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Research Papers

A trivalent subunit antigen glycoprotein vaccine as immunotherapy for genital herpes in the guinea pig genital infection model

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Pages 2785-2793 | Received 07 Feb 2017, Accepted 22 Apr 2017, Published online: 16 Jun 2017

References

  • Looker KJ, Magaret AS, Turner KM, Vickerman P, Gottlieb SL, Newman LM. Global estimates of prevalent and incident herpes simplex virus type 2 infections in 2012. PLoS One 2015; 10:e114989; PMID:25608026; https://doi.org/10.1371/journal.pone.0140765 10.1371/journal.pone.0114989 10.1371/journal.pone.0128615
  • Wald A. Genital HSV-1 infections. Sex Transm Infect 2006; 82:189-90; PMID:16731663; https://doi.org/10.1136/sti.2006.019935
  • Benedetti J, Corey L, Ashley R. Recurrence rates in genital herpes after symptomatic first-episode infection. Annals of internal medicine 1994; 121:847-54; PMID:7978697; https://doi.org/10.7326/0003-4819-121-11-199412010-00004
  • Gupta R, Warren T, Wald A. Genital herpes. Lancet 2007; 370:2127-37; PMID:18156035; https://doi.org/10.1016/S0140-6736(07)61908-4
  • Corey L, Adams HG, Brown ZA, Holmes KK. Genital herpes simplex virus infections: clinical manifestations, course, and complications. Ann Intern Med 1983; 98:958-72; PMID:6344712; https://doi.org/10.7326/0003-4819-98-6-958 10.7326/0003-4819-98-6-914
  • Tronstein E, Johnston C, Huang ML, Selke S, Magaret A, Warren T, Corey L, Wald A. Genital shedding of herpes simplex virus among symptomatic and asymptomatic persons with HSV-2 infection. Jama 2011; 305:1441-9; PMID:21486977; https://doi.org/10.1001/jama.2011.420
  • Tedder DG, Ashley R, Tyler KL, Levin MJ. Herpes simplex virus infection as a cause of benign recurrent lymphocytic meningitis. Ann Intern Med 1994; 121:334-8; PMID:8042822; https://doi.org/10.7326/0003-4819-121-5-199409010-00004
  • Brown ZA, Selke S, Zeh J, Kopelman J, Maslow A, Ashley RL, Watts DH, Berry S, Herd M, Corey L. The acquisition of herpes simplex virus during pregnancy. N Engl J Med 1997; 337:509-15; PMID:9262493; https://doi.org/10.1056/NEJM199712253372618 10.1056/NEJM199708213370801
  • Corey L, Wald A, Celum CL, Quinn TC. The effects of herpes simplex virus-2 on HIV-1 acquisition and transmission: a review of two overlapping epidemics. J Acquir Immune Defic Syndr 2004; 35:435-45; PMID:15021308; https://doi.org/10.1097/00126334-200404150-00001
  • Martin ET, Krantz E, Gottlieb SL, Magaret AS, Langenberg A, Stanberry L, Kamb M, Wald A. A pooled analysis of the effect of condoms in preventing HSV-2 acquisition. Archives of internal medicine 2009; 169:1233-40; PMID:19597073; https://doi.org/10.1001/archinternmed.2008.545 10.1001/archinternmed.2009.177
  • Tobian AA, Serwadda D, Quinn TC, Kigozi G, Gravitt PE, Laeyendecker O, Charvat B, Ssempijja V, Riedesel M, Oliver AE, et al. Male circumcision for the prevention of HSV-2 and HPV infections and syphilis. N Engl J Med 2009; 360:1298-309; PMID:19321868; https://doi.org/10.1056/NEJMoa0802556
  • Freeman EE, White RG, Bakker R, Orroth KK, Weiss HA, Buve A, Hayes RJ, Glynn JR. Population-level effect of potential HSV2 prophylactic vaccines on HIV incidence in sub-Saharan Africa. Vaccine 2009; 27:940-6; PMID:19071187; https://doi.org/10.1016/j.vaccine.2008.11.074
  • Corey L, Wald A, Patel R, Sacks SL, Tyring SK, Warren T, Douglas JM Jr, Paavonen J, Morrow RA, Beutner KR, et al. Once-daily valacyclovir to reduce the risk of transmission of genital herpes.[see comment]. New England Journal of Medicine 2004; 350:11-20; PMID:14702423; https://doi.org/10.1056/ENEJMicm020035 10.1056/NEJMoa035144
  • Reitano M, Tyring S, Lang W, Thoming C, Worm AM, Borelli S, Chambers LO, Robinson JM, Corey L. Valaciclovir for the suppression of recurrent genital herpes simplex virus infection: a large-scale dose range-finding study. International Valaciclovir HSV Study Group. J Infect Dis 1998; 178:603-10.
  • Skoberne M, Cardin R, Lee A, Kazimirova A, Zielinski V, Garvie D, Lundberg A, Larson S, Bravo FJ, Bernstein DI, et al. An adjuvanted herpes simplex virus 2 subunit vaccine elicits a T cell response in mice and is an effective therapeutic vaccine in Guinea pigs. J Virol 2013; 87:3930-42; PMID:23365421; https://doi.org/10.1128/JVI.02745-12
  • Yim KC, Carroll CJ, Tuyama A, Cheshenko N, Carlucci MJ, Porter DD, Prince GA, Herold BC. The cotton rat provides a novel model to study genital herpes infection and to evaluate preventive strategies. J Virol 2005; 79:14632-9; PMID:16282463; https://doi.org/10.1128/JVI.79.23.14632-14639.2005
  • Boukhvalova M, McKay J, Mbaye A, Sanford-Crane H, Blanco JC, Huber A, Herold BC. Efficacy of the Herpes Simplex Virus 2 (HSV-2) Glycoprotein D/AS04 Vaccine against Genital HSV-2 and HSV-1 Infection and Disease in the Cotton Rat Sigmodon hispidus Model. J Virol 2015; 89:9825-40; PMID:26178984; https://doi.org/10.1128/JVI.01387-15
  • Stanberry LR, Kern ER, Richards JT, Abbott TM, Overall JC, Jr. Genital herpes in guinea pigs: pathogenesis of the primary infection and description of recurrent disease. J Infect Dis 1982; 146:397-404; PMID:6286797; https://doi.org/10.1093/infdis/146.3.397
  • Awasthi S, Huang J, Shaw C, Friedman HM. Blocking herpes simplex virus 2 glycoprotein E immune evasion as an approach to enhance efficacy of a trivalent subunit antigen vaccine for genital herpes. J Virol 2014; 88:8421-32; PMID:24829358; https://doi.org/10.1128/JVI.03163-13 10.1128/JVI.01130-14
  • Feldman LT, Ellison AR, Voytek CC, Yang L, Krause P, Margolis TP. Spontaneous molecular reactivation of herpes simplex virus type 1 latency in mice. Proc Natl Acad Sci U S A 2002; 99:978-83; PMID:11773630; https://doi.org/10.1073/pnas.022301899
  • Awasthi S, Hook LM, Shaw CE, Pahar B, Stagray JA, Liu D, Veazey RS, Friedman HM. An HSV-2 Trivalent Vaccine Is Immunogenic in Rhesus Macaques and Highly Efficacious in Guinea Pigs. PLoS Pathog 2017; 13:e1006141; PMID:28103319; https://doi.org/10.1371/journal.ppat.1006141
  • Eisenberg RJ, Atanasiu D, Cairns TM, Gallagher JR, Krummenacher C, Cohen GH. Herpes virus fusion and entry: a story with many characters. Viruses 2012; 4:800-32; PMID:22754650; https://doi.org/10.3390/v4050800
  • Awasthi S, Lubinski JM, Shaw CE, Barrett SM, Cai M, Wang F, Betts M, Kingsley S, Distefano DJ, Balliet JW, et al. Immunization with a Vaccine Combining Herpes Simplex Virus 2 (HSV-2) Glycoprotein C (gC) and gD Subunits Improves the Protection of Dorsal Root Ganglia in Mice and Reduces the Frequency of Recurrent Vaginal Shedding of HSV-2 DNA in Guinea Pigs Compared to Immunization with gD Alone. J Virol 2011; 85:10472-86; PMID:21813597; https://doi.org/10.1128/JVI.00849-11
  • Phipps W, Saracino M, Magaret A, Selke S, Remington M, Huang ML, Warren T, Casper C, Corey L. Persistent genital herpes simplex virus-2 shedding years following the first clinical episode. J Infect Dis 2011; 203:180-7; PMID:21288817; https://doi.org/10.1093/infdis/jiq035
  • Douglas JM, Critchlow C, Benedetti J, Mertz GJ, Connor JD, Hintz MA, Fahnlander A, Remington M, Winter C, Corey L. A double-blind study of oral acyclovir for suppression of recurrences of genital herpes simplex virus infection. N Engl J Med 1984; 310:1551-6; PMID:6328298; https://doi.org/10.1056/NEJM198406143102402
  • Bernstein DI, Farley N, Bravo FJ, Earwood J, McNeal M, Fairman J, Cardin R. The adjuvant CLDC increases protection of a herpes simplex type 2 glycoprotein D vaccine in guinea pigs. Vaccine 2010; 28:3748-53; PMID:19857450; https://doi.org/10.1016/j.vaccine.2009.10.025
  • Cohen JI. Vaccination to reduce reactivation of herpes simplex virus 2. J Infect Dis 2017; 215:844-6.
  • Awasthi S, Friedman HM. Status of prophylactic and therapeutic genital herpes vaccines. Curr Opin Virol 2014; 6:6-12; PMID:24631871; https://doi.org/10.1016/j.coviro.2014.02.006
  • Bernstein DI, Wald A, Warren T, Fife K, Tyring S, Lee P, Van Wagoner N, Magaret A, Flechtner JB, Tasker S, et al. Therapeutic vaccine for genital herpes simplex virus-2 infection: Findings from a randomized trial. J Infect Dis 2017; PMID:28329211; https://doi.org/10.1093/infdis/jix004
  • Wald A, Link K. Risk of human immunodeficiency virus infection in herpes simplex virus type 2-seropositive persons: a meta-analysis. J Infect Dis 2002; 185:45-52; PMID:11756980; https://doi.org/10.1086/338231
  • Celum C, Wald A, Hughes J, Sanchez J, Reid S, Delany-Moretlwe S, Cowan F, Casapia M, Ortiz A, Fuchs J, et al. Effect of aciclovir on HIV-1 acquisition in herpes simplex virus 2 seropositive women and men who have sex with men: a randomised, double-blind, placebo-controlled trial. Lancet 2008; 371:2109-19; PMID:18572080; https://doi.org/10.1016/S0140-6736(08)60920-4
  • Celum C, Wald A, Lingappa JR, Magaret AS, Wang RS, Mugo N, Mujugira A, Baeten JM, Mullins JI, Hughes JP, et al. Acyclovir and transmission of HIV-1 from persons infected with HIV-1 and HSV-2. N Engl J Med 2010; 362:427-39; PMID:20089951; https://doi.org/10.1056/NEJMoa0904849
  • Freeman EE, Orroth KK, White RG, Glynn JR, Bakker R, Boily MC, Habbema D, Buvé A, Hayes R. Proportion of new HIV infections attributable to herpes simplex 2 increases over time: simulations of the changing role of sexually transmitted infections in sub-Saharan African HIV epidemics. Sex Transm Infect 2007; 83 Suppl 1:i17-24; PMID:17405782; https://doi.org/10.1136/sti.2006.023549
  • Freeman EE, Weiss HA, Glynn JR, Cross PL, Whitworth JA, Hayes RJ. Herpes simplex virus 2 infection increases HIV acquisition in men and women: systematic review and meta-analysis of longitudinal studies. Aids 2006; 20:73-83; PMID:16327322; https://doi.org/10.1097/01.aids.0000198081.09337.a7
  • Stanberry LR, Spruance SL, Cunningham AL, Bernstein DI, Mindel A, Sacks S, Tyring S, Aoki FY, Slaoui M, Denis M, et al. Glycoprotein-D-adjuvant vaccine to prevent genital herpes. N Engl J Med 2002; 347:1652-61; PMID:12444179; https://doi.org/10.1056/NEJMoa011915
  • Belshe RB, Leone PA, Bernstein DI, Wald A, Levin MJ, Stapleton JT, Gorfinkel I, Morrow RL, Ewell MG, Stokes-Riner A, et al. Efficacy results of a trial of a herpes simplex vaccine. N Engl J Med 2012; 366:34-43; PMID:22216840; https://doi.org/10.1056/NEJMicm1104023 10.1056/NEJMoa1103151
  • Corey L, Langenberg AG, Ashley R, Sekulovich RE, Izu AE, Douglas JM, Jr., Handsfield HH, Warren T, Marr L, Tyring S, et al. Recombinant glycoprotein vaccine for the prevention of genital HSV-2 infection: two randomized controlled trials. Chiron HSV Vaccine Study Group. Jama 1999; 282:331-40.
  • Cunningham AL, Lal H, Kovac M, Chlibek R, Hwang SJ, Diez-Domingo J, Godeaux O, Levin MJ, McElhaney JE, Puig-Barberà J, et al. Efficacy of the Herpes Zoster Subunit Vaccine in Adults 70 Years of Age or Older. N Engl J Med 2016; 375:1019-32; PMID:27626517; https://doi.org/10.1056/NEJMoa1603800
  • Lal H, Cunningham AL, Godeaux O, Chlibek R, Diez-Domingo J, Hwang SJ, Levin MJ, McElhaney JE, Poder A, Puig-Barberà J, et al. Efficacy of an Adjuvanted Herpes Zoster Subunit Vaccine in Older Adults. N Engl J Med 2015; 372(22):2087-96; https://doi.org/10.1056/NEJMoa1501184 10.1056/NEJMicm1400091
  • Schiffer JT, Mayer BT, Fong Y, Swan DA, Wald A. Herpes simplex virus-2 transmission probability estimates based on quantity of viral shedding. J R Soc Interface 2014; 11:20140160; https://doi.org/10.1098/rsif.2014.0160
  • Wald A, Huang ML, Carrell D, Selke S, Corey L. Polymerase chain reaction for detection of herpes simplex virus (HSV) DNA on mucosal surfaces: comparison with HSV isolation in cell culture. J Infect Dis 2003; 188:1345-51; PMID:14593592; https://doi.org/10.1086/379043
  • Wald A, Zeh J, Selke S, Ashley RL, Corey L. Virologic characteristics of subclinical and symptomatic genital herpes infections. N Engl J Med 1995; 333:770-5; PMID:7643884; https://doi.org/10.1056/NEJM199509213331205
  • Iwasaki A. Exploiting Mucosal Immunity for Antiviral Vaccines. Annu Rev Immunol 2016; 34:575-608; PMID:27168245; https://doi.org/10.1146/annurev-immunol-032414-112315
  • Awasthi S, Mahairas GG, Shaw CE, Huang ML, Koelle DM, Posavad C, Corey L, Friedman HM. A Dual-Modality Herpes Simplex Virus 2 Vaccine for Preventing Genital Herpes by Using Glycoprotein C and D Subunit Antigens To Induce Potent Antibody Responses and Adenovirus Vectors Containing Capsid and Tegument Proteins as T Cell Immunogens. J Virol 2015; 89:8497-509; PMID:26041292; https://doi.org/10.1128/JVI.01089-15
  • Awasthi S, Balliet JW, Flynn JA, Lubinski JM, Shaw CE, DiStefano DJ, Cai M, Brown M, Smith JF, Kowalski R, et al. Protection provided by a herpes simplex virus 2 (HSV-2) glycoprotein C and D subunit antigen vaccine against genital HSV-2 infection in HSV-1-seropositive guinea pigs. J Virol 2014; 88:2000-10; PMID:24284325; https://doi.org/10.1128/JVI.03163-13 10.1128/JVI.01130-14