1,883
Views
9
CrossRef citations to date
0
Altmetric
Commentaries

Vaccination against Lyme disease: Are we ready for it?

&
Pages 757-762 | Received 07 Aug 2015, Accepted 21 Aug 2015, Published online: 05 May 2016

References

  • Keller A, Graefen A, Ball M, Matzas M, Boisguerin V, Maixner F, Leidinger P, Backes C, Khairat R, Forster M, et al. New insights into the Tyrolean Iceman's origin and phenotype as inferred by whole-genome sequencing. Nat Commun 2012; 3:698; PMID:22426219; http://dx.doi.org/10.1038/ncomms1701
  • Cook MJ. Lyme borreliosis: a review of data on transmission time after tick attachment. Int J Gen Med 2015; 8:1-8z
  • Burgdorfer W, Barbour AG, Hayes SF, Benach JL, Grunwaldt E, Davis JP. Lyme disease-a tick-borne spirochetosis? Science 1982; 216:1317-9; PMID:7043737; http://dx.doi.org/10.1126/science.7043737
  • Wressnigg N, Pollabauer EM, Aichinger G, Portsmouth D, Low-Baselli A, Fritsch S, Livey I, Crowe BA, Schwendinger M, Brühl P, et al. Safety and immunogenicity of a novel multivalent OspA vaccine against Lyme borreliosis in healthy adults: a double-blind, randomised, dose-escalation phase 1/2 trial. Lancet Infect Dis 2013; 13:680-9; PMID:23665341; http://dx.doi.org/10.1016/S1473-3099(13)70110-5
  • Stanek G, Wormser GP, Gray J, Strle F. Lyme borreliosis. Lancet 2012; 379:461-73; PMID:21903253; http://dx.doi.org/10.1016/S0140-6736(11)60103-7
  • Auwaerter PG. Point: antibiotic therapy is not the answer for patients with persisting symptoms attributable to lyme disease. Clin Infect Dis 2007; 45:143-8; PMID:17578771; http://dx.doi.org/10.1086/518854
  • Mongodin EF, Casjens SR, Bruno JF, Xu Y, Drabek EF, Riley DR, Cantarel BL, Pagan PE, Hernandez YA, Vargas LC, et al. Inter- and intra-specific pan-genomes of Borrelia burgdorferi sensu lato: genome stability and adaptive radiation. BMC Genomics 2013; 14:693; PMID:24112474; http://dx.doi.org/10.1186/1471-2164-14-693
  • Tappe J, Jordan D, Janecek E, Fingerle V, Strube C. Revisited: Borrelia burgdorferi sensu lato infections in hard ticks (Ixodes ricinus) in the city of Hanover (Germany). Parasites Vectors 2014; 7:441; PMID:25233844; http://dx.doi.org/10.1186/1756-3305-7-441
  • Nelder MP, Russell C, Lindsay LR, Dhar B, Patel SN, Johnson S, Moore S, Kristjanson E, Li Y, Ralevski F. Population-based passive tick surveillance and detection of expanding foci of blacklegged ticks Ixodes scapularis and the Lyme disease agent Borrelia burgdorferi in Ontario, Canada. PLoS One 2014; 9:e105358; PMID:25171252; http://dx.doi.org/10.1371/journal.pone.0105358
  • Rauter C, Hartung T. Prevalence of Borrelia burgdorferi sensu lato genospecies in Ixodes ricinus ticks in Europe: a metaanalysis. Appl Environ Microbiol 2005; 71:7203-16; PMID:16269760; http://dx.doi.org/10.1128/AEM.71.11.7203-7216.2005
  • Shen AK, Mead PS, Beard CB. The Lyme disease vaccine-a public health perspective. Clin Infect Dis 2011; 52 Suppl 3:s247-52; http://dx.doi.org/10.1093/cid/ciq115
  • Lindgren E, Jaenson TG. Lyme borreliosis in Europe: influence of climate change, epidemiology, ecology and adaptation measures. Report No:EUR/04/5046240 Copenhagen: World Health Organization Regional Office for Europe; Climate Change and Adaptation Strategies for Human Health 2006
  • CDC provides estimate of Americans diagnosed with Lyme disease each year. Press release of the Centers for Disease Control and Prevention, August 13, 2013. http://www.cdc.gov/media/releases/2013/p0819-lyme-disease.html
  • Muller I, Freitag MH, Poggensee G, Scharnetzky E, Straube E, Schoerner C, Hlobil H, Hagedorn HJ, Stanek G, Schubert-Unkmeir A, et al. Evaluating frequency, diagnostic quality, and cost of Lyme borreliosis testing in Germany: a retrospective model analysis. Clin Dev Immunol 2012; 2012:595427; http://dx.doi.org/10.1155/2012/595427
  • Smith R, Takkinen J. Lyme borreliosis: Europe-wide coordinated surveillance and action needed? Euro Surveill 2006; 11:E060622 1
  • Hofhuis A, Harms M, van den Wijngaard C, Sprong H, van Pelt W. Continuing increase of tick bites and Lyme disease between 1994 and 2009. Ticks Tick-Borne Dis 2015; 6:69-74; PMID:25448421; http://dx.doi.org/10.1016/j.ttbdis.2014.09.006
  • Panelius J, Meri T, Seppala I, Eholuoto M, Alitalo A, Meri S. Outer surface protein E antibody response and its effect on complement factor H binding to OspE in Lyme borreliosis. Microbes Infection / Institut Pasteur 2008; 10:135-42; http://dx.doi.org/10.1016/j.micinf.2007.10.016
  • McKisic MD, Barthold SW. T-cell-independent responses to Borrelia burgdorferi are critical for protective immunity and resolution of lyme disease. Infect Immun 2000; 68:5190-7; PMID:10948143; http://dx.doi.org/10.1128/IAI.68.9.5190-5197.2000
  • Vaz A, Glickstein L, Field JA, McHugh G, Sikand VK, Damle N, Steere AC. Cellular and humoral immune responses to Borrelia burgdorferi antigens in patients with culture-positive early Lyme disease. Infect Immun 2001; 69:7437-44; PMID:11705918; http://dx.doi.org/10.1128/IAI.69.12.7437-7444.2001
  • Akin E, McHugh GL, Flavell RA, Fikrig E, Steere AC. The immunoglobulin (IgG) antibody response to OspA and OspB correlates with severe and prolonged Lyme arthritis and the IgG response to P35 correlates with mild and brief arthritis. Infect Immun 1999; 67:173-81; PMID:9864212
  • Embers ME, Hasenkampf NR, Jacobs MB, Philipp MT. Dynamic longitudinal antibody responses during Borrelia burgdorferi infection and antibiotic treatment of rhesus macaques. Clin Vaccine Immunol 2012; 19:1218-26; PMID:22718128; http://dx.doi.org/10.1128/CVI.00228-12
  • Burbelo PD, Issa AT, Ching KH, Cohen JI, Iadarola MJ, Marques A. Rapid, simple, quantitative, and highly sensitive antibody detection for lyme disease. Clin Vaccine Immunol 2010; 17:904-9; PMID:20392886; http://dx.doi.org/10.1128/CVI.00476-09
  • Dessau RB, Moller JK, Kolmos B, Henningsson AJ. Multiplex assay (Mikrogen recomBead) for detection of serum IgG and IgM antibodies to 13 recombinant antigens of Borrelia burgdorferi sensu lato in patients with neuroborreliosis: the more the better? J Med Microbiol 2015; 64:224-31; PMID:25587083; http://dx.doi.org/10.1099/jmm.0.000009
  • Jones KL, Seward RJ, Ben-Menachem G, Glickstein LJ, Costello CE, Steere AC. Strong IgG antibody responses to Borrelia burgdorferi glycolipids in patients with Lyme arthritis, a late manifestation of the infection. Clin Immunol 2009; 132:93-102; PMID:19342303; http://dx.doi.org/10.1016/j.clim.2009.03.510
  • Alitalo A, Meri T, Lankinen H, Seppala I, Lahdenne P, Hefty PS, Akins D, Meri S. Complement inhibitor factor H binding to Lyme disease spirochetes is mediated by inducible expression of multiple plasmid-encoded outer surface protein E paralogs. J Immunol 2002; 169:3847-53; PMID:12244181; http://dx.doi.org/10.4049/jimmunol.169.7.3847
  • Schuijt TJ, Hovius JW, van der Poll T, van Dam AP, Fikrig E. Lyme borreliosis vaccination: the facts, the challenge, the future. Trends Parasitol 2011; 27:40-7; PMID:20594913; http://dx.doi.org/10.1016/j.pt.2010.06.006
  • Rogovskyy AS, Bankhead T. Variable VlsE is critical for host reinfection by the Lyme disease spirochete. PLoS One 2013; 8:e61226; PMID:23593438; http://dx.doi.org/10.1371/journal.pone.0061226
  • McKisic MD, Redmond WL, Barthold SW. Cutting edge: T cell-mediated pathology in murine Lyme borreliosis. J Immunol 2000; 164:6096-9; PMID:10843657; http://dx.doi.org/10.4049/jimmunol.164.12.6096
  • Steere AC, Sikand VK, Meurice F, Parenti DL, Fikrig E, Schoen RT, Nowakowski J, Schmid CH, Laukamp S, Buscarino C, et al. Vaccination against Lyme disease with recombinant Borrelia burgdorferi outer-surface lipoprotein A with adjuvant. Lyme Disease Vaccine Study Group. N Engl J Med 1998; 339:209-15; PMID:9673298; http://dx.doi.org/10.1056/NEJM199807233390401
  • Sigal LH, Zahradnik JM, Lavin P, Patella SJ, Bryant G, Haselby R, Hilton E, Kunkel M, Adler-Klein D, Doherty T, et al. A vaccine consisting of recombinant Borrelia burgdorferi outer-surface protein A to prevent Lyme disease. Recombinant Outer-Surface Protein A Lyme Disease Vaccine Study Consortium. N Engl J Med 1998; 339:216-22; PMID:9673299; http://dx.doi.org/10.1056/NEJM199807233390402
  • Gross DM, Forsthuber T, Tary-Lehmann M, Etling C, Ito K, Nagy ZA, Field JA, Steere AC, Huber BT. Identification of LFA-1 as a candidate autoantigen in treatment-resistant Lyme arthritis. Science 1998; 281:703-6; PMID:9685265; http://dx.doi.org/10.1126/science.281.5377.703
  • Nigrovic LE, Thompson KM. The Lyme vaccine: a cautionary tale. Epidemiol Infect 2007; 135:1-8; PMID:16893489; http://dx.doi.org/10.1017/S0950268806007096
  • Willyard C. Resurrecting the 'yuppie vaccine. Nat Med 2014; 20:698-701; PMID:24999936; http://dx.doi.org/10.1038/nm0714-698
  • Recommendations for the Use of Lyme Disease Vaccine Recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR 1999; 48(RR-7):1-26
  • Turchick A, Czochor J. Vaccine development: how scientific collaboration and communication help prevent the spread of disease: an interview with erol fikrig, MD. Yale J Biol Med 2014; 87:519-25; PMID:25506284
  • Fikrig E, Telford SR, 3rd, Barthold SW, Kantor FS, Spielman A, Flavell RA. Elimination of Borrelia burgdorferi from vector ticks feeding on OspA-immunized mice. Proc Natl Acad Sci U S A 1992; 89:5418-21; PMID:1608951; http://dx.doi.org/10.1073/pnas.89.12.5418
  • Schwan TG, Piesman J. Temporal changes in outer surface proteins A and C of the lyme disease-associated spirochete, Borrelia burgdorferi, during the chain of infection in ticks and mice. J Clin Microbiol 2000; 38:382-8; PMID:10618120
  • de Silva AM, Telford SR, 3rd, Brunet LR, Barthold SW, Fikrig E. Borrelia burgdorferi OspA is an arthropod-specific transmission-blocking Lyme disease vaccine. J Exp Med 1996; 183:271-5; PMID:8551231; http://dx.doi.org/10.1084/jem.183.1.271
  • Gipson CL, de Silva AM. Interactions of OspA monoclonal antibody C3.78 with Borrelia burgdorferi within ticks. Infect Immun 2005; 73:1644-7; PMID:15731064; http://dx.doi.org/10.1128/IAI.73.3.1644-1647.2005
  • Wressnigg N, Barrett PN, Pollabauer EM, O'Rourke M, Portsmouth D, Schwendinger MG, Crowe BA, Livey I, Dvorak T, Schmitt B, et al. A Novel multivalent OspA vaccine against Lyme borreliosis is safe and immunogenic in an adult population previously infected with Borrelia burgdorferi sensu lato. Clin Vaccine Immunol 2014; 21:1490-9; PMID:25185574; http://dx.doi.org/10.1128/CVI.00406-14
  • Stubs G, Fingerle V, Zahringer U, Schumann RR, Rademann J, Schroder NW. Acylated cholesteryl galactosides are ubiquitous glycolipid antigens among Borrelia burgdorferi sensu lato. FEMS Immunol Med Microbiol 2011; 63:140-3; PMID:21635569; http://dx.doi.org/10.1111/j.1574-695X.2011.00827.x
  • Kazimirova M, Stibraniova I. Tick salivary compounds: their role in modulation of host defences and pathogen transmission. Frontiers Cellular Infection Microbiol 2013; 3:43; http://dx.doi.org/10.3389/fcimb.2013.00043
  • Ullmann AJ, Dolan MC, Sackal CA, Fikrig E, Piesman J, Zeidner NS. Immunization with adenoviral-vectored tick salivary gland proteins (SALPs) in a murine model of Lyme borreliosis. Ticks Tick-Borne Dis 2013; 4:160-3; PMID:23141105; http://dx.doi.org/10.1016/j.ttbdis.2012.08.006
  • Sprong H, Trentelman J, Seemann I, Grubhoffer L, Rego RO, Hajdusek O, Kopáček P, Šíma R, Nijhof AM, Anguita J, et al. ANTIDotE: anti-tick vaccines to prevent tick-borne diseases in Europe. Parasit Vectors 2014; 7:77; PMID:24559082; http://dx.doi.org/10.1186/1756-3305-7-77
  • Wikel SK, Ramachandra RN, Bergman DK, Burkot TR, Piesman J. Infestation with pathogen-free nymphs of the tick Ixodes scapularis induces host resistance to transmission of Borrelia burgdorferi by ticks. Infect Immun 1997; 65:335-8; PMID:8975935
  • Voordouw MJ, Tupper H, Onder O, Devevey G, Graves CJ, Kemps BD, Brisson D. Reductions in human Lyme disease risk due to the effects of oral vaccination on tick-to-mouse and mouse-to-tick transmission. Vector Borned Zoonotic Dis 2013; 13:203-14; http://dx.doi.org/10.1089/vbz.2012.1003
  • Nadelman RB, Nowakowski J, Fish D, Falco RC, Freeman K, McKenna D, Welch P, Marcus R, Agüero-Rosenfeld ME, Dennis DT, et al. Prophylaxis with single-dose doxycycline for the prevention of Lyme disease after an Ixodes scapularis tick bite. N Engl J Med 2001; 345:79-84; PMID:11450675; http://dx.doi.org/10.1056/NEJM200107123450201
  • Adrion ER, Aucott J, Lemke KW, Weiner JP. Health care costs, utilization and patterns of care following Lyme disease. PLoS One 2015; 10:e0116767; PMID:25650808; http://dx.doi.org/10.1371/journal.pone.0116767