918
Views
0
CrossRef citations to date
0
Altmetric
Commentary

Overcoming nutrient limitations for cell-based production of influenza vaccine

, , , &
Pages 1685-1688 | Received 02 Apr 2015, Accepted 18 Apr 2015, Published online: 06 Jul 2015

References

  • Niklas J, Heinzle E. Metabolic flux analysis in systems biology of mammalian cells. Springer: Genomics and Systems Biology of Mammalian Cell Culture; 2012:109-32.
  • Quek L-E, Dietmair S, Krömer JO, Nielsen LK. Metabolic flux analysis in mammalian cell culture. Metab Eng 2010; 12:161-71; PMID:19833223; http://dx.doi.org/10.1016/j.ymben.2009.09.002
  • Çelik E, Çalık P, Oliver SG. Metabolic flux analysis for recombinant protein production by Pichia pastoris using dual carbon sources: Effects of methanol feeding rate. Biotechnol Bioeng 2010; 105:317-29; PMID:19777584; http://dx.doi.org/10.1002/bit.22543
  • Fisher TN, Ginsberg HS. The reaction of influenza viruses with guinea pig polymorphonuclear leucocytes. II. The reduction of white blood cell glycolysis by influenza viruses and receptor-destroying enzyme (RDE). Virology 1956; 2:637-55; PMID:13371724; http://dx.doi.org/10.1016/0042-6822(56)90044-7
  • Genzel Y, Olmer R, Schäfer B, Reichl U. Wave microcarrier cultivation of MDCK cells for influenza virus production in serum containing and serum-free media. Vaccine 2006; 24:6074-87; PMID:16781022; http://dx.doi.org/10.1016/j.vaccine.2006.05.023
  • Klemperer H. Glucose breakdown in chick embryo cells infected with influenza virus. Virology 1961; 13:68-77; PMID:13756751; http://dx.doi.org/10.1016/0042-6822(61)90033-2
  • Genzel Y, Behrendt I, König S, Sann H, Reichl U. Metabolism of MDCK cells during cell growth and influenza virus production in large-scale microcarrier culture. Vaccine 2004; 22:2202-8; PMID:15149778; http://dx.doi.org/10.1016/j.vaccine.2003.11.041
  • Genzel Y, Fischer M, Reichl U. Serum-free influenza virus production avoiding washing steps and medium exchange in large-scale microcarrier culture. Vaccine 2006; 24:3261-72; PMID:16472544; http://dx.doi.org/10.1016/j.vaccine.2006.01.019
  • Billharz R, Zeng H, Proll SC, Korth MJ, Lederer S, Albrecht R, Goodman AG, Rosenzweig E, Tumpey TM, García-Sastre A, et al. The NS1 protein of the 1918 pandemic influenza virus blocks host interferon and lipid metabolism pathways. J Virol 2009; 83:10557-70; PMID:19706713; http://dx.doi.org/10.1128/JVI.00330-09
  • Munger J, Bennett BD, Parikh A, Feng X-J, McArdle J, Rabitz HA, Shenk T, Rabinowitz JD. Systems-level metabolic flux profiling identifies fatty acid synthesis as a target for antiviral therapy. Nat Biotechnol 2008; 26:1179-86; PMID:18820684; http://dx.doi.org/10.1038/nbt.1500
  • Lin S, Liu N, Yang Z, Song W, Wang P, Chen H, Lucio M, Schmitt-Kopplin P, Chen G, Cai Z. GC/MS-based metabolomics reveals fatty acid biosynthesis and cholesterol metabolism in cell lines infected with influenza A virus. Talanta 2010; 83:262-8; PMID:21035673; http://dx.doi.org/10.1016/j.talanta.2010.09.019
  • Peschel B, Frentzel S, Laske T, Genzel Y, Reichl U. Comparison of influenza virus yields and apoptosis-induction in an adherent and a suspension MDCK cell line. Vaccine 2013; 31:5693-9; PMID:24113260; http://dx.doi.org/10.1016/j.vaccine.2013.09.051
  • Bock A, Schulze Horsel J, Schwarzer J, Rapp E, Genzel Y, Reichl U. High density microcarrier cell cultures for influenza virus production. Biotechnol Prog 2011; 27:241-50; PMID:21312371; http://dx.doi.org/10.1002/btpr.539
  • Maranga L, Goochee CF. Metabolism of PER. C6TM cells cultivated under fed batch conditions at low glucose and glutamine levels. Biotechnol Bioeng 2006; 94:139-50; PMID:16523524; http://dx.doi.org/10.1002/bit.20890
  • Pohlscheidt M, Langer U, Minuth T, Bödeker B, Apeler H, Hörlein H-D, Paulsen D, Rübsamen-Waigmann H, Henzler HJ, Reichl U. Development and optimisation of a procedure for the production of Parapoxvirus ovis by large-scale microcarrier cell culture in a non-animal, non-human and non-plant-derived medium. Vaccine 2008; 26:1552-65; PMID:18295380; http://dx.doi.org/10.1016/j.vaccine.2008.01.032
  • Pohlscheidt M, Bodeker B, Langer U, Apeler H, Horlein HD, Rubsamen-Waigmann H, Reichl U, Henzler HJ. Interpretation data for bioreactors for the increase of scale of a microcarrier-based virus production process. Chemie Ingenieur Technik 2008; 80:821-30; http://dx.doi.org/10.1002/cite.200700125
  • Henry O, Dormond E, Perrier M, Kamen A. Insights into adenoviral vector production kinetics in acoustic filter based perfusion cultures. Biotechnol Bioeng 2004; 86:765-74; PMID:15162452; http://dx.doi.org/10.1002/bit.20074
  • Genzel Y, Vogel T, Buck J, Behrendta I, Ramireza DV, Schiednerc G, Jordand I, Reichla U. High cell density cultivations by alternating tangential flow (ATF) perfusion for influenza A virus production using suspension cells. Vaccine 2014; 32:2770-2781; PMID:24583003; http://dx.doi.org/10.1016/j.vaccine.2014.02.016
  • Genzel Y, Behrendt I, König S, Sann H, Reichl U. Metabolism of MDCK cells during cell growth and influenza virus production in large-scale microcarrier culture. Vaccine 2004; 22:2202-2208; PMID:15149778; http://dx.doi.org/10.1016/j.vaccine.2003.11.041
  • Lin C, Holland RE, Jr, Donofrio JC, McCoy MH, Tudor LR, Chambers TM. Caspase activation in equine influenza virus induced apoptotic cell death. Vet Microbiol 2002; 84:357-65; PMID:11750143; http://dx.doi.org/10.1016/S0378-1135(01)00468-0
  • Lin C, Zimmer SG, Lu Z, Holland RE, Dong Q, Chambers TM. The involvement of a stress-activated pathway in equine influenza virus-mediated apoptosis. Virology 2001; 287:202-13; PMID:11504555; http://dx.doi.org/10.1006/viro.2001.1010
  • Zhirnov O, Konakova T, Garten W, Klenk H-D. Caspase-dependent N-terminal cleavage of influenza virus nucleocapsid protein in infected cells. J Virol 1999; 73:10158-63; PMID:10559331
  • Horníčková Z. Different progress of MDCK cell death after infection by two different influenza virus isolates. Cell Biochem Funct 1997; 15:87-93; PMID:9253160; http://dx.doi.org/10.1002/(SICI)1099-0844(19970601)15:2%3c87::AID-CBF726%3e3.0.CO;2-6
  • Mersich S, Baumeister E, Riva D, Lewis A, Cadario M, Pontoriero A, Savy VL. Influenza circulating strains in Argentina exhibit differential induction of cytotoxicity and caspase-3 in vitro. J Clin Virol 2004; 31:134-9; PMID:15364270; http://dx.doi.org/10.1016/j.jcv.2004.01.004
  • Ritter JB, Wahl AS, Freund S, Genzel Y, Reichl U. Metabolic effects of influenza virus infection in cultured animal cells: Intra-and extracellular metabolite profiling. BMC Syst Biol 2010; 4:61; PMID:20465796; http://dx.doi.org/10.1186/1752-0509-4-61
  • Huang D, Xia-Hou K, Liu X-P, Zhao L, Fan L, Ye Z, Tan WS, Luo J, Chen Z. Rational design of medium supplementation strategy for improved influenza viruses production based on analyzing nutritional requirements of MDCK Cells. Vaccine 2014; 32:7091-7; PMID:25444832; http://dx.doi.org/10.1016/j.vaccine.2014.10.067
  • Rödig JV, Rapp E, Bohne J, Kampe M, Kaffka H, Bock A, Genzel Y, Reichl U. Impact of cultivation conditions on N‐glycosylation of influenza virus a hemagglutinin produced in MDCK cell culture. Biotechnol Bioeng 2013; 110(6):1691-703; PMID:23297157
  • Yang M, Butler M. Effects of ammonia on CHO cell growth, erythropoietin production, and glycosylation. Biotechnol Bioeng 2000; 68(4):370-80; PMID:10745205
  • Yang M, Butler M. Effect of ammonia on the glycosylation of human recombinant erythropoietin in culture. Biotechnol Prog 2000; 16:751-9; PMID:11027166; http://dx.doi.org/10.1021/bp000090b
  • Gillmeister MP, Tomiya N, Jacobia SJ, Lee YC, Gorfien SF, Betenbaugh MJ. An HPLC-MALDI MS method for N-glycan analyses using smaller size samples: application to monitor glycan modulation by medium conditions. Glycoconj J 2009; 26:1135-49; PMID:19412663; http://dx.doi.org/10.1007/s10719-009-9235-z

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.