Design of universal cancer vaccines using natural tumor vessel-specific antigens (SANTAVAC)

References

• Lollini P-L, Cavallo F, Nanni P, Forni G. Vaccines for tumour prevention. Nat Rev Cancer 2006; 6:204-16; PMID:16498443; http://dx.doi.org/10.1038/nrc1815
   PubMed Web of Science ®Google Scholar
• Schlom J. Therapeutic cancer vaccines: current status and moving forward. J Natl Cancer Inst 2012; 104:599-613; PMID:22395641; http://dx.doi.org/10.1093/jnci/djs033
   PubMed Web of Science ®Google Scholar
• Boehm T, Folkman J, Browder T, O’Reilly MS. Antiangiogenic therapy of experimental cancer does not induce acquired drug resistance. Nature 1997; 390:404-7; PMID:9389480; http://dx.doi.org/10.1038/37126
   PubMed Web of Science ®Google Scholar
• Bussolino F, Arese M, Audero E, Giraudo E, Marchiò S, Mitola S, Primo L, Serini G. Aspects of Tumor Angiogenesis. In: Preziosi L, editor. Cancer Modelling and Simulation. London: Chapman and Hall/CRC; 2003. page 1-22.
   Google Scholar
• Folkman J. Tumor angiogenesis: therapeutic implications. N Engl J Med 1971; 285:1182-6; PMID:4938153; http://dx.doi.org/10.1056/NEJM197108122850711
   PubMed Web of Science ®Google Scholar
• Folkman J. What is the evidence that tumors are angiogenesis dependent? J Natl Cancer Inst 1990; 82:4-6; PMID:1688381; http://dx.doi.org/10.1093/jnci/82.1.4
   PubMed Web of Science ®Google Scholar
• Pluda JM. Tumor-associated angiogenesis: mechanisms, clinical implications, and therapeutic strategies. Semin Oncol 1997; 24:203-18; PMID:9129690
   PubMed Web of Science ®Google Scholar
• Carmeliet P, Jain RK. Angiogenesis in cancer and other diseases. Nature 2000; 407:249-57; PMID:11001068; http://dx.doi.org/10.1038/35025220
   PubMed Web of Science ®Google Scholar
• Copier J, Dalgleish A. Overview of tumor cell-based vaccines. Int Rev Immunol 2006; 25:297-319; PMID:17169778; http://dx.doi.org/10.1080/08830180600992472
   PubMed Web of Science ®Google Scholar
• Old LJ. Cancer vaccines: an overview. Cancer Immun a J Acad Cancer Immunol 2008; 8 Suppl 1:1.
   PubMedGoogle Scholar
• Chiang CLL, Benencia F, Coukos G. Whole tumor antigen vaccines. Semin Immunol 2010; 22:132-43.
   PubMed Web of Science ®Google Scholar
• Wei YQ, Wang QR, Zhao X, Yang L, Tian L, Lu Y, Kang B, Lu CJ, Huang MJ, Lou YY, et al. Immunotherapy of tumors with xenogeneic endothelial cells as a vaccine. Nat Med 2000; 6:1160-6; PMID:11017149; http://dx.doi.org/10.1038/80506
   PubMed Web of Science ®Google Scholar
• Corsini E, Gelati M, Calatozzolo C, Alessandri G, Frigerio S, De Francesco M, Poiesi C, Parati E, Croci D, Boiardi A, et al. Immunotherapy with bovine aortic endothelial cells in subcutaneous and intracerebral glioma models in rats: Effects on survival time, tumor growth, and tumor neovascularization. Cancer Immunol Immunother 2004; 53:955-62; PMID:15449042; http://dx.doi.org/10.1007/s00262-004-0529-5
   PubMedGoogle Scholar
• Okaji Y, Tsuno NH, Kitayama J, Saito S, Takahashi T, Kawai K, Yazawa K, Asakage M, Hori N, Watanabe T, et al. Vaccination with autologous endothelium inhibits angiogenesis and metastasis of colon cancer through autoimmunity. Cancer Sci 2004; 95:85-90; PMID:14720332; http://dx.doi.org/10.1111/j.1349-7006.2004.tb03175.x
   PubMed Web of Science ®Google Scholar
• Chen X-Y, Zhang W, Zhang W, Wu S, Bi F, Su Y-J, Tan X-Y, Liu J-N, Zhang J. Vaccination with viable human umbilical vein endothelial cells prevents metastatic tumors by attack on tumor vasculature with both cellular and humoral immunity. Clin Cancer Res 2006; 12:5834-40; PMID:17020991; http://dx.doi.org/10.1158/1078-0432.CCR-06-1105
   PubMed Web of Science ®Google Scholar
• Okaji Y, Tsuno NH, Saito S, Yoneyama S, Tanaka M, Nagawa H, Takahashi K. Vaccines targeting tumour angiogenesis-a novel strategy for cancer immunotherapy. Eur J Surg Oncol 2006; 32:363-70.
   PubMed Web of Science ®Google Scholar
• Scappaticci FA, Nolan GP. Induction of anti-tumor immunity in mice using a syngeneic endothelial cell vaccine. Anticancer Res 2003; 23:1165-72; PMID:12820367
   PubMed Web of Science ®Google Scholar
• Ludewig B, Ochsenbein AF, Odermatt B, Paulin D, Hengartner H, Zinkernagel RM. Immunotherapy with dendritic cells directed against tumor antigens shared with normal host cells results in severe autoimmune disease. J Exp Med 2000; 191:795-804; PMID:10704461; http://dx.doi.org/10.1084/jem.191.5.795
   PubMed Web of Science ®Google Scholar
• Dudley ME, Wunderlich JR, Robbins PF, Yang JC, Hwu P, Schwartzentruber DJ, Topalian SL, Sherry R, Restifo NP, Hubicki AM, et al. Cancer regression and autoimmunity in patients after clonal repopulation with antitumor lymphocytes. Science 2002; 298:850-4; PMID:12242449
   PubMed Web of Science ®Google Scholar
• Phan GQ, Yang JC, Sherry RM, Hwu P, Topalian SL, Schwartzentruber DJ, Restifo NP, Haworth LR, Seipp CA, Freezer LJ, et al. Cancer regression and autoimmunity induced by cytotoxic T lymphocyte-associated antigen 4 blockade in patients with metastatic melanoma. Proc Natl Acad Sci U S A 2003; 100:8372-7; PMID:12826605
   PubMed Web of Science ®Google Scholar
• Maker A V, Phan GQ, Attia P, Yang JC, Sherry RM, Topalian SL, Kammula US, Royal RE, Haworth LR, Levy C, et al. Tumor regression and autoimmunity in patients treated with cytotoxic T lymphocyte-associated antigen 4 blockade and interleukin 2: a phase I/II study. Ann Surg Oncol 2005; 12:1005-16; PMID:16283570
   PubMed Web of Science ®Google Scholar
• Attia P, Phan GQ, Maker A V, Robinson MR, Quezado MM, Yang JC, Sherry RM, Topalian SL, Kammula US, Royal RE, et al. Autoimmunity correlates with tumor regression in patients with metastatic melanoma treated with anti-cytotoxic T-lymphocyte antigen-4. J Clin Oncol 2005; 23:6043-53; PMID:16087944
   PubMed Web of Science ®Google Scholar
• Finn OJ. Cancer vaccines: between the idea and the reality. Nat Rev Immunol 2003; 3:630-41; PMID:12974478; http://dx.doi.org/10.1038/nri1150
   PubMed Web of Science ®Google Scholar
• Hart MN, Sadewasser KL, Cancilla PA, DeBault LE. Experimental autoimmune type of vasculitis resulting from activation of mouse lymphocytes to cultured endothelium. Lab Invest 1983; 48:419-27; PMID:6834786
   PubMed Web of Science ®Google Scholar
• Matsuda M. Experimental glomerular tissue injury induced by immunization with cultured endothelial cell plasma membrane. Acta Pathol Jpn 1988; 38:823-39; PMID:3055806
   PubMedGoogle Scholar
• Aird WC. Phenotypic heterogeneity of the endothelium: I. Ssructure, function, and mechanisms. Circ Res 2007; 100:158-73; PMID:17272818; http://dx.doi.org/10.1161/01.RES.0000255691.76142.4a
   PubMed Web of Science ®Google Scholar
• Aird WC. Phenotypic heterogeneity of the endothelium: II. representative vascular beds. Circ Res 2007; 100:174-90; PMID:17272819; http://dx.doi.org/10.1161/01.RES.0000255690.03436.ae
   PubMed Web of Science ®Google Scholar
• St Croix B, Rago C, Velculescu V, Traverso G, Romans KE, Montgomery E, Lal A, Riggins GJ, Lengauer C, Vogelstein B, et al. Genes expressed in human tumor endothelium. Science 2000; 289:1197-202; PMID:10947988; http://dx.doi.org/10.1126/science.289.5482.1197
   PubMed Web of Science ®Google Scholar
• Khodarev NN, Yu J, Labay E, Darga T, Brown CK, Mauceri HJ, Yassari R, Gupta N, Weichselbaum RR. Tumour-endothelium interactions in co-culture: coordinated changes of gene expression profiles and phenotypic properties of endothelial cells. J Cell Sci 2003; 116:1013-22; PMID:12584245; http://dx.doi.org/10.1242/jcs.00281
   PubMed Web of Science ®Google Scholar
• Bhati R, Patterson C, Livasy CA, Fan C, Ketelsen D, Hu Z, Reynolds E, Tanner C, Moore DT, Gabrielli F, et al. Molecular characterization of human breast tumor vascular cells. Am J Pathol 2008; 172:1381-90; PMID:18403594; http://dx.doi.org/10.2353/ajpath.2008.070988
   PubMed Web of Science ®Google Scholar
• Hellebrekers DMEI, Castermans K, Viré E, Dings RPM, Hoebers NTH, Mayo KH, Oude Egbrink MGA, Molema G, Fuks F, van Engeland M, et al. Epigenetic regulation of tumor endothelial cell anergy: silencing of intercellular adhesion molecule-1 by histone modifications. Cancer Res 2006; 66:10770-7; PMID:17108113; http://dx.doi.org/10.1158/0008-5472.CAN-06-1609
   PubMed Web of Science ®Google Scholar
• Hellebrekers DMEI, Jair K-W, Viré E, Eguchi S, Hoebers NTH, Fraga MF, Esteller M, Fuks F, Baylin SB, van Engeland M, et al. Angiostatic activity of DNA methyltransferase inhibitors. Mol Cancer Ther 2006; 5:467-75; PMID:16505122; http://dx.doi.org/10.1158/1535-7163.MCT-05-0417
   PubMed Web of Science ®Google Scholar
• Hellebrekers DMEI, Melotte V, Viré E, Langenkamp E, Molema G, Fuks F, Herman JG, Van Criekinge W, Griffioen AW, van Engeland M. Identification of epigenetically silenced genes in tumor endothelial cells. Cancer Res 2007; 67:4138-48; PMID:17483324; http://dx.doi.org/10.1158/0008-5472.CAN-06-3032
   PubMed Web of Science ®Google Scholar
• Unger RE, Oltrogge JB, von Briesen H, Engelhardt B, Woelki U, Schlote W, Lorenz R, Bratzke H, Kirkpatrick CJ. Isolation and molecular characterization of brain microvascular endothelial cells from human brain tumors. In Vitro Cell Dev Biol Anim 2002; 38:273-81; PMID:12418924; http://dx.doi.org/10.1290/1071-2690(2002)038<0273:IAMCOB>2.0.CO;2
   PubMedGoogle Scholar
• Bussolati B, Deambrosis I, Russo S, Deregibus MC, Camussi G. Altered angiogenesis and survival in human tumor-derived endothelial cells. FASEB J 2003; 17:1159-61; PMID:12709414
   PubMed Web of Science ®Google Scholar
• Maciag T, Cerundolo J, Ilsley S, Kelley PR, Forand R. An endothelial cell growth factor from bovine hypothalamus: identification and partial characterization. Proc Natl Acad Sci U S A 1979; 76:5674-8; PMID:293671; http://dx.doi.org/10.1073/pnas.76.11.5674
   PubMed Web of Science ®Google Scholar
• Lokhov PG, Balashova EE. Tumor-induced endothelial cell surface heterogeneity directly affects endothelial cell escape from a cell-mediated immune response in vitro. Hum Vaccin Immunother 2013; 9:198-209; PMID:23442592; http://dx.doi.org/10.4161/hv.22828
   PubMed Web of Science ®Google Scholar
• Balashova EE, Lokhov PG. Proteolytically-cleaved fragments of cell surface proteins stimulate a cytotoxic immune response against tumor-activated endothelial cells in vitro. J Cancer Sci Ther 2010; 2:126-131; http://dx.doi.org/10.4172/1948-5956.1000037
   Google Scholar
• Lokhov PG, Balashova EE. Universal cancer vaccine: an update on the design of cancer vaccines generated from endothelial cells. Hum Vaccin Immunother 2013; 9:1549-52; PMID:23571178; http://dx.doi.org/10.4161/hv.24300
   PubMed Web of Science ®Google Scholar
• Lokhov PG, Balashova EE. Cellular cancer vaccines: an update on the development of vaccines generated from cell surface antigens. J Cancer 2010; 1:230-41; PMID:21151581; http://dx.doi.org/10.7150/jca.1.230
   PubMedGoogle Scholar
• Lokhov P, Balashova E, Dashtiev M. Cell proteomic footprint. Rapid Commun Mass Spectrom 2009; 23:680-2; PMID:19184978; http://dx.doi.org/10.1002/rcm.3928
   PubMedGoogle Scholar
• Thompson PL, Dessureault S. Tumor cell Vaccines. In: Shurin MR, Smolkin YS, editors. Immune-Mediated Diseases From Theory to Therapy. New York: Springer; 2007. page 345-55.
   Google Scholar
• De Gruijl TD, Van Den Eertwegh AJM, Pinedo HM, Scheper RJ. Whole-cell cancer vaccination: From autologous to allogeneic tumor- and dendritic cell-based vaccines. Cancer Immunology, Immunotherapy. 2008; 57:1569-77.
   Google Scholar
• Cheever MA, Allison JP, Ferris AS, Finn OJ, Hastings BM, Hecht TT, Mellman I, Prindiville SA, Viner JL, Weiner LM, et al. The prioritization of cancer antigens: a national cancer institute pilot project for the acceleration of translational research. Clin Cancer Res 2009; 15:5323-37; PMID:19723653; http://dx.doi.org/10.1158/1078-0432.CCR-09-0737
   PubMed Web of Science ®Google Scholar
• Lang JM, Andrei AC, McNeel DG. Prioritization of cancer antigens: keeping the target in sight. Expert Rev Vaccines 2009; 8:1657-61; PMID:19943761; http://dx.doi.org/10.1586/erv.09.134
   PubMed Web of Science ®Google Scholar
• Balashova EE, Lokhov PG. Proteolytically-cleaved fragments of cell-surface proteins from live tumor cells stimulate anti-tumor immune response in vitro. J Carcinog Mutagen 2010; 1:103; http://dx.doi.org/10.4172/2157-2518.1000103
   Google Scholar
• Balashova EE, Dashtiev MI, Lokhov PG. Proteomic Footprinting of Drug-Treated Cancer Cells as a Measure of Cellular Vaccine Efficacy for the Prevention of Cancer Recurrence. Mol Cell Proteomics 2012; 11:M111.014480-M111.014480; PMID:22074704; http://dx.doi.org/10.1074/mcp.M111.014480
   PubMedGoogle Scholar
• Kumar S, West DC, Ager A. Heterogeneity in endothelial cells from large vessels and microvessels. Differentiation 1987; 36:57-70; PMID:2451631; http://dx.doi.org/10.1111/j.1432-0436.1987.tb00181.x
   PubMed Web of Science ®Google Scholar
• Lang I, Pabst MA, Hiden U, Blaschitz A, Dohr G, Hahn T, Desoye G. Heterogeneity of microvascular endothelial cells isolated from human term placenta and macrovascular umbilical vein endothelial cells. Eur J Cell Biol 2003; 82:163-73; PMID:12751902; http://dx.doi.org/10.1078/0171-9335-00306
   PubMed Web of Science ®Google Scholar
• Shreeniwas R, Ogawa S, Cozzolino F, Torcia G, Braunstein N, Butura C, Brett J, Lieberman HB, Furie MB, Joseph-Silverstein J. Macrovascular and microvascular endothelium during long-term hypoxia: alterations in cell growth, monolayer permeability, and cell surface coagulant properties. J Cell Physiol 1991; 146:8-17; PMID:1990021; http://dx.doi.org/10.1002/jcp.1041460103
   PubMed Web of Science ®Google Scholar
• Hewett PW. Identification of tumour-induced changes in endothelial cell surface protein expression: an in vitro model. Int J Biochem Cell Biol 2001; 33:325-35; PMID:11312103; http://dx.doi.org/10.1016/S1357-2725(01)00020-6
   PubMedGoogle Scholar
• Swerlick RA, Lee KH, Wick TM, Lawley TJ. Human dermal microvascular endothelial but not human umbilical vein endothelial cells express CD36 in vivo and in vitro. J Immunol 1992; 148:78-83; PMID:1370173
   PubMed Web of Science ®Google Scholar
• Swerlick RA, Lee KH, Li LJ, Sepp NT, Caughman SW, Lawley TJ. Regulation of vascular cell adhesion molecule 1 on human dermal microvascular endothelial cells. J Immunol 1992; 149:698-705; PMID:1378077
   PubMed Web of Science ®Google Scholar
• Lee KH, Lawley TJ, Xu YL, Swerlick RA. VCAM-1-, ELAM-1-, and ICAM-1-independent adhesion of melanoma cells to cultured human dermal microvascular endothelial cells. J Invest Dermatol 1992; 98:79-85; PMID:1370233; http://dx.doi.org/10.1111/1523-1747.ep12495643
   PubMed Web of Science ®Google Scholar
• Takeichi N, Economou GC, Boone CW. Accelerated regeneration of trypsin-treated surface antigens of simian virus 40-transformed BALB/3T3 cells induced by X-irradiation. Cancer Res 1976; 36:1258-62; PMID:177205
   PubMed Web of Science ®Google Scholar
• Glick MC, Kimhi Y, Littauer UZ. Glycopeptides from surface membranes of neuroblastoma cells. Proc Natl Acad Sci U S A 1973; 70:1682-7; PMID:4515927; http://dx.doi.org/10.1073/pnas.70.6.1682
   PubMedGoogle Scholar
• Anglhileri LJ, Dermietzel LJ. Cell coat in tumor cells–effects of trypsin and EDTA: a biochemical and morphological study. Oncology 1976; 33:17-23; PMID:185564; http://dx.doi.org/10.1159/000225095
   PubMedGoogle Scholar
• Baumann H, Doyle D. Effect of trypsin on the cell surface proteins of hepatoma tissue culture cells. Characterization of a carbohydrate-rich glycopeptide released from a calcium binding membrane glycoprotein. J Biol Chem 1979; 254:3935-46; PMID:438168
   PubMed Web of Science ®Google Scholar
• Weiss L. The effects of trypsin on the size, viability and dry mass of sarcoma 37 cells. Exp Cell Res 1958; 14:80-3; PMID:13512305; http://dx.doi.org/10.1016/0014-4827(58)90214-3
   PubMedGoogle Scholar
• Barnard PJ, Weiss L, Ratcliffe T. Changes in the surface properties of embryonic chick neural retina cells after dissociation. Exp Cell Res 1969; 54:293-301; PMID:4975920; http://dx.doi.org/10.1016/0014-4827(69)90205-5
   PubMedGoogle Scholar
• Kraemer PM. Regeneration of sialic acid on the surface of Chinese hamster cells in culture. I. General characteristics of the replacement process. J Cell Physiol 1966; 68:85-90; PMID:5967192; http://dx.doi.org/10.1002/jcp.1040680112
   PubMedGoogle Scholar
• Kraemer PM. Sialic acid of mammalian cell lines. J Cell Physiol 1966; 67:23-34; PMID:5327858; http://dx.doi.org/10.1002/jcp.1040670104
   PubMedGoogle Scholar
• Kemp RB, Jones BM, Cunningham I, James MC. Quantitative investigation on the effect of puromycin on the aggregation of trypsin- and versene-dissociated chick fibroblast cells. J Cell Sci 1967; 2:323-40; PMID:4293085
   PubMed Web of Science ®Google Scholar
• Pitelka DR, Kerkof PR, Gagne HT, Smith S, Abraham S. Characteristics of cells dissociated from mouse mammary glands. I. Method of separation and morphology of parenchymal cells from lactating glands.
   Google Scholar
• De Luca C. The use of trypsin for the determination of cellular viability. Exp Cell Res 1965; 40:186-8; PMID:5891332; http://dx.doi.org/10.1016/0014-4827(65)90312-5
   PubMedGoogle Scholar
• Kraemer PM. Regeneration of sialic acid on the surface of Chinese hamster cells in culture. II. Incorporation of radioactivity from glucosamine-1-14C. J Cell Physiol 1967; 69:199-207; PMID:6033950; http://dx.doi.org/10.1002/jcp.1040690210
   PubMedGoogle Scholar
• Allen A, Snow C. The effect of trypsin or ethylenediaminetetraacetate on the surface of cells in tissue culture. Biochem J 1970; 117:32 P; PMID:4986872
   PubMedGoogle Scholar
• Snow C, Allen A. The release of radioactive nucleic acids and mucoproteins by trypsin and ethylenediaminetetra-acetate treatment of baby-hamster cells in tissue culture. Biochem J 1970; 119:707-14; PMID:4992781
   PubMed Web of Science ®Google Scholar
• Buck CA, Glick MC, Warren L. A comparative study of glycoproteins from the surface of control and Rous sarcoma virus transformed hamster cells. Biochemistry 1970; 9:4567-76; PMID:4319754; http://dx.doi.org/10.1021/bi00825a016
   PubMed Web of Science ®Google Scholar
• Vestling MM, Murphy CM, Fenselau C. Recognition of trypsin autolysis products by high-performance liquid chromatography and mass spectrometry. Anal Chem 1990; 62:2391-4; PMID:2291484; http://dx.doi.org/10.1021/ac00220a025
   PubMed Web of Science ®Google Scholar
• Shin BK, Wang H, Yim AM, Le Naour F, Brichory F, Jang JH, Zhao R, Puravs E, Tra J, Michael CW, et al. Global profiling of the cell surface proteome of cancer cells uncovers an abundance of proteins with chaperone function. J Biol Chem 2003; 278:7607-16; PMID:12493773; http://dx.doi.org/10.1074/jbc.M210455200
   PubMed Web of Science ®Google Scholar
• Jang JH, Hanash S. Profiling of the cell surface proteome. Proteomics 2003; 3:1947-54; PMID:14625857; http://dx.doi.org/10.1002/pmic.200300563
   PubMedGoogle Scholar
• Rodríguez-Ortega MJ, Norais N, Bensi G, Liberatori S, Capo S, Mora M, Scarselli M, Doro F, Ferrari G, Garaguso I, et al. Characterization and identification of vaccine candidate proteins through analysis of the group A Streptococcus surface proteome. Nat Biotechnol 2006; 24:191-7; http://dx.doi.org/10.1038/nbt1179
   PubMed Web of Science ®Google Scholar
• Lund R, Leth-Larsen R, Jensen ON, Ditzel HJ. Efficient isolation and quantitative proteomic analysis of cancer cell plasma membrane proteins for identification of metastasis-associated cell surface markers. J Proteome Res 2009; 8:3078-90; PMID:19341246; http://dx.doi.org/10.1021/pr801091k
   PubMedGoogle Scholar
• Garcia J, Faca V, Jarzembowski J, Zhang Q, Park J, Hanash S. Comprehensive profiling of the cell surface proteome of Sy5Y neuroblastoma cells yields a subset of proteins associated with tumor differentiation. J Proteome Res 2009; 8:3791-6; PMID:19505085; http://dx.doi.org/10.1021/pr800964v
   PubMedGoogle Scholar
• Van Der Pol L, Tramper J. Shear sensitivity of animal cells from a culture-medium perspective. Trends Biotechnol.1998; 16:323-8; PMID:9720320; http://dx.doi.org/10.1016/S0167-7799(98)01209-8
   PubMed Web of Science ®Google Scholar
• Lau JY, Tchao R. Stressed polystyrene causes increased membrane sensitivity of adherent cells to fluid shear force: technical note. Eur Cell Mater 2007; 14:40-43; discussion 43-44; PMID:17828704
   PubMed Web of Science ®Google Scholar
• McQueen A, Bailey JE. Influence of serum level, cell line, flow type and viscosity on flow-induced lysis of suspended mammalian cells. Biotechnol Lett 1989; 11:531-536; http://dx.doi.org/10.1007/BF01040030
   Web of Science ®Google Scholar
• McQueen A, Meilhoc E, Bailey JE. Flow effects on the viability and lysis of suspended mammalian cells. Biotechnol Lett 1987; 9:831-6; http://dx.doi.org/10.1007/BF01026191
   PubMed Web of Science ®Google Scholar
• Tchao R. Fluid shear force and turbulence-induced cell death in plastic tissue culture flasks. In Vitro Toxicol 1996; 9:93-100.
   Google Scholar
• Kyte JA. Cancer vaccination with telomerase peptide GV1001. Expert Opin Investig Drugs 2009; 18:687-94; PMID:19388882; http://dx.doi.org/10.1517/13543780902897631
   PubMed Web of Science ®Google Scholar
• Shaw VE, Naisbitt DJ, Costello E, Greenhalf W, Park BK, Neoptolemos JP, Middleton GW. Current status of GV1001 and other telomerase vaccination strategies in the treatment of cancer. Expert Rev Vaccines 2010; 9:1007-16; PMID:20822343; http://dx.doi.org/10.1586/erv.10.92
   PubMed Web of Science ®Google Scholar
• Gendler SJ, Lancaster CA, Taylor-Papadimitriou J, Duhig T, Peat N, Burchell J, Pemberton L, Lalani EN, Wilson D. Molecular cloning and expression of human tumor-associated polymorphic epithelial mucin. J Biol Chem 1990; 265:15286-93; PMID:1697589
   PubMed Web of Science ®Google Scholar
• Gendler SJ. MUC1, The renaissance molecule. J Mammary Gland Biol Neoplasia 2001; 6:339-53; PMID:11547902; http://dx.doi.org/10.1023/A:1011379725811
   PubMed Web of Science ®Google Scholar
• Singh R, Bandyopadhyay D. MUC1: a target molecule for cancer therapy. Cancer Biol Ther 2007; 6:481-6; PMID:18027437; http://dx.doi.org/10.4161/cbt.6.4.4201
   PubMed Web of Science ®Google Scholar
• McCarthy N. Running a MUC1. Nat Rev Cancer 2012; 12:317-317; PMID:22495322
   PubMedGoogle Scholar
• Paczesny S, Shi H, Saito H, Mannoni P, Fay J, Banchereau J, Palucka AK. Measuring melanoma-specific cytotoxic T lymphocytes elicited by dendritic cell vaccines with a tumor inhibition assay in vitro. J Immunother 2005; 28:148-57; PMID:15725959; http://dx.doi.org/10.1097/01.cji.0000154247.97254.ef
   PubMedGoogle Scholar
• Ossevoort MA, Feltkamp MC, van Veen KJ, Melief CJ, Kast WM. Dendritic cells as carriers for a cytotoxic T-lymphocyte epitope-based peptide vaccine in protection against a human papillomavirus type 16-induced tumor. J Immunother Emphasis Tumor Immunol 1995; 18:86-94; PMID:8574470; http://dx.doi.org/10.1097/00002371-199508000-00002
   PubMed Web of Science ®Google Scholar
• Kern PA, Knedler A, Eckel RH. Isolation and culture of microvascular endothelium from human adipose tissue. J Clin Invest 1983; 71:1822-9; PMID:6306056; http://dx.doi.org/10.1172/JCI110937
   PubMed Web of Science ®Google Scholar
• Correa de Sampaio P, Auslaender D, Krubasik D, Failla AV, Skepper JN, Murphy G, English WR. A heterogeneous in vitro three dimensional model of tumour-stroma interactions regulating sprouting angiogenesis. PLoS One 2012; 7; PMID:22363483; http://dx.doi.org/10.1371/journal.pone.0030753
   PubMedGoogle Scholar