Cimetidine down-regulates stability of Foxp3 protein via Stub1 in Treg cells

References

• Xie X, Geng S, Liu H, Li C, Yang Y, Wang B. Cimetidine synergizes with Praziquantel to enhance the immune response of HBV DNA vaccine via activating cytotoxic CD8(+) T cell. Hum Vaccin Immunother 2014; 10:1688-99; PMID:24643207; http://dx.doi.org/10.4161/hv.28517
   PubMed Web of Science ®Google Scholar
• Elder JB, Ganguli PC, Gillespie IE. Gastric cancer in patients who have taken cimetidine. Lancet 1979; 2:245; PMID:89345; http://dx.doi.org/10.1016/S0140-6736(79)90251-4
   PubMed Web of Science ®Google Scholar
• Kapinska-Mrowiecka M, Turowski G. [Efficacy of cimetidine in treatment of Herpes zoster in the first 5 days from the moment of disease manifestation]. Polski Tygodnik Lekarski 1996; 51:338-9; PMID:9273526
   PubMedGoogle Scholar
• Yoshioka T, Monafo WW, Ayvazian VH, Deitz F, Flynn D. Cimetidine inhibits burn edema formation. Am J Surg 1978; 136:681-5; PMID:717647; http://dx.doi.org/10.1016/0002-9610(78)90335-5
   PubMed Web of Science ®Google Scholar
• Flodgren P. Influence of human leukocyte interferon (HuIFN-alpha/Le/) and cimetidine on the proliferation of cultured melanoma cells in vitro. Anticancer Res 1985; 5:527-31; PMID:4062254
   PubMed Web of Science ®Google Scholar
• Tomita K, Izumi K, Okabe S. Roxatidine- and cimetidine-induced angiogenesis inhibition suppresses growth of colon cancer implants in syngeneic mice. J Pharmacol Sci 2003; 93:321-30; PMID:14646250; http://dx.doi.org/10.1254/jphs.93.321
   PubMed Web of Science ®Google Scholar
• Kumar A, Cleveland RP. “Immunoregulatory effects of cimetidine: inhibition of suppressor cell effector function in vivo”. Immunopharmacology and immunotoxicology 1988; 10:327-32; PMID:2974050; http://dx.doi.org/10.3109/08923978809041424
   PubMed Web of Science ®Google Scholar
• Griswold DE, Alessi S, Badger AM, Poste G, Hanna N. Inhibition of T suppressor cell expression by histamine type 2 (H2) receptor antagonists. J Immunol 1984; 132:3054-7; PMID:6202771
   PubMed Web of Science ®Google Scholar
• Siegel JN, Schwartz A, Askenase PW, Gershon RK. T-cell suppression and contrasuppression induced by histamine H2 and H1 receptor agonists, respectively. Proc Natl Acad Sci U S A 1982; 79:5052-6
   PubMed Web of Science ®Google Scholar
• Babayan RK, Osband ME, Carpinito GA, Ho ZS, Cohen EB, Krane RJ. The relationship of histamine H2 receptor-bearing suppressor cells with the growth and metastasis of FANFT-induced bladder cancer. J Surg Oncol 1983; 24:53-8; PMID:6224980; http://dx.doi.org/10.1002/jso.2930240113
   PubMed Web of Science ®Google Scholar
• Kumar A. Cimetidine: an immunomodulator. DICP 1990; 24:289-95; PMID:2138376
   PubMedGoogle Scholar
• Hahm KB, Kim WH, Lee SI, Kang JK, Park IS. Comparison of immunomodulative effects of the histamine-2 receptor antagonists cimetidine, ranitidine, and famotidine on peripheral blood mononuclear cells in gastric cancer patients. Scandinavian J Gastroenterol 1995; 30:265-71; http://dx.doi.org/10.3109/00365529509093275
   PubMed Web of Science ®Google Scholar
• Adams WJ, Morris DL, Ross WB, Lubowski DZ, King DW, Peters L. Cimetidine preserves non-specific immune function after colonic resection for cancer. Aust N Z J Surg 1994; 64:847-52; PMID:7980260; http://dx.doi.org/10.1111/j.1445-2197.1994.tb04562.x
   PubMedGoogle Scholar
• Wang J, Su B, Ding Z, Du X, Wang B. Cimetidine enhances immune response of HBV DNA vaccination via impairment of the regulatory function of regulatory T cells. Biochem Biophy Res Commun 2008; 372:491-6; http://dx.doi.org/10.1016/j.bbrc.2008.04.191
   PubMed Web of Science ®Google Scholar
• Chen XZ, Yang XD, Yang W, Chen Y, Liu LL, Shen JL, Sun X. [Study on immune response in BALB/c mice induced by ROP2 protein of Toxoplasma gondii with cimetidine]. Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi=Chinese journal of parasitology & parasitic diseases 2013; 31:99-103; PMID:24809187
   PubMedGoogle Scholar
• Li MJ, Lei JH, Wang T, Lu SJ, Guan F, Liu WQ, Li YL. Cimetidine enhances the protective effect of GST DNA vaccine against Schistosoma japonicum. Exp Parasitol 2011; 128:427-32; PMID:21624364; http://dx.doi.org/10.1016/j.exppara.2011.05.012
   PubMed Web of Science ®Google Scholar
• Zhang W, Wang J, Su B, Li R, Ding Z, Kang Y, Wang B. Cimetidine augments Th1/Th2 dual polarized immune responses to recombinant HBV antigens. Vaccine 2011; 29:4862-8; PMID:21481324; http://dx.doi.org/10.1016/j.vaccine.2011.03.091
   PubMed Web of Science ®Google Scholar
• Yamaura K, Yonekawa T, Nakamura T, Yano S, Ueno K. The histamine H2-receptor antagonist, cimetidine, inhibits the articular osteopenia in rats with adjuvant-induced arthritis by suppressing the osteoclast differentiation induced by histamine. J Pharmacolo Sci 2003; 92:43-9; http://dx.doi.org/10.1254/jphs.92.43
   PubMed Web of Science ®Google Scholar
• Jin ZW, Kumar A, Cleveland RP, Murray DL, Kaufman DB. Inhibition of suppressor cell function by cimetidine in a murine model. Clin Immunol Immunopathol 1986; 38:350-6; PMID:2935344; http://dx.doi.org/10.1016/0090-1229(86)90245-X
   PubMedGoogle Scholar
• Langman MJ, Dunn JA, Whiting JL, Burton A, Hallissey MT, Fielding JW, Kerr DJ. Prospective, double-blind, placebo-controlled randomized trial of cimetidine in gastric cancer. British Stomach Cancer Group. Br J Cancer 1999; 81:1356-62; PMID:10604733; http://dx.doi.org/10.1038/sj.bjc.6690457
   PubMed Web of Science ®Google Scholar
• Zhang L, Zhao Y. The regulation of Foxp3 expression in regulatory CD4(+)CD25(+)T cells: multiple pathways on the road. J Cell Physiol 2007; 211:590-7; PMID:17311282; http://dx.doi.org/10.1002/jcp.21001
   PubMed Web of Science ®Google Scholar
• Fontenot JD, Rasmussen JP, Williams LM, Dooley JL, Farr AG, Rudensky AY. Regulatory T cell lineage specification by the forkhead transcription factor foxp3. Immunity 2005; 22:329-41; PMID:15780990; http://dx.doi.org/10.1016/j.immuni.2005.01.016
   PubMed Web of Science ®Google Scholar
• Ozdemir C, Akdis M, Akdis CA. T regulatory cells and their counterparts: masters of immune regulation. Clin Exp Allergy 2009; 39:626-39; PMID:19422105; http://dx.doi.org/10.1111/j.1365-2222.2009.03242.x
   PubMed Web of Science ®Google Scholar
• Kim J, Lahl K, Hori S, Loddenkemper C, Chaudhry A, deRoos P, Rudensky A, Sparwasser T. Cutting edge: depletion of Foxp3+ cells leads to induction of autoimmunity by specific ablation of regulatory T cells in genetically targeted mice. J Immunol 2009; 183:7631-4; PMID:19923467; http://dx.doi.org/10.4049/jimmunol.0804308
   PubMed Web of Science ®Google Scholar
• Sakaguchi S, Wing K, Onishi Y, Prieto-Martin P, Yamaguchi T. Regulatory T cells: how do they suppress immune responses? Internat Immunol 2009; 21:1105-11; http://dx.doi.org/10.1093/intimm/dxp095
   PubMed Web of Science ®Google Scholar
• Croons V, Martinet W, Herman AG, Timmermans JP, De Meyer GR. Selective clearance of macrophages in atherosclerotic plaques by the protein synthesis inhibitor cycloheximide. J Pharmacol Exp Therapeut 2007; 320:986-93; http://dx.doi.org/10.1124/jpet.106.113944
   PubMed Web of Science ®Google Scholar
• Chen Z, Barbi J, Bu S, Yang HY, Li Z, Gao Y, Jinasena D, Fu J, Lin F, Chen C, et al. The ubiquitin ligase Stub1 negatively modulates regulatory T cell suppressive activity by promoting degradation of the transcription factor Foxp3. Immunity 2013; 39:272-85; PMID:23973223; http://dx.doi.org/10.1016/j.immuni.2013.08.006
   PubMed Web of Science ®Google Scholar
• Sauer S, Bruno L, Hertweck A, Finlay D, Leleu M, Spivakov M, Knight ZA, Cobb BS, Cantrell D, O'Connor E, et al. T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR. Proc Natl Acad Sci U S A 2008; 105:7797-802; PMID:18509048; http://dx.doi.org/10.1073/pnas.0800928105
   PubMed Web of Science ®Google Scholar
• Lv Y, Song S, Zhang K, Gao H, Ma R. CHIP regulates AKT/FoxO/Bim signaling in MCF7 and MCF10A cells. PloS one 2013; 8:e83312
   PubMedGoogle Scholar
• Deng G, Nagai Y, Xiao Y, Li Z, Dai S, Ohtani T, et al. Pim-2 kinase influences Tregulatory cell function and stability by mediating Foxp3 N-terminal phosphorylation. J Biol Chem 2015; http://dx.doi.org/10.1074/jbc.M115.638221
   Web of Science ®Google Scholar
• Ammann JU, Cooke A, Trowsdale J. Butyrophilin Btn2a2 inhibits TCR activation and phosphatidylinositol 3-kinase/Akt pathway signaling and induces Foxp3 expression in T lymphocytes. J Immunol 2013; 190:5030-6; PMID:23589618; http://dx.doi.org/10.4049/jimmunol.1203325
   PubMed Web of Science ®Google Scholar
• Peltier J, O'Neill A, Schaffer DV. PI3K/Akt and CREB regulate adult neural hippocampal progenitor proliferation and differentiation. Dev Neurobiol 2007; 67:1348-61; PMID:17638387; http://dx.doi.org/10.1002/dneu.20506
   PubMed Web of Science ®Google Scholar
• Jutel M, Blaser K, Akdis CA. Histamine in allergic inflammation and immune modulation. Inter Arch Allergy Immunol 2005; 137:82-92; http://dx.doi.org/10.1159/000085108
   PubMed Web of Science ®Google Scholar