Advanced search
Publication Cover
OncoImmunology Volume 9, 2020 - Issue 1
Submit an article Journal homepage
1,757
Views
1
CrossRef citations to date
0
Altmetric
Review

The consensus Immunoscore in phase 3 clinical trial (N0147) and impact on patient management decisions

Anastasia Lanzia INSERM, Laboratory of Integrative Cancer Immunology, Cordeliers Research Center, Paris, France;b Equipe Labellisée Ligue Contre le Cancer, Paris, France;c Centre de Recherche des Cordeliers, Sorbonne Université, Sorbonne Paris Cité, Université de Paris, Paris, FranceView further author information
,
F. A. Sinicroped Mayo Clinic, Rochester, MN, USAView further author information
,
A. B. Bensone Northwestern University, Chicago, IL, USAView further author information
&
Jérôme Galona INSERM, Laboratory of Integrative Cancer Immunology, Cordeliers Research Center, Paris, France;b Equipe Labellisée Ligue Contre le Cancer, Paris, France;c Centre de Recherche des Cordeliers, Sorbonne Université, Sorbonne Paris Cité, Université de Paris, Paris, FranceCorrespondence[email protected]
View further author information
Article: 1796003 | Received 08 Jul 2020, Accepted 11 Jul 2020, Published online: 20 Jul 2020

References

  • Quezada-Marin J, Lam AK, Ochiai A, Odze RD, Washington KM, Fukayama M, Rugge M, Klimstra DS, Nagtegaal ID, Tan P-H, et al. Gastrointestinal tissue-based molecular biomarkers: A practical categorization based on the 2019 WHO classification of epithelial digestive tumours. Histopathology. 2020. PMID: 32320495. doi:10.1111/his.14120.
  • Galon J, Costes A, Sanchez-Cabo F, Kirilovsky A, Mlecnik B, Lagorce-Pagès C, Tosolini M, Camus M, Berger A, Wind P, et al. Type, density, and location of immune cells within human colorectal tumors predict clinical outcome. Science. 2006;313:1960–3. PMID: 17008531. doi:10.1126/science.1129139.
  • Galon J, Fox BA, Bifulco CB, Masucci G, Rau T, Botti G, Marincola FM, Ciliberto G, Pages F, Ascierto PA, et al. Immunoscore and immunoprofiling in cancer: an update from the melanoma and immunotherapy bridge 2015. J Transl Med. 2016;14:273. PMID: 27650038. doi:10.1186/s12967-016-1029-z.
  • Kirilovsky A, Marliot F, El Sissy C, Haicheur N, Galon J, Pagès F. Rational bases for the use of the Immunoscore in routine clinical settings as a prognostic and predictive biomarker in cancer patients. Int Immunol. 2016;28:373–382. PMID: 27121213. doi:10.1093/intimm/dxw021.
  • Pages F, Galon J, Fridman WH. The essential role of the in situ immune reaction in human colorectal cancer. J Leukoc Biol. 2008;84:981–987. PMID: 18559950. doi:10.1189/jlb.1107773.
  • Pages F, Mlecnik B, Marliot F, Bindea G, Ou F-S, Bifulco C, Lugli A, Zlobec I, Rau TT, Berger MD, et al. International validation of the consensus Immunoscore for the classification of colon cancer: a prognostic and accuracy study. Lancet. 2018;391:2128–2139. PMID: 29754777. doi:10.1016/S0140-6736(18)30789-X.
  • Pagès F, André T, Taieb J, Vernerey D, Henriques J, Borg C, Marliot F, Ben Jannet R, Louvet C, Mineur L, et al. Prognostic and predictive value of the Immunoscore in stage III colon cancer patients treated with oxaliplatin in the prospective IDEA France PRODIGE-GERCOR cohort study. Ann Oncol. 2020;31:921–929. PMID: 32294529. doi:10.1016/j.annonc.2020.03.310.
  • Sinicrope FA, Shi Q, Hermitte F, Zemla TJ, Mlecnik B, Benson AB, Gill S, Goldberg RM, Kahlenberg MS, Nair SG, et al. Contribution of Immunoscore and molecular features to survival prediction in stage III colon cancer. JNCI Cancer Spectr. 2020;4:pkaa023. PMID: 32455336. doi:10.1093/jncics/pkaa023.
  • Grothey A, Venook AP. Optimizing adjuvant therapy for localized colon cancer and treatment selection in advanced colorectal cancer. J Natl Compr Canc Netw. 2018;16:611–615. PMID: 29784738. doi:10.6004/jnccn.2018.0038.
  • Vacchelli E, Galluzzi L, Fridman WH, Galon J, Sautès-Fridman C, Tartour E, Kroemer G. Trial watch: chemotherapy with immunogenic cell death inducers. Oncoimmunology. 2012;1:179–188. PMID: 22720239. doi:10.4161/onci.1.2.190262011ONCOIMM0105.
  • Mlecnik B, Van den Eynde M, Bindea G, Church SE, Vasaturo A, Fredriksen T, Lafontaine L, Haicheur N, Marliot F, Debetancourt D, et al. Comprehensive intrametastatic immune quantification and major impact of Immunoscore on survival. J Natl Cancer Inst. 2018;110:97–108. PMID: 28922789. doi:10.1093/jnci/djx123.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.