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Research Papers

Repulsive guidance molecule a blockade exerts the immunoregulatory function in DCs stimulated with ABP and LPS

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Pages 2169-2180 | Received 22 Oct 2015, Accepted 05 Mar 2016, Published online: 12 May 2016

References

  • Koeberle PD, Tura A, Tassew NG, Schlichter LC, Monnier PP. The repulsive guidance molecule, RGMa, promotes retinal ganglion cell survival in vitro and in vivo. Neuroscience 2010; 169:495-504; PMID:20457227; http://dx.doi.org/10.1093/10.1016/j.neuroscience.2010.04.079
  • Severyn CJ, Shinde U, Rotwein P. Molecular biology, genetics and biochemistry of the repulsive guidance molecule family. Biochem J 2009; 422:393-403; PMID:19698085; http://dx.doi.org/10.1042/BJ20090978
  • Matsunaga E, Nakamura H, Chedotal A. Repulsive guidance molecule plays multiple roles in neuronal differentiation and axon guidance. J Neurosci 2006; 26:6082-8; PMID:16738252.
  • Mirakaj V, Brown S, Laucher S, Steinl C, Klein G, Kohler D, Skutella T, Meisel C, Brommer B, Rosenberger P, et al. Repulsive guidance molecule-A (RGM-A) inhibits leukocyte migration and mitigates inflammation. Proc Natl Acad Sci U S A 2011; 108:6555-60;PMID:21467223; http://dx.doi.org/10.1073/pnas.1015605108
  • Muramatsu R, Kubo T, Mori M, Nakamura Y, Fujita Y, Akutsu T, Okuno T, Taniguchi J, Kumanogoh A, Yoshida M, et al. RGMa modulates T cell responses and is involved in autoimmune encephalomyelitis. Nat Med 2011; 17:488-94; PMID:21423182; http://dx.doi.org/10.1038/nm.2321
  • Mohammad MG, Hassanpour M, Tsai VW, Li H, Ruitenberg MJ, Booth DW, Serrats J, Hart PH, Symonds GP, Sawchenko PE, et al. Dendritic cells and multiple sclerosis: disease, tolerance and therapy. Int J Mol Sci 2012; 14:547-62; PMID:23271370; http://dx.doi.org/10.3390/ijms14010547
  • Martin-Fontecha A, Lanzavecchia A, Sallusto F. Dendritic cell migration to peripheral lymph nodes. Handb Exp Pharmacol 2009; 188: 31-49; PMID:19031020.
  • Dudek AM, Martin S, Garg AD, Agostinis P. Immature, semi-mature, and fully mature dendritic cells: Toward a DC-cancer cells interface that augments anticancer immunity. Front Immunol 2013; 4:438; PMID:24376443; http://dx.doi.org/10.3389/fimmu.2013.00438
  • Jalili A. Dendritic cells and their role in cancer immunotherapy. Iran J Immunol 2007; 4:127-44; PMID:17767012.
  • Strioga M, Schijns V, Powell DJ, Jr., Pasukoniene V, Dobrovolskiene N, Michalek J. Dendritic cells and their role in tumor immunosurveillance. Innate Immun 2013; 19:98-111; PMID:22732734; http://dx.doi.org/10.1177/1753425912449549
  • van Duivenvoorde LM, van Mierlo GJ, Boonman ZF, Toes RE. Dendritic cells: vehicles for tolerance induction and prevention of autoimmune diseases. Immunobiology 2006; 211:627-32; PMID:16920501.
  • Kim SJ, Diamond B. Modulation of tolerogenic dendritic cells and autoimmunity. Semin Cell Deve Biol 2015; 41:49-58; PMID:24747368.
  • Hayashi T, Yao S, Crain B, Promessi VJ, Shyu L, Sheng C, Kang M, Cottam HB, Carson DA, Corr M. Induction of tolerogenic dendritic cells by a PEGylated TLR7 ligand for treatment of type 1 diabetes. PloS one 2015; 10:e0129867; PMID:26076454.
  • Zhu M, Xu W, Su H, Huang Q, Wang B. Addition of CpG ODN and Poly (I:C) to a standard maturation cocktail generates monocyte-derived dendritic cells and induces a potent Th1 polarization with migratory capacity. Hum Vaccin Immunotherapeut 2015; 11:1596-605.
  • Chen Y, Meng Y, Cao Y, Wen H, Luo H, Gao X, Shan F. Novel analysis of maturation of murine bone-marrow-derived dendritic cells induced by Ginkgo Seed Polysaccharides. Hum Vaccin Immunother 2015; 11:1387-93; PMID:25806792; http://dx.doi.org/10.80/21645515.2015.1023971
  • Zou Y, Meng J, Chen W, Liu J, Li X, Li W, Lu C, Shan F. Modulation of phenotypic and functional maturation of murine dendritic cells (DCs) by purified Achyranthes bidentata polysaccharide (ABP). Int Immunopharmacol 2011; 11:1103-8; PMID:21439398; http://dx.doi.org/10.1016/j.intimp.2011.03.006
  • Kong Y, Rogers MR, Qin X. Effective neuroprotection by ischemic postconditioning is associated with a decreased expression of RGMa and inflammation mediators in ischemic rats. Neurochem Res 2013; 38:815-25; PMID:23389659; http://dx.doi.org/10.1007/s11064-013-0984-5
  • Kitayama M, Ueno M, Itakura T, Yamashita T. Activated microglia inhibit axonal growth through RGMa. PloS one 2011; 6:e25234; PMID:21957482.
  • Nohra R, Beyeen AD, Guo JP, Khademi M, Sundqvist E, Hedreul MT, Sellebjerg F, Smestad C, Oturai AB, Harbo HF, et al. RGMA and IL21R show association with experimental inflammation and multiple sclerosis. Gen Immun 2010; 11:279-93; PMID:20072140
  • Tanabe S, Yamashita T. Repulsive guidance molecule-a is involved in Th17-cell-induced neurodegeneration in autoimmune encephalomyelitis. Cell Rep 2014; 9:1459-70; PMID:25456136; http://dx.doi.org/10.1016/j.celrep.2014.10.038
  • Marsland BJ, Battig P, Bauer M, Ruedl C, Lassing U, Beerli RR, Dietmeier K, Ivanova L, Pfister T, Vogt L, et al. CCL19 and CCL21 induce a potent proinflammatory differentiation program in licensed dendritic cells. Immunity 2005; 22:493-505; PMID:15845453.
  • Frick JS, Grunebach F, Autenrieth IB. Immunomodulation by semi-mature dendritic cells: a novel role of Toll-like receptors and interleukin-6. Int J Med Microbiol 2010; 300:19-24; PMID:19781988; http://dx.doi.org/10.1016/j.ijmm.2009.08.010
  • Chorny A, Gonzalez-Rey E, Fernandez-Martin A, Pozo D, Ganea D, Delgado M. Vasoactive intestinal peptide induces regulatory dendritic cells with therapeutic effects on autoimmune disorders. Proc Natl Acad Sci U S A 2005; 102:13562-7.
  • Wakkach A, Fournier N, Brun V, Breittmayer JP, Cottrez F, Groux H. Characterization of dendritic cells that induce tolerance and T regulatory 1 cell differentiation in vivo. Immunity 2003; 18:605-17; PMID:12753738.
  • Fu H, Song S, Liu F, Ni Z, Tang Y, Shen X, Xiao L, Ding G, Wang Q. Dendritic cells transduced with SOCS1 gene exhibit regulatory DC properties and prolong allograft survival. Cell Mol Immunol 2009; 6:87-95; PMID:19403057; http://dx.doi.org/10.1038/cmi.2009.12
  • Narayanan KB, Park HH. Toll/interleukin-1 receptor (TIR) domain-mediated cellular signaling pathways. Apoptosis 2015; 20:196-209; PMID:25563856; http://dx.doi.org/10.1007/s10495-014-1073-1
  • Pasterkamp G, Van Keulen JK, De Kleijn DP. Role of Toll-like receptor 4 in the initiation and progression of atherosclerotic disease. Eur J Clin Invest 2004; 34:328-34; PMID:15147329.
  • O'Neill LA, Dinarello CA. The IL-1 receptor/toll-like receptor superfamily: crucial receptors for inflammation and host defense. Immunol Today 2000; 21:206-9; PMID:10782049.
  • Liaunardy-Jopeace A, Gay NJ. Molecular and cellular regulation of toll-like receptor-4 activity induced by lipopolysaccharide ligands. Front Immunol 2014; 5:473; PMID:25339952; http://dx.doi.org/10.3389/fimmu.2014.00473
  • Buchanan MM, Hutchinson M, Watkins LR, Yin H. Toll-like receptor 4 in CNS pathologies. J Neurochem 2010; 114:13-27; PMID:20402965; http://dx.doi.org/10.1111/j.1471-4159.2010.06736.x
  • Palsson-McDermott EM, O'Neill LA. Signal transduction by the lipopolysaccharide receptor, Toll-like receptor-4. Immunol 2004; 113:153-62; PMID:15379975.
  • Kubo T, Hata K, Yamaguchi A, Yamashita T. Rho-ROCK inhibitors as emerging strategies to promote nerve regeneration. Curr Pharmaceut Des 2007; 13:2493-9; PMID:17692017.
  • Yamashita T, Fujitani M, Yamagishi S, Hata K, Mimura F. Multiple signals regulate axon regeneration through the Nogo receptor complex. Mol Neurobiol 2005; 32:105-11; PMID:16215275.
  • Mueller BK, Mack H, Teusch N. Rho kinase, a promising drug target for neurological disorders. Nat Rev Drug Dis 2005; 4:387-98; PMID:15864268.
  • Wang T, Wu X, Yin C, Klebe D, Zhang JH, Qin X. CRMP-2 is involved in axon growth inhibition induced by RGMa in vitro and in vivo. Mol Neurobiol 2013; 47:903-13; PMID:23275173; http://dx.doi.org/10.1007/s12035-012-8385-3
  • Kubo T, Endo M, Hata K, Taniguchi J, Kitajo K, Tomura S, Yamaguchi A, Mueller BK, Yamashita T. Myosin IIA is required for neurite outgrowth inhibition produced by repulsive guidance molecule. J Neurochem 2008; 105:113-26; PMID:18005226.
  • Xia Y, Yu PB, Sidis Y, Beppu H, Bloch KD, Schneyer AL, Lin HY. Repulsive guidance molecule RGMa alters utilization of bone morphogenetic protein (BMP) type II receptors by BMP2 and BMP4. J Biol Chem 2007; 282:18129-40; PMID:17472960.
  • Babitt JL, Zhang Y, Samad TA, Xia Y, Tang J, Campagna JA, Schneyer AL, Woolf CJ, Lin HY. Repulsive guidance molecule (RGMa), a DRAGON homologue, is a bone morphogenetic protein co-receptor. J Biol Chem 2005; 280:29820-7; PMID:15975920.
  • Inaba K, Swiggard WJ, Steinman RM, Romani N, Schuler G, Brinster C. Isolation of dendritic cells. Current protocols in immunology / edited by John E Coligan [et al] 2009; Chapter 3:Unit 3.7-Unit 3.7; PMID:19653207; http://dx.doi.org/10.1002/0471142735.im0307s86

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