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Research Paper

H2N2 live attenuated influenza vaccine is safe and immunogenic for healthy adult volunteers

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Pages 970-982 | Received 10 Nov 2014, Accepted 05 Jan 2015, Published online: 01 May 2015

References

  • Mulder J, Masurel N. Pre-epidemic antibody against 1957 strain of Asiatic influenza in serum of older people living in the Netherlands. Lancet 1958; 1:810-4; PMID:13526279; http://dx.doi.org/10.1016/S0140-6736(58)91738-0
  • Schafer JR, Kawaoka Y, Bean WJ, Suss J, Senne D, Webster RG. Origin of the pandemic 1957 H2 influenza A virus and the persistence of its possible progenitors in the avian reservoir. Virology 1993; 194:781-8; PMID:7684877; http://dx.doi.org/10.1006/viro.1993.1319
  • Dunn FL. Pandemic influenza in 1957; review of international spread of new Asian strain. J Am Med Assoc 1958; 166:1140-8; PMID:13513331; http://dx.doi.org/10.1001/jama.1958.02990100028006
  • Simonsen L, Clarke MJ, Schonberger LB, Arden NH, Cox NJ, Fukuda K. Pandemic versus epidemic influenza mortality: a pattern of changing age distribution. J Infect Dis 1998; 178:53-60; PMID:9652423; http://dx.doi.org/10.1086/515616
  • Shortridge KF. H2N2 influenza viruses in domestic ducks. Lancet 1979; 1:439; PMID:84284; http://dx.doi.org/10.1016/S0140-6736(79)90911-5
  • Scholtissek C, Rohde W, Von Hoyningen V, Rott R. On the origin of the human influenza virus subtypes H2N2 and H3N2. Virology 1978; 87:13-20; PMID:664248; http://dx.doi.org/10.1016/0042-6822(78)90153-8
  • Kawaoka Y, Krauss S, Webster RG. Avian-to-human transmission of the PB1 gene of influenza A viruses in the 1957 and 1968 pandemics. J Virol 1989; 63:4603-8; PMID:2795713
  • Makarova NV, Kaverin NV, Krauss S, Senne D, Webster RG. Transmission of Eurasian avian H2 influenza virus to shorebirds in North America. J Gen Virol 1999; 80 ( Pt 12):3167-71; PMID:10567648
  • Glaser L, Zamarin D, Acland HM, Spackman E, Palese P, Garcia-Sastre A, Tewari D. Sequence analysis and receptor specificity of the hemagglutinin of a recent influenza H2N2 virus isolated from chicken in North America. Glycoconj J 2006; 23:93-9; PMID:16575526; http://dx.doi.org/10.1007/s10719-006-5441-0
  • Ma W, Vincent AL, Gramer MR, Brockwell CB, Lager KM, Janke BH, Gauger PC, Patnayak DP, Webby RJ, Richt JA. Identification of H2N3 influenza A viruses from swine in the United States. Proc Natl Acad Sci U S A 2007; 104:20949-54; PMID:18093945; http://dx.doi.org/10.1073/pnas.0710286104
  • Kilbourne ED. Influenza pandemics of the 20th century. Emerg Infect Dis 2006; 12:9-14; PMID:16494710; http://dx.doi.org/10.3201/eid1201.051254
  • WHO. WHO global influenza preparedness plan. WHO/CDS/CSR/GIP/2005.5 http://www.who.int/csr/resources/publications/influenza/en/WHO_CDS_CSR_GIP_2005_5.pdf. 2005.
  • WHO. Global pandemic influenza action plan to increase vaccine supply. Geneva, Belgium WHO/IVB/0613 WHO/ODS/EPR/GIP/20061 http://whqlibdocwhoint/hq/2006/WHO_IVB_0613_engpdf 2006.
  • Nabel GJ, Wei CJ, Ledgerwood JE. Vaccinate for the next H2N2 pandemic now. Nature 2011; 471:157-8; PMID:21390107; http://dx.doi.org/10.1038/471157a
  • Stohr K. Vaccinate before the next pandemic? Nature 2010; 465:161; PMID:20463719; http://dx.doi.org/10.1038/465161a
  • Coelingh KL, Luke CJ, Jin H, Talaat KR. Development of live attenuated influenza vaccines against pandemic influenza strains. Expert Rev Vaccines 2014; 13:855-71; PMID:24867587; http://dx.doi.org/10.1586/14760584.2014.922417
  • Rudenko L, van den Bosch H, Kiseleva I, Mironov A, Naikhin A, Larionova N, Bushmenkov D. Live attenuated pandemic influenza vaccine: clinical studies on A/17/California/2009/38 (H1N1) and licensing of the Russian-developed technology to WHO for pandemic influenza preparedness in developing countries. Vaccine 2011; 29 Suppl 1:A40-4; PMID:21684428; http://dx.doi.org/10.1016/j.vaccine.2011.04.122
  • Rudenko LG, Slepushkin AN, Monto AS, Kendal AP, Grigorieva EP, Burtseva EP, Rekstin AR, Beljaev AL, Bragina VE, Cox N, et al. Efficacy of live attenuated and inactivated influenza vaccines in schoolchildren and their unvaccinated contacts in Novgorod, Russia. J Infect Dis 1993; 168:881-7; PMID:8376833; http://dx.doi.org/10.1093/infdis/168.4.881
  • Gustin KM, Maines TR, Belser JA, van Hoeven N, Lu X, Dong L, Isakova-Sivak I, Chen LM, Voeten JT, Heldens JG, et al. Comparative immunogenicity and cross-clade protective efficacy of mammalian cell-grown inactivated and live attenuated H5N1 reassortant vaccines in ferrets. J Infect Dis 2011; 204:1491-9; PMID:21957153; http://dx.doi.org/10.1093/infdis/jir596
  • He XS, Holmes TH, Zhang C, Mahmood K, Kemble GW, Lewis DB, Dekker CL, Greenberg HB, Arvin AM. Cellular immune responses in children and adults receiving inactivated or live attenuated influenza vaccines. J Virol 2006; 80:11756-66; PMID:16971435; http://dx.doi.org/10.1128/JVI.01460-06
  • Rudenko L, Isakova-Sivak I, Donina S. H7N3 live attenuated influenza vaccine has a potential to protect against new H7N9 avian influenza virus. Vaccine 2013; 31:4702-5; PMID:23988294; http://dx.doi.org/10.1016/j.vaccine.2013.08.040
  • Isakova-Sivak I, de Jonge J, Smolonogina T, Rekstin A, van Amerongen G, van Dijken H, Mouthaan J, Roholl P, Kuznetsova V, Doroshenko E, et al. Development and pre-clinical evaluation of two LAIV strains against potentially pandemic H2N2 influenza virus. PloS one 2014; 9:e102339; PMID:25058039; http://dx.doi.org/10.1371/journal.pone.0102339
  • Anonymous. Development of a Clinical Trial Plan for Pandemic Influenza Vaccines. Department of Health and Human Services. National Institute of Allergy and Infection Diseases. September 22–23, 2003, Bethesda, Maryland. Meeting Summary. http://www.niaid.nih.gov/about/organization/dmid/Documents/pansummary.pdf. 2003.
  • Pyhala R. Antibody status to influenza A/Singapore/1/57(H2N2) in Finland during a period of outbreaks caused by H3N2 and H1N1 subtype viruses. J Hyg 1985; 95:437-45; PMID:4067298; http://dx.doi.org/10.1017/S0022172400062860
  • Gambaryan AS, Lomakina NF, Boravleva EY, Kropotkina EA, Mashin VV, Krasilnikov IV, Klimov AI, Rudenko LG. Comparative safety, immunogenicity, and efficacy of several anti-H5N1 influenza experimental vaccines in a mouse and chicken models (Testing of killed and live H5 vaccine). Influenza Other Respir Viruses 2012; 6:188-95; PMID:21951678; http://dx.doi.org/10.1111/j.1750-2659.2011.00291.x
  • Ambrose CS, Levin MJ, Belshe RB. The relative efficacy of trivalent live attenuated and inactivated influenza vaccines in children and adults. Influenza Other Respir Viruses 2011; 5:67-75; PMID:21306569; http://dx.doi.org/10.1111/j.1750-2659.2010.00183.x
  • Ambrose CS, Walker RE, Connor EM. Live attenuated influenza vaccine in children. Semin Pediatr Infect Dis 2006; 17:206-12; PMID:17055372; http://dx.doi.org/10.1053/j.spid.2006.08.007
  • Ambrose CS, Wu X, Belshe RB. The efficacy of live attenuated and inactivated influenza vaccines in children as a function of time postvaccination. Pediatr Infect Dis J 2010; 29:806-11; PMID:20458256; http://dx.doi.org/10.1097/INF.0b013e3181e2872f
  • Belshe RB, Edwards KM, Vesikari T, Black SV, Walker RE, Hultquist M, Kemble G, Connor EM, Group C-TCES. Live attenuated versus inactivated influenza vaccine in infants and young children. N Engl J Med 2007; 356:685-96; PMID:17301299; http://dx.doi.org/10.1056/NEJMoa065368
  • Clements ML, Betts RF, Murphy BR. Advantage of live attenuated cold-adapted influenza A virus over inactivated vaccine for A/Washington/80 (H3N2) wild-type virus infection. Lancet 1984; 1:705-8; PMID:6143042; http://dx.doi.org/10.1016/S0140-6736(84)92222-0
  • Fleming DM, Crovari P, Wahn U, Klemola T, Schlesinger Y, Langussis A, Oymar K, Garcia ML, Krygier A, Costa H, et al. Comparison of the efficacy and safety of live attenuated cold-adapted influenza vaccine, trivalent, with trivalent inactivated influenza virus vaccine in children and adolescents with asthma. Pediatr Infect Dis J 2006; 25:860-9; PMID:17006278; http://dx.doi.org/10.1097/01.inf.0000237797.14283.cf
  • Hoft DF, Babusis E, Worku S, Spencer CT, Lottenbach K, Truscott SM, Abate G, Sakala IG, Edwards KM, Creech CB, et al. Live and inactivated influenza vaccines induce similar humoral responses, but only live vaccines induce diverse T-cell responses in young children. J Infect Dis 2011; 204:845-53; PMID:21846636; http://dx.doi.org/10.1093/infdis/jir436
  • Aleksandrova GI, Mikutskaia BA, Sirotenko EA, Pleshanova RA, Shaposhnikova RP. [Results in the study of a special live influenza vaccine variant for the immunization of preschool and young school-age children]. Vestn Akad Med Nauk SSSR 1968; 23:41-5; PMID:5745694
  • Talaat KR, Karron RA, Liang PH, McMahon BA, Luke CJ, Thumar B, Chen GL, Min JY, Lamirande EW, Jin H, et al. An open-label phase I trial of a live attenuated H2N2 influenza virus vaccine in healthy adults. Influenza Other Respir Viruses 2012; 7:66-73; PMID:22417012
  • Chen GL, Lamirande EW, Yang CF, Jin H, Kemble G, Subbarao K. Evaluation of replication and cross-reactive antibody responses of H2 subtype influenza viruses in mice and ferrets. J Virol 2010; 84:7695-702; PMID:20504935; http://dx.doi.org/10.1128/JVI.00511-10
  • Lindstrom SE, Cox NJ, Klimov A. Genetic analysis of human H2N2 and early H3N2 influenza viruses, 1957-1972: evidence for genetic divergence and multiple reassortment events. Virology 2004; 328:101-19; PMID:15380362; http://dx.doi.org/10.1016/j.virol.2004.06.009
  • Rudenko L, Kiseleva I, Larionova N, Naykhin A, Donina S, Petukhova G, Dubrovina I, Bazhenova E, Stukova M, Erofeeva M, et al. Clinical Testing of Pre–pandemic Live Attenuated A/H5N2 Influenza Candidate Vaccine in Adult Volunteers. Vaccine 2015; In press.
  • Vesikari T, Karvonen A, Korhonen T, Edelman K, Vainionpaa R, Salmi A, Saville MK, Cho I, Razmpour A, Rappaport R, et al. A randomized, double-blind study of the safety, transmissibility and phenotypic and genotypic stability of cold-adapted influenza virus vaccine. Pediatr Infect Dis J 2006; 25:590-5; PMID:16804427; http://dx.doi.org/10.1097/01.inf.0000220229.51531.47
  • Rudenko L, Desheva J, Korovkin S, Mironov A, Rekstin A, Grigorieva E, Donina S, Gambaryan A, Katlinsky A. Safety and immunogenicity of live attenuated influenza reassortant H5 vaccine (phase I-II clinical trials). Influenza Other Respir Viruses 2008; 2:203-9; PMID:19453396; http://dx.doi.org/10.1111/j.1750-2659.2008.00064.x
  • Rudenko L, Kiseleva I, Naykhin AN, Erofeeva M, Stukova M, Donina S, Petukhova G, Pisareva M, Krivitskaya V, Grudinin M, et al. Assessment of human immune responses to H7 avian influenza virus of pandemic potential: results from a placebo-controlled, randomized double-blind phase I study of live attenuated H7N3 influenza vaccine. PloS One 2014; 9:e87962; PMID:24533064; http://dx.doi.org/10.1371/journal.pone.0087962
  • Ohmit SE, Petrie JG, Cross RT, Johnson E, Monto AS. Influenza hemagglutination-inhibition antibody titer as a correlate of vaccine-induced protection. J Infect Dis 2011; 204:1879-85; PMID:21998477; http://dx.doi.org/10.1093/infdis/jir661
  • Black S, Nicolay U, Vesikari T, Knuf M, Del Giudice G, Della Cioppa G, Tsai T, Clemens R, Rappuoli R. Hemagglutination inhibition antibody titers as a correlate of protection for inactivated influenza vaccines in children. Pediatr Infect Dis J 2011; 30:1081-5; PMID:21983214; http://dx.doi.org/10.1097/INF.0b013e3182367662
  • Kulkarni PS, Agarkhedkar S, Lalwani S, Bavdekar AR, Jog S, Raut SK, Parulekar V, Agarkhedkar SS, Palkar S, Mangrule S. Effectiveness of an Indian-made Attenuated influenza A(H1N1pdm 2009 vaccine: A case control study. Hum Vaccin Immunother 2014; 10; 566-71; PMID:24406308; http://dx.doi.org/10.4161/hv.27490.
  • Belshe RB, Gruber WC, Mendelman PM, Mehta HB, Mahmood K, Reisinger K, Treanor J, Zangwill K, Hayden FG, Bernstein DI, et al. Correlates of immune protection induced by live, attenuated, cold-adapted, trivalent, intranasal influenza virus vaccine. J Infect Dis 2000; 181:1133-7; PMID:10720541; http://dx.doi.org/10.1086/315323
  • Ambrose CS, Wu X, Jones T, Mallory RM. The role of nasal IgA in children vaccinated with live attenuated influenza vaccine. Vaccine 2012; 30:6794-801; PMID:23000125; http://dx.doi.org/10.1016/j.vaccine.2012.09.018
  • Forrest BD, Pride MW, Dunning AJ, Capeding MR, Chotpitayasunondh T, Tam JS, Rappaport R, Eldridge JH, Gruber WC. Correlation of cellular immune responses with protection against culture-confirmed influenza virus in young children. Clin Vaccine Immunol 2008; 15:1042-53; PMID:18448618; http://dx.doi.org/10.1128/CVI.00397-07
  • Girard MP, Katz JM, Pervikov Y, Hombach J, Tam JS. Report of the 7th meeting on Evaluation of Pandemic Influenza Vaccines in Clinical Trials, World Health Organization, Geneva, 17-18 February 2011. Vaccine 2011; 29:7579-86; PMID:21856358; http://dx.doi.org/10.1016/j.vaccine.2011.08.031
  • Hehme N, Engelmann H, Kunzel W, Neumeier E, Sanger R. Pandemic preparedness: lessons learnt from H2N2 and H9N2 candidate vaccines. Med Microbiol Immunol 2002; 191:203-8; PMID:12458361; http://dx.doi.org/10.1007/s00430-002-0147-9
  • Talaat KR, Luke CJ, Khurana S, Manischewitz J, King LR, McMahon BA, Karron RA, Lewis KD, Qin J, Follmann DA, et al. A live attenuated influenza A(H5N1) vaccine induces long-term immunity in the absence of a primary antibody response. J Infect Dis 2014; 209:1860-9; PMID:24604819; http://dx.doi.org/10.1093/infdis/jiu123
  • WHO. WHO Manual on animal influenza diagnosis and surveillance. Available from: http://www.bvsde.paho.org/bvsacd/cd52/animal.pdf accessed 12 August 2013. 2002.
  • Rowe T, Abernathy RA, Hu-Primmer J, Thompson WW, Lu X, Lim W, Fukuda K, Cox NJ, Katz JM. Detection of antibody to avian influenza A (H5N1) virus in human serum by using a combination of serologic assays. J Clin Microbiol 1999; 37:937-43; PMID:10074505
  • Curr Protoc Immunol. 2014; Chapter 3:Unit 3.12. PMID: 18432927; http://dx.doi.org/10.1002/0471142735.im0312s60.

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