Antibody repertoire profiling with mimotope arrays

References

• Galson JD, Truck J, Fowler A, Munz M, Cerundolo V, Pollard AJ, Lunter G, Kelly DF. In-Depth Assessment of Within-Individual and Inter-Individual Variation in the B Cell Receptor Repertoire. Front Immunol 2015; 6:531; PMID:26528292; http://dx.doi.org/10.3389/fimmu.2015.00531
   PubMed Web of Science ®Google Scholar
• Glanville J, Zhai W, Berka J, Telman D, Huerta G, Mehta GR, Ni I, Mei L, Sundar PD, Day GM, et al. Precise determination of the diversity of a combinatorial antibody library gives insight into the human immunoglobulin repertoire. Proc Natl Acad Sci 2009; 106:20216-21; http://dx.doi.org/10.1073/pnas.0909775106
   PubMed Web of Science ®Google Scholar
• Fesel C, Coutinho A. Dynamics of serum IgM autoreactive repertoires following immunization: strain specificity, inheritance and association with autoimmune disease susceptibility. Euro J Immunol 1998; 28:3616-29; PMID:9842904; http://dx.doi.org/10.1002/(SICI)1521-4141(199811)28:11%3c3616::AID-IMMU3616%3e3.0.CO;2-B
   PubMed Web of Science ®Google Scholar
• Lacroix-Desmazes S, Mouthon L, Coutinho A, Kazatchkine MD. Analysis of the natural human IgG antibody repertoire: life-long stability of reactivities towards self antigens contrasts with age-dependent diversification of reactivities against bacterial antigens. Euro J Immunol 1995; 25:2598-604; PMID:7589132; http://dx.doi.org/10.1002/eji.1830250929
   PubMed Web of Science ®Google Scholar
• Mouthon L, Haury M, Lacroix-Desmazes S, Barreau C, Coutinho A, Kazatchkine MD. Analysis of the normal human IgG antibody repertoire. Evidence that IgG autoantibodies of healthy adults recognize a limited and conserved set of protein antigens in homologous tissues. J Immunol 1995; 154:5769-78.
   PubMed Web of Science ®Google Scholar
• Nobrega A, Haury M, Grandien A, Malanchere E, Sundblad A, Coutinho A. Global analysis of antibody repertoires. II. Evidence for specificity, self-selection and the immunological ‘homunculus’ of antibodies in normal serum. Euro J Immunol 1993; 23:2851-9.
   PubMed Web of Science ®Google Scholar
• Schneider C, Smith DF, Cummings RD, Boligan KF, Hamilton RG, Bochner BS, Miescher S, Simon HU, Pashov A, Vassilev T, et al. The human IgG anti-carbohydrate repertoire exhibits a universal architecture and contains specificity for microbial attachment sites. Sci Transl Med 2015; 7:269ra1; http://dx.doi.org/10.1126/scitranslmed.3010524
   PubMed Web of Science ®Google Scholar
• Bovin NV. Natural antibodies to glycans. Biochemistry (Mosc) 2013; 78:786-97; PMID:24010841; http://dx.doi.org/10.1134/S0006297913070109
   PubMed Web of Science ®Google Scholar
• Stafford P, Wrapp D, Johnston S. General assessment of humoral activity in healthy humans. Mol Cell Proteomics 2016; 15(5):1610-21; PMID:26902205
   PubMed Web of Science ®Google Scholar
• Hughes AK, Cichacz Z, Scheck A, Coons SW, Johnston SA, Stafford P. Immunosignaturing Can Detect Products from Molecular Markers in Brain Cancer. PLoS One 2012; 7:e40201; PMID:22815729; http://dx.doi.org/10.1371/journal.pone.0040201
   PubMed Web of Science ®Google Scholar
• Fesel C, Coutinho A. Structured reactions of serum IgM repertoires to immunization are dependent on major histocompatibility complex genes. Scand J Immunol 1999; 49:251-7; PMID:10102642; http://dx.doi.org/10.1046/j.1365-3083.1999.00482.x
   PubMed Web of Science ®Google Scholar
• Lucas AH, Rittenhouse-Olson K, Kronenberg M, Apicella MA, Wang D, Schreiber JR, Taylor CE. Carbohydrate moieties as vaccine candidates: Meeting summary. Vaccine 2010; 28:1121-31; PMID:18579261; http://dx.doi.org/10.1016/j.vaccine.2008.05.055
   PubMed Web of Science ®Google Scholar
• Lucas AH, Apicella MA, Taylor CE. Carbohydrate Moieties as Vaccine Candidates. Clin Infect Dis 2005; 41:705-12; PMID:16080094; http://dx.doi.org/10.1086/432582
   PubMed Web of Science ®Google Scholar
• Astronomo RD, Burton DR. Carbohydrate vaccines: developing sweet solutions to sticky situations? Nat Rev Drug Discov 2010; 9:308-24; PMID:20357803; http://dx.doi.org/10.1038/nrd3012
   PubMed Web of Science ®Google Scholar
• Heimburg-Molinaro J, Lum M, Vijay G, Jain M, Almogren A, Rittenhouse-Olson K. Cancer vaccines and carbohydrate epitopes. Vaccine 2011; 29:8802-26; PMID:21964054; http://dx.doi.org/10.1016/j.vaccine.2011.09.009
   PubMed Web of Science ®Google Scholar
• von Gunten S, Smith DF, Cummings RD, Riedel S, Miescher S, Schaub A, Hamilton RG, Bochner BS. Intravenous immunoglobulin contains a broad repertoire of anticarbohydrate antibodies that is not restricted to the IgG2 subclass. J Allergy Clin Immunol 2009; 123:1268-76 e15; http://dx.doi.org/10.1016/j.jaci.2009.03.013
   PubMed Web of Science ®Google Scholar
• Monzavi-Karbassi B, Pashov A, Kieber-Emmons T. Tumor-Associated Glycans and Immune Surveillance. Vaccines 2013; 1:174-203; PMID:26343966; http://dx.doi.org/10.3390/vaccines1020174
   PubMedGoogle Scholar
• Huflejt ME, Vuskovic M, Vasiliu D, Xu H, Obukhova P, Shilova N, Tuzikov A, Galanina O, Arun B, Lu K, et al. Anti-carbohydrate antibodies of normal sera: findings, surprises and challenges. Mol Immunol 2009; 46:3037-49; PMID:19608278; http://dx.doi.org/10.1016/j.molimm.2009.06.010
   PubMed Web of Science ®Google Scholar
• Muthana SM, Gildersleeve JC. Factors Affecting Anti-Glycan IgG and IgM Repertoires in Human Serum. Sci Rep 2016; 6:19509; PMID:26781493; http://dx.doi.org/10.1038/srep19509
   PubMed Web of Science ®Google Scholar
• Avrameas S, Guilbert B, Mahana W, Matsiota P, Ternynck T. Recognition of self and non-self constituents by polyspecific autoreceptors. Int Rev Immunol 1988; 3:1-15; PMID:3073176; http://dx.doi.org/10.3109/08830188809051179
   PubMedGoogle Scholar
• Avrameas S. Natural autoantibodies: from ‘horror autotoxicus’ to ‘gnothi seauton’. Immunol Today 1991; 12:154-9; PMID:1715166.
   PubMedGoogle Scholar
• Reynolds AE, Kuraoka M, Kelsoe G. Natural IgM is produced by CD5- plasma cells that occupy a distinct survival niche in bone marrow. J Immunol 2015; 194:231-42; PMID:25429072; http://dx.doi.org/10.4049/jimmunol.1401203
   PubMed Web of Science ®Google Scholar
• Ochsenbein AF, Fehr T, Lutz C, Suter M, Brombacher F, Hengartner H, Zinkernagel RM. Control of early viral and bacterial distribution and disease by natural antibodies. Science 1999; 286:2156-9; PMID:10591647; http://dx.doi.org/10.1126/science.286.5447.2156
   PubMed Web of Science ®Google Scholar
• Vollmers HP, Brandlein S. Tumors: too sweet to remember? Mol Cancer 2007; 6:78; PMID:18053197; http://dx.doi.org/10.1186/1476-4598-6-78
   PubMed Web of Science ®Google Scholar
• Matter MS, Ochsenbein AF. Natural antibodies target virus-antibody complexes to organized lymphoid tissue. Autoimmun Rev 2008; 7:480-6; PMID:18558366; http://dx.doi.org/10.1016/j.autrev.2008.03.018
   PubMed Web of Science ®Google Scholar
• Avrameas S, Guilbert B, Dighiero G. Natural antibodies against tubulin, actin myoglobin, thyroglobulin, fetuin, albumin and transferrin are present in normal human sera, and monoclonal immunoglobulins from multiple myeloma and Waldenstrom's macroglobulinemia may express similar antibody specificities. Ann Immunol (Paris) 1981; 132C:231-6; PMID:6171189.
   PubMedGoogle Scholar
• Panda S, Zhang J, Tan NS, Ho B, Ding JL. Natural IgG antibodies provide innate protection against ficolin-opsonized bacteria. EMBO J 2013; 32:2905-19; PMID:24002211; http://dx.doi.org/10.1038/emboj.2013.199
   PubMed Web of Science ®Google Scholar
• Gutierrez JA, Guerriero V Jr. Quantitation of Hsp70 in tissues using a competitive enzyme-linked immunosorbent assay. J Immunol Methods 1991; 143:81-8; PMID:1919038; http://dx.doi.org/10.1016/0022-1759(91)90275-K
   PubMed Web of Science ®Google Scholar
• Baumgarth N, Herman OC, Jager GC, Brown LE, Herzenberg LA, Chen J. B-1 and B-2 cell-derived immunoglobulin M antibodies are nonredundant components of the protective response to influenza virus infection. J Exp Med 2000; 192:271-80; PMID:10899913; http://dx.doi.org/10.1084/jem.192.2.271
   PubMed Web of Science ®Google Scholar
• Schwartz-Albiez R, Monteiro RC, Rodriguez M, Binder CJ, Shoenfeld Y. Natural antibodies, intravenous immunoglobulin and their role in autoimmunity, cancer and inflammation. Clin Exp Immunol 2009; 158:43-50; PMID:19883423; http://dx.doi.org/10.1111/j.1365-2249.2009.04026.x
   PubMed Web of Science ®Google Scholar
• Li S, Rouphael N, Duraisingham S, Romero-Steiner S, Presnell S, Davis C, Schmidt DS, Johnson SE, Milton A, Rajam G, et al. Molecular signatures of antibody responses derived from a systems biology study of five human vaccines. Nat Immunol 2014; 15:195-204; PMID:24336226; http://dx.doi.org/10.1038/ni.2789
   PubMed Web of Science ®Google Scholar
• Desoubeaux G, Daguet A, Watier H. Therapeutic antibodies and infectious diseases, Tours, France, November 20−22, 2012. mAbs 2013; 5:626-32; PMID:23883703; http://dx.doi.org/10.4161/mabs.25300
   PubMed Web of Science ®Google Scholar
• Glanville J, D'Angelo S, Khan TA, Reddy ST, Naranjo L, Ferrara F, Bradbury AR. Deep sequencing in library selection projects: what insight does it bring? Curr Opin Struct Biol 2015; 33:146-60; PMID:26451649; http://dx.doi.org/10.1016/j.sbi.2015.09.001
   PubMed Web of Science ®Google Scholar
• Lavinder JJ, Horton AP, Georgiou G, Ippolito GC. Next-generation sequencing and protein mass spectrometry for the comprehensive analysis of human cellular and serum antibody repertoires. Curr Opin Chem Biol 2015; 24:112-20; PMID:25461729; http://dx.doi.org/10.1016/j.cbpa.2014.11.007
   PubMed Web of Science ®Google Scholar
• Khan TA, Friedensohn S, Gorter de Vries AR, Straszewski J, Ruscheweyh HJ, Reddy ST. Accurate and predictive antibody repertoire profiling by molecular amplification fingerprinting. Science Advances 2016; 2:e1501371
   Google Scholar
• Van Regenmortel MH. Specificity, polyspecificity, and heterospecificity of antibody-antigen recognition. J Mol Recognit 2014; 27:627-39; PMID:25277087; http://dx.doi.org/10.1002/jmr.2394
   PubMed Web of Science ®Google Scholar
• Stafford P, Halperin R, Legutki JB, Magee DM, Galgiani J, Johnston SA. Physical Characterization of the “Immunosignaturing Effect.” Mol Cell Proteomics 2012; 11:M111.011593; PMID:22261726; http://dx.doi.org/10.1074/mcp.M111.011593
   PubMedGoogle Scholar
• Haury M, Grandien A, Sundblad A, Coutinho A, Nobrega A. Global analysis of antibody repertoires. 1. An immunoblot method for the quantitative screening of a large number of reactivities. Scand J Immunol 1994; 39:79-87; PMID:8290896; http://dx.doi.org/10.1111/j.1365-3083.1994.tb03343.x
   PubMed Web of Science ®Google Scholar
• Mouthon L, Nobrega A, Nicolas N, Kaveri SV, Barreau C, Coutinho A, Kazatchkine MD. Invariance and restriction toward a limited set of self-antigens characterize neonatal IgM antibody repertoires and prevail in autoreactive repertoires of healthy adults. Proc Natl Acad Sci U S A 1995; 92:3839-43; PMID:7731992; http://dx.doi.org/10.1073/pnas.92.9.3839
   PubMed Web of Science ®Google Scholar
• Nobrega A, Stransky B, Nicolas N, Coutinho A. Regeneration of Natural Antibody Repertoire After Massive Ablation of Lymphoid System: Robust Selection Mechanisms Preserve Antigen Binding Specificities. J Immunol 2002; 169:2971-8; PMID:12218111; http://dx.doi.org/10.4049/jimmunol.169.6.2971
   PubMed Web of Science ®Google Scholar
• Cohen IR. The cognitive paradigm and the immunological homunculus. Immunol Today 1992; 13:490-4; PMID:1463581; http://dx.doi.org/10.1016/0167-5699(92)90024-2
   PubMedGoogle Scholar
• Varela F, Coutinho A. Second generation immune networks. Immunol Today 1991; 12:159-66; PMID:1878127; http://dx.doi.org/10.1016/S0167-5699(05)80046-5
   PubMedGoogle Scholar
• Coutinho A, Avrameas S. Speculations on immunosomatics: potential diagnostic and therapeutic value of immune homeostasis concepts [editorial]. Scand J Immunol 1992; 36:527-32; PMID:1411298; http://dx.doi.org/10.1111/j.1365-3083.1992.tb03220.x
   PubMed Web of Science ®Google Scholar
• Quintana FJ, Hagedorn PH, Elizur G, Merbl Y, Domany E, Cohen IR. Functional immunomics: microarray analysis of IgG autoantibody repertoires predicts the future response of mice to induced diabetes. Proc Natl Acad Sci U S A 2004; 101 Suppl 2:14615-21; PMID:15308778; http://dx.doi.org/10.1073/pnas.0404848101
   PubMed Web of Science ®Google Scholar
• Quintana FJ, Cohen IR. The natural autoantibody repertoire and autoimmune disease. Biomed Pharmacother 2004; 58:276-81; PMID:15194162; http://dx.doi.org/10.1016/j.biopha.2004.04.011
   PubMed Web of Science ®Google Scholar
• Quintana FJ, Merbl Y, Sahar E, Domany E, Cohen IR. Antigen-chip technology for accessing global information about the state of the body. Lupus 2006; 15:428-30; PMID:16898177; http://dx.doi.org/10.1191/0961203306lu2328oa
   PubMed Web of Science ®Google Scholar
• Merbl Y, Zucker-Toledano M, Quintana FJ, Cohen IR. Newborn humans manifest autoantibodies to defined self molecules detected by antigen microarray informatics. J Clin Invest 2007; 117:712-8; PMID:17332892; http://dx.doi.org/10.1172/JCI29943
   PubMed Web of Science ®Google Scholar
• Madi A, Hecht I, Bransburg-Zabary S, Merbl Y, Pick A, Zucker-Toledano M, Quintana FJ, Tauber AI, Cohen IR, Ben-Jacob E. Organization of the autoantibody repertoire in healthy newborns and adults revealed by system level informatics of antigen microarray data. Proc Natl Acad Sci 2009; 106:14484-9; http://dx.doi.org/10.1073/pnas.0901528106
   PubMed Web of Science ®Google Scholar
• Madi A, Kenett DY, Bransburg-Zabary S, Merbl Y, Quintana FJ, Tauber AI, Cohen IR, Ben-Jacob E. Network Theory Analysis of Antibody-Antigen Reactivity Data: The Immune Trees at Birth and Adulthood. PLoS One 2011; 6:e17445; PMID:21408156; http://dx.doi.org/10.1371/journal.pone.0017445
   PubMed Web of Science ®Google Scholar
• Merbl Y, Itzchak R, Vider-Shalit T, Louzoun Y, Quintana FJ, Vadai E, Eisenbach L, Cohen IR. A Systems Immunology Approach to the Host-Tumor Interaction: Large-Scale Patterns of Natural Autoantibodies Distinguish Healthy and Tumor-Bearing Mice. PLoS One 2009; 4:e6053; PMID:19557135; http://dx.doi.org/10.1371/journal.pone.0006053
   PubMedGoogle Scholar
• Cekaite L, Hovig E, Sioud M. Monitoring B cell response to immunoselected phage-displayed peptides by microarrays. Methods Mol Biol (Clifton, NJ) 2009; 524:273-85; http://dx.doi.org/10.1007/978-1-59745-450-6_20
   PubMedGoogle Scholar
• Sioud M, Hansen MH. Profiling the immune response in patients with breast cancer by phage-displayed cDNA libraries. Euro J Immunol 2001; 31:716-25; PMID:11241275; http://dx.doi.org/10.1002/1521-4141(200103)31:3%3c716::AID-IMMU716%3e3.0.CO;2-9
   PubMed Web of Science ®Google Scholar
• Sahin U, Tureci O, Schmitt H, Cochlovius B, Johannes T, Schmits R, Stenner F, Luo G, Schobert I, Pfreundschuh M. Human neoplasms elicit multiple specific immune responses in the autologous host. Proc Natl Acad Sci U S A 1995; 92:11810-3; PMID:8524854; http://dx.doi.org/10.1073/pnas.92.25.11810
   PubMed Web of Science ®Google Scholar
• Dimitrov JD, Pashov A, Vassilev T. Antibody Polyspecificity: What Does It Matter? In: Lutz HU, ed. Naturally Occurring Antibodies (NAbs). Austin, TX: Springer, 2012:268.
   Google Scholar
• Notkins AL. Polyreactivity of antibody molecules. Trends Immunol 2004; 25:174-9; PMID:15039043; http://dx.doi.org/10.1016/j.it.2004.02.004
   PubMed Web of Science ®Google Scholar
• Van Regenmortel MH. Immunoinformatics may lead to a reappraisal of the nature of B cell epitopes and of the feasibility of synthetic peptide vaccines. J Mol Recognit 2006; 19:183-7; PMID:16680720; http://dx.doi.org/10.1002/jmr.768
   PubMed Web of Science ®Google Scholar
• Kieber-Emmons T, Luo P, Qiu J, Chang TY, O I, Blaszczyk-Thurin M, Steplewski Z. Vaccination with carbohydrate peptide mimotopes promotes anti-tumor responses. Nat Biotechnol 1999; 17:660-5; PMID:10404158; http://dx.doi.org/10.1038/10870
   PubMed Web of Science ®Google Scholar
• Cekaite L, Haug O, Myklebost O, Aldrin M, Ostenstad B, Holden M, Frigessi A, Hovig E, Sioud M. Analysis of the humoral immune response to immunoselected phage-displayed peptides by a microarray-based method. Proteomics 2004; 4:2572-82; PMID:15352232; http://dx.doi.org/10.1002/pmic.200300768
   PubMed Web of Science ®Google Scholar
• Sioud M, Hansen M, Dybwad A. Profiling the immune responses in patient sera with peptide and cDNA display libraries. Int J Mol Med 2000; 6:123-8; PMID:10891554
   PubMed Web of Science ®Google Scholar
• Matochko WL, Chu K, Jin B, Lee SW, Whitesides GM, Derda R. Deep sequencing analysis of phage libraries using Illumina platform. Methods 2012; 58:47-55; PMID:22819855; http://dx.doi.org/10.1016/j.ymeth.2012.07.006
   PubMed Web of Science ®Google Scholar
• Ryvkin A, Ashkenazy H, Smelyanski L, Kaplan G, Penn O, Weiss-Ottolenghi Y, Privman E, Ngam PB, Woodward JE, May GD, et al. Deep Panning: steps towards probing the IgOme. PLoS One 2012; 7:e41469; PMID:22870226; http://dx.doi.org/10.1371/journal.pone.0041469
   PubMedGoogle Scholar
• Matochko WL, Cory Li S, Tang SK, Derda R. Prospective identification of parasitic sequences in phage display screens. Nucleic Acids Res 2014; 42:1784-98; PMID:24217917; http://dx.doi.org/10.1093/nar/gkt1104
   PubMed Web of Science ®Google Scholar
• Cretich M, Chiari M. Peptide Microarrays: Methods and Protocols. Springer New York, 2015.
   Google Scholar
• Halperin RF, Stafford P, Johnston SA. Exploring antibody recognition of sequence space through random-sequence peptide microarrays. Mol Cell Proteomics 2011; 10:M110 000786; PMID:21062935; http://dx.doi.org/10.1074/mcp.M110.000786
   PubMed Web of Science ®Google Scholar
• Legutki JB, Zhao ZG, Greving M, Woodbury N, Johnston SA, Stafford P. Scalable high-density peptide arrays for comprehensive health monitoring. Nat Commun 2014; 5:4785; PMID:25183057; http://dx.doi.org/10.1038/ncomms5785
   PubMed Web of Science ®Google Scholar
• Sykes KF, Legutki JB, Stafford P. Immunosignaturing: a critical review. Trends Biotechnol 2013; 31:45-51; PMID:23219199; http://dx.doi.org/10.1016/j.tibtech.2012.10.012
   PubMed Web of Science ®Google Scholar
• Singh H, Ansari HR, Raghava GP. Improved method for linear B-cell epitope prediction using antigen's primary sequence. PLoS One 2013; 8:e62216; PMID:23667458; http://dx.doi.org/10.1371/journal.pone.0062216
   PubMed Web of Science ®Google Scholar
• Hart GW, Copeland RJ. Glycomics Hits the Big Time. Cell 2010; 143:672-6; PMID:21111227; http://dx.doi.org/10.1016/j.cell.2010.11.008
   PubMed Web of Science ®Google Scholar
• Jandus C, Boligan KF, Chijioke O, Liu H, Dahlhaus M, Demoulins T, Schneider C, Wehrli M, Hunger RE, Baerlocher GM, et al. Interactions between Siglec-7/9 receptors and ligands influence NK cell-dependent tumor immunosurveillance. J Clin Invest 2014; 124(4):1810-20; PMID:24569453.
   PubMed Web of Science ®Google Scholar
• Rosen SD. Ligands for L-selectin: homing, inflammation, and beyond. Annu Rev Immunol 2004; 22:129-56; PMID:15032576; http://dx.doi.org/10.1146/annurev.immunol.21.090501.080131
   PubMed Web of Science ®Google Scholar
• St Hill CA, Krieser K, Farooqui M. Neutrophil interactions with sialyl Lewis X on human nonsmall cell lung carcinoma cells regulate invasive behavior. Cancer 2011; 117:4493-505; PMID:21437888; http://dx.doi.org/10.1002/cncr.26059
   PubMed Web of Science ®Google Scholar
• Carlin AF, Uchiyama S, Chang YC, Lewis AL, Nizet V, Varki A. Molecular mimicry of host sialylated glycans allows a bacterial pathogen to engage neutrophil Siglec-9 and dampen the innate immune response. Blood 2009; 113:3333-6; PMID:19196661; http://dx.doi.org/10.1182/blood-2008-11-187302
   PubMed Web of Science ®Google Scholar
• Feldman C, Anderson R. Review: Current and new generation pneumococcal vaccines. J Infect 2014; 69(4):309-25.
   PubMed Web of Science ®Google Scholar
• Gasparini R, Panatto D. Meningococcal glycoconjugate vaccines. Hum Vaccin 2011; 7:170-82; PMID:21178398; http://dx.doi.org/10.4161/hv.7.2.13717
   PubMed Web of Science ®Google Scholar
• Boligan K, Mesa C, Fernandez L, von Gunten S. Cancer intelligence acquired (CIA): tumor glycosylation and sialylation codes dismantling antitumor defense. Cell Mol Life Sci 2014; 72:1-18
   PubMed Web of Science ®Google Scholar
• Song X, Xia B, Lasanajak Y, Smith DF, Cummings RD. Quantifiable fluorescent glycan microarrays. Glycoconjugate Journal 2008; 25:15-25; PMID:17763939; http://dx.doi.org/10.1007/s10719-007-9066-8
   PubMed Web of Science ®Google Scholar
• Solís D, Bovin NV, Davis AP, Jiménez-Barbero J, Romero A, Roy R, Smetana K Jr, Gabius HJ. A guide into glycosciences: How chemistry, biochemistry and biology cooperate to crack the sugar code. Biochimica et Biophysica Acta (BBA) - General Subjects 2015; 1850:186-235; http://dx.doi.org/10.1016/j.bbagen.2014.03.016
   PubMed Web of Science ®Google Scholar
• Stowell SR, Arthur CM, McBride R, Berger O, Razi N, Heimburg-Molinaro J, Rodrigues LC, Gourdine JP, Noll AJ, von Gunten S, et al. Microbial glycan microarrays define key features of host-microbial interactions. Nat Chem Biol 2014; 10:470-6; PMID:24814672; http://dx.doi.org/10.1038/nchembio.1525
   PubMed Web of Science ®Google Scholar
• Grader-Beck T, Boin F, von Gunten S, Smith D, Rosen A, Bochner BS. Antibodies recognising sulfated carbohydrates are prevalent in systemic sclerosis and associated with pulmonary vascular disease. Ann Rheum Dis 2011; 70:2218-24; PMID:21873333; http://dx.doi.org/10.1136/ard.2011.153130
   PubMed Web of Science ®Google Scholar
• Bochner BS, Alvarez RA, Mehta P, Bovin NV, Blixt O, White JR, Schnaar RL. Glycan array screening reveals a candidate ligand for Siglec-8. J Biol Chem 2005; 280:4307-12; PMID:15563466; http://dx.doi.org/10.1074/jbc.M412378200
   PubMed Web of Science ®Google Scholar
• Blixt O, Head S, Mondala T, Scanlan C, Huflejt ME, Alvarez R, Bryan MC, Fazio F, Calarese D, Stevens J, et al. Printed covalent glycan array for ligand profiling of diverse glycan binding proteins. Proc Natl Acad Sci U S A 2004; 101:17033-8; PMID:15563589; http://dx.doi.org/10.1073/pnas.0407902101
   PubMed Web of Science ®Google Scholar
• Oyelaran O, McShane LM, Dodd L, Gildersleeve JC. Profiling human serum antibodies with a carbohydrate antigen microarray. J Proteome Res 2009; 8:4301-10; PMID:19624168; http://dx.doi.org/10.1021/pr900515y
   PubMed Web of Science ®Google Scholar
• Arthur CM, Cummings RD, Stowell SR. Using glycan microarrays to understand immunity. Curr Opin Chem Biol 2014; 18:55-61; PMID:24486647; http://dx.doi.org/10.1016/j.cbpa.2013.12.017
   PubMed Web of Science ®Google Scholar
• Drickamer K, Taylor ME. Glycan arrays for functional glycomics. Genome Biol 2002; 3:REVIEWS1034; PMID:12537579; http://dx.doi.org/10.1186/gb-2002-3-12-reviews1034
   PubMedGoogle Scholar
• Fukui S, Feizi T, Galustian C, Lawson AM, Chai W. Oligosaccharide microarrays for high-throughput detection and specificity assignments of carbohydrate-protein interactions. Nat Biotech 2002; 20:1011-7; http://dx.doi.org/10.1038/nbt735
   PubMed Web of Science ®Google Scholar
• Wang L, Cummings RD, Smith DF, Huflejt M, Campbell CT, Gildersleeve JC, Gerlach JQ, Kilcoyne M, Joshi L, Serna S, et al. Cross-platform comparison of glycan microarray formats. Glycobiology 2014; 24:507-17; PMID:24658466; http://dx.doi.org/10.1093/glycob/cwu019
   PubMed Web of Science ®Google Scholar
• Zhang Y, Gildersleeve JC. General Procedure for the Synthesis of Neoglycoproteins and Immobilization on Epoxide-Modified Glass Slides. In: Chevolot Y, ed. Carbohydrate Microarrays: Methods and Protocols. Totowa, NJ: Humana Press, 2012:155-65.
   Google Scholar
• Song X, Lasanajak Y, Xia B, Heimburg-Molinaro J, Rhea JM, Ju H, Zhao C, Molinaro RJ, Cummings RD, Smith DF. Shotgun glycomics: a microarray strategy for functional glycomics. Nat Meth 2011; 8:85-90; http://dx.doi.org/10.1038/nmeth.1540
   PubMed Web of Science ®Google Scholar
• Pletz MW, Maus U, Krug N, Welte T, Lode H. Pneumococcal vaccines: mechanism of action, impact on epidemiology and adaption of the species. Int J Antimicrob Agents 2008; 32:199-206; PMID:18378430; http://dx.doi.org/10.1016/j.ijantimicag.2008.01.021
   PubMed Web of Science ®Google Scholar
• Mykietiuk A, Carratalà J, Domínguez A, Manzur A, Fernández-Sabé N, Dorca J, Tubau F, Manresa F, Gudiol F. Effect of prior pneumococcal vaccination on clinical outcome of hospitalized adults with community-acquired pneumococcal pneumonia. Euro J Clin Microbiol Infect Dis 2006; 25:457-62; PMID:16773389; http://dx.doi.org/10.1007/s10096-006-0161-8
   PubMed Web of Science ®Google Scholar
• Kamboj KK, Kirchner HL, Kimmel R, Greenspan NS, Schreiber JR. Significant Variation in Serotype-Specific Immunogenicity of the Seven-Valent Streptococcus pneumoniae Capsular Polysaccharide-CRM197 Conjugate Vaccine Occurs Despite Vigorous T Cell Help Induced by the Carrier Protein. J Infect Dis 2003; 187:1629-38; PMID:12721943; http://dx.doi.org/10.1086/374785
   PubMed Web of Science ®Google Scholar
• Gilewski T, Ragupathi G, Bhuta S, Williams LJ, Musselli C, Zhang XF, Bornmann WG, Spassova M, Bencsath KP, Panageas KS, et al. Immunization of metastatic breast cancer patients with a fully synthetic globo H conjugate: a phase I trial. Proc Natl Acad Sci U S A 2001; 98:3270-5; PMID:11248068; http://dx.doi.org/10.1073/pnas.051626298
   PubMed Web of Science ®Google Scholar
• Jeon I, Iyer K, Danishefsky SJ. A Practical Total Synthesis of Globo-H for Use in Anticancer Vaccines. J Organic Chem 2009; 74:8452-5; PMID:19874068; http://dx.doi.org/10.1021/jo901682p
   PubMed Web of Science ®Google Scholar
• Wang LX, Ni J, Singh S, Li H. Binding of high-mannose-type oligosaccharides and synthetic oligomannose clusters to human antibody 2G12: implications for HIV-1 vaccine design. Chem Biol 2004; 11:127-34; PMID:15113002.
   PubMed Web of Science ®Google Scholar
• Zhang Y, Wang F. Carbohydrate drugs: current status and development prospect. Drug Discov Ther 2015; 9:79-87; PMID:25994058; http://dx.doi.org/10.5582/ddt.2015.01028
   PubMed Web of Science ®Google Scholar
• Fuentes D, Avellanet J, Garcia A, Iglesias N, Gabri MR, Alonso DF, Vazquez AM, Perez R, Montero E. Combined therapeutic effect of a monoclonal anti-idiotype tumor vaccine against NeuGc-containing gangliosides with chemotherapy in a breast carcinoma model. Breast Cancer Res Treat 2010; 120:379-89; PMID:19377876; http://dx.doi.org/10.1007/s10549-009-0399-9
   PubMed Web of Science ®Google Scholar
• Geissner A, Pereira CL, Leddermann M, Anish C, Seeberger PH. Deciphering Antigenic Determinants of Streptococcus pneumoniae Serotype 4 Capsular Polysaccharide using Synthetic Oligosaccharides. ACS Chem Biol 2016; 11:335-44; PMID:26674834; http://dx.doi.org/10.1021/acschembio.5b00768
   PubMed Web of Science ®Google Scholar
• Chang J, Serrano Y, Garrido R, Rodríguez LM, Pedroso J, Cardoso F, Valdés Y, García D, Fernández-Santana V, Verez-Bencomo V. Relevance of O-acetyl and phosphoglycerol groups for the antigenicity of Streptococcus pneumoniae serotype 18C capsular polysaccharide. Vaccine 2012; 30:7090-6; PMID:23036500; http://dx.doi.org/10.1016/j.vaccine.2012.09.047
   PubMed Web of Science ®Google Scholar