Immunotherapy or other anti-cancer treatments and risk of exacerbation and mortality in cancer patients with COVID-19: a systematic review and meta-analysis

References

• Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, Zhang L, Fan G, Xu J, Gu X, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020;395(10223):497–9. doi:10.1016/S0140-6736(20)30183-5.
   PubMed Web of Science ®Google Scholar
• Wang D, Hu B, Hu C, Zhu F, Liu X, Zhang J, Wang B, Xiang H, Cheng Z, Xiong Y,et al. Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China. JAMA. 2020;323(11):1061–1069.  doi: 10.1001/jama.2020.1585.
   Web of Science ®Google Scholar
• Yang F, Shi S, Zhu J, Shi J, Dai K, Chen X. Clinical characteristics and outcomes of cancer patients with COVID-19. J Med Virol. 2020. doi:10.1002/jmv.25972.
   Google Scholar
• Yu J, Ouyang W, Chua MLK, Xie C. SARS-CoV-2 transmission in cancer patients of a tertiary hospital in Wuhan. medRxiv. 2020:2020.02.22.20025320
   Google Scholar
• Liang W, Guan W, Chen R, Wang W, Li J, Xu K, Li C, Ai Q, Lu W, Liang H, et al. Cancer patients in SARS-CoV-2 infection: a nationwide analysis in China. Lancet Oncol. 2020;21(3):335–337. doi:10.1016/S1470-2045(20)30096-6.
   PubMed Web of Science ®Google Scholar
• Addeo A, Obeid M, Friedlaender A. COVID-19 and lung cancer: risks, mechanisms and treatment interactions. J Immunother Cancer. 2020;8(1):e000892. doi: 10.1136/jitc-2020-000892.
   Web of Science ®Google Scholar
• Wang H, Zhang L. Risk of COVID-19 for patients with cancer. Lancet Oncol. 2020;21:e181. doi:10.1016/S1470-2045(20)30149-2.
   PubMed Web of Science ®Google Scholar
• Sidaway P. COVID-19 and cancer: what we know so far. Nat Rev Clin Oncol. 2020;17:336. doi:10.1038/s41571-020-0366-2.
   PubMed Web of Science ®Google Scholar
• Zhang H, Zhou P, Wei Y, Yue H, Wang Y, Hu M, Zhang S, Cao T, Yang C, Li M, et al. Histopathologic changes and SARS-CoV-2 Immunostaining in the lung of a patient with COVID-19. Ann Intern Med. 2020;172(9):629–632. doi:10.7326/M20-0533.
   PubMed Web of Science ®Google Scholar
• Schrag D, Hershman DL, Basch E. Oncology practice during the COVID-19 pandemic. JAMA. 2020;323(20):2005. doi:10.1001/jama.2020.6236.
   PubMed Web of Science ®Google Scholar
• Moujaess E, Kourie HR, Ghosn M. Cancer patients and research during COVID-19 pandemic: a systematic review of current evidence. Crit Rev Oncol Hematol. 2020;150:102972. doi:10.1016/j.critrevonc.2020.102972.
   PubMed Web of Science ®Google Scholar
• Gosain R, Abdou Y, Singh A, Rana N, Puzanov I, Ernstoff MS. COVID-19 and cancer: a comprehensive review. Curr Oncol Rep. 2020;22:53. doi:10.1007/s11912-020-00934-7.
   PubMed Web of Science ®Google Scholar
• Zhang L, Zhu F, Xie L, Wang C, Wang J, Chen R, Jia P, Guan HQ, Peng L, Chen Y, et al. Clinical characteristics of COVID-19-infected cancer patients: a retrospective case study in three hospitals within Wuhan, China. Ann Oncol. 2020;31(7):894–901. doi:10.1016/j.annonc.2020.03.296.
   PubMed Web of Science ®Google Scholar
• Robinson A, Gyawali B, Booth CM. Risk of COVID-19 in patients with cancer. JAMA Oncol. 2020;6(9):1471. doi:10.1001/jamaoncol.2020.2586.
   PubMedGoogle Scholar
• Tian J, Yuan X, Xiao J, Zhong Q, Yang C, Liu B, Cai Y, Lu Z, Wang J, Wang Y, et al. Clinical characteristics and risk factors associated with COVID-19 disease severity in patients with cancer in Wuhan, China: a multicentre, retrospective, cohort study. Lancet Oncol. 2020;21(7):893–903. doi:10.1016/S1470-2045(20)30309-0.
   PubMed Web of Science ®Google Scholar
• Kuderer NM, Choueiri TK, Shah DP, Shyr Y, Rubinstein SM, Rivera DR, Shete S, Hsu C-Y, Desai A, de Lima Lopes G, et al. Clinical impact of COVID-19 on patients with cancer (CCC19): a cohort study. Lancet. 2020;395(10241):1907–1918. doi:10.1016/S0140-6736(20)31187-9.
   PubMed Web of Science ®Google Scholar
• Sharma A, Malviya R, Kumar V, Gupta R, Awasthi R. Severity and risk of COVID-19 in cancer patients: an evidence-based learning. Dermatol Ther. 2020;e13778. doi: 10.1111/dth.13778.
   PubMed Web of Science ®Google Scholar
• Ouyang W, Hu J, Zhang H, Xie C. The management of patients with lung cancer during the outbreak of coronavirus disease 2019. J Thorac Oncol. 2020;15:e106–e7. doi:10.1016/j.jtho.2020.05.003.
   PubMed Web of Science ®Google Scholar
• Huang B, Zhu J, Wu XY, Gao XH. Should patients stop their radiotherapy or chemotherapy during the COVID-19 pandemic. Am J Cancer Res. 2020;10:1518–1521.
   PubMed Web of Science ®Google Scholar
• Moher D, Liberati A, Tetzlaff J, Altman DG, Group P. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. BMJ. 2009;339:b2535. doi:10.1136/bmj.b2535.
   PubMed Web of Science ®Google Scholar
• Barber DL, Wherry EJ, Masopust D, Zhu B, Allison JP, Sharpe AH, Freeman GJ, Ahmed R. Restoring function in exhausted CD8 T cells during chronic viral infection. Nature. 2006;439(7077):682–687. doi:10.1038/nature04444.
   PubMed Web of Science ®Google Scholar
• Fairfax BP, Taylor CA, Watson RA, Nassiri I, Danielli S, Fang H, Mahé EA, Cooper R, Woodcock V, Traill Z. Peripheral CD8(+) T cell characteristics associated with durable responses to immune checkpoint blockade in patients with metastatic melanoma. Nat Med. 2020;26:193–199. doi:10.1038/s41591-019-0734-6.
   PubMed Web of Science ®Google Scholar
• Stang A. Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses. Eur J Epidemiol. 2010;25:603–605. doi:10.1007/s10654-010-9491-z.
   PubMed Web of Science ®Google Scholar
• Altman DG, Bland JM. Interaction revisited: the difference between two estimates. BMJ. 2003;326:219. doi:10.1136/bmj.326.7382.219.
   PubMed Web of Science ®Google Scholar
• Ma J, Yin J, Qian Y, Wu Y. Clinical characteristics and prognosis in cancer patients with COVID-19: a single center’s retrospective study. J Infect. 2020;81:318–356. doi:10.1016/j.jinf.2020.04.006.
   PubMed Web of Science ®Google Scholar
• Dai M, Liu D, Liu M, Zhou F, Li G, Chen Z, Zhang Z, You H, Wu M, Zheng Q, et al. Patients with cancer appear more vulnerable to SARS-CoV-2: a multicenter study during the COVID-19 outbreak. Cancer Discov. 2020;10:783–791.
   PubMed Web of Science ®Google Scholar
• Lee LY, Cazier J-B, Angelis V, Arnold R, Bisht V, Campton NA, Chackathayil J, Cheng VW, Curley HM, Fittall MW, et al. COVID-19 mortality in patients with cancer on chemotherapy or other anticancer treatments: a prospective cohort study. Lancet. 2020;395(10241):1919–1926. doi:10.1016/S0140-6736(20)31173-9.
   PubMed Web of Science ®Google Scholar
• Luo J, Rizvi H, Preeshagul IR, Egger JV, Hoyos D, Bandlamudi C, McCarthy CG, Falcon CJ, Schoenfeld AJ, Arbour KC, et al. COVID-19 in patients with lung cancer. Ann Oncol. 2020. doi:10.1016/j.annonc.2020.06.007.
   Google Scholar
• Mehta V, Goel S, Kabarriti R, Cole D, Goldfinger M, Acuna-Villaorduna A, Pradhan K, Thota R, Reissman S, Sparano JA, et al. Case fatality rate of cancer patients with COVID-19 in a New York hospital system. Cancer Discov. 2020;10(7):935–941. doi:10.1158/2159-8290.CD-20-0516.
   PubMed Web of Science ®Google Scholar
• Robilotti EV, Babady NE, Mead PA, Rolling T, Perez-Johnston R, Bernardes M, Bogler Y, Caldararo M, Figueroa CJ, Glickman MS, et al. Determinants of severity in cancer patients with COVID-19 illness. medRxiv. 2020;26(8):1218–1223. doi: 10.1038/s41591-020-0979-0.
   PubMedGoogle Scholar
• Stroppa EM, Toscani I, Citterio C, Anselmi E, Zaffignani E, Codeluppi M, Cavanna L. Coronavirus disease-2019 in cancer patients. A report of the first 25 cancer patients in a western country (Italy). Future Oncol. 2020;16(20):1425–1432. doi:10.2217/fon-2020-0369.
   PubMed Web of Science ®Google Scholar
• Yang K, Sheng Y, Huang C, Jin Y, Xiong N, Jiang K, Lu H, Liu J, Yang J, Dong Y. Clinical characteristics, outcomes, and risk factors for mortality in patients with cancer and COVID-19 in Hubei, China: a multicentre, retrospective, cohort study. Lancet Oncol. 2020;21(7):904–913. doi:10.1016/S1470-2045(20)30310-7.
   PubMed Web of Science ®Google Scholar
• Yarza R, Bover M, Paredes D, Lopez-Lopez F, Jara-Casas D, Castelo-Loureiro A, Baena J, Mazarico JM, Folgueira MD, Meléndez-Carmona MÁ, et al. SARS-CoV-2 infection in cancer patients undergoing active treatment: analysis of clinical features and predictive factors for severe respiratory failure and death. Eur J Cancer. 2020;135:242–250. doi:10.1016/j.ejca.2020.06.001.
   PubMed Web of Science ®Google Scholar
• Zhang H, Wang L, Chen Y, Wu Q, Chen G, Shen X, Wang Q, Yan Y, Yu Y, Zhong Y, et al. Outcomes of novel coronavirus disease 2019 (COVID-19) infection in 107 patients with cancer from Wuhan, China. Cancer. 2020;126(17):4023–4031. doi: 10.1002/cncr.33042.
   Google Scholar
• Garassino MC, Whisenant JG, Huang L-C, Trama A, Torri V, Agustoni F, Baena J, Banna G, Berardi R, Bettini AC, et al. COVID-19 in patients with thoracic malignancies (TERAVOLT): first results of an international, registry-based, cohort study. Lancet Oncol. 2020;21(7):914–922. doi:10.1016/S1470-2045(20)30314-4.
   PubMed Web of Science ®Google Scholar
• Assaad S, Avrillon V, Fournier M-L, Mastroianni B, Russias B, Swalduz A, Cassier P, Eberst L, Steineur M-P, Kazes M, et al. High mortality rate in cancer patients with symptoms of COVID-19 with or without detectable SARS-COV-2 on RT-PCR. Eur J Cancer. 2020;135:251–259. doi:10.1016/j.ejca.2020.05.028.
   PubMed Web of Science ®Google Scholar
• Martín‐Moro F, Marquet J, Piris M, Michael BM, Saez AJ, Corona M, Jiménez C, Astibia B, García I, Rodríguez E, et al. Survival study of hospitalised patients with concurrent COVID-19 and haematological malignancies. Br J Haematol. 2020;190(1):e16–e20. doi:10.1111/bjh.16801.
   PubMed Web of Science ®Google Scholar
• Al-Quteimat OM, Amer AM. The impact of the COVID-19 pandemic on cancer patients. Am J Clin Oncol. 2020;43:452–455. doi:10.1097/COC.0000000000000712.
   PubMed Web of Science ®Google Scholar
• a BW, b YH. Which type of cancer patients are more susceptible to the SARS-COX-2: evidence from a meta-analysis and bioinformatics analysis. Critical reviews in oncology/hematology. 2020.
   Google Scholar
• Davis AP, Boyer M, Lee JH, Kao SC. COVID-19: the use of immunotherapy in metastatic lung cancer. Immunotherapy. 2020;12:545–548. doi:10.2217/imt-2020-0096.
   PubMed Web of Science ®Google Scholar
• Xu Z, Shi L, Wang Y, Zhang J, Huang L, Zhang C, Liu S, Zhao P, Liu H, Zhu L, et al. Pathological findings of COVID-19 associated with acute respiratory distress syndrome. Lancet Respir Med. 2020;8(4):420–422. doi:10.1016/S2213-2600(20)30076-X.
   PubMed Web of Science ®Google Scholar
• Tsamakis K, Gavriatopoulou M, Schizas D, Stravodimou A, Mougkou A, Tsiptsios D, Sioulas V, Spartalis E, Sioulas A, Tsamakis C, et al. Oncology during the COVID-19 pandemic: challenges, dilemmas and the psychosocial impact on cancer patients. Oncol Lett. 2020;20:441–447. doi:10.3892/ol.2020.11599.
   PubMed Web of Science ®Google Scholar
• Rassy E, Khoury-Abboud RM, Ibrahim N, Kattan C, Assi T, Kattan J. What the oncologist needs to know about COVID-19 infection in cancer patients. Future Oncol. 2020;16:1153–1156. doi:10.2217/fon-2020-0312.
   PubMed Web of Science ®Google Scholar
• van de Haar J, Hoes LR, Coles CE, Seamon K, Frohling S, Jager D, Valenza F, de Braud F, De Petris L, Bergh J, et al. Caring for patients with cancer in the COVID-19 era. Nat Med. 2020;26(5):665–671. doi:10.1038/s41591-020-0874-8.
   PubMed Web of Science ®Google Scholar
• Im SJ, Hashimoto M, Gerner MY, Lee J, Kissick HT, Burger MC, Shan Q, Hale JS, Lee J, Nasti TH, et al. Defining CD8+ T cells that provide the proliferative burst after PD-1 therapy. Nature. 2016;537(7620):417–421. doi:10.1038/nature19330.
   PubMed Web of Science ®Google Scholar
• Huang AC, Postow MA, Orlowski RJ, Mick R, Bengsch B, Manne S, Xu W, Harmon S, Giles JR, Wenz B, et al. T-cell invigoration to tumour burden ratio associated with anti-PD-1 response. Nature. 2017;545(7652):60–65. doi:10.1038/nature22079.
   PubMed Web of Science ®Google Scholar
• Wu TD, Madireddi S, de Almeida PE, Banchereau R, Chen YJ, Chitre AS, Chiang EY, Iftikhar H, O’Gorman WE, Au-Yeung A, et al. Peripheral T cell expansion predicts tumour infiltration and clinical response. Nature. 2020;579(7798):274–278. doi:10.1038/s41586-020-2056-8.
   PubMed Web of Science ®Google Scholar
• Wu Q, Chu Q, Zhang H, Yang B, He X, Zhong Y, Yuan X, Chua MLK, Xie C. Clinical outcomes of coronavirus disease 2019 (COVID-19) in cancer patients with prior exposure to immune checkpoint inhibitors. Cancer Commun (Lond). 2020;40:374–379. doi:10.1002/cac2.12077.
   PubMed Web of Science ®Google Scholar