1,695
Views
5
CrossRef citations to date
0
Altmetric
Research Papers

Panblok-H1+advax H1N1/2009pdm vaccine: Insights into rapid development of a delta inulin adjuvanted recombinant pandemic influenza vaccine

, , , , &
Pages 1261-1271 | Received 29 Jun 2016, Accepted 31 Dec 2016, Published online: 16 Mar 2017

References

  • Vierk KA, Koehler KM, Fein SB, Street DA. Prevalence of self-reported food allergy in American adults and use of food labels. J Allergy Clin Immunol 2007; 119(6):1504-10; PMID:17451802; https://doi.org/10.1016/j.jaci.2007.03.011
  • Vesikari T, Block SL, Guerra F, Lattanzi M, Holmes S, Izu A, Gaitatzis N, Hilbert AK, Groth N. Immunogenicity, Safety, and Reactogenicity of a Mammalian Cell-Culture-Derived Influenza Vaccine in Healthy Children and Adolescents 3 to 17 Years of Age. Pediatr Infect Dis J 2012; 31(5):494-500; PMID:22301476; https://doi.org/10.1097/INF.0b013e31824bb179
  • Kida H, Webster RG, Yanagawa R. Inhibition of virus-induced hemolysis with monoclonal antibodies to different antigenic areas on the hemagglutinin molecule of A/seal/Massachusetts/1/80 (H7N7) influenza virus. Arch Virol 1983; 76(2):91-9; PMID:6191738; https://doi.org/10.1007/BF01311693
  • Yoden S, Kida H, Kuwabara M, Yanagawa R, Webster RG. Spin-labeling of influenza virus hemagglutinin permits analysis of the conformational change at low pH and its inhibition by antibody. Virus Res 1986; 4(3):251-61; PMID:3017016; https://doi.org/10.1016/0168-1702(86)90004-3
  • Institute of Medicine (US) Forum on Medical and Public Health Preparedness for Catastrophic Events; Institute of Medicine (US) Forum on Drug Discovery, Development, and Translation. The Public Health Emergency Medical Countermeasures Enterprise: Innovative Strategies to Enhance Products from Discovery Through Approval: Workshop Summary. Washington (DC): National Academies Press (US); 2010; PMID:22171399; https://doi.org/10.17226/12856
  • Treanor JJ, El Sahly H, King J, Graham I, Izikson R, Kohberger R, Patriarca P, Cox M. Protective efficacy of a trivalent recombinant hemagglutinin protein vaccine (FluBlok(R)) against influenza in healthy adults: a randomized, placebo-controlled trial. Vaccine 2011; 29(44):7733-9; PMID:21835220; https://doi.org/10.1016/j.vaccine.2011.07.128
  • Crawford J, Wilkinson B, Vosnesensky A, Smith G, Garcia M, Stone H, Perdue ML. Baculovirus-derived hemagglutinin vaccines protect against lethal influenza infections by avian H5 and H7 subtypes. Vaccine 1999; 17(18):2265-74; PMID:10403594; https://doi.org/10.1016/S0264-410X(98)00494-0
  • Treanor JJ, Wilkinson BE, Masseoud F, Hu-Primmer J, Battaglia R, O'Brien D, Wolff M, Rabinovich G, Blackwelder W, Katz JM. Safety and immunogenicity of a recombinant hemagglutinin vaccine for H5 influenza in humans. Vaccine 2001; 19(13–14):1732-7; PMID:11166898; https://doi.org/10.1016/S0264-410X(00)00395-9
  • Petrovsky N, Aguilar JC. Vaccine adjuvants: current state and future trends. Immunol Cell Biol 2004; 82(5):488-96; PMID:15479434; https://doi.org/10.1111/j.0818-9641.2004.01272.x
  • Cooper PD, Petrovsky N. Delta inulin: a novel, immunologically active, stable packing structure comprising beta-D-[2 ->1] poly(fructo-furanosyl) alpha-D-glucose polymers. Glycobiology 2011; 21(5):595-606; PMID:21147758; https://doi.org/10.1093/glycob/cwq201
  • Honda-Okubo Y, Kolpe A, Li L, Petrovsky N. A single immunization with inactivated H1N1 influenza vaccine formulated with delta inulin adjuvant (Advax) overcomes pregnancy-associated immune suppression and enhances passive neonatal protection. Vaccine 2014; 32(36):4651-9; PMID:24958701; https://doi.org/10.1016/j.vaccine.2014.06.057
  • Honda-Okubo Y, Ong CH, Petrovsky N. Advax delta inulin adjuvant overcomes immune immaturity in neonatal mice thereby allowing single-dose influenza vaccine protection. Vaccine 2015; 33(38):4892-900; PMID:26232344; https://doi.org/10.1016/j.vaccine.2015.07.051
  • Honda-Okubo Y, Saade F, Petrovsky N. Advax, a polysaccharide adjuvant derived from delta inulin, provides improved influenza vaccine protection through broad-based enhancement of adaptive immune responses. Vaccine 2012; 30(36):5373-81; PMID:22728225; https://doi.org/10.1016/j.vaccine.2012.06.021
  • Saade F, Honda-Okubo Y, Trec S, Petrovsky N. A novel hepatitis B vaccine containing Advax, a polysaccharide adjuvant derived from delta inulin, induces robust humoral and cellular immunity with minimal reactogenicity in preclinical testing. Vaccine 2013; PMID:23306367
  • Honda-Okubo Y, Barnard D, Ong CH, Peng BH, Tseng CT, Petrovsky N. Severe acute respiratory syndrome-associated coronavirus vaccines formulated with delta inulin adjuvants provide enhanced protection while ameliorating lung eosinophilic immunopathology. J Virol 2015; 89(6):2995-3007; PMID:25520500; https://doi.org/10.1128/JVI.02980-14
  • Bielefeldt-Ohmann H, Prow NA, Wang W, Tan CS, Coyle M, Douma A, Hobson-Peters J, Kidd L, Hall RA, Petrovsky N. Safety and immunogenicity of a delta inulin-adjuvanted inactivated Japanese encephalitis virus vaccine in pregnant mares and foals. Vet Res 2014; 45:130; PMID:25516480; https://doi.org/10.1186/s13567-014-0130-7
  • Petrovsky N, Larena M, Siddharthan V, Prow NA, Hall RA, Lobigs M, Morrey J. An inactivated cell culture Japanese encephalitis vaccine (JE-ADVAX) formulated with delta inulin adjuvant provides robust heterologous protection against West Nile encephalitis via cross-protective memory B cells and neutralizing antibody. J Virol 2013; 87(18):10324-33; PMID:23864620; https://doi.org/10.1128/JVI.00480-13
  • Wong TM, Petrovsky N, Bissel SJ, Wiley CA, Ross TM. Delta inulin-derived adjuvants that elicit Th1 phenotype following vaccination reduces respiratory syncytial virus lung titers without a reduction in lung immunopathology. Hum Vaccin Immunother 2016; 12(8):2096-2105, 1–10; PMID:27215855; https://doi.org/10.1080/21645515.2016.1162931
  • Feinen B, Petrovsky N, Verma A, Merkel TJ. Advax-adjuvanted recombinant protective antigen provides protection against inhalational anthrax that is further enhanced by addition of murabutide adjuvant. Clin Vaccine Immunol 2014; 21(4):580-6; PMID:24554695; https://doi.org/10.1128/CVI.00019-14
  • Rodriguez-Del Rio E, Marradi M, Calderon-Gonzalez R, Frande-Cabanes E, Penadés S, Petrovsky N, Alvarez-Dominguez C. A gold glyco-nanoparticle carrying a Listeriolysin O peptide and formulated with Advax delta inulin adjuvant induces robust T-cell protection against listeria infection. Vaccine 2015; 33(12):1465-73; PMID:25659269; https://doi.org/10.1016/j.vaccine.2015.01.062
  • Cristillo AD, Ferrari MG, Hudacik L, Lewis B, Galmin L, Bowen B, Thompson D, Petrovsky N, Markham P, Pal R. Induction of mucosal and systemic antibody and T-cell responses following prime-boost immunization with novel adjuvanted human immunodeficiency virus-1-vaccine formulations. J Gen Virol 2011; 92(Pt 1):128-40; PMID:21169215; https://doi.org/10.1099/vir.0.023242-0
  • Cosseddu GM, Polci A, Pinoni C, Capobianco Dondona A, Iapaolo F, Orsini G, Izzo F, Bortone G, Ronchi FG, Di Ventura M, et al. Evaluation of humoral response and protective efficacy of an inactivated vaccine against Peste des Petits Ruminants virus in goats. Transbound Emerg Dis 2016; 63(5):e447-52; PMID:25594237; https://doi.org/10.1111/tbed.12314
  • Petrovsky N, Cooper PD. Advax, a novel microcrystalline polysaccharide particle engineered from delta inulin, provides robust adjuvant potency together with tolerability and safety. Vaccine 2015; 33(44):5920-6; PMID:26407920; https://doi.org/10.1016/j.vaccine.2015.09.030
  • Layton RC, Petrovsky N, Gigliotti AP, Pollock Z, Knight J, Donart N, Pyles J, Harrod KS, Gao P, Koster F. Delta inulin polysaccharide adjuvant enhances the ability of split-virion H5N1 vaccine to protect against lethal challenge in ferrets. Vaccine 2011; 29(37):6242-51; PMID:21736913; https://doi.org/10.1016/j.vaccine.2011.06.078
  • Gordon D, Kelley P, Heinzel S, Cooper P, Petrovsky N. Immunogenicity and safety of Advax, a novel polysaccharide adjuvant based on delta inulin, when formulated with hepatitis B surface antigen: A randomized controlled Phase 1 study. Vaccine 2014; 32(48):6469-77, Sep 27. pii: S0264-410X(14)01293-6; PMID:25267153; https://doi.org/10.1016/j.vaccine.2014.09.034
  • Gordon DL, Sajkov D, Honda-Okubo Y, Wilks SH, Aban M, Barr IG, Petrovsky N. Human Phase 1 trial of low-dose inactivated seasonal influenza vaccine formulated with Advax delta inulin adjuvant. Vaccine 2016; 34(33):3780-6; PMID:27342914; https://doi.org/10.1016/j.vaccine.2016.05.071
  • Heddle R, Russo P, Petrovsky N, Hanna R, Smith A. Immunotherapy – 2076. A controlled study of delta inulin-adjuvanted honey bee venom immunotherapy. World Allergy Organ J 2013; 6(Suppl 1):P158-P158; https://doi.org/10.1186/1939-4551-6-S1-P158
  • Cohen J, Enserink M. Swine flu. After delays, WHO agrees: the 2009 pandemic has begun. Science 2009; 324(5934):1496-7; PMID:19541958; https://doi.org/10.1126/science.324_1496
  • Effectiveness of 2008–09 trivalent influenza vaccine against 2009 pandemic influenza A (H1N1) - United States, May-June 2009. MMWR Morb Mortal Wkly Rep 2009; 58(44):1241-5; PMID:19910912
  • Chowell G, Bertozzi SM, Colchero MA, Lopez-Gatell H, Alpuche-Aranda C, Hernandez M, Miller MA. Severe respiratory disease concurrent with the circulation of H1N1 influenza. N Engl J Med 2009; 361(7):674-9; PMID:19564633; https://doi.org/10.1056/NEJMoa0904023
  • Rajapaksha H, Petrovsky N. In silico structural homology modelling and docking for assessment of pandemic potential of a novel H7N9 influenza virus and its ability to be neutralized by existing anti-hemagglutinin antibodies. PLoS One 2014; 9(7):e102618; PMID:25047593; https://doi.org/10.1371/journal.pone.0102618
  • Barclay TG, Rajapaksha H, Thilagam A, Qian G, Ginic-Markovic M, Cooper PD, Gerson A, Petrovsky N. Physical characterization and in silico modeling of inulin polymer conformation during vaccine adjuvant particle formation. Carbohydr Polym 2016; 143:108-15; PMID:27083349; https://doi.org/10.1016/j.carbpol.2016.01.062
  • Webster RG, Cox N, Stöhr K. WHO Manual on Animal Influenza Diagnosis and Surveillance (WHO/CDS/CSR/NCS/2002.5). 2002; Rev. 1:p37-9. Available from: http://www.who.int/iris/handle/10665/68026
  • Gordon DL, Sajkov D, Woodman RJ, Honda-Okubo Y, Cox MM, Heinzel S, Petrovsky N. Randomized clinical trial of immunogenicity and safety of a recombinant H1N1/2009 pandemic influenza vaccine containing Advax polysaccharide adjuvant. Vaccine 2012; 30(36):5407-16; PMID:22717330; https://doi.org/10.1016/j.vaccine.2012.06.009
  • Tan S, Gordon DL, Honda-Okubo Y, Petrovsky N, Phillips P, Huddleston S, Sadlon TA. Serological responses following influenza A H1N1 2009 infection in adults. J Infect 2011; 62(5):388-93; PMID:21420426; https://doi.org/10.1016/j.jinf.2011.03.002
  • He W, Mullarkey CE, Miller MS. Measuring the neutralization potency of influenza A virus hemagglutinin stalk/stem-binding antibodies in polyclonal preparations by microneutralization assay. Methods 2015; 90:95-100; PMID:25957674; https://doi.org/10.1016/j.ymeth.2015.04.037
  • Zhu FC, Wang H, Fang HH, Yang JG, Lin XJ, Liang XF, Zhang XF, Pan HX, Meng FY, Hu YM, et al. A novel influenza A (H1N1) vaccine in various age groups. N Engl J Med 2009; 361(25):2414-23; PMID:19846844; https://doi.org/10.1056/NEJMoa0908535
  • Li L, Honda-Okubo Y, Li C, Sajkov D, Petrovsky N. Delta Inulin Adjuvant Enhances Plasmablast Generation, Expression of Activation-Induced Cytidine Deaminase and B-Cell affinity maturation in human subjects receiving seasonal influenza vaccine. PLoS One 2015; 10(7):e0132003; PMID:26177480; https://doi.org/10.1371/journal.pone.0132003
  • Stephenson I, Das RG, Wood JM, Katz JM. Comparison of neutralising antibody assays for detection of antibody to influenza A/H3N2 viruses: an international collaborative study. Vaccine 2007; 25(20):4056-63; PMID:17412461; https://doi.org/10.1016/j.vaccine.2007.02.039
  • Verschoor CP, Singh P, Russell ML, Bowdish DM, Brewer A, Cyr L, Ward BJ, Loeb M. Microneutralization assay titres correlate with protection against seasonal influenza H1N1 and H3N2 in children. PLoS One 2015; 10(6):e0131531; PMID:26107625; https://doi.org/10.1371/journal.pone.0131531
  • Wilkinson TM, Li CK, Chui CS, Huang AK, Perkins M, Liebner JC, Lambkin-Williams R, Gilbert A, Oxford J, Nicholas B, et al. Preexisting influenza-specific CD4+ T cells correlate with disease protection against influenza challenge in humans. Nat Med 2012; 18(2):274-80; PMID:22286307; https://doi.org/10.1038/nm.2612
  • Langley JM, Risi G, Caldwell M, Gilderman L, Berwald B, Fogarty C, Poling T, Riff D, Baron M, Frenette L, et al. Dose-sparing H5N1 A/Indonesia/05/2005 pre-pandemic influenza vaccine in adults and elderly adults: a phase III, placebo-controlled, randomized study. J Infect Dis 2011; 203(12):1729-38; PMID:21606531; https://doi.org/10.1093/infdis/jir172
  • Geeraedts F, Bungener L, Pool J, ter Veer W, Wilschut J, Huckriede A. Whole inactivated virus influenza vaccine is superior to subunit vaccine in inducing immune responses and secretion of proinflammatory cytokines by DCs. Influenza Other Respi Viruses 2008; 2(2):41-51; https://doi.org/10.1111/j.1750-2659.2008.00038.x
  • Koyama S, Ishii KJ, Kumar H, Tanimoto T, Coban C, Uematsu S, Kawai T, Akira S. Differential role of TLR- and RLR-signaling in the immune responses to influenza A virus infection and vaccination. J Immunol 2007; 179(7):4711-20; PMID:17878370; https://doi.org/10.4049/jimmunol.179.7.4711
  • Wang K, Holtz KM, Anderson K, Chubet R, Mahmoud W, Cox MM. Expression and purification of an influenza hemagglutinin–one step closer to a recombinant protein-based influenza vaccine. Vaccine 2006; 24(12):2176-85; PMID:16310896; https://doi.org/10.1016/j.vaccine.2005.11.005
  • Feshchenko E, Rhodes DG, Felberbaum R, McPherson C, Rininger JA, Post P, Cox MM. Pandemic influenza vaccine: characterization of A/California/07/2009 (H1N1) recombinant hemagglutinin protein and insights into H1N1 antigen stability. BMC Biotechnol 2012; 12:77; PMID:23110350; https://doi.org/10.1186/1472-6750-12-77
  • Goddard TD, Huang CC, Ferrin TE. Software extensions to UCSF chimera for interactive visualization of large molecular assemblies. Structure 2005; 13(3):473-82; PMID:15766548; https://doi.org/10.1016/j.str.2005.01.006
  • Trott O, Olson AJ. AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading. J Comput Chem 2010; 31(2):455-61; PMID:19499576

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.