Why the recent ACIP recommendations regarding conjugate pneumococcal vaccine in adults may be irrelevant

References

• Tomczyk S, Bennett NM, Stoecker C, et al. Use of 13-valent pneumococcal conjugate vaccine and 23-valent pneumococcal polysaccharide vaccine among adults aged >/=65 years: recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Morb Mortal Wkly Rep 2014;63:822-5; PMID:25233284
   PubMed Web of Science ®Google Scholar
• Felton LD, Ekwurtzel GM, Simmons JS, Dublin LI. Studies on immunizing substances in pneumococci. Public Health Rep 1938;53:1855; PMID:19315683; http://dx.doi.org/10.2307/4582685
   PubMedGoogle Scholar
• Kaufman P. Studies on old age pneumonia : prophylactic effect of pneumococcus polysaccharide against pneumonia. Archives of internal medicine 1941;67:304-19; http://dx.doi.org/10.1001/archinte.1941.00200020066004
   Google Scholar
• MacLeod CM, Hodges RG, Heidelberger M, Bernhard WG. Prevention of pneumococcal pneumonia by immunization with specific capsular polysaccharides. J Exp Med 1945;82:445-65; http://dx.doi.org/10.1084/jem.82.6.445
   Web of Science ®Google Scholar
• Shapiro ED, Berg AT, Austrian R, Schroeder D, Parcells V, Margolis A, Adair RK, Clemens JD. The protective efficacy of polyvalent pneumococcal polysaccharide vaccine. N Engl J Med 1991;325:1453-60; PMID:1944423; http://dx.doi.org/10.1056/NEJM199111213252101
   PubMed Web of Science ®Google Scholar
• Bolan G, Broome CV, Facklam RR, Plikaytis BD, Fraser DW, Schlech WF, 3rd. Pneumococcal vaccine efficacy in selected populations in the United States. Ann Intern Med 1986;104:1-6; PMID:3940476; http://dx.doi.org/10.7326/0003-4819-104-1-1
   PubMed Web of Science ®Google Scholar
• Moberley SA, Holden J, Tatham DP, Andrews RM. Vaccines for preventing pneumococcal infection in adults. Cochrane Database Syst Rev 2008:CD000422; PMID:18253977
   PubMedGoogle Scholar
• Moberley S, Holden J, Tatham DP, Andrews RM. Vaccines for preventing pneumococcal infection in adults. Cochrane Database Syst Rev 2013; 1:CD000422; PMID:23440780
   PubMed Web of Science ®Google Scholar
• Huss A, Scott P, Stuck AE, Trotter C, Egger M. Efficacy of pneumococcal vaccination in adults: a meta-analysis. CMAJ 2009;180:48-58; PMID:19124790; http://dx.doi.org/10.1503/cmaj.080734
   PubMed Web of Science ®Google Scholar
• Koivula I, Sten M, Leinonen M, Makela PH. Clinical efficacy of pneumococcal vaccine in the elderly: a randomized, single-blind population-based trial. Am J Med 1997;103:281-90; PMID:9382120; http://dx.doi.org/10.1016/S0002-9343(97)00149-6
   PubMed Web of Science ®Google Scholar
• Ortqvist A, Hedlund J, Burman LA, et al. Randomised trial of 23-valent pneumococcal capsular polysaccharide vaccine in prevention of pneumonia in middle-aged and elderly people. Swedish Pneumococcal Vaccination Study Group. Lancet 1998;351:399-403; PMID:9482293; http://dx.doi.org/10.1016/S0140-6736(97)07358-3
   PubMed Web of Science ®Google Scholar
• Ochoa-Gondar O, Vila-Corcoles A, Rodriguez-Blanco T, Gomez-Bertomeu F, Figuerola-Massana E, Raga-Luria X, Hospital-Guardiola I. Effectiveness of the 23-Valent Pneumococcal Polysaccharide Vaccine Against Community-Acquired Pneumonia in the General Population Aged >=60 Years: 3 Years of Follow-up in the CAPAMIS Study. Clin Infect Dis 2014;58:909-17; PMID:24532544; http://dx.doi.org/10.1093/cid/ciu002
   PubMed Web of Science ®Google Scholar
• Musher DM, Sampath R, Rodriguez-Barradas MC. The potential role for protein-conjugate pneumococcal vaccine in adults: what is the supporting evidence? Clin Infect Dis 2011;52:633-40; PMID:21292668; http://dx.doi.org/10.1093/cid/ciq207
   PubMed Web of Science ®Google Scholar
• van Werkhoven CH, Huijts SM, Bolkenbaas M, Grobbee DE, Bonten MJ. The impact of age on the efficacy of 13-valent pneumococcal conjugate vaccine in elderly. Clin Infect Dis 2015; PMID:26265498
   PubMed Web of Science ®Google Scholar
• Ridda I, Macintyre CR, Lindley R, Gao Z, Sullivan JS, Yuan FF, McIntyre PB. Immunological responses to pneumococcal vaccine in frail older people. Vaccine 2009;27:1628-36; PMID:19100304; http://dx.doi.org/10.1016/j.vaccine.2008.11.098
   PubMed Web of Science ®Google Scholar
• Karlsson J, Hogevik H, Anderssson K, Roshani L, Andreasson B, Wenneras C. Pneumococcal vaccine responses in elderly patients with multiple myeloma, Waldenstrom's macroglobulinemia, and monoclonal gammopathy of undetermined significance Trials Vaccinol 2013;2:31-8; http://dx.doi.org/10.1016/j.trivac.2013.09.001
   Google Scholar
• Jackson LA, Gurtman A, van Cleeff M, Jansen KU, Jayawardene D, Devlin C, Scott DA, Emini EA, Gruber WC, Schmoele-Thoma B. Immunogenicity and safety of a 13-valent pneumococcal conjugate vaccine compared to a 23-valent pneumococcal polysaccharide vaccine in pneumococcal vaccine-naive adults. Vaccine 2013;31:3577-84; PMID:23688526; http://dx.doi.org/10.1016/j.vaccine.2013.04.085
   PubMed Web of Science ®Google Scholar
• Dinleyici EC, Yargic ZA. Current knowledge regarding the investigational 13-valent pneumococcal conjugate vaccine. Expert Rev Vaccines 2009;8:977-86; PMID:19627181; http://dx.doi.org/10.1586/erv.09.68
   PubMed Web of Science ®Google Scholar
• Abzug MJ, Song LY, Levin MJ, Nachman SA, Borkowsky W, Pelton SI; International Maternal Pediatric Adolescent AIDS Clinical Trials Group P1024 and P1061s Protocol Teams. Antibody persistence and immunologic memory after sequential pneumococcal conjugate and polysaccharide vaccination in HIV-infected children on highly active antiretroviral therapy. Vaccine 2013;31:4782-90; PMID:23954381; http://dx.doi.org/10.1016/j.vaccine.2013.08.002
   PubMed Web of Science ®Google Scholar
• Bhorat AE, Madhi SA, Laudat F, Sundaraiyer V, Gurtman A, Jansen KU, Scott DA, Emini EA, Gruber WC, Schmoele-Thoma B. Immunogenicity and safety of the 13-valent pneumococcal conjugate vaccine in HIV-infected individuals naive to pneumococcal vaccination. AIDS 2015;29:1345-54; PMID:25888646; http://dx.doi.org/10.1097/QAD.0000000000000689
   PubMed Web of Science ®Google Scholar
• Musher DM, Rueda AM, Nahm MH, Graviss EA, Rodriguez-Barradas MC. Initial and subsequent response to pneumococcal polysaccharide and protein-conjugate vaccines administered sequentially to adults who have recovered from pneumococcal pneumonia. J Infect Dis 2008;198:1019-27; PMID:18710324; http://dx.doi.org/10.1086/591629
   PubMed Web of Science ®Google Scholar
• Jackson LA, Gurtman A, van Cleeff M, Frenck RW, Treanor J, Jansen KU, Scott DA, Emini EA, Gruber WC, Schmoele-Thoma B. Influence of initial vaccination with 13-valent pneumococcal conjugate vaccine or 23-valent pneumococcal polysaccharide vaccine on anti-pneumococcal responses following subsequent pneumococcal vaccination in adults 50 years and older. Vaccine 2013;31:3594-602; PMID:23688525; http://dx.doi.org/10.1016/j.vaccine.2013.04.084
   PubMed Web of Science ®Google Scholar
• Greenberg RN, Gurtman A, Frenck RW, Strout C, Jansen KU, Trammel J, Scott DA, Emini EA, Gruber WC, Schmoele-Thoma B. Sequential administration of 13-valent pneumococcal conjugate vaccine and 23-valent pneumococcal polysaccharide vaccine in pneumococcal vaccine-naive adults 60-64 years of age. Vaccine 2014;32:2364-74; PMID:24606865; http://dx.doi.org/10.1016/j.vaccine.2014.02.002
   PubMed Web of Science ®Google Scholar
• Cordonnier C, Ljungman P, Juergens C, Maertens J, Selleslag D, Sundaraiyer V, Giardina PC, Clarke K, Gruber WC, Scott DA, et al. Immunogenicity, Safety, and Tolerability of 13-Valent Pneumococcal Conjugate Vaccine Followed by 23-Valent Pneumococcal Polysaccharide Vaccine in Recipients of Allogeneic Hematopoietic Stem Cell Transplant Aged >/=2 Years: An Open-Label Study. Clin Infect Dis 2015;61:313-23; PMID:25870329; http://dx.doi.org/10.1093/cid/civ287
   PubMed Web of Science ®Google Scholar
• Lesprit P, Pedrono G, Molina JM, Goujard C, Girard PM, Sarrazin N, Katlama C, Yéni P, Morineau P, Delfraissy JF, et al. Immunological efficacy of a prime-boost pneumococcal vaccination in HIV-infected adults. Aids 2007;21:2425-34; PMID:18025879; http://dx.doi.org/10.1097/QAD.0b013e3282887e91
   PubMed Web of Science ®Google Scholar
• Kobayashi H. Intervals between PCV13 and PPSV23 vaccines: evidence supporting currently recommended intervals and proposed changes. 2015. Available at http:///wwwcdcgov/vaccinesacip/meetings/downloads/slides-2015-06/pneumo-02-kobayashipdf
   Google Scholar
• Bonten MJ, Huijts SM, Bolkenbaas M, Webber C, Patterson S, Gault S, van Werkhoven CH, van Deursen AM, Sanders EA, Verheij TJ, et al. Polysaccharide conjugate vaccine against pneumococcal pneumonia in adults. N Engl J Med 2015;372:1114-25; PMID:25785969; http://dx.doi.org/10.1056/NEJMoa1408544
   PubMed Web of Science ®Google Scholar
• Pilishvili T, Lexau C, Farley MM, Hadler J, Harrison LH, Bennett NM, Reingold A, Thomas A, Schaffner W, Craig AS, et al. Sustained reductions in invasive pneumococcal disease in the era of conjugate vaccine. J Infect Dis 2010;201(1):32-41; PMID:19947881; http://dx.doi.org/10.1086/648593
   PubMed Web of Science ®Google Scholar
• Feikin DR, Kagucia EW, Loo JD, Link-Gelles R, Puhan MA, Cherian T, Levine OS, Whitney CG, O'Brien KL, Moore MR; Serotype Replacement Study Group. Serotype-specific changes in invasive pneumococcal disease after pneumococcal conjugate vaccine introduction: a pooled analysis of multiple surveillance sites. PLoS Med 2013; 10:e1001517; PMID:24086113; http://dx.doi.org/10.1371/journal.pmed.1001517
   PubMed Web of Science ®Google Scholar
• Smith KJ, Wateska AR, Nowalk MP, Raymund M, Nuorti JP, Zimmerman RK. Cost-effectiveness of adult vaccination strategies using pneumococcal conjugate vaccine compared with pneumococcal polysaccharide vaccine. JAMA 2012;307:804-12
   PubMed Web of Science ®Google Scholar
• Dagan R, Juergens C, Trammel J, Patterson S, Greenberg D, Givon-Lavi N, Porat N, Gurtman A, Gruber WC, Scott DA. Efficacy of 13-Valent Pneumococcal Conjugate Vaccine (PCV13) Versus That of 7-Valent PCV (PCV7) Against Nasopharyngeal Colonization of Antibiotic-Nonsusceptible Streptococcus pneumoniae. J Infect Dis 2015;211:1144-53; PMID:25355940; http://dx.doi.org/10.1093/infdis/jiu576
   PubMed Web of Science ®Google Scholar
• Dagan R. Impact of pneumococcal conjugate vaccine on infections caused by antibiotic-resistant Streptococcus pneumoniae. Clin Microbiol Infect 2009; 15 Suppl 3:16-20; PMID:19366365; http://dx.doi.org/10.1111/j.1469-0691.2009.02726.x
   PubMed Web of Science ®Google Scholar
• Pelton SI, Loughlin AM, Marchant CD. Seven valent pneumococcal conjugate vaccine immunization in two Boston communities: changes in serotypes and antimicrobial susceptibility among Streptococcus pneumoniae isolates. Pediatr Infect Dis J 2004;23:1015-22; PMID:15545856; http://dx.doi.org/10.1097/01.inf.0000143645.58215.f0
   PubMed Web of Science ®Google Scholar
• Moore MR, Link-Gelles R, Schaffner W, Lynfield R, Lexau C, Bennett NM, Petit S, Zansky SM, Harrison LH, Reingold A, et al. Effect of use of 13-valent pneumococcal conjugate vaccine in children on invasive pneumococcal disease in children and adults in the USA: analysis of multisite, population-based surveillance. Lancet Infect Dis 2015;15:301-9; PMID:25656600; http://dx.doi.org/10.1016/S1473-3099(14)71081-3
   PubMed Web of Science ®Google Scholar
• Musher DM, Roig IL, Cazares G, Stager CE, Logan N, Safar H. Can an etiologic agent be identified in adults who are hospitalized for community-acquired pneumonia: results of a one-year study. J Infect 2013;67:11-8; PMID:23523447; http://dx.doi.org/10.1016/j.jinf.2013.03.003
   PubMed Web of Science ®Google Scholar
• Jain S, Self WH, Wunderink RG, Fakhran S, Balk R, Bramley AM, Reed C, Grijalva CG, Anderson EJ, Courtney DM, et al. Community-Acquired Pneumonia Requiring Hospitalization among U.S. Adults. N Engl J Med 2015;373:415-27; PMID:26172429; http://dx.doi.org/10.1056/NEJMoa1500245
   PubMed Web of Science ®Google Scholar
• Jiang Y, Gauthier A, Keeping S, Carroll S. Cost-effectiveness of vaccinating the elderly and at-risk adults with the 23-valent pneumococcal polysaccharide vaccine or 13-valent pneumococcal conjugate vaccine in the UK. Expert Rev Pharmacoecon Outcomes Res 2014;14:913-27; PMID:25189087; http://dx.doi.org/10.1586/14737167.2014.950232
   PubMed Web of Science ®Google Scholar