Mycobacterial Hsp65 antigen upregulates the cellular immune response of healthy individuals compared with tuberculosis patients

References

• WHO. Fact sheet NO 104. 2015; http://wwwhoint/mediacentre/factsheets/fs104/en/
   Google Scholar
• Karp CL, Wilson CB, Stuart LM. Tuberculosis vaccines: barriers and prospects on the quest for a transformative tool. Immunol Rev 2015; 264:363-81; PMID:25703572; http://dx.doi.org/10.1111/imr.12270
   PubMed Web of Science ®Google Scholar
• Nathan C, Barry CE, 3rd. TB drug development: immunology at the table. Immunol Rev 2015; 264:308-18; PMID:25703568; http://dx.doi.org/10.1111/imr.12275
   PubMed Web of Science ®Google Scholar
• Orme IM. Tuberculosis vaccine types and timings. Clin Vacc Immunol 2015; 22:249-57; PMID:25540272; http://dx.doi.org/10.1128/CVI.00718-14
   PubMed Web of Science ®Google Scholar
• Frick M. The Tuberculosis Vaccine Pipeline: A New Path to the Same Destination? UK HIV i-Base/Treatment Action Group 2015; 2015; http://www.pipelinereport.org/2015/tb-vaccines
   Google Scholar
• Weiner J, 3rd, Kaufmann SH. Recent advances towards tuberculosis control: vaccines and biomarkers. J Int Med 2014; 275:467-80; PMID:24635488; http://dx.doi.org/10.1111/joim.12212
   PubMed Web of Science ®Google Scholar
• O'Shea MK, McShane H. A review of clinical models for the evaluation of human TB vaccines. Hum Vacc Immunother 2016; 12:1177-87; PMID:26810964; http://dx.doi.org/10.1080/21645515.2015.1134407
   PubMed Web of Science ®Google Scholar
• Montagnani C, Chiappini E, Galli L, de Martino M. Vaccine against tuberculosis: what's new? BMC Infect Dis 2014; 14 Suppl 1:S2; PMID:24564340; http://dx.doi.org/10.1186/1471-2334-14-S1-S2
   PubMed Web of Science ®Google Scholar
• Lowrie DB, Silva CL, Colston MJ, Ragno S, Tascon RE. Protection against tuberculosis by a plasmid DNA vaccine. Vaccine 1997; 15:834-38; PMID:9234527; http://dx.doi.org/10.1016/S0264-410X(97)00073-X
   PubMed Web of Science ®Google Scholar
• Bonato VL, Lima VM, Tascon RE, Lowrie DB, Silva CL. Identification and characterization of protective T cells in hsp65 DNA-vaccinated and Mycobacterium tuberculosis-infected mice. Infect Immun 1998; 66:169-75.
   PubMed Web of Science ®Google Scholar
• Lowrie DB, Tascon RE, Bonato VL, Lima VM, Faccioli LH, Stavropoulos E, Colston MJ, Hewinson RG, Moelling K, Silva CL. Therapy of tuberculosis in mice by DNA vaccination. Nature 1999; 400:269-71; PMID:10421369; http://dx.doi.org/10.1038/22326
   PubMed Web of Science ®Google Scholar
• Bonato VL, Goncalves ED, Soares EG, Santos Junior RR, Sartori A, Coelho-Castelo AA, Silva CL. Immune regulatory effect of pHSP65 DNA therapy in pulmonary tuberculosis: activation of CD8+ cells, interferon-gamma recovery and reduction of lung injury. Immunology 2004; 113:130-38; PMID:15312144; http://dx.doi.org/10.1111/j.1365-2567.2004.01931.x
   PubMed Web of Science ®Google Scholar
• Goncalves ED, Bonato VL, da Fonseca DM, Soares EG, Brandao IT, Soares AP, Silva CL. Improve protective efficacy of a TB DNA-HSP65 vaccine by BCG priming. Genet Vacc Ther 2007; 5:7; PMID:17714584; http://dx.doi.org/10.1186/1479-0556-5-7
   PubMedGoogle Scholar
• Rosada RS, de la Torre LG, Frantz FG, Trombone AP, Zarate-Blades CR, Fonseca DM, Souza PR, Brandao IT, Masson AP, Soares EG, et al. Protection against tuberculosis by a single intranasal administration of DNA-hsp65 vaccine complexed with cationic liposomes. BMC Immunol 2008; 9:38; PMID:18647414; http://dx.doi.org/10.1186/1471-2172-9-38
   PubMed Web of Science ®Google Scholar
• de Paula L, Silva CL, Carlos D, Matias-Peres C, Sorgi CA, Soares EG, Souza PR, Blades CR, Galleti FC, Bonato VL, et al. Comparison of different delivery systems of DNA vaccination for the induction of protection against tuberculosis in mice and guinea pigs. Genet Vacc Ther 2007; 5:2; PMID:17250766; http://dx.doi.org/10.1186/1479-0556-5-2
   PubMedGoogle Scholar
• Souza PR, Zarate-Blades CR, Hori JI, Ramos SG, Lima DS, Schneider T, Rosada RS, Torre LG, Santana MH, Brandao IT, et al. Protective efficacy of different strategies employing Mycobacterium leprae heat-shock protein 65 against tuberculosis. Exp Opin Biol Ther 2008; 8:1255-64; PMID:18694348; http://dx.doi.org/10.1517/14712598.8.9.1255
   PubMed Web of Science ®Google Scholar
• Franco LH, Wowk PF, Silva CL, Trombone AP, Coelho-Castelo AA, Oliver C, Jamur MC, Moretto EL, Bonato VL. A DNA vaccine against tuberculosis based on the 65 kDa heat-shock protein differentially activates human macrophages and dendritic cells. Genet Vacc Ther 2008; 6:3; PMID:18208592; http://dx.doi.org/10.1186/1479-0556-6-3
   PubMedGoogle Scholar
• Michaluart P, Abdallah KA, Lima FD, Smith R, Moyses RA, Coelho V, Victora GD, Socorro-Silva A, Volsi EC, Zarate-Blades CR, et al. Phase I trial of DNA-hsp65 immunotherapy for advanced squamous cell carcinoma of the head and neck. Cancer Gene Ther 2008; 15:676-84; PMID:18535616; http://dx.doi.org/10.1038/cgt.2008.35
   PubMed Web of Science ®Google Scholar
• Victora GD, Socorro-Silva A, Volsi EC, Abdallah K, Lima FD, Smith RB, Moyses RA, Zarate-Blades CR, Michaluart P, Silva CL, et al. Immune response to vaccination with DNA-Hsp65 in a phase I clinical trial with head and neck cancer patients. Cancer Gene Ther 2009; 16:598-608; PMID:19197326; http://dx.doi.org/10.1038/cgt.2009.9
   PubMed Web of Science ®Google Scholar
• Smith SG, Zelmer A, Blitz R, Fletcher HA, Dockrell HM. Polyfunctional CD4 T-cells correlate with in vitro mycobacterial growth inhibition following Mycobacterium bovis BCG-vaccination of infants. Vaccine 2016; 34:5298-305; PMID:27622301; http://dx.doi.org/10.1016/j.vaccine.2016.09.002
   PubMed Web of Science ®Google Scholar
• Smith SG, Smits K, Joosten SA, van Meijgaarden KE, Satti I, Fletcher HA, Caccamo N, Dieli F, Mascart F, McShane H, et al. Intracellular cytokine staining and flow cytometry: considerations for application in clinical trials of novel tuberculosis vaccines. PloS One 2015; 10:e0138042; PMID:26367374; http://dx.doi.org/10.1371/journal.pone.0138042
   PubMed Web of Science ®Google Scholar
• Al-Attiyah RJ, Mustafa AS. Mycobacterial antigen-induced T helper type 1 (Th1) and Th2 reactivity of peripheral blood mononuclear cells from diabetic and non-diabetic tuberculosis patients and Mycobacterium bovis bacilli Calmette-Guerin (BCG)-vaccinated healthy subjects. Clin Exp Immunol 2009; 158:64-73; PMID:19737232; http://dx.doi.org/10.1111/j.1365-2249.2009.04000.x
   PubMed Web of Science ®Google Scholar
• Coelho-Castelo AA, Trombone AP, Rosada RS, Santos RR, Jr., Bonato VL, Sartori A, Silva CL. Tissue distribution of a plasmid DNA encoding Hsp65 gene is dependent on the dose administered through intramuscular delivery. Genet Vacc Ther 2006; 4:1; PMID:16445866; http://dx.doi.org/10.1186/1479-0556-4-1
   PubMedGoogle Scholar
• Mor G, Klinman DM, Shapiro S, Hagiwara E, Sedegah M, Norman JA, Hoffman SL, Steinberg AD. Complexity of the cytokine and antibody response elicited by immunizing mice with Plasmodium yoelii circumsporozoite protein plasmid DNA. J Immunol 1995; 155:2039-46; PMID:7636255
   PubMed Web of Science ®Google Scholar
• Cresswell P, Ackerman AL, Giodini A, Peaper DR, Wearsch PA. Mechanisms of MHC class I-restricted antigen processing and cross-presentation. Immunol Rev 2005; 207:145-57; PMID:16181333; http://dx.doi.org/10.1111/j.0105-2896.2005.00316.x
   PubMed Web of Science ®Google Scholar
• Giodini A, Cresswell P. Hsp90-mediated cytosolic refolding of exogenous proteins internalized by dendritic cells. EMBO J 2008; 27:201-11; PMID:18046456; http://dx.doi.org/10.1038/sj.emboj.7601941
   PubMed Web of Science ®Google Scholar
• Portaro FC, Hayashi MA, De Arauz LJ, Palma MS, Assakura MT, Silva CL, de Camargo AC. The Mycobacterium leprae hsp65 displays proteolytic activity. Mutagenesis studies indicate that the M. leprae hsp65 proteolytic activity is catalytically related to the HslVU protease. Biochemistry 2002; 41:7400-6; PMID:12044173; http://dx.doi.org/10.1021/bi011999l
   PubMed Web of Science ®Google Scholar
• Woodworth JS, Fortune SM, Behar SM. Bacterial protein secretion is required for priming of CD8+ T cells specific for the Mycobacterium tuberculosis antigen CFP10. Infect Immun 2008; 76:4199-205; PMID:18591224; http://dx.doi.org/10.1128/IAI.00307-08
   PubMed Web of Science ®Google Scholar
• Sodhi A, Gong J, Silva C, Qian D, Barnes PF. Clinical correlates of interferon gamma production in patients with tuberculosis. Clin Infect Dis 1997; 25:617-20; PMID:9314449; http://dx.doi.org/10.1086/513769
   PubMed Web of Science ®Google Scholar
• Dlugovitzky D, Bay ML, Rateni L, Urizar L, Rondelli CF, Largacha C, Farroni MA, Molteni O, Bottasso OA. In vitro synthesis of interferon-gamma, interleukin-4, transforming growth factor-beta and interleukin-1 beta by peripheral blood mononuclear cells from tuberculosis patients: relationship with the severity of pulmonary involvement. Scand J Immunol 1999; 49:210-17; PMID:10075027; http://dx.doi.org/10.1046/j.1365-3083.1999.00492.x
   PubMed Web of Science ®Google Scholar
• Sahiratmadja E, Alisjahbana B, de Boer T, Adnan I, Maya A, Danusantoso H, Nelwan RH, Marzuki S, van der Meer JW, van Crevel R, et al. Dynamic changes in pro- and anti-inflammatory cytokine profiles and gamma interferon receptor signaling integrity correlate with tuberculosis disease activity and response to curative treatment. Infect Immun 2007; 75:820-9; PMID:17145950; http://dx.doi.org/10.1128/IAI.00602-06
   PubMed Web of Science ®Google Scholar
• Jurado JO, Pasquinelli V, Alvarez IB, Pena D, Rovetta AI, Tateosian NL, Romeo HE, Musella RM, Palmero D, Chuluyan HE, et al. IL-17 and IFN-gamma expression in lymphocytes from patients with active tuberculosis correlates with the severity of the disease. J Leukocyte Biol 2012; 91:991-1002; PMID:22416258; http://dx.doi.org/10.1189/jlb.1211619
   PubMed Web of Science ®Google Scholar
• Hirsch CS, Toossi Z, Othieno C, Johnson JL, Schwander SK, Robertson S, Wallis RS, Edmonds K, Okwera A, Mugerwa R, et al. Depressed T-cell interferon-gamma responses in pulmonary tuberculosis: analysis of underlying mechanisms and modulation with therapy. J Infect Dis 1999; 180:2069-73; PMID:10558973; http://dx.doi.org/10.1086/315114
   PubMed Web of Science ®Google Scholar
• Al-Attiyah R, Mustafa AS, Abal AT, Madi NM, Andersen P. Restoration of mycobacterial antigen-induced proliferation and interferon-gamma responses in peripheral blood mononuclear cells of tuberculosis patients upon effective chemotherapy. FEMS Immunol Med Microbiol 2003; 38:249-56; PMID:14522460; http://dx.doi.org/10.1016/S0928-8244(03)00166-4
   PubMedGoogle Scholar
• Kassa D, Ran L, Geberemeskel W, Tebeje M, Alemu A, Selase A, Tegbaru B, Franken KL, Friggen AH, van Meijgaarden KE, et al. Analysis of immune responses against a wide range of Mycobacterium tuberculosis antigens in patients with active pulmonary tuberculosis. Clin Vacc Immunol 2012; 19:1907-15; PMID:23015647; http://dx.doi.org/10.1128/CVI.00482-12
   PubMed Web of Science ®Google Scholar
• Munk ME, Schoel B, Kaufmann SH. T cell responses of normal individuals towards recombinant protein antigens of Mycobacterium tuberculosis. Eur J Immunol 1988; 18:1835-8; PMID:2462503; http://dx.doi.org/10.1002/eji.1830181128
   PubMed Web of Science ®Google Scholar
• Zarate-Blades CR, Rodrigues RF, Souza PR, Rios WM, Soares LS, Rosada RS, Brandao IT, Masson AP, Floriano EM, Ramos SG, et al. Evaluation of the overall IFN-gamma and IL-17 pro-inflammatory responses after DNA therapy of tuberculosis. Hum Vacc Immunother 2013; 9:1093-103; PMID:23324590; http://dx.doi.org/10.4161/hv.23417
   PubMed Web of Science ®Google Scholar
• Gazzinelli RT, Wysocka M, Hieny S, Scharton-Kersten T, Cheever A, Kuhn R, Muller W, Trinchieri G, Sher A. In the absence of endogenous IL-10, mice acutely infected with Toxoplasma gondii succumb to a lethal immune response dependent on CD4+ T cells and accompanied by overproduction of IL-12, IFN-gamma and TNF-alpha. J Immunol 1996; 157:798-805; PMID:8752931
   PubMed Web of Science ®Google Scholar
• Wilson EH, Wille-Reece U, Dzierszinski F, Hunter CA. A critical role for IL-10 in limiting inflammation during toxoplasmic encephalitis. J Neuroimmunol 2005; 165:63-74; PMID:16005735; http://dx.doi.org/10.1016/j.jneuroim.2005.04.018
   PubMed Web of Science ®Google Scholar
• Hunter CA, Ellis-Neyes LA, Slifer T, Kanaly S, Grunig G, Fort M, Rennick D, Araujo FG. IL-10 is required to prevent immune hyperactivity during infection with Trypanosoma cruzi. J Immunol 1997; 158:3311-6; PMID:9120288
   PubMed Web of Science ®Google Scholar
• Suvas S, Azkur AK, Kim BS, Kumaraguru U, Rouse BT. CD4+CD25+ regulatory T cells control the severity of viral immunoinflammatory lesions. J Immunol 2004; 172:4123-32; PMID:15034024; http://dx.doi.org/10.4049/jimmunol.172.7.4123
   PubMed Web of Science ®Google Scholar
• Schandene L, Alonso-Vega C, Willems F, Gerard C, Delvaux A, Velu T, Devos R, de Boer M, Goldman M. B7/CD28-dependent IL-5 production by human resting T cells is inhibited by IL-10. J Immunol 1994; 152:4368-74; PMID:7512591
   PubMed Web of Science ®Google Scholar
• Joss A, Akdis M, Faith A, Blaser K, Akdis CA. IL-10 directly acts on T cells by specifically altering the CD28 co-stimulation pathway. Eur J Immunol 2000; 30:1683-90; PMID:10898505; http://dx.doi.org/10.1002/1521-4141(200006)30:6%3c1683::AID-IMMU1683%3e3.0.CO;2-A
   PubMed Web of Science ®Google Scholar
• Grunig G, Corry DB, Leach MW, Seymour BW, Kurup VP, Rennick DM. Interleukin-10 is a natural suppressor of cytokine production and inflammation in a murine model of allergic bronchopulmonary aspergillosis. J Exp Med 1997; 185:1089-99; PMID:9091582; http://dx.doi.org/10.1084/jem.185.6.1089
   PubMed Web of Science ®Google Scholar
• Wilson MS, Elnekave E, Mentink-Kane MM, Hodges MG, Pesce JT, Ramalingam TR, Thompson RW, Kamanaka M, Flavell RA, Keane-Myers A, et al. IL-13Ralpha2 and IL-10 coordinately suppress airway inflammation, airway-hyperreactivity, and fibrosis in mice. J Clin Investigat 2007; 117:2941-51; PMID:17885690; http://dx.doi.org/10.1172/JCI31546
   PubMed Web of Science ®Google Scholar
• Hoffmann KF, Cheever AW, Wynn TA. IL-10 and the dangers of immune polarization: excessive type 1 and type 2 cytokine responses induce distinct forms of lethal immunopathology in murine schistosomiasis. J Immunol 2000; 164:6406-16; PMID:10843696; http://dx.doi.org/10.4049/jimmunol.164.12.6406
   PubMed Web of Science ®Google Scholar
• Belkaid Y, Piccirillo CA, Mendez S, Shevach EM, Sacks DL. CD4+CD25+ regulatory T cells control Leishmania major persistence and immunity. Nature 2002; 420:502-7; PMID:12466842; http://dx.doi.org/10.1038/nature01152
   PubMed Web of Science ®Google Scholar
• Redford PS, Murray PJ, O'Garra A. The role of IL-10 in immune regulation during M. tuberculosis infection. Mucosal Immunol 2011; 4:261-70; PMID:21451501; http://dx.doi.org/10.1038/mi.2011.7
   PubMed Web of Science ®Google Scholar
• Li C, Sanni LA, Omer F, Riley E, Langhorne J. Pathology of Plasmodium chabaudi chabaudi infection and mortality in interleukin-10-deficient mice are ameliorated by anti-tumor necrosis factor alpha and exacerbated by anti-transforming growth factor beta antibodies. Infect Immun 2003; 71:4850-6; PMID:12933825; http://dx.doi.org/10.1128/IAI.71.9.4850-4856.2003
   PubMed Web of Science ®Google Scholar
• Edelmann W, Schleiss K, Joss A. Ecological, energetic and economic comparison of anaerobic digestion with different competing technologies to treat biogenic wastes. Water Sci Technol 2000; 41:263-73; PMID:11382001
   PubMed Web of Science ®Google Scholar
• Li C, Corraliza I, Langhorne J. A defect in interleukin-10 leads to enhanced malarial disease in Plasmodium chabaudi chabaudi infection in mice. Infect Immun 1999; 67:4435-42; PMID:10456884
   PubMed Web of Science ®Google Scholar
• Suzuki Y, Sher A, Yap G, Park D, Neyer LE, Liesenfeld O, Fort M, Kang H, Gufwoli E. IL-10 is required for prevention of necrosis in the small intestine and mortality in both genetically resistant BALB/c and susceptible C57BL/6 mice following peroral infection with Toxoplasma gondii. J Immunol 2000; 164:5375-82; PMID:10799901; http://dx.doi.org/10.4049/jimmunol.164.10.5375
   PubMed Web of Science ®Google Scholar
• Coelho-Castelo AA, Santos Junior RR, Bonato VL, Jamur MC, Oliver C, Silva CL. B-lymphocytes in bone marrow or lymph nodes can take up plasmid DNA after intramuscular delivery. Hum Gene Ther 2003; 14:1279-85; PMID:12952599; http://dx.doi.org/10.1089/104303403767740812
   PubMed Web of Science ®Google Scholar
• Sathler-Avelar R, Vitelli-Avelar DM, Massara RL, de Lana M, Pinto Dias JC, Teixeira-Carvalho A, Eloi-Santos SM, Martins-Filho OA. Etiological treatment during early chronic indeterminate Chagas disease incites an activated status on innate and adaptive immunity associated with a type 1-modulated cytokine pattern. Microbes Infect 2008; 10:103-13; PMID:18248755; http://dx.doi.org/10.1016/j.micinf.2007.10.009
   PubMed Web of Science ®Google Scholar