The promise and challenge of epitope-focused vaccines

References

• Plotkin SL, A. PS. A short history of vaccination. In: Plotkin SA, Orenstein W, Offit PA, eds. Vaccines. Philadelphia: Saunders, 2012:1-15.
   Google Scholar
• Lozano R, Naghavi M, Foreman K, Lim S, Shibuya K, Aboyans V, Abraham J, Adair T, Aggarwal R, Ahn SY, et al. Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet 2012; 380:2095-128; PMID:23245604; http://dx.doi.org/10.1016/S0140-6736(12)61728-0
   PubMed Web of Science ®Google Scholar
• Moseman EA, McGavern DB. The great balancing act: regulation and fate of antiviral T-cell interactions. Immunol Rev 2013; 255:110-24; PMID:23947351; http://dx.doi.org/10.1111/imr.12093
   PubMed Web of Science ®Google Scholar
• Fowler VG, Jr., Proctor RA. Where does a Staphylococcus aureus vaccine stand? Clin Microbiol Infect 2014; 20 Suppl 5:66-75; PMID:24476315; http://dx.doi.org/10.1111/1469-0691.12570
   PubMed Web of Science ®Google Scholar
• Ekiert DC, Bhabha G, Elsliger MA, Friesen RH, Jongeneelen M, Throsby M, Goudsmit J, Wilson IA. Antibody Recognition of a Highly Conserved Influenza Virus Epitope. Science 2009; 324(5924):246-51; PMID:19251591.
   PubMed Web of Science ®Google Scholar
• Kwong PD, Wyatt R, Robinson J, Sweet RW, Sodroski J, Hendrickson WA. Structure of an HIV gp120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing human antibody. Nature 1998; 393:648-59; PMID:9641677; http://dx.doi.org/10.1038/31405
   PubMed Web of Science ®Google Scholar
• Oscherwitz J, Gotch FM, Cease KB, Berzofsky JA. New insights and approaches regarding B and T cell epitopes in HIV vaccine design. AIDS 1999; 13:S163-S74; PMID:10885773.
   PubMedGoogle Scholar
• Kim HW, Canchola JG, Brandt CD, Pyles G, Chanock RM, Jensen K, Parrott RH. Respiratory syncytial virus disease in infants despite prior administration of antigenic inactivated vaccine. Am J Epidemiol 1969; 89:422-34; PMID:4305198.
   PubMed Web of Science ®Google Scholar
• Screaton G, Mongkolsapaya J, Yacoub S, Roberts C. New insights into the immunopathology and control of dengue virus infection. Nat Rev Immunol 2015; 15:745-59; PMID:26603900; http://dx.doi.org/10.1038/nri3916
   PubMed Web of Science ®Google Scholar
• Sette A, Rappuoli R. Reverse vaccinology: developing vaccines in the era of genomics. Immunity 2010; 33:530-41; PMID:21029963; http://dx.doi.org/10.1016/j.immuni.2010.09.017
   PubMed Web of Science ®Google Scholar
• Cozzi R, Scarselli M, Ferlenghi I. Structural vaccinology: a three-dimensional view for vaccine development. Curr Top Med Chem 2013; 13:2629-37; PMID:24066888; http://dx.doi.org/10.2174/15680266113136660187
   PubMed Web of Science ®Google Scholar
• Adhikari RP, Karauzum H, Sarwar J, Abaandou L, Mahmoudieh M, Boroun AR, Vu H, Nguyen T, Devi VS, Shulenin S, et al. Novel structurally designed vaccine for S. aureus α-hemolysin: protection against bacteremia and pneumonia. PLoS One 2012; 7:e38567; PMID:22701668; http://dx.doi.org/10.1371/journal.pone.0038567
   PubMed Web of Science ®Google Scholar
• Reason D, Liberato J, Sun J, Keitel W, Zhou J. Frequency and domain specificity of toxin-neutralizing paratopes in the human antibody response to anthrax vaccine adsorbed. Infect Immun 2009; 77:2030-5; PMID:19223482; http://dx.doi.org/10.1128/IAI.01254-08
   PubMed Web of Science ®Google Scholar
• Reason DC, Ullal A, Liberato J, Sun J, Keitel W, Zhou J. Domain specificity of the human antibody response to Bacillus anthracis protective antigen. Vaccine 2008; 26:4041-7; PMID:18565627; http://dx.doi.org/10.1016/j.vaccine.2008.05.023
   PubMed Web of Science ®Google Scholar
• Mohamed N, Li J, Ferreira CS, Little SF, Friedlander AM, Spitalny GL, Casey LS. Enhancement of anthrax lethal toxin cytotoxicity: a subset of monoclonal antibodies against protective antigen increases lethal toxin-mediated killing of murine macrophages. Infect Immun 2004; 72:3276-83; PMID:15155630; http://dx.doi.org/10.1128/IAI.72.6.3276-3283.2004
   PubMed Web of Science ®Google Scholar
• Little SF, Webster WM, Fisher DE. Monoclonal antibodies directed against protective antigen of Bacillus anthracis enhance lethal toxin activity in vivo. FEMS Immunol Med Microbiol 2011; 62:11-22; PMID:21231965; http://dx.doi.org/10.1111/j.1574-695X.2011.00782.x
   PubMedGoogle Scholar
• Kulshreshtha P, Tiwari A, Priyanka, Joon S, Sinha S, Bhatnagar R. Investigation of a panel of monoclonal antibodies and polyclonal sera against anthrax toxins resulted in identification of an anti-lethal factor antibody with disease-enhancing characteristics. Mol Immunol 2015; 68:185-93; PMID:26364143; http://dx.doi.org/10.1016/j.molimm.2015.07.019
   PubMed Web of Science ®Google Scholar
• Huisman W, Martina BE, Rimmelzwaan GF, Gruters RA, Osterhaus AD. Vaccine-induced enhancement of viral infections. Vaccine 2009; 27:505-12; PMID:19022319; http://dx.doi.org/10.1016/j.vaccine.2008.10.087
   PubMed Web of Science ®Google Scholar
• Lin SC, Liu WC, Jan JT, Wu SC. Glycan masking of hemagglutinin for adenovirus vector and recombinant protein immunizations elicits broadly neutralizing antibodies against H5N1 avian influenza viruses. PLoS One 2014; 9:e92822; PMID:24671139; http://dx.doi.org/10.1371/journal.pone.0092822
   PubMed Web of Science ®Google Scholar
• Oscherwitz J, Yu F, Jacobs JL, Cease KB. Recombinant vaccine displaying the loop-neutralizing determinant from protective antigen completely protects rabbits from experimental inhalation anthrax. Clin Vaccine Immunol 2013; 20:341-9; PMID:23283638; http://dx.doi.org/10.1128/CVI.00612-12
   PubMed Web of Science ®Google Scholar
• Oscherwitz J, Cease KB. Identification and validation of a linear protective neutralizing epitope in the β-pore domain of α toxin. PLoS One 2015; 10:e0116882; PMID:25635901; http://dx.doi.org/10.1371/journal.pone.0116882
   PubMedGoogle Scholar
• Oscherwitz J, Yu F, Jacobs JL, Liu TH, Johnson PR, Cease KB. Synthetic peptide vaccine targeting a cryptic neutralizing epitope in domain 2 of Bacillus anthracis protective antigen. Infect Immun 2009; 77:3380-8; PMID:19487468; http://dx.doi.org/10.1128/IAI.00358-09
   PubMed Web of Science ®Google Scholar
• Oscherwitz J, Yu F, Cease KB. A synthetic peptide vaccine directed against the 2β2-2β3 loop of domain 2 of protective antigen protects rabbits from inhalation anthrax. J Immunol 2010; 185:3661-8; PMID:20696862; http://dx.doi.org/10.4049/jimmunol.1001749
   PubMed Web of Science ®Google Scholar
• Oscherwitz J, Quinn CP, Cease KB. Anthrax vaccine recipients lack antibody against the loop neutralizing determinant: A protective neutralizing epitope from Bacillus anthracis protective antigen. Vaccine 2015; 33(20):2342-6.
   PubMed Web of Science ®Google Scholar
• Oscherwitz J, Yu F, Cease KB. A heterologous helper T-cell epitope enhances the immunogenicity of a multiple-antigenic-peptide vaccine targeting the cryptic loop-neutralizing determinant of Bacillus anthracis protective antigen. Infect Immun 2009; 77:5509-18; PMID:19805525; http://dx.doi.org/10.1128/IAI.00899-09
   PubMed Web of Science ®Google Scholar
• Oscherwitz J, Munoz-Planillo R, Yu F, Nunez G, Cease KB. In vivo mapping of a protective linear neutralizing epitope at the N-terminus of α hemolysin from Staphylococcus aureus. Mol Immunol 2014; 60:62-71; PMID:24769493; http://dx.doi.org/10.1016/j.molimm.2014.03.012
   PubMed Web of Science ®Google Scholar
• Calvo-Calle JM, Hammer J, Sinigaglia F, Clavijo P, Moya-Castro ZR, Nardin EH. Binding of malaria T cell epitopes to DR and DQ molecules in vitro correlates with immunogenicity in vivo: identification of a universal T cell epitope in the Plasmodium falciparum circumsporozoite protein. J Immunol 1997; 159:1362-73; PMID:9233633.
   PubMed Web of Science ®Google Scholar
• Panina-Bordignon P, Tan A, Termijtelen A, Demotz S, Corradin G, Lanzavecchia A. Universally immunogenic T cell epitopes: promiscuous binding to human MHC class II and promiscuous recognition by T cells. Eur J Immunol 1989; 19:2237-42; PMID:2481588; http://dx.doi.org/10.1002/eji.1830191209
   PubMed Web of Science ®Google Scholar
• Lockhart S. Conjugate vaccines. Expert Rev Vaccines 2003; 2:633-48; PMID:14711325; http://dx.doi.org/10.1586/14760584.2.5.633
   PubMedGoogle Scholar
• Whitacre DC, Espinosa DA, Peters CJ, Jones JE, Tucker AE, Peterson DL, Zavala FP, Milich DR. P. falciparum and P. vivax Epitope-Focused VLPs Elicit Sterile Immunity to Blood Stage Infections. PLoS One 2015; 10:e0124856; PMID:25933001; http://dx.doi.org/10.1371/journal.pone.0124856
   PubMedGoogle Scholar
• Quinn CP, Sabourin CL, Niemuth NA, Li H, Semenova VA, Rudge TL, Mayfield HJ, Schiffer J, Mittler RS, Ibegbu CC, et al. A three-dose intramuscular injection schedule of anthrax vaccine adsorbed generates sustained humoral and cellular immune responses to protective antigen and provides long-term protection against inhalation anthrax in rhesus macaques. Clin Vaccine Immunol 2012; 19:1730-45; PMID:22933399; http://dx.doi.org/10.1128/CVI.00324-12
   PubMed Web of Science ®Google Scholar
• Oscherwitz J, Feldman D, Yu F, Cease KB. Epitope-focused peptide immunogens in human use adjuvants protect rabbits from experimental inhalation anthrax. Vaccine 2015; 33:430-6; PMID:25454087; http://dx.doi.org/10.1016/j.vaccine.2014.11.042
   PubMed Web of Science ®Google Scholar
• Dormitzer PR, Ulmer JB, Rappuoli R. Structure-based antigen design: a strategy for next generation vaccines. Trends Biotechnol 2008; 26:659-67; PMID:18977045; http://dx.doi.org/10.1016/j.tibtech.2008.08.002
   PubMed Web of Science ®Google Scholar
• Schickli JH, Whitacre DC, Tang RS, Kaur J, Lawlor H, Peters CJ, Jones JE, Peterson DL, McCarthy MP, Van Nest G, et al. Palivizumab epitope-displaying virus-like particles protect rodents from RSV challenge. J Clin Invest 2015; 125:1637-47; PMID:25751145; http://dx.doi.org/10.1172/JCI78450
   PubMed Web of Science ®Google Scholar
• Correia BE, Bates JT, Loomis RJ, Baneyx G, Carrico C, Jardine JG, Rupert P, Correnti C, Kalyuzhniy O, Vittal V, et al. Proof of principle for epitope-focused vaccine design. Nature 2014; 507(7491):201-6.
   PubMed Web of Science ®Google Scholar
• Finn OJ, Beatty PL. Cancer immunoprevention. Curr Opin Immunol 2016; 39:52-8; PMID:26799207; http://dx.doi.org/10.1016/j.coi.2016.01.002
   PubMed Web of Science ®Google Scholar