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Review

Effect of antipyretic analgesics on immune responses to vaccination

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Pages 2391-2402 | Received 18 Feb 2016, Accepted 22 Apr 2016, Published online: 19 Jul 2016

References

  • Taddio A, Manley J, Potash L, Ipp M, Sgro M, Shah V. Routine immunization practices: use of topical anesthetics and oral analgesics. Pediatrics 2007; 120:e637-43; PMID:17766503; http://dx.doi.org/10.1542/peds.2006-3351
  • Manley J, Taddio A. Acetaminophen and ibuprofen for prevention of adverse reactions associated with childhood immunization. Ann Pharmacother 2007; 41:1227-32; PMID:17519301; http://dx.doi.org/10.1345/aph.1H647
  • Ipp MM, Gold R, Greenberg S, Goldbach M, Kupfert BB, Lloyd DD, Maresky DC, Saunders N, Wise SA. Acetaminophen prophylaxis of adverse reactions following vaccination of infants with diphtheria-pertussis-tetanus toxoids-polio vaccine. Pediatr Infect Dis J 1987; 6:721-5; PMID:3313232; http://dx.doi.org/10.1097/00006454-198708000-00005
  • Lewis K, Cherry JD, Sachs MH, Woo DB, Hamilton RC, Tarle JM, Overturf GD. The effect of prophylactic acetaminophen administration on reactions to DTP vaccination. Am J Dis Child 1988; 142:62-5; PMID:3277388
  • Aoki FY, Yassi A, Cheang M, Murdzak C, Hammond GW, Sekla LH, Wright B. Effects of acetaminophen on adverse effects of influenza vaccination in health care workers. CMAJ 1993; 149:1425-30; PMID:8221426
  • Uhari M, Hietala J, Viljanen MK. Effect of prophylactic acetaminophen administration on reaction to DTP vaccination. Acta Paediatr Scand 1988; 77:747-51; PMID:3059756; http://dx.doi.org/10.1111/j.1651-2227.1988.tb10741.x
  • Long SS, Deforest A, Smith DG, Lazaro C, Wassilak GF. Longitudinal study of adverse reactions following diphtheria-tetanus-pertussis vaccine in infancy. Pediatrics 1990; 85:294-302; PMID:2304782
  • Andrews NJ, Walker WT, Finn A, Heath PT, Collinson AC, Pollard AJ, Snape MD, Faust SN, Waight PA, Hoschler K, et al. Predictors of immune response and reactogenicity to AS03B-adjuvanted split virion and non-adjuvanted whole virion H1N1 (2009) pandemic influenza vaccines. Vaccine 2011; 29:7913-9; PMID:21875635; http://dx.doi.org/10.1016/j.vaccine.2011.08.076
  • Prymula R, Siegrist CA, Chlibek R, Zemlickova H, Vackova M, Smetana J, Lommel P, Kaliskova E, Borys D, Schuerman L. Effect of prophylactic paracetamol administration at time of vaccination on febrile reactions and antibody responses in children: two open-label, randomised controlled trials. Lancet 2009; 374:1339-50; PMID:19837254; http://dx.doi.org/10.1016/S0140-6736(09)61208-3
  • Jackson LA, Peterson D, Dunn J, Hambidge SJ, Dunstan M, Starkovich P, Yu O, Benoit J, Dominguez-Islas CP, Carste B, et al. A randomized placebo-controlled trial of acetaminophen for prevention of post-vaccination fever in infants. PLoS One 2011; 6:e20102; PMID:21698100; http://dx.doi.org/10.1371/journal.pone.0020102
  • Homme JH, Fischer PR. Prophylactic paracetamol at the time of infant vaccination reduces the risk of fever but also reduces antibody response. Evidence-Based Medicine 2010; 15:50-1; PMID:20436123; http://dx.doi.org/10.1136/ebm1049
  • CDC. Vaccine Information Safety, DTap 05/17/2007 http://www.cdc.gov/vaccines/hcp/vis/vis-statements/dtap.html. Accessed online 04/06/2016
  • Brady MT, Swanson JT. More study needed on antipyretics' effect on vaccine responses. AAP News 2010; 31-1
  • WHO Weekly Epidemiological Record 25 September 2015; 90(39): 505-510
  • Das RR, Panigrahi I, Naik SS. The effect of prophylactic antipyretic administration on post-vaccination adverse reactions and antibody response in children: a systematic review. PLoS One 2014; 9:e106629; PMID:25180516; http://dx.doi.org/10.1371/journal.pone.0106629
  • Swift HF. The action of sodium salicylate upon the formation of immune bodies. J Exp Med 1922; 36:735-60; PMID:19868706; http://dx.doi.org/10.1084/jem.36.6.735
  • Phipps RP, Stein SH, Roper RL. A new view of prostaglandin E regulation of the immune response. Immunol Today 1991; 12:349-52; PMID:1958288; http://dx.doi.org/10.1016/0167-5699(91)90064-Z
  • Goodwin JS, Ceuppens J. Regulation of the immune response by prostaglandins. J Clin Immunol 1983; 3:295-315; PMID:6140268; http://dx.doi.org/10.1007/BF00915791
  • Schleimer RP, Benjamini E. Effects of Prostaglandin Synthesis Inhibition on the Immune Response. Immunopharmacol 1981; 3:205-19
  • Simkin NJ, Jelinek DF, Lipsky PE. Inhibition of human B cell responsiveness by prostaglandin E2. J Immuno 1987; 138(4):1074-1081
  • Ishizuka M, Takeuchi T, Umezawa H. Promotion of antibody formation by prostaglandin. Experientia 1974 Oct; 30:1207-8; PMID:4611783; http://dx.doi.org/10.1007/BF01923694
  • Jelinek DF, Thompson PA, Lipsky PE. Regulation of human B cell activation by prostaglandin E2. Suppression of the generation of immunoglobulin-secreting cells. J Clin Invest 1985; 75:1339-49; PMID:3872889; http://dx.doi.org/10.1172/JCI111835
  • Ambrose CT. Inhibition of the secondary antibody response in vitro by salicylate and gentisate. J Exp Med 1966; 124:461-82; PMID:5922744; http://dx.doi.org/10.1084/jem.124.3.461
  • Alm GV, Pachman LM. The effects of sodium salicylate on the anamnestic immune response in vitro. Experientia 1971; 27:924-5; PMID:4947882; http://dx.doi.org/10.1007/BF02135747
  • Panush RS, Ossakow SJ. Effects of acetaminophen on normal human peripheral blood lymphocytes: enhancement of mitogen- and antigen-stimulated incorporation of tritiated thymidine. Clin Exp Immunol 1979; 38:539-48; PMID:535186
  • Goodwin JS, Selinger DS, Messner RP, Reed WP. Effect of indomethacin in vivo on humoral and cellular immunity in humans. Infect Immun 1978; 19:430-3; PMID:631882
  • Song JY, Cheong HJ, Seo YB, Kim IS, Noh JY, Heo JY, Choi WS, Lee J, Kim WJ. Comparison of the long-term immunogenicity of two pandemic influenza A/H1N1 2009 Vaccines, the MF59-adjuvanted and unadjuvanted vaccines, in Adults. Clin Vaccine Immunol 2012; 19:638-41; PMID:22379067; http://dx.doi.org/10.1128/CVI.00026-12
  • Miller MS, Gardner TJ, Krammer F, Aguado LC, Tortorella D, Basler CF, Palese P. Neutralizing antibodies against previously encountered influenza virus strains increase over time: a longitudinal analysis. Sci Transl Med 2013; 5:198ra07; http://dx.doi.org/10.1126/scitranslmed.3006637
  • Andrews SF, Kaur K, Pauli NT, Huang M, Huang Y, Wilson PC. High preexisting serological antibody levels correlate with diversification of the influenza vaccine response. J Virol 2015; 89:3308-17; PMID:25589639; http://dx.doi.org/10.1128/JVI.02871-14
  • Chernesky M, O'Neill D, Pickard L, Castriciano S, Kraftcheck D, Sellors J, McLean D, Flett N, Mahony J. Immunogenicity and adverse reactions of influenza vaccination in elderly patients given acetaminophen or placebo. Clin Diagn Virol 1993; 1:129-36; PMID:15566726; http://dx.doi.org/10.1016/0928-0197(93)90021-V
  • Gross PA, Levandowski RA, Russo C, Weksler M, Bonelli J, Dran S, Munk G, Deichmiller S, Hilsen R, Panush RF. Vaccine immune response and side effects with the use of acetaminophen with influenza vaccine. Clin Diagn Lab Immunol 1994; 1:134-8; PMID:7496933
  • Lafferty WP, Selinger DS, Schiffman G, Goodwin JS. Response to pneumococcal vaccine in the elderly: no enhancement by indomethacin. J Immunopharmacol 1981; 3:241-50; PMID:7338631; http://dx.doi.org/10.3109/08923978109026429
  • Ceuppens JL, Desmyter J. Effect of prostaglandin synthesis inhibition in vivo on the immune response following hepatitis B vaccination in normal subjects. Int J Immunopharmacol 1987; 9:803-10; PMID:2962954; http://dx.doi.org/10.1016/0192-0561(87)90076-2
  • Hsia J, Tang T, Parrott M, Rogalla K. Augmentation of the immune response to influenza vaccine by acetylsalicylic acid: a clinical trial in a geriatric population. Methods Find Exp Clin Pharmacol 1994; 16:677-83; PMID:7746030
  • Prymula R, Habib A, Francois N, Borys D, Schuerman L. Immunological memory and nasopharyngeal carriage in 4-year-old children previously primed and boosted with 10-valent pneumococcal non-typeable Haemophilus influenzae protein D conjugate vaccine (PHiD-CV) with or without concomitant prophylactic paracetamol. Vaccine 2013; 31:2080-8; PMID:23391599; http://dx.doi.org/10.1016/j.vaccine.2013.01.044
  • Prymula R, Esposito S, Zuccotti GV, Xie F, Toneatto D, Kohl I, Dull PM. A phase 2 randomized controlled trial of a multicomponent meningococcal serogroup B vaccine (I). Hum Vaccin Immunother 2014; 10:1993-2004; PMID:25424809; http://dx.doi.org/10.4161/hv.28666
  • David Salisbury MR, Karen N, editors. Immunisation against infectious disease [Internet]. Public Health England, Department of Health. 2013, updated edition. [Updated 2015 Sep 22; cited 2016 April 9]. Available from: https://www.gov.uk/government/uploads/system/uloads/attachment.data/file/462629/2904512 Green Book Chapter 22 v6 0W.PDF
  • Doedee AM, Boland GJ, Pennings JL, De Klerk A, Berbers GA, Van Der Klis FR, de Melker HE, van Loveren H, Janssen R. Effects of prophylactic and therapeutic paracetamol treatment during vaccination on hepatitis B antibody levels in adults: Two open-label, randomized controlled trials. PLoS One 2014; 9:e98175; PMID:24897504; http://dx.doi.org/10.1371/journal.pone.0098175
  • Wysocki J, Center KJ, Brzostek J, Majda-Stanislawska E, Giardina P, Sundaraiyer V, Patterson S, Gruber WC, Scott D, Gurtman A. Does Use of Prophylactic Antipyretics (PAP) Affect Immune Response To Vaccination In Infants? Pneumonia 2014; 3:197
  • Duke University, Centers for Disease Control and Prevention. The Effect of Prophylactic Antipyretics on Immune Responses and Fever After 2014–2015 and 2015–2016 Inactivated Influenza Vaccine. In: ClinicalTrials.gov [Internet]. Besthesda, MD: National Library of Medicine (US). 2014 [Cited 2016 March 26]. Available from https://clinicaltrials.gov/ct2/show/NCT02212990 NLM Identifier: NCT02212990
  • Walter EB HC, Harrington L, McGee CE, Grohskopf L, Museru O, Broder K. Pilot Study to Assess the Effect of Prophylactic Antipyretics on Immune Responses and Fever after Inactivated Influenza Vaccine (IIV) in Young Children [Abstract]. In: Proceedings of the 18th Annual Conference on Vacccine Research, National Foundation for Infectious Diseases, April 13–15, 2015; Bethesda, MD. Abstract number S32
  • Auerbach BS, Wilson ME, Lake AM, Deforest A, Steinhoff M, Halsey NA. Dose-response to acellular pertussis vaccine and comparison with whole cell pertussis vaccine at 15–24 months and 4–6 years of age. Acellular Pertussis Vaccine Study Team. Vaccine 1992; 10:14-20; PMID:1539456; http://dx.doi.org/10.1016/0264-410X(92)90413-E
  • Marcinak JF, Ward M, Frank AL, Boyer KM, Froeschle JE, Hosbach PH, 4th. Comparison of the safety and immunogenicity of acellular (BIKEN) and whole-cell pertussis vaccines in 15- to 20-month-old children. Am J Dis Child 1993; 147:290-4; PMID:8438810
  • Mills E, Gold R, Thipphawong J, Barreto L, Guasparini R, Meekison W, Cunning L, Russell M, Harrison D, Boyd M, et al. Safety and immunogenicity of a combined five-component pertussis-diphtheria-tetanus-inactivated poliomyelitis-Haemophilus B conjugate vaccine administered to infants at two, four and six months of age. Vaccine 1998; 16:576-85; PMID:9569468; http://dx.doi.org/10.1016/S0264-410X(97)00241-7
  • Jackson ML, Bellamy A, Wolff M, Hill H, Jackson LA. Low-dose aspirin use does not diminish the immune response to monovalent H1N1 influenza vaccine in older adults. Epidemiol Infect 2016; 144:768-71; PMID:26330204; http://dx.doi.org/10.1017/S0950268815002058
  • Staite ND, Panayi GS. Regulation of human immunoglobulin production in vitro by prostaglandin E2. Clin Exp Immunol 1982; 49:115-22; PMID:6957277
  • Martinez F, Coleman JW. The effects of selected drugs, including chlorpromazine and non-steroidal anti-inflammatory agents, on polyclonal IgG synthesis and interleukin 1 production by human peripheral blood mononuclear cells in vitro. Clin Exp Immunol 1989; 76:252-7; PMID:2788047
  • Ceuppens JL, Goodwin JS. Endogenous prostaglandin E2 enhances polyclonal immunoglobulin production by tonically inhibiting T suppressor cell activity. Cell Immunol 1982; 70:41-54; PMID:6214316; http://dx.doi.org/10.1016/0008-8749(82)90131-9
  • Bancos S, Bernard MP, Topham DJ, Phipps RP. Ibuprofen and other widely used non-steroidal anti-inflammatory drugs inhibit antibody production in human cells. Cell Immunol 2009; 258:18-28; PMID:19345936; http://dx.doi.org/10.1016/j.cellimm.2009.03.007
  • Phillips C. Prostaglandin E2 production is enhanced in mice genetically selected to produce high affinity antibody responses. Cell Immunol 1989; 119:382-92; PMID:2522824; http://dx.doi.org/10.1016/0008-8749(89)90252-9
  • Taddio A, Ipp M, Thivakaran S, Jamal A, Parikh C, Smart S, Sovran J, Stephens D, Katz J. Survey of the prevalence of immunization non-compliance due to needle fears in children and adults. Vaccine 2012; 30:4807-12; PMID:22617633; http://dx.doi.org/10.1016/j.vaccine.2012.05.011
  • Whaley K, Sloane DJ. Studies of the action of some anti-inflammatory drugs on complement mediated immune haemolysis. Br J Clin Pharmacol 1975; 2(2):123-129; PMID:1234496; http://dx.doi.org/10.1111/j.1365-2125.1975.tb01567.x
  • Hofbauer R, Speiser W, Kapiotis S. Ibuprofen inhibits leukocyte migration through endothelial cell monolayers. Life Sci 1998; 62:1775-81; PMID:9585108; http://dx.doi.org/10.1016/S0024-3205(98)00139-8
  • Kapiotis S, Sengoelge G, Sperr WR, Baghestanian M, Quehenberger P, Bevec D, Li SR, Menzel EJ, Mühl A, Zapolska D, et al. Ibuprofen Inhibits Pyrogen-dependent Expression of VCAM-1 and ICAM-1 on human endothelial cells. Life Sci 1996; 58(23):2167-81; PMID:8649201; http://dx.doi.org/10.1016/0024-3205(96)00210-X
  • Pierce JW, Read MA, Ding H, Luscinskas FW, Collins T. Salicylates inhibit I kappa B-α phosphorylation, endothelial-leukocyte adhesion molecule expression, and neutrophil transmigration. J Immunol 1996; 156:3961-9; PMID:8621937
  • Kim HJ, Lee YH, Im SA, Kim K, Lee CK. Cyclooxygenase Inhibitors, Aspirin and Ibuprofen, Inhibit MHC-restricted Antigen Presentation in Dendritic Cells. Immune Netw 2010; 10:92-8; PMID:20631879; http://dx.doi.org/10.4110/in.2010.10.3.92
  • Graham GG, Scott KF. Mechanism of action of paracetamol. Am J Ther 2005; 12:46-55; PMID:15662292; http://dx.doi.org/10.1097/00045391-200501000-00008
  • Hinz B, Cheremina O, Brune K. Acetaminophen (paracetamol) is a selective cyclooxygenase-2 inhibitor in man. FASEB J 2008; 22:383-90; PMID:17884974; http://dx.doi.org/10.1096/fj.07-8506com
  • Vane JR. Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. Nat New Biol 1971; 231:232-5; PMID:5284360; http://dx.doi.org/10.1038/newbio231232a0
  • Bernard MP, Bancos S, Chapman TJ, Ryan EP, Treanor JJ, Rose RC, Topham DJ, Phipps RP. Chronic inhibition of cyclooxygenase-2 attenuates antibody responses against vaccinia infection. Vaccine 2010; 28:1363-72; PMID:19941994; http://dx.doi.org/10.1016/j.vaccine.2009.11.005
  • Ryan EP, Pollock SJ, Murant TI, Bernstein SH, Felgar RE, Phipps RP. Activated Human B Lymphocytes Express Cyclooxygenase-2 and Cyclooxygenase Inhibitors Attenuate Antibody Production. J Immunol 2005; 174:2619-26; PMID:15728468; http://dx.doi.org/10.4049/jimmunol.174.5.2619
  • Chang CL, Ma B, Pang X, Wu TC, Hung CF. Treatment with cyclooxygenase-2 inhibitors enables repeated administration of vaccinia virus for control of ovarian cancer. Mol Ther 2009; 17:1365-72; PMID:19471247; http://dx.doi.org/10.1038/mt.2009.118
  • Ryan EP, Malboeuf CM, Bernard M, Rose RC, Phipps RP. Cyclooxygenase-2 Inhibition Attenuates Antibody Responses against Human Papillomavirus-Like Particles. J Immunol 2006; 177:7811-9; PMID:17114452; http://dx.doi.org/10.4049/jimmunol.177.11.7811
  • Purssell E. Cyclooxygenase inhibitors inhibit antibody response through interference with MAPK/ERK pathways and BLIMP-1 inhibition. Med Hypotheses 2014; 83:372-7; PMID:25012778; http://dx.doi.org/10.1016/j.mehy.2014.06.015
  • Yin MJ, Yamamoto Y, Gaynor RB. The anti-inflammatory agents aspirin and salicylate inhibit the activity of I(kappa)B kinase-β. Nature 1998; 396:77-80; PMID:9817203; http://dx.doi.org/10.1038/23948
  • Stuhlmeier KM, Li H, Kao JJ. Ibuprofen: New Explanation for an Old Phenomenon. Biochem Pharmacol 1999; 57:313-20; PMID:9890559; http://dx.doi.org/10.1016/S0006-2952(98)00301-3
  • Paccani SR, Patrussi L, Ulivieri C, Masferrer JL, D'Elios MM, Baldari CT. Nonsteroidal anti-inflammatory drugs inhibit a Fyn-dependent pathway coupled to Rac and stress kinase activation in TCR signaling. Blood 2005; 105:2042-8; PMID:15514010; http://dx.doi.org/10.1182/blood-2004-04-1299
  • Rossi A, Kapahi P, Natoli G, Takahashi T, Chen Y, Karin M, Santoro MG. Anti-inflammatory cyclopentenone prostaglandins are direct inhibitors of IkappaB kinase. Nature 2000; 403:103-8; PMID:10638762; http://dx.doi.org/10.1038/47520
  • Paccani SR, Boncristiano M, Ulivieri C, D'Elios MM, Del Prete G, Baldari CT. Nonsteroidal anti-inflammatory drugs suppress T-cell activation by inhibiting p38 MAPK induction. J Biol Chem 2002; 277:1509-13; PMID:11700329; http://dx.doi.org/10.1074/jbc.M110676200
  • Bernard MP, Phipps RP. Inhibition of cyclooxygenase-2 impairs the expression of essential plasma cell transcription factors and human B-lymphocyte differentiation. Immunology 2010; 129:87-96; PMID:20050331; http://dx.doi.org/10.1111/j.1365-2567.2009.03152.x
  • De Silva NS, Klein U. Dynamics of B cells in germinal centres. Nat Rev Immunol 2015; 15:137-48; PMID:25656706; http://dx.doi.org/10.1038/nri3804
  • Fukuda T, Yoshida T, Okada S, Hatano M, Miki T, Ishibashi K, Okabe S, Koseki H, Hirosawa S, Taniguchi M, et al. Disruption of the Bcl6 gene results in an impaired germinal center formation. J Exp Med 1997; 186:439-48; PMID:9236196; http://dx.doi.org/10.1084/jem.186.3.439
  • Willis SN, Good-Jacobson KL, Curtis J, Light A, Tellier J, Shi W, Smyth GK, Tarlinton DM, Belz GT, Corcoran LM, et al. Transcription factor IRF4 regulates germinal center cell formation through a B cell-intrinsic mechanism. J Immunol 2014; 192:3200-6; PMID:24591370; http://dx.doi.org/10.4049/jimmunol.1303216
  • Wilker PR, Kohyama M, Sandau MM, Albring JC, Nakagawa O, Schwarz JJ, Murphy KM. Transcription factor Mef2c is required for B cell proliferation and survival after antigen receptor stimulation. Nat Immunol 2008; 9:603-12; PMID:18438409; http://dx.doi.org/10.1038/ni.1609
  • Hess J, Nielsen PJ, Fischer KD, Bujard H, Wirth T. The B lymphocyte-specific coactivator BOB.1/OBF.1 is required at multiple stages of B-cell development. Mol Cell Biol 2001; 21:1531-9; PMID:11238890; http://dx.doi.org/10.1128/MCB.21.5.1531-1539.2001
  • Calado DP, Sasaki Y, Godinho SA, Pellerin A, Kochert K, Sleckman BP, de Alborán IM, Janz M, Rodig S, Rajewsky K. The cell-cycle regulator c-Myc is essential for the formation and maintenance of germinal centers. Nat Immunol 2012; 13:1092-100; PMID:23001146; http://dx.doi.org/10.1038/ni.2418
  • Reed SG, Orr MT, Fox CB. Key roles of adjuvants in modern vaccines. Nat Med 2013; 19(12):1597-608; PMID:24309663; http://dx.doi.org/10.1038/nm.3409
  • Evans SS, Repasky EA, Fisher DT. Fever and the thermal regulation of immunity: the immune system feels the heat. Nat Rev Immunol 2015; 15:335-49; PMID:25976513; http://dx.doi.org/10.1038/nri3843

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