1,796
Views
9
CrossRef citations to date
0
Altmetric
Reviews - Solicited

Update on oral immunotherapy for egg allergy

, , , &
Pages 2452-2461 | Received 04 Apr 2017, Accepted 03 Jun 2017, Published online: 18 Oct 2017

References

  • Rona RJ , Keil T , Summers C , Gislason D , Zuidmeer L , Sodergren E , Sigurdardottir ST , Lindner T , Goldhahn K , Dahlstrom J , et al. The prevalence of food allergy: a meta-analysis. J Allergy Clin Immunol 2007; 120(3):638-46; PMID:17628647; https://doi.org/10.1016/j.jaci.2007.05.026
  • Bollinger ME , Dahlquist LM , Mudd K , Sonntag C , Dillinger L , McKenna K. The impact of food allergy on the daily activities of children and their families. Ann Allergy Asthma Immunol 2006; 96(3):415-21; PMID:16597075; https://doi.org/10.1016/S1081-1206(10)60908-8
  • Gaffin JM , Sheehan WJ , Morrill J , Cinar M , Borras Coughlin IM , Sawicki GS , Twarog FJ , Young MC , Schneider LC , Phipatanakul W . Tree nut allergy, egg allergy, and asthma in children. Clin Pediatr (Phila) 2011; 50(2):133-9; PMID:21098525; https://doi.org/10.1177/0009922810384720
  • Nickel R , Kulig M , Forster J , Bergmann R , Bauer CP , Lau S , Guggenmoos-Holzmann I , Wahn U . Sensitization to hen's egg at the age of twelve months is predictive for allergic sensitization to common indoor and outdoor allergens at the age of three years. J Allergy Clin Immunol 1997; 99(5):613-7; PMID:9155826; https://doi.org/10.1016/S0091-6749(97)70021-6
  • Wood RA . The natural history of food allergy. Pediatrics 2003; 111(6 Pt 3):1631-7; PMID:12777603
  • Sicherer SH , Wood RA , Vickery BP , Jones SM , Liu AH , Fleischer DM , Dawson P , Mayer L , Burks AW , Grishin A , et al. The natural history of egg allergy in an observational cohort. J Allergy Clin Immunol 2014; 133(2):492-9; PMID:24636473; https://doi.org/10.1016/j.jaci.2013.12.1041
  • Savage JH , Matsui EC , Skripak JM , Wood RA . The natural history of egg allergy. J Allergy Clin Immunol 2007; 120(6):1413-7; PMID:18073126; https://doi.org/10.1016/j.jaci.2007.09.040
  • Patriarca C , Romano A , Venuti A , Schiavino D , Di Rienzo V , Nucera E , Pellegrino S . Oral specific hyposensitization in the management of patients allergic to food. Allergol Immunopathol (Madr) 1984; 12(4):275-81; PMID:6507224
  • Begin P , Chinthrajah RS , Nadeau KC . Oral immunotherapy for the treatment of food allergy. Hum Vaccin Immunother 2014; 10(8):2295-302; PMID:25424935; https://doi.org/10.4161/hv.29233
  • Escudero C , Rodríguez Del Río P , Sánchez-García S , Pérez-Rangel I , Pérez-Farinós N , García-Fernández C , Ibáñez MD . Early sustained unresponsiveness after short-course egg oral immunotherapy: a randomized controlled study in egg-allergic children. Clin Exp Allergy 2015; 45(12):1833-43; PMID:26236997; https://doi.org/10.1111/cea.12604
  • Staden U , Rolinck-Werninghaus C , Brewe F , Wahn U , Niggemann B , Beyer K . Specific oral tolerance induction in food allergy in children: efficacy and clinical patterns of reaction. Allergy 2007; 62(11):1261-9; PMID:17919140; https://doi.org/10.1111/j.1398-9995.2007.01501.x
  • Morisset M , Moneret-Vautrin DA , Guenard L , Cuny JM , Frentz P , Hatahet R , Hanss Ch , Beaudouin E , Petit N , Kanny G . Oral desensitization in children with milk and egg allergies obtains recovery in a significant proportion of cases. A randomized study in 60 children with cow's milk allergy and 90 children with egg allergy. Eur Ann Allergy Clin Immunol 2007; 39(1):12-9; PMID:17375736
  • Burks AW , Jones SM , Wood RA , Fleischer DM , Sicherer SH , Lindblad RW , Stablein D , Henning AK , Vickery BP , Liu AH , et al. Oral immunotherapy for treatment of egg allergy in children. N Engl J Med 2012; 367(3):233-43; PMID:22808958; https://doi.org/10.1056/NEJMoa1200435
  • Jones SM , Burks AW , Keet C , Vickery BP , Scurlock AM , Wood RA , Liu AH , Sicherer SH , Henning AK , Lindblad RW , et al. Long-term treatment with egg oral immunotherapy enhances sustained unresponsiveness that persists after cessation of therapy. J Allergy Clin Immunol 2016; 137(4):1117-27 e1-10; PMID:26924470; https://doi.org/10.1016/j.jaci.2015.12.1316
  • Dello Iacono I , Tripodi S , Calvani M , Panetta V , Verga MC , Miceli Sopo S . Specific oral tolerance induction with raw hen's egg in children with very severe egg allergy: a randomized controlled trial. Pediatr Allergy Immunol 2013; 24(1):66-74; PMID:22957889; https://doi.org/10.1111/j.1399-3038.2012.01349.x
  • Fuentes-Aparicio V , Alvarez-Perea A , Infante S , Zapatero L , D'Oleo A , Alonso-Lebrero E . Specific oral tolerance induction in paediatric patients with persistent egg allergy. Allergol Immunopathol (Madr) 2013; 41(3):143-50; PMID:22835606; https://doi.org/10.1016/j.aller.2012.02.007
  • Meglio P , Giampietro PG , Carello R , Gabriele I , Avitabile S , Galli E . Oral food desensitization in children with IgE-mediated hen's egg allergy: a new protocol with raw hen's egg. Pediatr Allergy Immunol 2013; 24(1):75-83; PMID:22882430; https://doi.org/10.1111/j.1399-3038.2012.01341.x
  • Caminiti L , Pajno GB , Crisafulli G , Chiera F , Collura M , Panasci G , Ruggeri P , Guglielmo F , Passalacqua G . Oral Immunotherapy for Egg Allergy: A Double-Blind Placebo-Controlled Study, with Postdesensitization Follow-Up. J Allergy Clin Immunol Pract 2015; 3(4):532-9; PMID:25725940; https://doi.org/10.1016/j.jaip.2015.01.017
  • Akashi M , Yasudo H , Narita M , Nomura I , Akasawa A , Ebisawa M , Takahashi T , Ohya Y . Randomized Controlled Trial of Oral Immunotherapy for Egg Allergy in Japanese patients. Pediatr Int 2016; 59(5):534-39.
  • Perez-Rangel I , Rodríguez Del Río P , Escudero C , Sánchez-García S , Sánchez-Hernández JJ , Ibáñez MD . Efficacy and safety of high-dose rush oral immunotherapy in persistent egg allergic children: A randomized clinical trial. Ann Allergy Asthma Immunol 2017; 118(3):356-64. e3; https://doi.org/10.1016/j.anai.2016.11.023
  • Vazquez-Ortiz M , Alvaro M , Piquer M , Dominguez O , Machinena A , Martín-Mateos MA , Plaza AM . Baseline specific IgE levels are useful to predict safety of oral immunotherapy in egg-allergic children. Clin Exp Allergy 2014; 44(1):130-41; PMID:24355019; https://doi.org/10.1111/cea.12233
  • Yanagida N , Sato S , Asaumi T , Nagakura K , Ogura K , Ebisawa M . Safety and Efficacy of Low-Dose Oral Immunotherapy for Hen's Egg Allergy in Children. Int Arch Allergy Immunol 2016; 171(3–4):265-268; PMID:28049193; https://doi.org/10.1159/000454807
  • Patriarca G , Nucera E , Pollastrini E , Roncallo C , De Pasquale T , Lombardo C , Pedone C , Gasbarrini G , Buonomo A , Schiavino D . Oral specific desensitization in food-allergic children. Dig Dis Sci 2007; 52(7):1662-72; PMID:17245630; https://doi.org/10.1007/s10620-006-9245-7
  • Buchanan AD , Green TD , Jones SM , Scurlock AM , Christie L , Althage KA , Steele PH , Pons L , Helm RM , Lee LA . Egg oral immunotherapy in nonanaphylactic children with egg allergy. J Allergy Clin Immunol 2007; 119(1):199-205; PMID:17208602; https://doi.org/10.1016/j.jaci.2006.09.016
  • Vickery BP , Pons L , Kulis M , Steele P , Jones SM , Burks AW . Individualized IgE-based dosing of egg oral immunotherapy and the development of tolerance. Ann Allergy Asthma Immunol 2010; 105(6):444-50; PMID:21130382; https://doi.org/10.1016/j.anai.2010.09.030
  • Itoh N , Itagaki Y , and Kurihara K . Rush specific oral tolerance induction in school-age children with severe egg allergy: one year follow up. Allergol Int 2010; 59(1):43-51; PMID:19946197; https://doi.org/10.2332/allergolint.09-OA-0107
  • Garcia Rodriguez R , Urra JM , Feo-Brito F , Galindo PA , Borja J , Gómez E , Lara P , Guerra F . Oral rush desensitization to egg: efficacy and safety. Clin Exp Allergy 2011; 41(9):1289-96; PMID:21457166; https://doi.org/10.1111/j.1365-2222.2011.03722.x
  • Ojeda P , Ojeda I , Rubio G , Pineda F . Home-based oral immunotherapy protocol with pasteurized egg for children allergic to hen's egg. Isr Med Assoc J 2012; 14(1):34-9; PMID:22624440
  • Ruiz Garcia M , Haroun E , Landivar ME , Torres Hernandez JA , Sastre J . Commercial dehydrated egg white for specific oral tolerance induction (SOTI): an easier treatment for egg allergy. J Investig Allergol Clin Immunol 2012; 22(7):529-31; PMID:23397680
  • Sudo K , Taniuchi S , Takahashi M , Soejima K , Hatano Y , Nakano K , Shimo T , Koshino H , Kaneko K . Home-based oral immunotherapy (OIT) with an intermittent loading protocol in children unlikely to outgrow egg allergy. Allergy Asthma Clin Immunol 2014; 10(1):11; PMID:24572125; https://doi.org/10.1186/1710-1492-10-11
  • Perezabad L , Reche M , Valbuena T , López-Fandiño R , Molina E , López-Expósito I . Clinical efficacy and immunological changes subjacent to egg oral immunotherapy. Ann Allergy Asthma Immunol 2015; 114(6):504-9; PMID:25935429; https://doi.org/10.1016/j.anai.2015.04.006
  • Bravin K , Luyt D . Home-Based Oral Immunotherapy With a Baked Egg Protocol. J Investig Allergol Clin Immunol 2016; 26(1):61-3; PMID:27012022
  • Sampson HA . Anaphylaxis and emergency treatment. Pediatrics 2003; 111(6 Pt 3):1601-8; PMID:12777599
  • Clark AT and Ewan PW . Food allergy in childhood. Arch Dis Child 2004; 89(2):197; PMID:14736644; https://doi.org/10.1136/adc.2003.032193
  • Muraro A , Roberts G , Clark A , Eigenmann PA , Halken S , Lack G , Moneret-Vautrin A , Niggemann B , Rancé F , EAACI Task Force on Anaphylaxis in Children . The management of anaphylaxis in childhood: position paper of the European academy of allergology and clinical immunology. Allergy 2007; 62(8):857-71; PMID:17590200; https://doi.org/10.1111/j.1398-9995.2007.01421.x
  • Giavi S , Vissers YM , Muraro A , Lauener R , Konstantinopoulos AP , Mercenier A , Wermeille A , Lazzarotto F , Frei R , Bonaguro R , et al. Oral immunotherapy with low allergenic hydrolysed egg in egg allergic children. Allergy 2016; 71(11):1575-1584; PMID:27059671; https://doi.org/10.1111/all.12905
  • Cox L , Larenas-Linnemann D , Lockey RF , Passalacqua G . Speaking the same language: The World Allergy Organization Subcutaneous Immunotherapy Systemic Reaction Grading System. J Allergy Clin Immunol 2010; 125(3):569-74, 574 e1-574 e7; PMID:20144472; https://doi.org/10.1016/j.jaci.2009.10.060
  • Cox L , Nelson H , Lockey R , Calabria C , Chacko T , Finegold I , Nelson M , Weber R , Bernstein DI , Blessing-Moore J , et al. Allergen immunotherapy: a practice parameter third update. J Allergy Clin Immunol 2011; 127(1 Suppl):S1-55; PMID:21122901; https://doi.org/10.1016/j.jaci.2010.09.034
  • Ibanez MD , Escudero C , Sánchez-García S , Rodríguez del Río P . Comprehensive Review of Current Knowledge on Egg Oral Immunotherapy. J Investig Allergol Clin Immunol 2015; 25(5):316-28; quiz 2 p following 328; PMID:26727760
  • Lucendo AJ , Arias A , and Tenias JM . Relation between eosinophilic esophagitis and oral immunotherapy for food allergy: a systematic review with meta-analysis. Ann Allergy Asthma Immunol 2014; 113(6):624-9; PMID:25216976; https://doi.org/10.1016/j.anai.2014.08.004
  • Ridolo E , De Angelis GL , Dall'aglio P . Eosinophilic esophagitis after specific oral tolerance induction for egg protein. Ann Allergy Asthma Immunol 2011; 106(1):73-4; PMID:21195949; https://doi.org/10.1016/j.anai.2010.10.010
  • Lemon-Mule H , Sampson HA , Sicherer SH , Shreffler WG , Noone S , Nowak-Wegrzyn A . Immunologic changes in children with egg allergy ingesting extensively heated egg. J Allergy Clin Immunol 2008; 122(5):977-983 e1; PMID:18851876; https://doi.org/10.1016/j.jaci.2008.09.007
  • Konstantinou GN , Giavi S , Kalobatsou A , Vassilopoulou E , Douladiris N , Saxoni-Papageorgiou P , Papadopoulos NG . Consumption of heat-treated egg by children allergic or sensitized to egg can affect the natural course of egg allergy: hypothesis-generating observations. J Allergy Clin Immunol 2008; 122(2):414-5; PMID:18585768; https://doi.org/10.1016/j.jaci.2008.05.032
  • Leonard SA , Caubet JC , Kim JS , Groetch M , Nowak-Węgrzyn A . Baked milk- and egg-containing diet in the management of milk and egg allergy. J Allergy Clin Immunol Pract 2015; 3(1):13-23; quiz 24; PMID:25577613; https://doi.org/10.1016/j.jaip.2014.10.001
  • Bloom KA , Huang FR , Bencharitiwong R , Bardina L , Ross A , Sampson HA , Nowak-Węgrzyn A . Effect of heat treatment on milk and egg proteins allergenicity. Pediatr Allergy Immunol 2014; 25(8):740-6; PMID:25251921; https://doi.org/10.1111/pai.12283
  • Shin M , Lee J , Ahn K , Lee SI , Han Y . The influence of the presence of wheat flour on the antigenic activities of egg white proteins. Allergy Asthma Immunol Res 2013; 5(1):42-7; PMID:23277877; https://doi.org/10.4168/aair.2013.5.1.42
  • Hildebrandt S , Kratzin HD , Schaller R , Fritsché R , Steinhart H , Paschke A . In vitro determination of the allergenic potential of technologically altered hen's egg. J Agric Food Chem 2008; 56(5):1727-33; PMID:18260628; https://doi.org/10.1021/jf0725981
  • Hacini-Rachinel F , Vissers YM , Doucet-Ladevéze R , Blanchard C , Demont A , Perrot M , Panchaud A , Prioult G , Mercenier A , Nutten S . Low-allergenic hydrolyzed egg induces oral tolerance in mice. Int Arch Allergy Immunol 2014; 164(1):64-73; PMID:24902890; https://doi.org/10.1159/000363110
  • Ballmer-Weber BK , Brockow K , Fiocchi A , Theler B , Vogel L , Ring J , Szépfalusi Z , Mazzina O , Schaller R , Fritsché R , et al. Hydrolysed egg displays strong decrease in allergenicity and is well tolerated by egg-allergic patients. Allergy 2016; 71(5):728-32; PMID:26836363; https://doi.org/10.1111/all.12852
  • Dhanapala P , Withanage-Dona D , Tang ML , Doran T , Suphioglu C . Hypoallergenic Variant of the Major Egg White Allergen Gal d 1 Produced by Disruption of Cysteine Bridges. Nutrients 2017; 9(2); PMID:28230769
  • Boushey HA, Jr. Experiences with monoclonal antibody therapy for allergic asthma. J Allergy Clin Immunol 2001; 108(2 Suppl):S77-83; PMID:11498677; https://doi.org/10.1067/mai.2001.116434
  • Maurer M , Rosén K , Hsieh HJ , Saini S , Grattan C , Gimenéz-Arnau A , Agarwal S , Doyle R , Canvin J , Kaplan A , et al. Omalizumab for the treatment of chronic idiopathic or spontaneous urticaria. N Engl J Med 2013; 368(10):924-35; PMID:23432142; https://doi.org/10.1056/NEJMoa1215372
  • Vigo PG , Girgis KR , Pfuetze BL , Critchlow ME , Fisher J , Hussain I . Efficacy of anti-IgE therapy in patients with atopic dermatitis. J Am Acad Dermatol 2006; 55(1):168-70; PMID:16781320; https://doi.org/10.1016/j.jaad.2005.12.045
  • Chervinsky P , Casale T , Townley R , Tripathy I , Hedgecock S , Fowler-Taylor A , Shen H , Fox H . Omalizumab, an anti-IgE antibody, in the treatment of adults and adolescents with perennial allergic rhinitis. Ann Allergy Asthma Immunol 2003; 91(2):160-7; PMID:12952110; https://doi.org/10.1016/S1081-1206(10)62171-0
  • Savage JH , Courneya JP , Sterba PM , Macglashan DW , Saini SS , Wood RA . Kinetics of mast cell, basophil, and oral food challenge responses in omalizumab-treated adults with peanut allergy. J Allergy Clin Immunol 2012; 130(5):1123-29 e2; PMID:22800401; https://doi.org/10.1016/j.jaci.2012.05.039
  • Holgate ST , Djukanović R , Casale T , Bousquet J . Anti-immunoglobulin E treatment with omalizumab in allergic diseases: an update on anti-inflammatory activity and clinical efficacy. Clin Exp Allergy 2005; 35(4):408-16; PMID:15836747; https://doi.org/10.1111/j.1365-2222.2005.02191.x
  • MacGlashan DW, Jr. , Bochner BS , Adelman DC , Jardieu PM , Togias A , McKenzie-White J , Sterbinsky SA , Hamilton RG , Lichtenstein LM . Down-regulation of Fc(epsilon)RI expression on human basophils during in vivo treatment of atopic patients with anti-IgE antibody. J Immunol 1997; 158(3):1438-45; PMID:9013989
  • Schneider LC , Rachid R , LeBovidge J , Blood E , Mittal M , Umetsu DT . A pilot study of omalizumab to facilitate rapid oral desensitization in high-risk peanut-allergic patients. J Allergy Clin Immunol 2013; 132(6):1368-74; PMID:24176117; https://doi.org/10.1016/j.jaci.2013.09.046
  • Wood RA , Kim JS , Lindblad R , Nadeau K , Henning AK , Dawson P , Plaut M , Sampson HA . A randomized, double-blind, placebo-controlled study of omalizumab combined with oral immunotherapy for the treatment of cow's milk allergy. J Allergy Clin Immunol 2016; 137(4):1103-10 e1-11; PMID:26581915; https://doi.org/10.1016/j.jaci.2015.10.005
  • Nadeau KC , Schneider LC , Hoyte L , Borras I , Umetsu DT . Rapid oral desensitization in combination with omalizumab therapy in patients with cow's milk allergy. J Allergy Clin Immunol 2011; 127(6):1622-4; PMID:21546071; https://doi.org/10.1016/j.jaci.2011.04.009
  • Begin P , Dominguez T , Wilson SP , Bacal L , Mehrotra A , Kausch B , Trela A , Tavassoli M , Hoyte E , O'Riordan G , et al. Phase 1 results of safety and tolerability in a rush oral immunotherapy protocol to multiple foods using Omalizumab. Allergy Asthma Clin Immunol 2014; 10(1):7; PMID:24576338; https://doi.org/10.1186/1710-1492-10-7
  • Martorell-Calatayud C , Michavila-Gómez A , Martorell-Aragonés A , Molini-Menchón N , Cerdá-Mir JC , Félix-Toledo R , De Las Marinas-Álvarez MD . Anti-IgE-assisted desensitization to egg and cow's milk in patients refractory to conventional oral immunotherapy. Pediatr Allergy Immunol 2016; 27(5):544-6; PMID:27003835; https://doi.org/10.1111/pai.12567
  • Lafuente I , Mazon A , Nieto M , Uixera S , Pina R , Nieto A . Possible recurrence of symptoms after discontinuation of omalizumab in anti-IgE-assisted desensitization to egg. Pediatr Allergy Immunol 2014; 25(7):717-9; PMID:24902874; https://doi.org/10.1111/pai.12259
  • Vila L , Moreno A , Gamboa PM , Martínez-Aranguren R , Sanz ML . Decrease in antigen-specific CD63 basophil expression is associated with the development of tolerance to egg by SOTI in children. Pediatr Allergy Immunol 2013; 24(5):463-8; PMID:23682931; https://doi.org/10.1111/pai.12070
  • Wright BL , Kulis M , Orgel KA , Burks AW , Dawson P , Henning AK , Jones SM , Wood RA , Sicherer SH , Lindblad RW , et al. Component-resolved analysis of IgA, IgE, and IgG4 during egg OIT identifies markers associated with sustained unresponsiveness. Allergy 2016; 71(11):1552-1560; PMID:27015954; https://doi.org/10.1111/all.12895
  • Carraro S , Frigo AC , Perin M , Stefani S , Cardarelli C , Bozzetto S , Baraldi E , Zanconato S . Impact of oral immunotherapy on quality of life in children with cow milk allergy: a pilot study. Int J Immunopathol Pharmacol 2012; 25(3):793-8; PMID:23058033; https://doi.org/10.1177/039463201202500329
  • Factor JM , Mendelson L , Lee J , Nouman G , Lester MR . Effect of oral immunotherapy to peanut on food-specific quality of life. Ann Allergy Asthma Immunol 2012; 109(5):348-352 e2; PMID:23062391; https://doi.org/10.1016/j.anai.2012.08.015
  • Epstein Rigbi N , Katz Y , Goldberg MR , Levy MB , Nachshon L , Elizur A . Patient quality of life following induction of oral immunotherapy for food allergy. Pediatr Allergy Immunol 2016; 27(3):263-8; PMID:26681071; https://doi.org/10.1111/pai.12528
  • Anagnostou K , Islam S , King Y , Foley L , Pasea L , Bond S , Palmer C , Deighton J , Ewan P , Clark A . Assessing the efficacy of oral immunotherapy for the desensitisation of peanut allergy in children (STOP II): a phase 2 randomised controlled trial. Lancet 2014; 383(9925):1297-304; PMID:24485709; https://doi.org/10.1016/S0140-6736(13)62301-6
  • Otani IM , Bégin P , Kearney C , Dominguez TL , Mehrotra A , Bacal LR , Wilson S , Nadeau K . Multiple-allergen oral immunotherapy improves quality of life in caregivers of food-allergic pediatric subjects. Allergy Asthma Clin Immunol 2014; 10(1):25; PMID:24860608; https://doi.org/10.1186/1710-1492-10-25

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.