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OncoImmunology Volume 9, 2020 - Issue 1
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Review

Reviving the role of MET in liver cancer therapy and vaccination: an autophagic perspective

Xing Huanga Zhejiang Provincial Key Laboratory of Pancreatic Disease, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China;b Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, ChinaCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-8886-2777View further author information
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Gang Zhanga Zhejiang Provincial Key Laboratory of Pancreatic Disease, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China;b Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, ChinaView further author information
,
Xueli Baia Zhejiang Provincial Key Laboratory of Pancreatic Disease, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China;b Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, ChinaView further author information
&
Tingbo Lianga Zhejiang Provincial Key Laboratory of Pancreatic Disease, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China;b Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, ChinaCorrespondence[email protected]
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Article: 1818438 | Received 21 Aug 2020, Accepted 30 Aug 2020, Published online: 13 Sep 2020

References

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  • Huang X, Gan G, Wang X, Xu T, Xie W. The HGF-MET axis coordinates liver cancer metabolism and autophagy for chemotherapeutic resistance. Autophagy. 2019;15(7):1258–1279. doi:10.1080/15548627.2019.1580105.
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  • Liu GY, Sabatini DM. mTOR at the nexus of nutrition, growth, ageing and disease. Nat Rev Mol Cell Biol. 2020;21:183–203.
  • Jones RG, Pearce EJ. MenTORing immunity: mTOR signaling in the development and function of tissue-resident immune cells. Immunity. 2017;46(5):730–742. doi:10.1016/j.immuni.2017.04.028.
  • Do MH, Wang X, Zhang X, Chou C, Nixon BG, Capistrano KJ, Peng M, Efeyan A, Sabatini DM, Li MO. Nutrient mTORC1 signaling underpins regulatory T cell control of immune tolerance. J Exp Med. 2020;217(1):e20190848.
  • Huang X, Xu X, Wang X, Tang T, Li E, Zhang X, Xu J, Shen H, Guo C, Xu T, et al. The AKT-independent MET-V-ATPase-MTOR axis suppresses liver cancer vaccination. Signal Transduction Targeted Ther. 2020;5(1):122. doi:10.1038/s41392-020-0179-x.

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