580
Views
2
CrossRef citations to date
0
Altmetric
Commentaries

Multiantigenic subunitary vaccines against tuberculosis in clinical trials: Where do we stand and where do we need to go?

, &
Pages 1193-1195 | Received 11 Dec 2015, Accepted 22 Dec 2015, Published online: 06 Apr 2016

References

  • van Panhuis WG, Grefenstette J, Jung SY, Chok NS, Cross A, Eng H, Lee BY, Zadorozhny V, Brown S, Cummings D, Burke DS. Contagious diseases in the United States from 1888 to the present. New Engl J Med 2013; 369:2152-8; PMID:24283231; http://dx.doi.org/10.1056/NEJMms1215400
  • Organization WH. Global vaccine action plan 2011-2020. 2013. http://www.who.int/immunization/global_vaccine_action_plan/gvap_secretariat_report_2015.pdf?ua=1
  • De Gregorio E, Rappuoli R. From empiricism to rational design: a personal perspective of the evolution of vaccine development. Nat Rev Immunol 2014; 14:505-14; PMID:24925139; http://dx.doi.org/10.1038/nri3694
  • Pasteur L. De l'attenuation du virus du cholera des poules. C R Acad Sci 1880; 673-80
  • Organization WH. Tuberculosis Factsheet N°104. 2014. http://www.who.int/mediacentre/factsheets/fs104/en
  • Calmette AG, C. Contribution à l'étude de l'immunité antituberculose chez les bovidés. Ann Inst Pasteur 1914; 28:329-37
  • Romanus V, Hallander HO, Wahlen P, Olinder-Nielsen AM, Magnusson PH, Juhlin I. Atypical mycobacteria in extrapulmonary disease among children. Incidence in Sweden from 1969 to 1990, related to changing BCG-vaccination coverage. Tubercle lung Dis: Off J Int Union Against Tuberculosis Lung Dis 1995; 76:300-10; PMID:7579311; http://dx.doi.org/10.1016/S0962-8479(05)80028-0
  • Buddle BM, Parlane NA, Wedlock DN, Heiser A. Overview of vaccination trials for control of tuberculosis in cattle, wildlife and humans. Transbound Emerg Dis 2013; 60 Suppl 1:136-46; PMID:24171859; http://dx.doi.org/10.1111/tbed.12092
  • Moyle PM, Toth I. Modern subunit vaccines: development, components, and research opportunities. ChemMedChem 2013; 8:360-76; PMID:23316023; http://dx.doi.org/10.1002/cmdc.201200487
  • Andersen P. TB vaccines: progress and problems. Trends Immunol 2001; 22:160-8
  • Mbow ML, De Gregorio E, Valiante NM, Rappuoli R. New adjuvants for human vaccines. Curr Opin Immunol 2010; 22:411-6; PMID:11286732; PMID:20466528; http://dx.doi.org/10.1016/j.coi.2010.04.004
  • Belisle JT, Vissa VD, Sievert T, Takayama K, Brennan PJ, Besra GS. Role of the major antigen of Mycobacterium tuberculosis in cell wall biogenesis. Science 1997; 276:1420-2; PMID:9162010; http://dx.doi.org/10.1126/science.276.5317.1420
  • D'Souza S, Rosseels V, Romano M, Tanghe A, Denis O, Jurion F, Castiglione N, Vanonckelen A, Palfliet K, Huygen K. Mapping of murine Th1 helper T-Cell epitopes of mycolyl transferases Ag85A, Ag85B, and Ag85C from Mycobacterium tuberculosis. Infect Immun 2003; 71:483-93; PMID:12496199; http://dx.doi.org/10.1128/IAI.71.1.483-493.2003
  • Junqueira-Kipnis AP, Marques Neto LM, Kipnis A. Role of Fused Mycobacterium tuberculosis Immunogens and Adjuvants in Modern Tuberculosis Vaccines. Front Immunol 2014; 5:188; PMID:AMBIGUOUS; http://dx.doi.org/10.3389/fimmu.2014.00188
  • van Dissel JT, Arend SM, Prins C, Bang P, Tingskov PN, Lingnau K, Nouta J, Klein MR, Rosenkrands I, Ottenhoff TH, et al. Ag85B-ESAT-6 adjuvanted with IC31 promotes strong and long-lived Mycobacterium tuberculosis specific T cell responses in naive human volunteers. Vaccine 2010; 28:3571-81; PMID:20226890; http://dx.doi.org/10.1016/j.vaccine.2010.02.094
  • Geldenhuys H, Mearns H, Miles DJ, Tameris M, Hokey D, Shi Z, Bennett S, Andersen P, Kromann I, Hoff ST, et al. The tuberculosis vaccine H4:IC31 is safe and induces a persistent polyfunctional CD4 T cell response in South African adults: A randomized controlled trial. Vaccine 2015; 33:3592-9; PMID:26048780; http://dx.doi.org/10.1016/j.vaccine.2015.05.036
  • Singh S, Saraav I, Sharma S. Immunogenic potential of latency associated antigens against Mycobacterium tuberculosis. Vaccine 2014; 32:712-6; PMID:24300592; http://dx.doi.org/10.1016/j.vaccine.2013.11.065
  • Luabeya AK, Kagina BM, Tameris MD, Geldenhuys H, Hoff ST, Shi Z, Kromann I, Hatherill M, Mahomed H, Hanekom WA, et al. First-in-human trial of the post-exposure tuberculosis vaccine H56:IC31 in Mycobacterium tuberculosis infected and non-infected healthy adults. Vaccine 2015; 33:4130-40; PMID:26095509; http://dx.doi.org/10.1016/j.vaccine.2015.06.051
  • Von Eschen K, Morrison R, Braun M, Ofori-Anyinam O, De Kock E, Pavithran P, Koutsoukos M, Moris P, Cain D, et al. The candidate tuberculosis vaccine Mtb72F/AS02A: Tolerability and immunogenicity in humans. Hum Vaccin 2009; 5:475-82; PMID:19587528; http://dx.doi.org/10.4161/hv.8570
  • Leroux-Roels I, Leroux-Roels G, Ofori-Anyinam O, Moris P, De Kock E, Clement F, Dubois MC, Koutsoukos M, Demoitie MA, Cohen J, et al. Evaluation of the safety and immunogenicity of two antigen concentrations of the Mtb72F/AS02(A) candidate tuberculosis vaccine in purified protein derivative-negative adults. Clin Vaccine Immunol 2010; 17:1763-71; PMID:20861328; http://dx.doi.org/10.1128/CVI.00133-10
  • Spertini F, Audran R, Lurati F, Ofori-Anyinam O, Zysset F, Vandepapeliere P, Moris P, Demoitie MA, Mettens P, Vinals C, et al. The candidate tuberculosis vaccine Mtb72F/AS02 in PPD positive adults: a randomized controlled phase I/II study. Tuberculosis (Edinb) 2013; 93:179-88; PMID:23219236; http://dx.doi.org/10.1016/j.tube.2012.10.011
  • Leroux-Roels I, Forgus S, De Boever F, Clement F, Demoitie MA, Mettens P, Moris P, Ledent E, Leroux-Roels G, Ofori-Anyinam O. Improved CD4(+) T cell responses to Mycobacterium tuberculosis in PPD-negative adults by M72/AS01 as compared to the M72/AS02 and Mtb72F/AS02 tuberculosis candidate vaccine formulations: a randomized trial. Vaccine 2013; 31:2196-206; PMID:22643213; http://dx.doi.org/10.1016/j.vaccine.2012.05.035
  • Penn-Nicholson A, Geldenhuys H, Burny W, van der Most R, Day CL, Jongert E, Moris P, Hatherill M, Ofori-Anyinam O, Hanekom W, et al. Safety and immunogenicity of candidate vaccine M72/AS01E in adolescents in a TB endemic setting. Vaccine 2015; 33:4025-34; PMID:26072017; http://dx.doi.org/10.1016/j.vaccine.2015.05.088
  • Devasundaram S, Deenadayalan A, Raja A. In silico analysis of potential human T Cell antigens from Mycobacterium tuberculosis for the development of subunit vaccines against tuberculosis. Immunol Invest 2014; 43:137-59; PMID:24467664; http://dx.doi.org/10.3109/08820139.2013.857353

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.