutations Associated with Acquired Resistance to PD-1 Blockade in Melanoma. New England Journal of Medicine. 2016;375(9):819–29. doi:10.1056/NEJMoa1604958. PMID:27433843
  • Giannakis M, Mu X, Shukla S, Qian Z, Cohen O, Nishihara R, Bahl S, Cao Y, Amin-Mansour A, Yamauchi M, et al. Genomic Correlates of Immune-Cell Infiltrates in Colorectal Carcinoma. Cell reports. 2016;15(4):857–65. doi:10.1016/j.celrep.2016.03.075.
  • Cerami E, Gao J, Dogrusoz U, Gross BE, Sumer SO, Aksoy BA, Jacobsen A, Byrne CJ, Heuer ML, Larsson E, et al. The cBio Cancer Genomics Portal: An open platform for exploring multidimensional cancer genomics data. Cancer Discovery. 2012;2(5):401–4. doi:10.1158/2159-8290.CD-12-0095. PMID:22588877
  • Gao J, Aksoy BA, Dogrusoz U, Dresdner G, Gross B, Sumer SO, Sun Y, Jacobsen A, Sinha R, Larsson E, et al. Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal. Science Signaling. 2013;6(269):pl1–pl1. doi:10.1126/scisignal.2004088. PMID:23550210
  • Kloor M. Immunoselective Pressure and Human Leukocyte Antigen Class I Antigen Machinery Defects in Microsatellite Unstable Colorectal Cancers. Cancer Res. 2005;65(14):6418–24. doi:10.1158/0008-5472.CAN-05-0044. PMID:16024646
  • Woerner SM, Yuan YP, Benner A, Korff S, Von Knebel Doeberitz M, Bork P. SelTarbase, a database of human mononucleotide-microsatellite mutations and their potential impact to tumorigenesis and immunology. Nucleic Acids Res. 2009;38(SUPPL.1):682–9. doi:10.1093/nar/gkp839
  • Koelzer VH, Baker K, Kassahn D, Baumhoer D, Zlobec I. Prognostic impact of β-2-microglobulin expression in colorectal cancers stratified by mismatch repair status. J Clin Pathol. 2012;65(11):996–1002. doi:10.1136/jclinpath-2012-200742. PMID:22859396
  • Sveen A, Johannessen B, Tengs T, Danielsen SA, Eilertsen IA, Lind GE, Berg KCG, Leithe E, Meza-Zepeda LA, Domingo E, et al. Multilevel genomics of colorectal cancers with microsatellite instability—clinical impact of JAK1 mutations and consensus molecular subtype 1. Genome Medicine. 2017;9(1):46. doi:10.1186/s13073-017-0434-0. PMID:28539123
  • Ren Y, Zhang Y, Liu RZ, Fenstermacher DA, Wright KL, Teer JK, Wu J. JAK1 truncating mutations in gynecologic cancer define new role of cancer-associated protein tyrosine kinase aberrations. Sci Rep. 2013;3:3042. doi:10.1038/srep03042. PMID:24154688
  • Albacker LA, Wu J, Smith P, Warmuth M, Stephens PJ, Zhu P, Yu L, Chmielecki J. Loss of function JAK1 mutations occur at high frequency in cancers with microsatellite instability and are suggestive of immune evasion Reis RM, editor. PLOS ONE. 2017;12(11):e0176181. doi:10.1371/journal.pone.0176181. PMID:29121062
  • Czéh M, Loddenkemper C, Shalapour S, Schön C, Robine S, Goldscheid E, Stein H, Schüler T, Willimsky G, Blankenstein T. The immune response to sporadic colorectal cancer in a novel mouse model. Oncogene. 2010;29(50):6591–602. doi:10.1038/onc.2010.388. PMID:20818425
  • Meissner TB, Li A, Biswas A, Lee K-H, Liu Y-J, Bayir E, Iliopoulos D, van den Elsen PJ, Kobayashi KS. NLR family member NLRC5 is a transcriptional regulator of MHC class I genes. Proc Natl Acad Sci. 2010;107(31):13794–9. doi:10.1073/pnas.1008684107.
  • Biswas A, Meissner TB, Kawai T, Kobayashi KS. Cutting Edge: Impaired MHC Class I Expression in Mice Deficient for Nlrc5/Class I Transactivator. J Immunol. 2012;189(2):516–20. doi:10.4049/jimmunol.1200064. PMID:22711889
  • Robbins GR, Truax AD, Davis BK, Zhang L, Brickey WJ, Ting JP-Y. Regulation of Class I Major Histocompatibility Complex (MHC) by Nucleotide-binding Domain, Leucine-rich Repeat-containing (NLR) Proteins. J Biol Chem. 2012;287(29):24294–303. doi:10.1074/jbc.M112.364604. PMID:22645137
  • Staehli F, Ludigs K, Heinz LX, Seguin-Estevez Q, Ferrero I, Braun M, Schroder K, Rebsamen M, Tardivel A, Mattmann C, et al. NLRC5 Deficiency Selectively Impairs MHC Class I- Dependent Lymphocyte Killing by Cytotoxic T Cells. J Immunol. 2012;188(8):3820–8. doi:10.4049/jimmunol.1102671. PMID:22412192
  • Tong Y, Cui J, Li Q, Zou J, Wang HY, Wang R-F. Enhanced TLR-induced NF-κB signaling and type I interferon responses in NLRC5 deficient mice. Cell Research. 2012;22(5):822–35. doi:10.1038/cr.2012.53. PMID:22473004
  • Yao Y, Wang Y, Chen F, Huang Y, Zhu S, Leng Q, Wang H, Shi Y, Qian Y. NLRC5 regulates MHC class I antigen presentation in host defense against intracellular pathogens. Cell Research. 2012;22(5):836–47. doi:10.1038/cr.2012.56. PMID:22491475
  • Chelbi ST, Guarda G. NLRC5, a promising new entry in tumor immunology. Journal for ImmunoTherapy of Cancer. 2016;4(1):39. doi:10.1186/s40425-016-0143-z. PMID:27437103
  • Yoshihama S, Roszik J, Downs I, Meissner TB, Vijayan S, Chapuy B, Sidiq T, Shipp MA, Lizee GA, Kobayashi KS. NLRC5/MHC class I transactivator is a target for immune evasion in cancer. Proc Natl Acad Sci. 2016;113(21):5999–6004. doi:10.1073/pnas.1602069113.
  • Chelbi ST, Dang AT, Guarda G. Emerging Major Histocompatibility Complex Class I-Related Functions of NLRC5. Adv Immunol. 2017;133:89–119. doi:10.1016/bs.ai.2016.11.003
  • de Kruijf EM, van Nes JGH, Sajet A, Tummers QRJG, Putter H, Osanto S, Speetjens FM, Smit VTHBM, Liefers GJ, van de Velde CJH, et al. The Predictive Value of HLA Class I Tumor Cell Expression and Presence of Intratumoral Tregs for Chemotherapy in Patients with Early Breast Cancer. Clin Cancer Res. 2010;16(4):1272–80. doi:10.1158/1078-0432.CCR-09-1844. PMID:20145162