1,224
Views
12
CrossRef citations to date
0
Altmetric
Research Papers

Immunogenicity and protective efficacy of an EV71 virus-like particle vaccine against lethal challenge in newborn mice

, , , , , , , , , , , , , , & show all
Pages 2406-2413 | Received 09 Feb 2015, Accepted 17 May 2015, Published online: 16 Sep 2015

References

  • Mirand A, Henquell C, Archimbaud C, Ughetto S, Antona D, Bailly JL, Peigue-Lafeuille H. Outbreak of hand, foot and mouth disease/herpangina associated with coxsackievirus A6 and A10 infections in 2010, France: a large citywide, prospective observational study. Clini Microbiol Infect 2012; 18:E110-8; PMID:22404077; http://dx.doi.org/10.1111/j.1469-0691.2012.03789.x
  • Lu QB, Zhang XA, Wo Y, Xu HM, Li XJ, Wang XJ, Ding SJ, Chen XD, He C, Liu LJ, et al. Circulation of Coxsackievirus A10 and A6 in hand-foot-mouth disease in China, 2009–2011. PLoS One 2012; 7:e52073; PMID:23272213; http://dx.doi.org/10.1371/journal.pone.0052073
  • Solomon T, Lewthwaite P, Perera D, Cardosa MJ, McMinn P, Ooi MH. Virology, epidemiology, pathogenesis, and control of enterovirus 71. Lancet Infect Dis 2010; 10:778-90; PMID:20961813; http://dx.doi.org/10.1016/S1473-3099(10)70194-8
  • Mao Q, Wang Y, Yao X, Bian L, Wu X, Xu M, Liang Z. Coxsackievirus A16: epidemiology, diagnosis, and vaccine. Hum Vaccines Immunother 2014; 10:360-7; PMID:24231751; http://dx.doi.org/10.1080/21645515.2015.1008870
  • Yi L, Lu J, Kung HF, He ML. The virology and developments toward control of human enterovirus 71. Critical Rev Microbiol 2011; 37:313-27; PMID:21651436; http://dx.doi.org/10.3109/1040841X.2011.580723
  • McMinn PC. An overview of the evolution of enterovirus 71 and its clinical and public health significance. Fems Microbiol Rev 2002; 26:91-107; PMID:12007645; http://dx.doi.org/10.1111/j.1574-6976.2002.tb00601.x
  • Iwai M, Masaki A, Hasegawa S, Obara M, Horimoto E, Nakamura K, Tanaka Y, Endo K, Tanaka K, Ueda J, et al. Genetic changes of coxsackievirus A16 and enterovirus 71 isolated from hand, foot, and mouth disease patients in Toyama, Japan between 1981 and 2007. Japan J Infect Dis 2009; 62:254-9; PMID:19628900
  • Chang LY, Lin TY, Huang YC, Tsao KC, Shih SR, Kuo ML, Ning HC, Chung PW, Kang CM. Comparison of enterovirus 71 and coxsackie-virus A16 clinical illnesses during the Taiwan enterovirus epidemic, 1998. Pediatr Infect Dis J 1999; 18:1092-6; PMID:10608631; http://dx.doi.org/10.1097/00006454-199912000-00013
  • Schmidt NJ, Lennette EH, Ho HH. An apparently new enterovirus isolated from patients with disease of the central nervous system. J Infect Dis 1974; 129:304-9; PMID:4361245; http://dx.doi.org/10.1093/infdis/129.3.304
  • Fujimoto T, Chikahira M, Yoshida S, Ebira H, Hasegawa A, Totsuka A, Nishio O. Outbreak of central nervous system disease associated with hand, foot, and mouth disease in Japan during the summer of 2000: detection and molecular epidemiology of enterovirus 71. Microbiol Immunol 2002; 46:621-7; PMID:12437029; http://dx.doi.org/10.1111/j.1348-0421.2002.tb02743.x
  • Ho M, Chen ER, Hsu KH, Twu SJ, Chen KT, Tsai SF, Wang JR, Shih SR. An epidemic of enterovirus 71 infection in Taiwan. Taiwan Enterovirus Epidemic Working Group. N Engl J Med 1999; 341:929-35; PMID:10498487; http://dx.doi.org/10.1056/NEJM199909233411301
  • Bendig JW, Fleming DM. Epidemiological, virological, and clinical features of an epidemic of hand, foot, and mouth disease in England and Wales. Commun Dis Rep CDR Rev 1996; 6:R81-6; PMID:8664928
  • NNDRS. http://wwwnhfpcgovcn/zhuzhan/yqxx/listshtml 2014
  • Zhu FC, Meng FY, Li JX, Li XL, Mao QY, Tao H, Zhang YT, Yao X, Chu K, Chen QH, et al. Efficacy, safety, and immunology of an inactivated alum-adjuvant enterovirus 71 vaccine in children in China: a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial. Lancet 2013; 381:2024-32; PMID:23726161; http://dx.doi.org/10.1016/S0140-6736(13)61049-1
  • Paavonen J, Jenkins D, Bosch FX, Naud P, Salmeron J, Wheeler CM, Chow SN, Apter DL, Kitchener HC, Castellsague X, et al. Efficacy of a prophylactic adjuvanted bivalent L1 virus-like-particle vaccine against infection with human papillomavirus types 16 and 18 in young women: an interim analysis of a phase III double-blind, randomised controlled trial. Lancet 2007; 369:2161-70; PMID:17602732; http://dx.doi.org/10.1016/S0140-6736(07)60946-5
  • Liu H, Ma Y, Wang H, Liu Q. Quantitative evaluation of the effect of the hepatitis B vaccine based on the HBsAg- and anti-HBs-positive rates in the Chinese population over the last 33 years. Vaccine 2012; 30:3483-7; PMID:22433962; http://dx.doi.org/10.1016/j.vaccine.2012.02.053
  • www.clinicaltrials.gov ( Identifier NCT01897701)
  • Sun S, Jiang L, Liang Z, Mao Q, Su W, Zhang H, Li X, Jin J, Xu L, Zhao D, et al. Evaluation of monovalent and bivalent vaccines against lethal Enterovirus 71 and Coxsackievirus A16 infection in newborn mice. Hum Vaccines Immunother 2014; 10:2885-95; PMID:25483672; http://dx.doi.org/10.4161/hv.29823
  • Mao Q, Dong C, Li X, Gao Q, Guo Z, Yao X, Wang Y, Gao F, Li F, Xu M, et al. Comparative analysis of the immunogenicity and protective effects of inactivated EV71 vaccines in mice. PLoS One 2012; 7:e46043; PMID:23029378; http://dx.doi.org/10.1371/journal.pone.0046043
  • Bek EJ, Hussain KM, Phuektes P, Kok CC, Gao Q, Cai F, Gao Z, McMinn PC. Formalin-inactivated vaccine provokes cross-protective immunity in a mouse model of human enterovirus 71 infection. Vaccine 2011; 29:4829-38; PMID:21550375; http://dx.doi.org/10.1016/j.vaccine.2011.04.070
  • Giersing BK, Dubovsky F, Saul A, Denamur F, Minor P, Meade B. Potency assay design for adjuvanted recombinant proteins as malaria vaccines. Vaccine 2006; 24:4264-70; PMID:16767804; http://dx.doi.org/10.1016/j.vaccine.2006.01.005
  • DJ. F. Probit analysis. 3rd ed. London: Cambrige university press. 1971
  • DJ. F. Statistical methodology in biological assay. 3rd ed. London: Charles Griffin and Company. 1978
  • Sokol RR RF. Biometry: the principles and practice of statistics in biological research. 3rd ed. Newyork: W.H. Freeman and Company. 1995
  • Gaines RE, Tydeman MS. Iterative weighted regression analysis of logit responses: a computer program for analysis of bioassays and immunoassays. Comput Programs Biomed 1982; 15:13-21; PMID:7128120; http://dx.doi.org/10.1016/0010-468X(82)90052-6
  • Commission EP. Statistical analysis of results of bioligical assays and test. European Pharmacopoeia, 5th ed. Strasburg: Council of Europe, 475-504
  • 2010 P. Pharmacopoeia of the People's Republic of China ( 2010 Edition):
  • Zhu F, Xu W, Xia J, Liang Z, Liu Y, Zhang X, Tan X, Wang L, Mao Q, Wu J, et al. Efficacy, safety, and immunogenicity of an enterovirus 71 vaccine in China. N Engl J Med 2014; 370:818-28; PMID:24571754; http://dx.doi.org/10.1056/NEJMoa1304923
  • Li R, Liu L, Mo Z, Wang X, Xia J, Liang Z, Zhang Y, Li Y, Mao Q, Wang J, et al. An inactivated enterovirus 71 vaccine in healthy children. N Engl J Med 2014; 370:829-37; PMID:24571755; http://dx.doi.org/10.1056/NEJMoa1303224
  • Cheng A, Fung CP, Liu CC, Lin YT, Tsai HY, Chang SC, Chou AH, Chang JY, Jiang RH, Hsieh YC, et al. A Phase I, randomized, open-label study to evaluate the safety and immunogenicity of an enterovirus 71 vaccine. Vaccine 2013; 31:2471-6; PMID:23541623; http://dx.doi.org/10.1016/j.vaccine.2013.03.015
  • Li HY, Han JF, Qin CF, Chen R. Virus-like particles for enterovirus 71 produced from Saccharomyces cerevisiae potently elicits protective immune responses in mice. Vaccine 2013; 31:3281-7; PMID:23726823; http://dx.doi.org/10.1016/j.vaccine.2013.05.019
  • Lin YL, Yu CI, Hu YC, Tsai TJ, Kuo YC, Chi WK, Lin AN, Chiang BL. Enterovirus type 71 neutralizing antibodies in the serum of macaque monkeys immunized with EV71 virus-like particles. Vaccine 2012; 30:1305-12; PMID:22214888; http://dx.doi.org/10.1016/j.vaccine.2011.12.081
  • Chung YC, Ho MS, Wu JC, Chen WJ, Huang JH, Chou ST, Hu YC. Immunization with virus-like particles of enterovirus 71 elicits potent immune responses and protects mice against lethal challenge. Vaccine 2008; 26:1855-62; PMID:18329759; http://dx.doi.org/10.1016/j.vaccine.2008.01.058
  • Liang Z, Wang J. EV71 vaccine, an invaluable gift for children. Clin Translat Immunol 2014; 3:e28; PMID:25505956; http://dx.doi.org/10.1038/cti.2014.24
  • de Moura WC, de Araujo HP, Cabello PH, Romijn PC, Leite JP. Potency evaluation of rabies vaccine for human use: the impact of the reduction in the number of animals per dilution. J Virol Methods 2009; 158:84-92; PMID:19428574; http://dx.doi.org/10.1016/j.jviromet.2009.01.017
  • Leslie DE, Nicholson S, Dimitrakakis M, Johnston N, Gust ID. Humoral immune responses in mice using gamma inulin preparations as adjuvants for hepatitis B vaccines. Immunol Cell Biol 1990; 68 (Pt 2):107-12; PMID:1696560; http://dx.doi.org/10.1038/icb.1990.15
  • Li SW, Zhang J, Li YM, Ou SH, Huang GY, He ZQ, Ge SX, Xian YL, Pang SQ, Ng MH, et al. A bacterially expressed particulate hepatitis E vaccine: antigenicity, immunogenicity and protectivity on primates. Vaccine 2005; 23:2893-901; PMID:15780738; http://dx.doi.org/10.1016/j.vaccine.2004.11.064
  • Li SW, Zhao Q, Wu T, Chen S, Zhang J, Xia NS. The development of a recombinant hepatitis E vaccine HEV 239. Hum Vaccines Immunother 2015:11(4):908-14; PMID:25714510
  • Liang Z, Mao Q, Gao Q, Li X, Dong C, Yu X, Yao X, Li F, Yin W, Li Q, et al. Establishing China's national standards of antigen content and neutralizing antibody responses for evaluation of enterovirus 71 (EV71) vaccines. Vaccine 2011; 29:9668-74; PMID:22015395; http://dx.doi.org/10.1016/j.vaccine.2011.10.018
  • Wu CN, Lin YC, Fann C, Liao NS, Shih SR, Ho MS. Protection against lethal enterovirus 71 infection in newborn mice by passive immunization with subunit VP1 vaccines and inactivated virus. Vaccine 2001; 20:895-904; PMID:11738755; http://dx.doi.org/10.1016/S0264-410X(01)00385-1
  • Chiu CH, Chu C, He CC, Lin TY. Protection of neonatal mice from lethal enterovirus 71 infection by maternal immunization with attenuated Salmonella enterica serovar Typhimurium expressing VP1 of enterovirus 71. Microb infect 2006; 8:1671-8; PMID:16815726; http://dx.doi.org/10.1016/j.micinf.2006.01.021
  • Huang BY, Wang XP, Tang WJ, Wang WL, Ruan L. The 50% effective dose (ED50a) of seasonal spilt influenza vaccine in mice. Chin J Exp Clin Virol 2011; 25:92-5; PMID:21863626
  • Einstein MH, Takacs P, Chatterjee A, Sperling RS, Chakhtoura N, Blatter MM, Lalezari J, David MP, Lin L, Struyf F, et al. Comparison of long-term immunogenicity and safety of human papillomavirus (HPV)-16/18 AS04-adjuvanted vaccine and HPV-6/11/16/18 vaccine in healthy women aged 18–45 years: End-of-study analysis of a Phase III randomized trial. Hum Vaccines Immunother 2014; 10:3435-45; PMID:25483701; http://dx.doi.org/10.4161/hv.36121
  • Einstein MH, Levin MJ, Chatterjee A, Chakhtoura N, Takacs P, Catteau G, Dessy FJ, Moris P, Lin L, Struyf F, et al. Comparative humoral and cellular immunogenicity and safety of human papillomavirus (HPV)-16/18 AS04-adjuvanted vaccine and HPV-6/11/16/18 vaccine in healthy women aged 18–45 years: Follow-up through Month 48 in a Phase III randomized study. Hum Vaccines Immunother 2014; 10:3455-65; PMID:25483700; http://dx.doi.org/10.4161/hv.36117
  • Li X, Fan P, Jin J, Su W, An D, Xu L, Sun S, Zhang Y, Meng X, Gao F, et al. Establishment of cell lines with increased susceptibility to EV71/CA16 by stable overexpression of SCARB2. Virol J 2013; 10:250; PMID:23919614; http://dx.doi.org/10.1186/1743-422X-10-250
  • Wu X, Mao Q, Yao X, Chen P, Chen X, Shao J, Sun S, Zhang Y, Meng X, Gao F, et al. Development and evaluation of a pseudovirus-luciferase assay for rapid and quantitative detection of neutralizing antibodies against enterovirus 71. PLoS One 2013; 8:e64116; PMID:23755115; http://dx.doi.org/10.1371/journal.pone.0064116
  • Jin J, Xu L, Guo S, Sun S, Zhang S, Zhu C, Kong W, Jiang C. Safe and Objective Assay of Enterovirus 71 Neutraliziong Antibodies Via Pseudovirus Chem Res Chinese Universities 2012; 28:91-95
  • Zhang H, An D, Liu W, Mao Q, Jin J, Xu L, Sun S, Jiang L, Li X, Shao J, et al. Analysis of cross-reactive neutralizing antibodies in human HFMD serum with an EV71 pseudovirus-based assay. PLoS One 2014; 9:e100545; PMID:24964084; http://dx.doi.org/10.1371/journal.pone.0100545
  • Mao Q, Wang Y, Gao R, Shao J, Yao X, Lang S, Wang C, Mao P, Liang Z, Wang J. A neonatal mouse model of coxsackievirus A16 for vaccine evaluation. J Virol 2012; 86:11967-76; PMID:22951825; http://dx.doi.org/10.1128/JVI.00902-12

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.