The current state of food allergy therapeutics

References

• Sicherer SH. Epidemiology of food allergy. J Allergy Clin Immunol. 2011;127:594-602. doi:10.1016/j.jaci.2010.11.044. PMID:21236480
   PubMed Web of Science ®Google Scholar
• Toit du G , Tsakok T , Lack S , Lack G . Prevention of food allergy. J Allergy Clin Immunol. 2016;137:998-1010. doi:10.1016/j.jaci.2016.02.005. PMID:27059727
   PubMed Web of Science ®Google Scholar
• Burks AW , Tang M , Sicherer S , Muraro A , Eigenmann PA , Ebisawa M , Fiocchi A , Chiang W , Beyer K , Wood R , et al. ICON: Food allergy. J Allergy Clin Immunol. 2012;129:906-20. doi:10.1016/j.jaci.2012.02.001. PMID:22365653
   PubMed Web of Science ®Google Scholar
• Bock S , Atkins F . The natural history of peanut allergy. J Allergy Clin Immunol. 1989;83:900-4. doi:10.1016/0091-6749(89)90103-6. PMID:2715549
   PubMed Web of Science ®Google Scholar
• Wood RA . Food allergen immunotherapy: Current status and prospects for the future. J Allergy Clin Immunol. 2016;137:973-82. doi:10.1016/j.jaci.2016.01.001. PMID:27059725
   PubMed Web of Science ®Google Scholar
• Jones SM , Burks AW , Keet C , Vickery BP , Scurlock AM , Wood RA , Liu AH , Sicherer SH , Henning AK , Lindblad RW , et al. Long-term treatment with egg oral immunotherapy enhances sustained unresponsiveness that persists after cessation of therapy. J Allergy Clin Immunol. 2016;137:1117-27. e1–10. doi:10.1016/j.jaci.2015.12.1316. PMID:26924470
   PubMed Web of Science ®Google Scholar
• Burks AW , Jones SM , Wood RA , Fleischer DM , Sicherer SH , Lindblad RW , Stablein D , Henning AK , Vickery BP , Liu AH , et al. Oral immunotherapy for treatment of egg allergy in children. N Engl J Med. 2012;367:233-43. doi:10.1056/NEJMoa1200435. PMID:22808958
   PubMed Web of Science ®Google Scholar
• Kim EH , Bird JA , Kulis M , Laubach S , Pons L , Shreffler W , Steele P , Kamilaris J , Vickery B , Burks AW . Sublingual immunotherapy for peanut allergy: Clinical and immunologic evidence of desensitization. J Allergy Clin Immunol. 2011;127:640-1. doi:10.1016/j.jaci.2010.12.1083. PMID:21281959
   PubMed Web of Science ®Google Scholar
• Syed A , Garcia MA , Lyu SC , Bucayu R , Kohli A , Ishida S , Berglund JP , Tsai M , Maecker H , O'Riordan G , et al. Peanut oral immunotherapy results in increased antigen-induced regulatory T-cell function and hypomethylation of forkhead box protein 3 (FOXP3). J Allergy Clin Immunol. 2014;133:500-11. doi:10.1016/j.jaci.2013.12.1037. PMID:24636474
   PubMed Web of Science ®Google Scholar
• Ryan JF , Hovde R , Glanville J , Lyu S-C , Ji X , Gupta S , Tibshirani RJ , Jay DC , Boyd SD , Chinthrajah RS , et al. Successful immunotherapy induces previously unidentified allergen-specific CD4+ T-cell subsets. Proc Natl Acad Sci USA. 2016;113:E1286-95. doi:10.1073/pnas.1520180113. PMID:26811452
   PubMed Web of Science ®Google Scholar
• Oppenheimer JJ , Nelson HS , Bock SA , Christensen F , Leung DY . Treatment of peanut allergy with rush immunotherapy. J Allergy Clin Immunol. 1992;90:256-62. doi:10.1016/0091-6749(92)90080-L. PMID:1500630
   PubMed Web of Science ®Google Scholar
• Nelson HS , Lahr J , Rule R , Bock A , Leung D . Treatment of anaphylactic sensitivity to peanuts by immunotherapy with injections of aqueous peanut extract. J Allergy Clin Immunol. 1997;99:744-51. doi:10.1016/S0091-6749(97)80006-1. PMID:9215240
   PubMed Web of Science ®Google Scholar
• Patriarca G , Nucera E , Roncallo C , Pollastrini E , Bartolozzi F , De Pasquale T , Buonomo A , Gasbarrini G , Di Campli C , Schiavino D . Oral desensitizing treatment in food allergy: clinical and immunological results. Aliment Pharmacol Ther. 2003;17:459-65. doi:10.1046/j.1365-2036.2003.01468.x. PMID:12562461
   PubMed Web of Science ®Google Scholar
• Longo G , Barbi E , Berti I , Meneghetti R , Pittalis A , Ronfani L , Ventura A . Specific oral tolerance induction in children with very severe cow's milk–induced reactions. J Allergy Clin Immunol. 2008;121:343-7. doi:10.1016/j.jaci.2007.10.029. PMID:18158176
   PubMed Web of Science ®Google Scholar
• Jones SM , Pons L , Roberts JL , Scurlock AM , Perry TT , Kulis M , Shreffler WG , Steele P , Henry KA , Adair M , et al. Clinical efficacy and immune regulation with peanut oral immunotherapy. J Allergy Clin Immunol. 2009;124:292-7. doi:10.1016/j.jaci.2009.05.022. PMID:19577283
   PubMed Web of Science ®Google Scholar
• Blumchen K , Ulbricht H , Staden U , Dobberstein K , Beschorner J , de Oliveira LCL , Shreffler WG , Sampson HA , Niggemann B , Wahn U , et al. Oral peanut immunotherapy in children with peanut anaphylaxis. J Allergy Clin Immunol. 2010;126:83-91. e1. doi:10.1016/j.jaci.2010.04.030. PMID:20542324
   PubMed Web of Science ®Google Scholar
• Tang MLK , Ponsonby AL , Orsini F , Tey D , Robinson M , Su EL , Licciardi P , Burks W , Donath S . Administration of a probiotic with peanut oral immunotherapy: A randomized trial. J Allergy Clin Immunol. 2015;135:737-8. doi:10.1016/j.jaci.2014.11.034. PMID:25592987
   PubMed Web of Science ®Google Scholar
• Fleischer DM , Burks AW , Vickery BP , Scurlock AM , Wood RA , Jones SM , Sicherer SH , Liu AH , Stablein D , Henning AK , et al. Sublingual immunotherapy for peanut allergy: A randomized, double-blind, placebo-controlled multicenter trial. J Allergy Clin Immunol. 2013;131:119-127. e7. doi:10.1016/j.jaci.2012.11.011. PMID:23265698
   PubMed Web of Science ®Google Scholar
• Burks AW , Wood RA , Jones SM , Sicherer SH , Fleischer DM , Scurlock AM , Vickery BP , Liu AH , Henning AK , Lindblad R , et al. Sublingual immunotherapy for peanut allergy: Long-term follow-up of a randomized multicenter trial. J Allergy Clin Immunol. 2015;135:1240-3. doi:10.1016/j.jaci.2014.12.1917. PMID:25656999
   PubMed Web of Science ®Google Scholar
• Jones SM , Sicherer SH , Burks AW , Leung DYM , Lindblad RW , Dawson P , Henning AK , Berin MC , Chiang D , Vickery BP , et al. Epicutaneous immunotherapy for the treatment of peanut allergy in children and young adults. J Allergy Clin Immunol. 2016;115:171-8
   Google Scholar
• Hussey Freeland DM , Fan-Minogue H , Spergel JM , Chatila TA , Nadeau KC . Advances in food allergy oral immunotherapy: toward tolerance. Curr Opin Immunol. 2016;42:119-23. doi:10.1016/j.coi.2016.08.002. PMID:27745972
   PubMed Web of Science ®Google Scholar
• MacGinnite A . Update on potential therapies for IgE-mediated food allergy. Curr Allergy Asthma Rep. 2017;17:4. doi:10.1007/s11882-017-0671-8. PMID:28181151
   PubMed Web of Science ®Google Scholar
• Albin S , Nowak-Węgrzyn A . Potential treatments for food allergy. Immunol Allergy Clin North Am. 2015;35:77-100. doi:10.1016/j.iac.2014.09.011. PMID:25459578
   PubMed Web of Science ®Google Scholar
• Gernez Y , Nowak-Węgrzyn A . Immunotherapy for food allergy: Are we there yet? J Allergy Clin Immunol Pract. 2017;5:250-72. doi:10.1016/j.jaip.2016.12.004. PMID:28283151
   PubMed Web of Science ®Google Scholar
• Yee CSK , Rachid R . The heterogeneity of oral immunotherapy clinical trials: Implications and future directions. Curr Allergy Asthma Rep. 2016;16:25. doi:10.1007/s11882-016-0602-0. PMID:26922433
   PubMed Web of Science ®Google Scholar
• Vickery BP , Scurlock AM , Kulis M , Steele PH , Kamilaris J , Berglund JP , Burk C , Hiegel A , Carlisle S , Christie L , et al. Sustained unresponsiveness to peanut in subjects who have completed peanut oral immunotherapy. J Allergy Clin Immunol. 2014;133:468-75. doi:10.1016/j.jaci.2013.11.007. PMID:24361082
   PubMed Web of Science ®Google Scholar
• Keet CA , Seopaul S , Knorr S , Narisety S , Skripak J , Wood RA . Long-term follow-up of oral immunotherapy for cow's milk allergy. J Allergy Clin Immunol. 2013;132:737-739. e6. doi:10.1016/j.jaci.2013.05.006. PMID:23806635
   PubMed Web of Science ®Google Scholar
• Keet CA , Frischmeyer-Guerrerio PA , Thyagarajan A , Schroeder JT , Hamilton RG , Boden S , Steele P , Driggers S , Burks AW , Wood RA . The safety and efficacy of sublingual and oral immunotherapy for milk allergy. J Allergy Clin Immunol. 2012;129:448-55. e1–5. doi:10.1016/j.jaci.2011.10.023. PMID:22130425
   PubMed Web of Science ®Google Scholar
• Narisety SD , Frischmeyer-Guerrerio PA , Keet CA , Gorelik M , Schroeder J , Hamilton RG , Wood RA . A randomized, double-blind, placebo-controlled pilot study of sublingual versus oral immunotherapy for the treatment of peanut allergy. J Allergy Clin Immunol. 2015;135:1275-82. e1–6. doi:10.1016/j.jaci.2014.11.005. PMID:25528358
   PubMed Web of Science ®Google Scholar
• Tordesillas L , Mondoulet L , Blazquez AB , Benhamou PH , Sampson HA , Berin MC . Epicutaneous immunotherapy induces gastrointestinal LAP+ regulatory T cells and prevents food-induced anaphylaxis. J Allergy Clin Immunol. 2017;139:189-201. e4. doi:10.1016/j.jaci.2016.03.057. PMID:27417020
   PubMed Web of Science ®Google Scholar
• Jones SM , Agbotounou WK , Fleischer DM , Burks AW , Pesek RD , Harris MW , Martin L , Thebault C , Ruban C , Benhamou PH . Safety of epicutaneous immunotherapy for the treatment of peanut allergy: A phase 1 study using the Viaskin patch. J Allergy Clin Immunol. 2016;137:1258-1261. e10. doi:10.1016/j.jaci.2016.01.008. PMID:26920463
   PubMed Web of Science ®Google Scholar
• Hoffmann HJ , Valovirta E , Pfaar O , Moingeon P , Schmid JM , Skaarup SH , Cardell LO , Simonsen K , Larché M , Durham SR , et al. Novel approaches and perspectives in allergen immunotherapy. Allergy. 2017;69:643.
   Google Scholar
• Lemon-Mulé H , Sampson HA , Sicherer SH , Shreffler WG , Noone S , Nowak-Węgrzyn A . Immunologic changes in children with egg allergy ingesting extensively heated egg. J Allergy Clin Immunol. 2008;122:977-983. e1. doi:10.1016/j.jaci.2008.09.007. PMID:18851876
   PubMed Web of Science ®Google Scholar
• Nowak-Węgrzyn A , Fiocchi A . Rare, medium, or well done? The effect of heating and food matrix on food protein allergenicity. Curr Opin Allergy Clin Immunol. 2009;9:234-7. doi:10.1097/ACI.0b013e32832b88e7. PMID:19444093
   PubMed Web of Science ®Google Scholar
• Miceli Sopo S , Greco M , Monaco S , Bianchi A , Cuomo B , Liotti L , Iacono ID . Matrix effect on baked milk tolerance in children with IgE cow milk allergy. Allergol Immunopathol (Madr). 2016;44:517-23. doi:10.1016/j.aller.2016.03.005. PMID:27480790
   PubMed Web of Science ®Google Scholar
• Miceli Sopo S , Greco M , Cuomo B , Bianchi A , Liotti L , Monaco S , Dello Iacono I . Matrix effect on baked egg tolerance in children with IgE-mediated hen's egg allergy. Pediatr Allergy Immunol. 2016;27:465-70. doi:10.1111/pai.12570. PMID:27019388
   PubMed Web of Science ®Google Scholar
• Wood RA , Sicherer SH , Vickery BP , Jones SM , Liu AH , Fleischer DM , Henning AK , Mayer L , Burks AW , Grishin A , et al. The natural history of milk allergy in an observational cohort. J Allergy Clin Immunol. 2013;131:805-812. e4. doi:10.1016/j.jaci.2012.10.060. PMID:23273958
   PubMed Web of Science ®Google Scholar
• Sicherer SH , Wood RA , Vickery BP , Jones SM , Liu AH , Fleischer DM , Dawson P , Mayer L , Burks AW , Grishin A , et al. The natural history of egg allergy in an observational cohort. J Allergy Clin Immunol. 2014;133:492-8. doi:10.1016/j.jaci.2013.12.1041. PMID:24636473
   PubMed Web of Science ®Google Scholar
• Kim JS , Nowak-Węgrzyn A , Sicherer SH , Noone S , Moshier EL , Sampson HA . Dietary baked milk accelerates the resolution of cow's milk allergy in children. J Allergy Clin Immunol. 2011;128:125-131. e2. doi:10.1016/j.jaci.2011.04.036. PMID:21601913
   PubMed Web of Science ®Google Scholar
• Leonard SA , Sampson HA , Sicherer SH , Noone S , Moshier EL , Godbold J , Nowak-Węgrzyn A . Dietary baked egg accelerates resolution of egg allergy in children. J Allergy Clin Immunol. 2012;130:473-80. e1. doi:10.1016/j.jaci.2012.06.006. PMID:22846751
   PubMed Web of Science ®Google Scholar
• Bartnikas LM , Sheehan WJ , Schneider LC , Phipatanakul W . Predicting food challenge outcomes for baked milk: Role of specific IgE and skin prick testing. J Allergy Clin Immunol. 2012;129:AB21. doi:10.1016/j.jaci.2011.12.940
   Web of Science ®Google Scholar
• Turner PJ , Mehr S , Joshi P , Tan J , Wong M , Kakakios A , Campbell DE . Safety of food challenges to extensively heated egg in egg-allergic children: A prospective cohort study. Pediatr Allergy Immunol. 2013;24:450-5. doi:10.1111/pai.12093. PMID:23773122
   PubMed Web of Science ®Google Scholar
• Nowak-Węgrzyn A , Bloom KA , Sicherer SH , Shreffler WG , Noone S , Wanich N , Sampson HA . Tolerance to extensively heated milk in children with cow's milk allergy. J Allergy Clin Immunol. 2008;122:342-2. doi:10.1016/j.jaci.2008.05.043. PMID:18620743
   PubMed Web of Science ®Google Scholar
• Zhou Y , Kawasaki H , Hsu S-C , Lee RT , Yao X , Plunkett B , Fu J , Yang K , Lee YC , Huang SK . Oral tolerance to food-induced systemic anaphylaxis mediated by the C-type lectin SIGNR1. Nat Med. 2010;16:1128-33. doi:10.1038/nm.2201. PMID:20835248
   PubMed Web of Science ®Google Scholar
• Rupa P , Nakamura S , Katayama S , Mine Y . Effects of ovalbumin glycoconjugates on alleviation of orally induced egg allergy in mice via dendritic-cell maturation and T-cell activation. Mol Nutr Food Res. 2013;58:405-17. doi:10.1002/mnfr.201300067. PMID:24124125
   PubMed Web of Science ®Google Scholar
• Prickett SR , Voskamp AL , Dacumos-Hill A , Symons K , Rolland JM , O'Hehir RE . Ara h 2 peptides containing dominant CD4+ T-cell epitopes: Candidates for a peanut allergy therapeutic. J Allergy Clin Immunol. 2011;127:608-15. e1–5. doi:10.1016/j.jaci.2010.09.027. PMID:21093025
   PubMed Web of Science ®Google Scholar
• Prickett SR , Voskamp AL , Phan T , Dacumos-Hill A , Mannering SI , Rolland JM , O'Hehir RE . Ara h 1 CD4+ T cell epitope-based peptides: Candidates for a peanut allergy therapeutic. Clin Exp Allergy. 2013;43:684-97. doi:10.1016/j.jaci.2015.12.1327. PMID:23711131
   PubMed Web of Science ®Google Scholar
• Ramesh M , Yuenyongviwat A , Konstantinou GN , Lieberman J , Pascal M , Masilamani M , Sampson HA . Peanut T-cell epitope discovery: Ara h 1. J Allergy Clin Immunol. 2016;137:1764-4. PMID:26953158
   PubMed Web of Science ®Google Scholar
• Anzengruber J , Bublin M , Bönisch E , Janesch B , Tscheppe A , Braun ML , Varga EM , Hafner C , Breiteneder H , Schäffer C . Lactobacillus buchneri S-layer as carrier for an Ara h 2-derived peptide for peanut allergen-specific immunotherapy. Mol Immunol. 2017;85:81-8. doi:10.1016/j.molimm.2017.02.005. PMID:28212503
   PubMed Web of Science ®Google Scholar
• Ueno HM , Kato T , Ohnishi H , Kawamoto N , Kato Z , Kaneko H , Kondo N , Nakano T . T-cell epitope-containing hypoallergenic β-lactoglobulin for oral immunotherapy in milk allergy. Pediatr Allergy Immunol. 2016;27:818-24. doi:10.1111/pai.12642. PMID:27540712
   PubMed Web of Science ®Google Scholar
• Giavi S , Vissers YM , Muraro A , Lauener R , Konstantinopoulos AP , Mercenier A , Wermeille A , Lazzarotto F , Frei R , Bonaguro R , et al. Oral immunotherapy with low allergenic hydrolysed egg in egg allergic children. Allergy. 2016;71:1575-84. doi:10.1111/all.12905. PMID:27059671
   PubMed Web of Science ®Google Scholar
• Wai CYY , Leung NYH , Leung PSC , Chu KH . T cell epitope immunotherapy ameliorates allergic responses in a murine model of shrimp allergy. Clin Exp Allergy. 2016;46:491-503. doi:10.1111/cea.12684. PMID:26610061
   PubMed Web of Science ®Google Scholar
• Lozano-Ojalvo D , López-Fandiño R . Immunomodulating peptides for food allergy prevention and treatment. Crit Rev Food Sci Nutr. 2017; [epub ahead of print]. doi:10.1080/10408398.2016.1275519
   PubMed Web of Science ®Google Scholar
• Li XM , Srivastava K , Grishin A , Huang CK , Schofield B , Burks W , Sampson HA . Persistent protective effect of heat-killed Escherichia coli producing “engineered,” recombinant peanut proteins in a murine model of peanut allergy. J Allergy Clin Immunol. 2003;112:159-67. doi:10.1067/mai.2003.1622. PMID:12847493
   PubMed Web of Science ®Google Scholar
• Li XM , Srivastava K , Huleatt JW , Bottomly K , Burks AW , Sampson HA . Engineered recombinant peanut protein and heat-killed Listeria monocytogenes coadministration protects against peanut-induced anaphylaxis in a murine model. J Immunol. 2003;170:3289-95. doi:10.4049/jimmunol.170.6.3289. PMID:12626588
   PubMed Web of Science ®Google Scholar
• Wood RA , Sicherer SH , Burks AW , Grishin A , Henning AK , Lindblad R , Stablein D , Sampson HA . A phase 1 study of heat/phenol-killed, E. coli-encapsulated, recombinant modified peanut proteins Ara h 1, Ara h 2, and Ara h 3 (EMP-123) for the treatment of peanut allergy. Allergy. 2013;68:803-8. doi:10.1111/all.12158. PMID:23621498
   PubMed Web of Science ®Google Scholar
• Tsai WC , Wu TC , Chiang BL , Wen HW . Cloning, expression, and purification of recombinant major mango allergen Man i 1 in Escherichia coli. Protein Expr Purif. 2017;130:35-43. doi:10.1016/j.pep.2016.06.009. PMID:27350535
   PubMed Web of Science ®Google Scholar
• Zuidmeer-Jongejan L , Huber H , Swoboda I , Rigby N , Versteeg SA , Jensen BM , Quaak S , Akkerdaas JH , Blom L , Asturias J , et al. Development of a hypoallergenic recombinant parvalbumin for first-in-man subcutaneous immunotherapy of fish allergy. Int Arch Allergy Immunol. 2015;166:41-51. doi:10.1159/000371657. PMID:25765512
   PubMed Web of Science ®Google Scholar
• Srivastava KD , Siefert A , Fahmy TM , Caplan MJ , Li XM , Sampson HA . Investigation of peanut oral immunotherapy with CpG/peanut nanoparticles in a murine model of peanut allergy. J Allergy Clin Immunol. 2016;138:536-543. e4. doi:10.1016/j.jaci.2016.01.047. PMID:27130858
   PubMed Web of Science ®Google Scholar
• Hsu C , Smarr CB , Byrne AJ , Miller SD , Bryce PJ . Rapid induction of tolerance to peanut by antigen-coupled cell transfer. J Allergy Clin Immunol. 2012;129:AB1. doi:10.1016/j.jaci.2011.12.863
   Web of Science ®Google Scholar
• Dawicki W , Li C , Town J , Zhang X , Gordon JR . Therapeutic reversal of food allergen sensitivity by mature retinoic acid–differentiated dendritic cell induction of LAG3+CD49b−Foxp3− regulatory T cells. J Allergy Clin Immunol. 2016;139:705-715. e1. doi:10.1016/j.jaci.2011.01.051. PMID:27697499
   PubMed Web of Science ®Google Scholar
• Sampson HA , Leung DYM , Burks AW , Lack G , Bahna SL , Jones SM , Wong DA . A phase II, randomized, double-blind, parallel-group, placebo-controlled oral food challenge trial of Xolair (omalizumab) in peanut allergy. Jo Allergy Clin Immunol. 2011;127:1309-1310. e1. PMID:21397314
   PubMed Web of Science ®Google Scholar
• Savage JH , Courneya JP , Sterba PM , MacGlashan DW , Saini SS , Wood RA . Kinetics of mast cell, basophil, and oral food challenge responses in omalizumab-treated adults with peanut allergy. J Allergy Clin Immunol. 2012;130:1123-1129. e2. doi:10.1016/j.jaci.2012.05.039. PMID:22800401
   PubMed Web of Science ®Google Scholar
• Schneider LC , Rachid R , LeBovidge J , Blood E , Mittal M , Umetsu DT . A pilot study of omalizumab to facilitate rapid oral desensitization in high-risk peanut-allergic patients. J Allergy Clin Immunol. 2013;132:1368-74. doi:10.1016/j.jaci.2013.09.046. PMID:24176117
   PubMed Web of Science ®Google Scholar
• Nadeau KC , Schneider LC , Hoyte L , Borras I , Umetsu DT . Rapid oral desensitization in combination with omalizumab therapy in patients with cow's milk allergy. J Allergy Clin Immunol. 2011;127:1622-4. doi:10.1016/j.jaci.2011.04.009. PMID:21546071
   PubMed Web of Science ®Google Scholar
• Bégin P , Dominguez T , Wilson SP , Bacal L , Mehrotra A , Kausch B , Trela A , Tavassoli M , Hoyte E , O'Riordan G , et al. Phase 1 results of safety and tolerability in a rush oral immunotherapy protocol to multiple foods using Omalizumab. Allergy Asthma Clin Immunol. 2014;10:7. doi:10.1186/1710-1492-10-7. PMID:24576338
   PubMed Web of Science ®Google Scholar
• Martorell-Calatayud C , Michavila-Gómez A , Martorell-Aragonés A , Molini-Menchón N , Cerdá-Mir JC , Félix-Toledo R , De Las Marinas-Álvarez MD . Anti-IgE-assisted desensitization to egg and cow's milk in patients refractory to conventional oral immunotherapy. Pediatr Allergy Immunol. 2016;27:544-6. doi:10.1111/pai.12567. PMID:27003835
   PubMed Web of Science ®Google Scholar
• MacGinnitie AJ , Rachid R , Gragg H , Little SV , Lakin P , Cianferoni A , Heimall J , Makhija M , Robison R , Chinthrajah RS , et al. Omalizumab facilitates rapid oral desensitization for peanut allergy. J Allergy Clin Immunol. 2017;139:873-8. doi:10.1016/j.jaci.2016.08.010. PMID:27609658
   PubMed Web of Science ®Google Scholar
• Zitnik SE , Rüschendorf F , Müller S , Sengler C , Lee YA , Griffioen RW , Meglio P , Wahn U , Witt H , Nickel R . IL13variants are associated with total serum IgE and early sensitization to food allergens in children with atopic dermatitis. Pediatr Allergy Immunol. 2009;20:551-5. doi:10.1111/j.1399-3038.2008.00815.x. PMID:19220774
   PubMed Web of Science ®Google Scholar
• Liu X , Beaty TH , Deindl P , Huang SK , Lau S , Sommerfeld C , Fallin MD , Kao WH , Wahn U , Nickel R . Associations between specific serum IgE response and 6 variants within the genes IL4, IL13, and IL4RA in German children. J Allergy Clin Immunol. 2004;113:489-95. doi:10.1016/j.jaci.2003.12.037. PMID:15007352
   PubMed Web of Science ®Google Scholar
• Bauer RN , Manohar M , Singh AM , Jay DC , Nadeau KC . The future of biologics: Applications for food allergy. J Allergy Clin Immunol. 2015;135:312-23. doi:10.1016/j.jaci.2014.12.1908. PMID:25662303
   PubMed Web of Science ®Google Scholar
• Srivastava KD , Kattan JD , Zou ZM , Li JH , Zhang L , Wallenstein S , Goldfarb J , Sampson HA , Li XM . The Chinese herbal medicine formula FAHF-2 completely blocks anaphylactic reactions in a murine model of peanut allergy. J Allergy Clin Immunol. 2005;115:171-8. doi:10.1016/j.jaci.2004.10.003. PMID:15637565
   PubMed Web of Science ®Google Scholar