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Research Paper

Modeling specific antibody responses to natural immunization to predict a correlate of protection against infection before commencing a clinical vaccine trial

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Pages 2316-2321 | Received 15 Dec 2016, Accepted 07 May 2017, Published online: 18 Oct 2017

References

  • Cappelletty D. Microbiology of bacterial respiratory infections. Pediatr Infect Dis J 1998; 17:S55-61; PMID:9727651; https://doi.org/10.1097/00006454-199808001-00002
  • Margolis E , Yates A , Levin BR . The ecology of nasal colonization of Streptococcus pneumoniae, Haemophilus influenzae and Staphylococcus aureus: the role of competition and interactions with host's immune response. BMC Microbiology 2010; 10:59; PMID:20178591; https://doi.org/10.1186/1471-2180-10-59
  • Bogaert D , De Groot R , Hermans PW . Streptococcus pneumoniae colonisation: the key to pneumococcal disease. Lancet Infect Dis 2004; 4:144-54; PMID:14998500; https://doi.org/10.1016/S1473-3099(04)00938-7
  • Garcia-Rodriguez JA , Fresnadillo Martinez MJ . Dynamics of nasopharyngeal colonization by potential respiratory pathogens. J Antimicrob Chemother 2002; 50 Suppl S2:59-73; PMID:12556435; https://doi.org/10.1093/jac/dkf506
  • Murphy TF , Bakaletz LO , Smeesters PR . Microbial interactions in the respiratory tract. Pediatr Infect Dis J 2009; 28:S121-6; PMID:19918134; https://doi.org/10.1097/INF.0b013e3181b6d7ec
  • Kaur R , Casey JR , Pichichero ME . Serum antibody response to five Streptococcus pneumoniae proteins during acute otitis media in otitis-prone and non-otitis-prone children. Pediatr Infect Dis J 2011; 30:645-50; PMID:21487325; https://doi.org/10.1097/INF.0b013e31821c2d8b
  • Kaur R , Casey JR , Pichichero ME . Serum antibody response to three non-typeable Haemophilus influenzae outer membrane proteins during acute otitis media and nasopharyngeal colonization in otitis prone and non-otitis prone children. Vaccine 2011; 29:1023-8; PMID:21129398; https://doi.org/10.1016/j.vaccine.2010.11.055
  • Pichichero ME , Kaur R , Casey JR , Sabirov A , Khan MN , Almudevar A . Antibody response to Haemophilus influenzae outer membrane protein D, P6, and OMP26 after nasopharyngeal colonization and acute otitis media in children. Vaccine 2010; 28:7184-92; PMID:20800701; https://doi.org/10.1016/j.vaccine.2010.08.063
  • Pichichero ME , Kaur R , Casey JR , Xu Q , Almudevar A , Ochs M . Antibody response to Streptococcus pneumoniae proteins PhtD, LytB, PcpA, PhtE and Ply after nasopharyngeal colonization and acute otitis media in children. Hum Vaccin Immunother 2012; 8:799-805; PMID:22495112; https://doi.org/10.4161/hv.19820
  • Ren D , Almudevar AL , Murphy TF , Lafontaine ER , Campagnari AA , Luke-Marshall N , Casey JR , Pichichero ME . Serum antibody response to Moraxella catarrhalis proteins OMP CD, OppA, Msp22, Hag, and PilA2 after nasopharyngeal colonization and acute otitis media in children. Vaccine 2015; 33:5809-14; PMID:26392013; https://doi.org/10.1016/j.vaccine.2015.09.023
  • Ren D , Almudevar AL , Pichichero ME . Synchrony in serum antibody response to conserved proteins of Streptococcus pneumoniae in young children. Hum Vaccin Immunother 2015; 11:489-97; PMID:25692218; https://doi.org/10.4161/21645515.2014.990861
  • Khan MN , Kaur R , Pichichero ME . Bactericidal antibody response against P6, protein D, and OMP26 of nontypeable Haemophilus influenzae after acute otitis media in otitis-prone children. FEMS ImmunolMedMicrobiol 2012; 65:439-47
  • Alderson MR . Status of research and development of pediatric vaccines for Streptococcus pneumoniae. Vaccine 2016; 34:2959-61; PMID:27083428; https://doi.org/10.1016/j.vaccine.2016.03.107
  • Moffitt KL , Malley R . Next generation pneumococcal vaccines. Curr Opin Immunol 2011; 23:407-13; PMID:21514128; https://doi.org/10.1016/j.coi.2011.04.002
  • Pichichero ME , Khan MN , Xu Q . Next generation protein based Streptococcus pneumoniae vaccines. Hum Vaccin Immunother 2016; 12:194-205; PMID:26539741; https://doi.org/10.1080/21645515.2015.1052198
  • Feldman C , Anderson R . Review: current and new generation pneumococcal vaccines. J Infect 2014; 69:309-25; PMID:24968238; https://doi.org/10.1016/j.jinf.2014.06.006
  • Khan MN , Xu Q , Pichichero ME . Protection against Streptococcus pneumoniae Invasive Pathogenesis by a protein-based vaccine is achieved by suppression of nasopharyngeal bacterial density during influenza a virus coinfection. Infect Immun 2017; 85:e00530-16; https://doi.org/10.1128/IAI.00530-16
  • Verhoeven D , Xu Q , Pichichero ME . Vaccination with a Streptococcus pneumoniae trivalent recombinant PcpA, PhtD and PlyD1 protein vaccine candidate protects against lethal pneumonia in an infant murine model. Vaccine 2014; 32:3205-10; PMID:24731814; https://doi.org/10.1016/j.vaccine.2014.04.004
  • Verhoeven D , Perry S , Pichichero ME . Contributions to Protection from Streptococcus pneumoniae Infection Using the Monovalent Recombinant Protein Vaccine Candidates PcpA, PhtD, and PlyD1 in an Infant Murine Model during Challenge. Clin Vaccine Immunol 2014; 21:1037-45; PMID:24850621; https://doi.org/10.1128/CVI.00052-14
  • Xu Q , Surendran N , Verhoeven D , Klapa J , Ochs M , Pichichero ME . Trivalent pneumococcal protein recombinant vaccine protects against lethal Streptococcus pneumoniae pneumonia and correlates with phagocytosis by neutrophils during early pathogenesis. Vaccine 2015; 33:993-1000; PMID:25597944; https://doi.org/10.1016/j.vaccine.2015.01.014
  • Xu Q , Casey JR , Almudevar A , Pichichero ME . Correlation of Higher Antibody Levels to Pneumococcal Proteins with Protection from Pneumococcal Acute Otitis Media but not Protection from Nasopharyngeal Colonization in Young Children. Clin Microbiol Infect 2017; 23(7):487; PMID:28143785; https://doi.org/10.1016/j.cmi.2017.01.011
  • Xu Q , Casey JR , Pichichero ME . Higher levels of mucosal antibody to pneumococcal vaccine candidate proteins are associated with reduced acute otitis media caused by Streptococcus pneumoniae in young children. Mucosal Immunol 2015; 8:1110-7; PMID:25648056; https://doi.org/10.1038/mi.2015.1
  • Brooks WA , Chang LJ , Sheng X , Hopfer R , Team PPRS . Safety and immunogenicity of a trivalent recombinant PcpA, PhtD, and PlyD1 pneumococcal protein vaccine in adults, toddlers, and infants: A phase I randomized controlled study. Vaccine 2015; 33:4610-7; PMID:26143615; https://doi.org/10.1016/j.vaccine.2015.06.078
  • Prevaes SM , van Wamel WJ , de Vogel CP , Veenhoven RH , van Gils EJ , van Belkum A , Sanders EA , Bogaert D . Nasopharyngeal colonization elicits antibody responses to staphylococcal and pneumococcal proteins that are not associated with a reduced risk of subsequent carriage. Infect Immun 2012; 80:2186-93; PMID:22451514; https://doi.org/10.1128/IAI.00037-12
  • Simell B , Ahokas P , Lahdenkari M , Poolman J , Henckaerts I , Kilpi TM , Käyhty H . Pneumococcal carriage and acute otitis media induce serum antibodies to pneumococcal surface proteins CbpA and PhtD in children. Vaccine 2009; 27:4615-21; PMID:19524618; https://doi.org/10.1016/j.vaccine.2009.05.071
  • Holmlund E , Quiambao B , Ollgren J , Nohynek H , Kayhty H . Development of natural antibodies to pneumococcal surface protein A, pneumococcal surface adhesin A and pneumolysin in Filipino pregnant women and their infants in relation to pneumococcal carriage. Vaccine 2006; 24:57-65; PMID:16115703; https://doi.org/10.1016/j.vaccine.2005.07.055
  • Xu Q , Almudervar A , Casey JR , Pichichero ME . Nasopharyngeal bacterial interactions in children. Emerging Infect Dis 2012; 18:1738-45; PMID:23092680; https://doi.org/10.3201/eid1811.111904
  • Xu Q , Casey JR , Chang A , Pichichero ME . When co-colonizing the nasopharynx haemophilus influenzae predominates over Streptococcus pneumoniae except serotype 19A strains to cause acute otitis media. Pediatr Infect Dis J 2012; 31:638-40; PMID:22301480; https://doi.org/10.1097/INF.0b013e31824ba6f7
  • Casey JR , Adlowitz DG , Pichichero ME . New patterns in the otopathogens causing acute otitis media six to eight years after introduction of pneumococcal conjugate vaccine. Pediatr Infect Dis J 2010; 29:304-9; PMID:19935445
  • Pichichero ME , Casey JR . Emergence of a multiresistant serotype 19A pneumococcal strain not included in the 7-valent conjugate vaccine as an otopathogen in children. JAMA 2007; 298:1772-8; PMID:17940232; https://doi.org/10.1001/jama.298.15.1772
  • Nabors GS , Braun PA , Herrmann DJ , Heise ML , Pyle DJ , Gravenstein S , Schilling M , Ferguson LM , Hollingshead SK , Briles DE , et al. Immunization of healthy adults with a single recombinant pneumococcal surface protein A (PspA) variant stimulates broadly cross-reactive antibodies to heterologous PspA molecules. Vaccine 2000; 18:1743-54; PMID:10699322; https://doi.org/10.1016/S0264-410X(99)00530-7

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