Cell-type specific MyD88 signaling is required for intestinal tumor initiation and progression to malignancy

References

• Elinav E, Nowarski R, Thaiss CA, Hu B, Jin C, Flavell RA. Inflammation-induced cancer: crosstalk between tumours, immune cells and microorganisms. Nature Rev Cancer. 2013;13:759–71. doi:10.1038/nrc3611.
   PubMed Web of Science ®Google Scholar
• Greten FR, Eckmann L, Greten TF, Park JM, Li ZW, Egan LJ, Kagnoff MF, Karin M. IKKbeta links inflammation and tumorigenesis in a mouse model of colitis-associated cancer. Cell. 2004;118:285–96. doi:10.1016/j.cell.2004.07.013. PMID:15294155.
   PubMed Web of Science ®Google Scholar
• Pikarsky E, Porat RM, Stein I, Abramovitch R, Amit S, Kasem S, Gutkovich-Pyest E, Urieli-Shoval S, Galun E, Ben-Neriah Y. NF-kappa B functions as a tumour promoter in inflammation-associated cancer. Nature. 2004;431:461–6. doi:10.1038/nature02924. PMID:15329734.
   PubMed Web of Science ®Google Scholar
• Kelly MG, Alvero AB, Chen R, Silasi DA, Abrahams VM, Chan S, Visintin I, Rutherford T, Mor G. TLR-4 signaling promotes tumor growth and paclitaxel chemoresistance in ovarian cancer. Cancer Res. 2006;66:3859–68. doi:10.1158/0008-5472.CAN-05-3948. PMID:16585214.
   PubMed Web of Science ®Google Scholar
• Achyut BR, Ghoshal UC, Moorchung N, Mittal B. Association of Toll-like receptor-4 (Asp299Gly and Thr399Ileu) gene polymorphisms with gastritis and precancerous lesions. Hum Immunol. 2007;68:901–7. doi:10.1016/j.humimm.2007.10.006. PMID:18082569.
   PubMed Web of Science ®Google Scholar
• Tahara T, Arisawa T, Wang F, Shibata T, Nakamura M, Sakata M, Hirata I, Nakano H. Toll-like receptor 2 -196 to 174del polymorphism influences the susceptibility of Japanese people to gastric cancer. Cancer Sci. 2007;98:1790–4. doi:10.1111/j.1349-7006.2007.00590.x. PMID:17711514.
   PubMed Web of Science ®Google Scholar
• Wang EL, Qian ZR, Nakasono M, Tanahashi T, Yoshimoto K, Bando Y, Kudo E, Shimada M, Sano T. High expression of Toll-like receptor 4/myeloid differentiation factor 88 signals correlates with poor prognosis in colorectal cancer. Br J Cancer. 2010;102:908–15. doi:10.1038/sj.bjc.6605558. PMID:20145615.
   PubMed Web of Science ®Google Scholar
• Kawai T, Akira S. The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors. Nat Immunol. 2010;11:373–84. doi:10.1038/ni.1863. PMID:20404851.
   PubMed Web of Science ®Google Scholar
• Akira S, Takeda K. Toll-like receptor signalling. Nature Rev Immunol. 2004;4:499–511. doi:10.1038/nri1391.
   PubMed Web of Science ®Google Scholar
• Kumar H, Kawai T, Akira S. Pathogen recognition by the innate immune system. Int Rev Immunol. 2011;30:16–34. doi:10.3109/08830185.2010.529976. PMID:21235323.
   PubMed Web of Science ®Google Scholar
• Salcedo R, Worschech A, Cardone M, Jones Y, Gyulai Z, Dai RM, Wang E, Ma W, Haines D, O'hUigin C, et al. MyD88-mediated signaling prevents development of adenocarcinomas of the colon: role of interleukin 18. J Exp Med. 2010;207:1625–36. doi:10.1084/jem.20100199. PMID:20624890.
   PubMed Web of Science ®Google Scholar
• Banerjee A, Thamphiwatana S, Carmona EM, Rickman B, Doran KS, Obonyo M. Deficiency of the myeloid differentiation primary response molecule MyD88 leads to an early and rapid development of Helicobacter-induced gastric malignancy. Infect Immun. 2014;82:356–63. doi:10.1128/IAI.01344-13. PMID:24166959.
   PubMed Web of Science ®Google Scholar
• Rakoff-Nahoum S, Medzhitov R. Regulation of spontaneous intestinal tumorigenesis through the adaptor protein MyD88. Science. 2007;317:124–7. doi:10.1126/science.1140488. PMID:17615359.
   PubMed Web of Science ®Google Scholar
• Lee SH, Hu LL, Gonzalez-Navajas J, Seo GS, Shen C, Brick J, Herdman S, Varki N, Corr M, Lee J, et al. ERK activation drives intestinal tumorigenesis in Apc(min/+) mice. Nat Med. 2010;16:665–70. doi:10.1038/nm.2143. PMID:20473309.
   PubMed Web of Science ®Google Scholar
• Moresco EVY, LaVine D, Beutler B. Toll-like receptors. Curr Biol. 2013;21:R488–R93. doi:10.1016/j.cub.2011.05.039.
   Web of Science ®Google Scholar
• Gais P, Reim D, Jusek G, Rossmann-Bloeck T, Weighardt H, Pfeffer K, Altmayr F, Janssen KP, Holzmann B. Cutting edge: divergent cell-specific functions of MyD88 for inflammatory responses and organ injury in septic peritonitis. J Immunol. 2012;188:5833–7. doi:10.4049/jimmunol.1200038. PMID:22586041.
   PubMed Web of Science ®Google Scholar
• el Marjou F, Janssen KP, Chang BH, Li M, Hindie V, Chan L, Louvard D, Chambon P, Metzger D, Robine S. Tissue-specific and inducible Cre-mediated recombination in the gut epithelium. Genesis. 2004;39:186–93. doi:10.1002/gene.20042. PMID:15282745.
   PubMed Web of Science ®Google Scholar
• Clausen BE, Burkhardt C, Reith W, Renkawitz R, Förster I. Conditional gene targeting in macrohages and granulocytes using LysMcre mice. Transgenic Res. 1999;8:265–77. doi:10.1023/A:1008942828960. PMID:10621974.
   PubMed Web of Science ®Google Scholar
• Fodde R, Edelmann W, Yang K, van Leeuwen C, Carlson C, Renault B, Breukel C, Alt E, Lipkin M, Khan PM, et al. A targeted chain-termination mutation in the mouse Apc gene results in multiple intestinal tumors. Proc Nat Acad Sci U S A. 1994;91:8969–73. doi:10.1073/pnas.91.19.8969.
   PubMed Web of Science ®Google Scholar
• Rohde F, Rimkus C, Friederichs J, Rosenberg R, Marthen C, Doll D, et al. Expression of osteopontin, a target gene of de-regulated Wnt signaling, predicts survival in colon cancer. Int J Cancer J Int Du Cancer. 2007;121:1717–23. doi:10.1002/ijc.22868. PMID:8090754.
   PubMed Web of Science ®Google Scholar
• Zaph C, Troy AE, Taylor BC, Berman-Booty LD, Guild KJ, Du Y, Yost EA, Gruber AD, May MJ, Greten FR, et al. Epithelial-cell-intrinsic IKK-beta expression regulates intestinal immune homeostasis. Nature. 2007;446:552–6. doi:10.1038/nature05590. PMID:17322906.
   PubMed Web of Science ®Google Scholar
• Xie L, Jiang FC, Zhang LM, He WT, Liu JH, Li MQ, Zhang X, Xing S, Guo H, Zhou P. Targeting of MyD88 homodimerization by novel synthetic inhibitor TJ-M2010-5 in preventing colitis-associated colorectal cancer. J Natl Cancer Inst. 2015;108(4):djv364. doi:10.1093/jnci/djv364. PMID:26712311.
   PubMedGoogle Scholar
• Grivennikov SI, Wang K, Mucida D, Stewart CA, Schnabl B, Jauch D, Taniguchi K, Yu GY, Osterreicher CH, Hung KE, et al. Adenoma-linked barrier defects and microbial products drive IL-23/IL-17-mediated tumour growth. Nature. 2012;491:254–8. doi:10.1038/nature11465. PMID:23034650.
   PubMed Web of Science ®Google Scholar
• Cremonesi E, Governa V, Garzon JFG, Mele V, Amicarella F, Muraro MG, Trella E, Galati-Fournier V, Oertli D, Däster SR, et al. Gut microbiota modulate T cell trafficking into human colorectal cancer. Gut. 2018;gutjnl-2016-313498. doi:10.1136/gutjnl-2016-313498. PMID:29437871.
   PubMed Web of Science ®Google Scholar
• Jia RJ, Cao L, Zhang L, Jing W, Chen R, Zhu MH, Zhu MH, Guo SW, Wu GB, Fan XY, et al. Enhanced myeloid differentiation factor 88 promotes tumor metastasis via induction of epithelial-mesenchymal transition in human hepatocellular carcinoma. Cell Death Disease. 2014;5:e1103. doi:10.1038/cddis.2014.71. PMID:24603331.
   PubMed Web of Science ®Google Scholar
• Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell. 2011;144:646–74. doi:10.1016/j.cell.2011.02.013. PMID:21376230.
   PubMed Web of Science ®Google Scholar
• Clevers H. The intestinal crypt, a prototype stem cell compartment. Cell. 2013;154:274–84. doi:10.1016/j.cell.2013.07.004. PMID:23870119.
   PubMed Web of Science ®Google Scholar
• Neal MD, Sodhi CP, Jia H, Dyer M, Egan CE, Yazji I, Good M, Afrazi A, Marino R, Slagle D, et al. Toll-like receptor 4 is expressed on intestinal stem cells and regulates their proliferation and apoptosis via the p53 up-regulated modulator of apoptosis. J Biol Chem. 2012;287:37296–308. doi:10.1074/jbc.M112.375881. PMID:22955282.
   PubMed Web of Science ®Google Scholar
• Scheeren FA, Kuo AH, van Weele LJ, Cai S, Glykofridis I, Sikandar SS, Zabala M, Qian D, Lam JS, Johnston D, et al. A cell-intrinsic role for TLR2-MYD88 in intestinal and breast epithelia and oncogenesis. Nat Cell Biol. 2014;16:1238–48. doi:10.1038/ncb3058. PMID:25362351.
   PubMed Web of Science ®Google Scholar
• Janssen KP, el-Marjou F, Pinto D, Sastre X, Rouillard D, Fouquet C, Soussi T, Louvard D, Robine S. Targeted expression of oncogenic K-ras in intestinal epithelium causes spontaneous tumorigenesis in mice. Gastroenterology. 2002;123:492–504. doi:10.1053/gast.2002.34786. PMID:12145803.
   PubMed Web of Science ®Google Scholar