Controlled Human Malaria Infection (CHMI) differentially affects cell-mediated and antibody responses to CSP and AMA1 induced by adenovirus vaccines with and without DNA-priming

References

• Chuang I, Sedegah M, Cicatelli S, Spring M, Polhemus M, Tamminga C, Patterson N, Guerrero M, Bennett JW, McGrath MG, et al. DNA prime/adenovirus boost malaria vaccine encoding P. falciparum CSP and AMA1 induces sterile protection associated with cell-mediated immunity. PLoS One 2013; 8:1371; PMID:23457473; http://dx.doi.org/10.1371/journal.pone.0055571
   PubMed Web of Science ®Google Scholar
• Tamminga C, Sedegah M, Maiolatesi S, Fedders C, Reyes S, Reyes A, Vasquez C, Alcorta Y, Chuang I, Spring M, et al. Human adenovirus 5-vectored Plasmodium falciparum NMRC-M3V-Ad-PfCA vaccine encoding CSP and AMA1 is safe, well-tolerated and immunogenic but does not protect against controlled human malaria infection. Hum Vaccin Immunother 2013; 9:2165-2177; PMID:23899517; http://dx.doi.org/10.4161/hv.24941
   PubMed Web of Science ®Google Scholar
• Sedegah M, Hollingdale MR, Farooq F, Ganeshan H, Belmonte M, Kim Y, Peters B, Sette A, Huang J, McGrath S, et al. Sterile Immunity to Malaria after DNA Prime/Adenovirus Boost Immunization Is Associated with Effector Memory CD8+T Cells Targeting AMA1 Class I Epitopes. PLoS One 2014; 9:e106241; PMID:25211344; http://dx.doi.org/10.1371/journal.pone.0106241
   PubMed Web of Science ®Google Scholar
• Zarling S, Berenzon D, Dalai S, Liepinsh D, Steers N, Krzych U. The survival of memory CD8 T cells that is mediated by IL-15 correlates with sustained protection against malaria. J Immunol 2013; 190:5128-5141; PMID:23589611; http://dx.doi.org/10.4049/jimmunol.1203396
   PubMed Web of Science ®Google Scholar
• Nganou-Makamdop K, van Gemert GJ, Arens T, Hermsen CC, Sauerwein RW. Long term protection after immunization with P. berghei sporozoites correlates with sustained IFNgamma responses of hepatic CD8+ memory T cells. PLoS One 2012; 7:e36508; PMID:22563506; http://dx.doi.org/10.1371/journal.pone.0036508
   PubMed Web of Science ®Google Scholar
• Epstein JE, Tewari K, Lyke KE, Sim BK, Billingsley PF, Laurens MB, Gunasekera A, Chakravarty S, James ER, Sedegah M, et al. Live attenuated malaria vaccine designed to protect through hepatic CD8(+) T cell immunity. Science 2011; 334:475-480; PMID:21903775; http://dx.doi.org/10.1126/science.1211548
   PubMed Web of Science ®Google Scholar
• Sedegah M, Tamminga C, McGrath S, House B, Ganeshan H, Lejano J, Abot E, Banania G, Sayo R, Farooq F, et al. Adenovirus 5-vectored P. falciparum Vaccine Expressing CSP and AMA1. Part A: Safety and Immunogenicity in Seronegative Adults. PLoS One 2011; 6:e24586; PMID:22003383; http://dx.doi.org/10.1371/journal.pone.0024586
   PubMed Web of Science ®Google Scholar
• Tamminga C, Sedegah M, Regis D, Chuang I, Epstein JE, Spring M, Mendoza-Silveiras J, McGrath S, Maiolatesi S, Reyes S, et al. Adenovirus-5-vectored P. falciparum vaccine expressing CSP and AMA1. Part B: safety, immunogenicity and protective efficacy of the CSP component. PLoS One 2011; 6:e25868; PMID:22003411; http://dx.doi.org/10.1371/journal.pone.0025868
   PubMed Web of Science ®Google Scholar
• Tamminga C, Sedegah M, Maiolatesi S, Fedders C, Reyes S, Reyes A, Vasquez C, Alcorta Y, Chuang I, Spring M, et al. Human Adenovirus 5-Vectored Plasmodium falciparum NMRC-M3V-Ad-PfCA Vaccine encoding CSP and AMA1 is safe, well tolerated and immunogenic but does not protect against controlled human malaria infection. Hum Vaccin Immunother 2013; 9:2165-2177; PMID:23899517; http://dx.doi.org/10.4161/hv.24941
   PubMed Web of Science ®Google Scholar
• Teirlinck AC, McCall MB, Roestenberg M, Scholzen A, Woestenenk R, de Mast Q, van der Ven AJ, Hermsen CC, Luty AJ, Sauerwein RW. Longevity and composition of cellular immune responses following experimental Plasmodium falciparum malaria infection in humans. PLoS Pathog 2011; 7:e1002389; PMID:22144890; http://dx.doi.org/10.1371/journal.ppat.1002389
   PubMed Web of Science ®Google Scholar
• Elias SC, Choudhary P, de Cassan SC, Biswas S, Collins KA, Halstead FD, Bliss CM, Ewer KJ, Hodgson SH, Duncan CJ, et al. Analysis of human B-cell responses following ChAd63-MVA MSP1 and AMA1 immunization and controlled malaria infection. Immunology 2014; 141:628-644; PMID:24303947; http://dx.doi.org/10.1111/imm.12226
   PubMed Web of Science ®Google Scholar
• Stoyanov CT, Boscardin SB, Deroubaix S, Barba-Spaeth G, Franco D, Nussenzweig RS, Nussenzweig M, Rice CM. Immunogenicity and protective efficacy of a recombinant yellow fever vaccine against the murine malarial parasite Plasmodium yoelii. Vaccine 2010; 28:4644-4652; PMID:20451637; http://dx.doi.org/10.1016/j.vaccine.2010.04.071
   PubMed Web of Science ®Google Scholar
• Biswas S, Choudhary P, Elias SC, Miura K, Milne KH, de Cassan SC, Collins KA, Halstead FD, Bliss CM, Ewer KJ, et al. Assessment of Humoral Immune Responses to Blood-Stage Malaria Antigens following ChAd63-MVA Immunization, Controlled Human Malaria Infection and Natural Exposure. PLoS One 2014; 9:e107903; PMID:25254500; http://dx.doi.org/10.1371/journal.pone.0107903
   PubMed Web of Science ®Google Scholar
• Ockenhouse CF, Sun PF, Lanar DE, Wellde BT, Hall BT, Kester K, Stoute JA, Magill A, Krzych U, Farley L, et al. Phase I/IIa safety, immunogenicity, and efficacy trial of NYVAC-Pf7, a pox-vectored, multiantigen, multistage vaccine candidate for Plasmodium falciparum malaria. J Infect Dis 1998; 177:1664-1673; PMID:9607847; http://dx.doi.org/10.1086/515331
   PubMed Web of Science ®Google Scholar
• Hamid MM, Remarque EJ, El Hassan IM, Hussain AA, Narum DL, Thomas AW, Kocken CH, Weiss WR, Faber BW. Malaria infection by sporozoite challenge induces high functional antibody titres against blood stage antigens after a DNA prime, poxvirus boost vaccination strategy in Rhesus macaques. Malar J 2011; 10:29; PMID:21303498; http://dx.doi.org/10.1186/1475-2875-10-29
   PubMed Web of Science ®Google Scholar
• Tartz S, Deschermeier C, Retzlaff S, Heussler V, Sebo P, Fleischer B, Jacobs T. Plasmodium berghei sporozoite challenge of vaccinated BALB/c mice leads to the induction of humoral immunity and improved function of CD8(+) memory T cells. Eur J Immunol 2012; 43:693-704; PMID:23229763; http://dx.doi.org/10.1002/eji.201142262
   PubMed Web of Science ®Google Scholar
• Epstein JE, Tewari K, Lyke KE, Sim BK, Billingsley PF, Laurens MB, Gunasekera A, Chakravarty S, James ER, Sedegah M, et al. Live Attenuated Malaria Vaccine Designed to Protect through Hepatic CD8+ T Cell Immunity. Science 2011; 334(6055):475-480; PMID:21903775; http://dx.doi.org/10.1126/science.1211548
   PubMed Web of Science ®Google Scholar
• Seder RA, Chang LJ, Enama ME, Zephir KL, Sarwar UN, Gordon IJ, Holman LA, James ER, Billingsley PF, Gunasekera A, et al. Protection against malaria by intravenous immunization with a nonreplicating sporozoite vaccine. Science 2013; 341:1359-1365; PMID:23929949; http://dx.doi.org/10.1126/science.1241800
   PubMed Web of Science ®Google Scholar
• Sedegah M, Hollingdale MR, Farooq F, Ganeshan H, Belmonte M, Kim Y, Peters B, Sette A, Huang J, McGrath MG, et al. Sterile Immunity to Hepatic Stage Malaria after DNA Prime/Adenovirus Boost Immunization is Associated with Effector Memory CD8+T Cells Targeting AMA1 Class I Epitopes. PLoS One 2014; 9(9):e106241; PMID:25211344; http://dx.doi.org/10.1371/journal.pone.0106241
   PubMedGoogle Scholar
• Krzych U, Dalai S, Zarling S, Pichugin A. Memory CD8 T cells specific for plasmodia liver-stage antigens maintain protracted protection against malaria. Front Immunol 2012; 3:370; PMID:23233854; http://dx.doi.org/10.3389/fimmu.2012.00370
   PubMed Web of Science ®Google Scholar
• Tse SW, Radtke AJ, Zavala F. Induction and maintenance of protective CD8+ T cells against malaria liver stages: implications for vaccine development. Mem Inst Oswaldo Cruz 2011; 106(Suppl 1):172-178; PMID:21881772; http://dx.doi.org/10.1590/S0074-02762011000900022
   PubMed Web of Science ®Google Scholar
• Tse SW, Cockburn IA, Zhang H, Scott AL, Zavala F. Unique transcriptional profile of liver-resident memory CD8 T cells induced by immunization with malaria sporozoites. Genes Immun 2013; 14(5):302-9; PMID:23594961; http://dx.doi.org/10.1038/gene.2013.20
   PubMed Web of Science ®Google Scholar
• Chen Q, Amaladoss A, Ye W, Liu M, Dummler S, Kong F, Wong LH, Loo HL, Loh E, Tan SQ, et al. Human natural killer cells control Plasmodium falciparum infection by eliminating infected red blood cells. Proc Natl Acad Sci U S A 2014; 111:1479-1484; PMID:24474774; http://dx.doi.org/10.1073/pnas.1323318111
   PubMed Web of Science ®Google Scholar
• Horowitz A, Hafalla JC, King E, Lusingu J, Dekker D, Leach A, Moris P, Cohen J, Vekemans J, Villafana T, et al. Antigen-specific IL-2 secretion correlates with NK cell responses after immunization of Tanzanian children with the RTS,S/AS01 malaria vaccine. J Immunol 2012; 188:5054-5062; PMID:22504653; http://dx.doi.org/10.4049/jimmunol.1102710
   PubMed Web of Science ®Google Scholar
• McCall MB, Roestenberg M, Ploemen I, Teirlinck A, Hopman J, de Mast Q, Dolo A, Doumbo OK, Luty A, van der Ven AJ, et al. Memory-like IFN-gamma response by NK cells following malaria infection reveals the crucial role of T cells in NK cell activation by P. falciparum. Eur J Immunol 2010; 40:3472-3477; PMID:21072880; http://dx.doi.org/10.1002/eji.201040587
   PubMed Web of Science ®Google Scholar
• Quinn KM, Da Costa A, Yamamoto A, Berry D, Lindsay RW, Darrah PA, Wang L, Cheng C, Kong WP, Gall JG, et al. Comparative analysis of the magnitude, quality, phenotype, and protective capacity of simian immunodeficiency virus gag-specific CD8+ T cells following human-, simian-, and chimpanzee-derived recombinant adenoviral vector immunization. J Immunol 2013; 190:2720-2735; PMID:23390298; http://dx.doi.org/10.4049/jimmunol.1202861
   PubMed Web of Science ®Google Scholar
• Yang SH, Lee CG, Park SH, Im SJ, Kim YM, Son JM, Wang JS, Yoon SK, Song MK, Ambrozaitis A, et al. Correlation of antiviral T-cell responses with suppression of viral rebound in chronic hepatitis B carriers: a proof-of-concept study. Gene Ther 2006; 13:1110-1117; PMID:16525482; http://dx.doi.org/10.1038/sj.gt.3302751
   PubMed Web of Science ®Google Scholar
• Wherry EJ, Blattman JN, Murali-Krishna K, van der Most R, Ahmed R. Viral persistence alters CD8 T-cell immunodominance and tissue distribution and results in distinct stages of functional impairment. J Virol 2003; 77:4911-4927; PMID:12663797; http://dx.doi.org/10.1128/JVI.77.8.4911-4927.2003
   PubMed Web of Science ®Google Scholar
• Hafalla JC, Claser C, Couper KN, Grau GE, Renia L, de Souza JB, Riley EM. The CTLA-4 and PD-1/PD-L1 inhibitory pathways independently regulate host resistance to Plasmodium-induced acute immune pathology. PLoS Pathog 2012; 8:e1002504; PMID:22319445; http://dx.doi.org/10.1371/journal.ppat.1002504
   PubMedGoogle Scholar
• Keir ME, Butte MJ, Freeman GJ, Sharpe AH. PD-1 and its ligands in tolerance and immunity. Annu Rev Immunol 2008; 26:677-704; PMID:18173375; http://dx.doi.org/10.1146/annurev.immunol.26.021607.090331
   PubMed Web of Science ®Google Scholar
• Sharpe AH, Wherry EJ, Ahmed R, Freeman GJ. The function of programmed cell death 1 and its ligands in regulating autoimmunity and infection. Nat Immunol 2007; 8:239-245; PMID:17304234; http://dx.doi.org/10.1038/ni1443
   PubMed Web of Science ®Google Scholar
• Wykes MN, Horne-Debets JM, Leow CY, Karunarathne DS. Malaria drives T cells to exhaustion. Front Microbiol 2014; 5:249; PMID:24904561; http://dx.doi.org/10.3389/fmicb.2014.00249
   PubMedGoogle Scholar
• Illingworth J, Butler NS, Roetynck S, Mwacharo J, Pierce SK, Bejon P, Crompton PD, Marsh K, Ndungu FM. Chronic exposure to Plasmodium falciparum is associated with phenotypic evidence of B and T cell exhaustion. J Immunol 2013; 190:1038-1047; PMID:23264654; http://dx.doi.org/10.4049/jimmunol.1202438
   PubMed Web of Science ®Google Scholar
• Thera MA, Doumbo OK, Coulibaly D, Laurens MB, Ouattara A, Kone AK, Guindo AB, Traore K, Traore I, Kouriba B, et al. A field trial to assess a blood-stage malaria vaccine. N Engl J Med 2011; 365:1004-1013; PMID:21916638; http://dx.doi.org/10.1056/NEJMoa1008115
   PubMed Web of Science ®Google Scholar
• Bergmann-Leitner ES, Duncan EH, Burge JR, Spring M, Angov E. Miniaturization of a high-throughput pLDH-based Plasmodium falciparum growth inhibition assay for small volume samples from preclinical and clinical vaccine trials. Am J Trop Med Hyg 2008; 78:468-471; PMID:18337345
   PubMed Web of Science ®Google Scholar
• Hamann D, Baars PA, Rep MH, Hooibrink B, Kerkhof-Garde SR, Klein MR, van Lier RA. Phenotypic and functional separation of memory and effector human CD8+ T cells. J Exp Med 1997; 186:1407-1418; PMID:9348298; http://dx.doi.org/10.1084/jem.186.9.1407
   PubMed Web of Science ®Google Scholar
• Tamminga C. Adenovirus-5-Vectored P. falciparumVaccine Expressing CSP and AMA1. Part B: Safety, immunogenicity and Protective Efficacy of the CSP Component. PLoS One 2011; 6:e25868; PMID:22003411; http://dx.doi.org/10.1371/journal.pone.0025868
   PubMed Web of Science ®Google Scholar
• Wessa P. Free Statistics Software. Offic Res Dev Edu 2014; 1(1):23-r7
   Google Scholar