1,586
Views
25
CrossRef citations to date
0
Altmetric
Research Papers

Cellular immune responses of older adults to four influenza vaccines: Results of a randomized, controlled comparison

, , , , , , & show all
Pages 2048-2057 | Received 02 Feb 2017, Accepted 29 May 2017, Published online: 25 Jul 2017

References

  • Bernstein E, Kaye D, Abrutyn E, Gross P, Dorfman M, Murasko DM. Immune response to influenza vaccination in a large healthy elderly population. Vaccine 1999; 17:82-94; PMID:10078611; https://doi.org/10.1016/S0264-410X(98)00117-0
  • Murasko DM, Bernstein ED, Gardner EM, Gross P, Munk G, Dran S, Abrutyn E. Role of humoral and cell-mediated immunity in protection from influenza disease after immunization of healthy elderly. Exp Gerontol 2002; 37:427-39; PMID:11772530; https://doi.org/10.1016/S0531-5565(01)00210-8
  • McElhaney JE. Influenza vaccine responses in older adults. Ageing Res Rev 2011; 10:379-88; PMID:21055484; https://doi.org/10.1016/j.arr.2010.10.008
  • McElhaney JE, Effros RB. Immunosenescence: What does it mean to health outcomes in older adults? Curr Opin Immunol 2009; 21:418-24; PMID:19570667; https://doi.org/10.1016/j.coi.2009.05.23
  • McElhaney JE, Xie D, Hager WD, Barry MB, Wang Y, Kleppinger A, Ewen C, Kane KP, Bleackley RC, Mcelhaney JE, et al. T cell responses are better correlates of vaccine protection in the elderly 1. J Immunol 2006; 176:6333-9; PMID:16670345; https://doi.org/10.4049/jimmunol.176.10.6333
  • McElhaney JE, Ewen C, Zhou X, Kane KP, Xie D, Hager WD, Barry MB, Kleppinger A, Wang Y, Bleackley RC. Granzyme B: Correlates with protection and enhanced CTL response to influenza vaccination in older adults. Vaccine 2009; 27:2418-25; PMID:19368783; https://doi.org/10.1016/j.vaccine.2009.01.136
  • Goronzy JJ, Fulbright JW, Crowson CS, Poland G a, O'Fallon WM, Weyand CM. Value of immunological markers in predicting responsiveness to influenza vaccination in elderly individuals. J Virol 2001; 75:12182-7; PMID:11711609; https://doi.org/10.1128/JVI.75.24.12182-12187.2001
  • Saurwein-Teissl M, Lung TL, Marx F, Gschösser C, Asch E, Blasko I, Parson W, Böck G, Schönitzer D, Trannoy E, et al. Lack of antibody production following immunization in old age: Association with CD8(+)CD28(-) T cell clonal expansions and an imbalance in the production of Th1 and Th2 cytokines. J Immunol 2002; 168:5893-9; PMID:12023394; https://doi.org/10.4049/jimmunol.168.11.5893
  • Effros RB. Role of T lymphocyte replicative senescence in vaccine efficacy. Vaccine 2007; 25:599-604; PMID:17014937; https://doi.org/10.1016/j.vaccine.2006.08.032
  • Shahid Z, Kleppinger A, Gentleman B, Falsey AR, McElhaney JE. Clinical and immunologic predictors of influenza illness among vaccinated older adults. Vaccine 2010; 28:6145-51; PMID:20646987; https://doi.org/10.1016/j.vaccine.2010.07.036
  • Wilkinson TM, Li CK., Chui CSC, Huang AKY, Perkins M, Liebner JC, Lambkin-Williams R, Gilbert A, Oxford J, Nicholas B, et al. Preexisting influenza-specific CD4+ T cells correlate with disease protection against influenza challenge in humans. Nat Med [Internet] 2012; 18:276-82; PMID:22286307; https://doi.org/10.1038/nm.2612
  • Sridhar S, Begom S, Bermingham A, Hoschler K, Adamson W, Carman W, Bean T, Barclay W, Deeks JJ, Lalvani A. Cellular immune correlates of protection against symptomatic pandemic influenza. Nat Med [Internet] 2013; 19:1305-12; PMID:24056771; https://doi.org/10.1038/nm.3350
  • Mosterín Höpping A, McElhaney J, Fonville JM, Powers DC, Beyer WEP, Smith DJ. The confounded effects of age and exposure history in response to influenza vaccination. Vaccine 2016; 34:540-6; PMID:26667611; https://doi.org/10.1016/j.vaccine.20105.11.058
  • Jameson J, Cruz J, Terajima M, Ennis FA. Human CD8+ and CD4+ T lymphocyte memory to influenza a viruses of swine and avian species. J Immunol [Internet] 1999; 162:7578-83; PMID:10358215
  • Wang M, Lamberth K, Harndahl M, Røder G, Stryhn A, Larsen MV, Nielsen M, Lundegaard C, Tang ST, Dziegiel MH, et al. CTL epitopes for influenza a including the H5N1 bird flu; genome-, pathogen-, and HLA-wide screening. Vaccine 2007; 25:2823-31; PMID:17254671; https://doi.org/10.1016/j.vaccine.2006.12.038
  • Grant EJ, Quiñones-Parra SM, Clemens EB, Kedzierska K. Human influenza viruses and CD8(+) T cell responses. Curr Opin Virol [Internet] 2016; 16:132-42; PMID:26974887; https://doi.org/10.1016/j.coviro.2016.01.016
  • Co M, Orphin L, Cruz J, Pazoles P, Green K, Potts J, Leporati A, Babon J, Evans J, Ennis F, et al. In vitro evidence that commercial influenza vaccines are not similar in their ability to activate human T cell responses. Vaccine [Internet] 2009; 27:319-27; PMID:18977404; https://doi.org/10.1016/j.vaccine.2008.09.092
  • Couch RB, Bayas JM, Caso C, Mbawuike IN, Lopez CN, Claeys C, El Idrissi M, Herve C, Laupeze B, Oostvogels L, et al. Superior antigen-specific CD4+ T-cell response with AS03-adjuvantation of a trivalent influenza vaccine in a randomised trial of adults aged 65 and older. BMC Infect Dis 2014; 14:425; PMID:25078387; https://doi.org/10.1186/1471-2334-14-425
  • Moris P, van der Most R, Leroux-Roels I, Clement F, Dramé M, Hanon E, Leroux-Roels GG, Van Mechelen M. H5N1 influenza vaccine formulated with AS03(A) induces strong cross-reactive and polyfunctional CD4 T-cell responses. J Clin Immunol [Internet] 2011; 31:443-54; PMID:21174144; https://doi.org/10.1007/s10875-010-9490-6
  • Nougarede N, Bisceglia H, Rozières A, Goujon C, Boudet F, Laurent P, Vanbervliet B, Rodet K, Hennino A, Nicolas JF. Nine µg intradermal influenza vaccine and 15 μg intramuscular influenza vaccine induce similar cellular and humoral immune responses in adults. Hum Vaccines Immunother 2014; 10:2713-20; PMID:25483667; https://doi.org/10.4161/hv.29695
  • Scheifele DW, McNeil SA, Ward BJ, Dionne M, Cooper C, Coleman B, Loeb M, Rubinstein E, McElhaney J, Hatchette T, et al. Safety, immunogenicity, and tolerability of three influenza vaccines in older adults: Results of a randomized, controlled comparison. Hum Vaccin Immunother 2013; 9:2460-73; PMID:23839537 ; https://doi.org/10.4161/hv.25580
  • Wagar LE, Gentleman B, Pircher H, McElhaney JE, Watts TH. Influenza-specific T cells from older people are enriched in the late effector subset and their presence inversely correlates with vaccine response. PLoS One [Internet] 2011; 6:e23698; PMID:21887299; https://doi.org/10.1371/journal.pone.0023698
  • Del Giudice G, Rappuoli R. Inactivated and adjuvanted influenza vaccines. Curr Top Microbiol Immunol 2015; 386:151-80; PMID:25038938; https://doi.org/10.1007/82.2014.406
  • Haq K, Fulop T, Tedder G, Gentleman B, Garneau H, Meneilly GS, Kleppinger A, Pawelec G, McElhaney JE. Cytomegalovirus seropositivity predicts a decline in the t cell but not the antibody response to influenza in vaccinated older adults independent of type 2 diabetes status. J Gerontol A Biol Sci Med Sci 2016; 00:1-8; PMID:27789617; https://doi.org/10.1093/gerona/glw216
  • McElhaney JE, Zhou X, Talbot HK, Soethout E, Bleackley RC, Granville DJ, Pawelec G. The unmet need in the elderly: How immunosenescence, CMV infection, co-morbidities and frailty are a challenge for the development of more effective influenza vaccines. Vaccine 2012; 30:2060-7; PMID:22289511; https://doi.org/10.1016/j.vaccine.2012.01.015
  • Zhou X, McElhaney JE. Age-related changes in memory and effector T cells responding to influenza A/H3N2 and pandemic A/H1N1 strains in humans. Vaccine 2011; 29:2169-77; PMID:22289511; https://doi.org/10.1016/j.vaccine.2012.01.015
  • Skowronski DM, Hottes TS, McElhaney JE, Janjua NZ, Sabaiduc S, Chan T, Gentleman B, Purych D, Gardy J, Patrick DM, et al. Immuno-epidemiologic correlates of pandemic H1N1 surveillance observations: Higher antibody and lower cell-mediated immune responses with advanced age. J Infect Dis 2011; 203:158-67; PMID:21288814; https://doi.org/10.1093/infdis/jiq039
  • McElhaney JE, Beran J, Devaster JM, Esen M, Launay O, Leroux-Roels G, Ruiz-Palacios GM, van Essen GA, Caplanusi A, Claeys C, et al. AS03-adjuvanted versus non-adjuvanted inactivated trivalent influenza vaccine against seasonal influenza in elderly people: A phase 3 randomised trial. Lancet Infect Dis 2013; 13:485-96; PMID:23518156; https://doi.org/10.1016/S1473-3099(13)70046-X
  • Blimkie D, Fortuno ES, Yan H, Cho P, Ho K, Turvey SE, Marchant A, Goriely S, Kollmann TR. Variables to be controlled in the assessment of blood innate immune responses to Toll-like receptor stimulation. J Immunol Methods 2011; 366:89-99; PMID:21277305; https://doi.org/10.1016/j.jim.2011.01.009
  • Smolen KK, Gelinas L, Franzen L, Dobson S, Dawar M, Ogilvie G, Krajden M, Fortuno ES, Kollmann TR. Age of recipient and number of doses differentially impact human B and T cell immune memory responses to HPV vaccination. Vaccine 2012; 30:3572-9; PMID:22469863; https://doi.org/10.1016/j.vaccine.2012.03.051
  • Behzad H, Huckriede ALW, Haynes L, Gentleman B, Coyle K, Wilschut JC, Kollmann TR, Reed SG, McElhaney JE. GLA-SE, a synthetic toll-like receptor 4 agonist, enhances T-cell responses to influenza vaccine in older adults. J Infect Dis 2012; 205:466-73; PMID:22147791; https://doi.org/10.1093/infdis/jir769

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.