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Review

Decorating and loading ghosts with allergens for allergen immunotherapy

, , , , & ORCID Icon
Pages 2428-2433 | Received 23 Jun 2017, Accepted 04 Aug 2017, Published online: 18 Oct 2017

References

  • Marek J , Lothar J , Roland S , Hanns M , Helmut F , Oliver C. Allergen-specific immunotherapy with recombinant grass pollen allergens. J Allergy Clin Immunol. 2005;116(3):608–613. doi:10.1016/j.jaci.2005.06.004. PMID:16159631
  • Flöistrup H , Swartz J , Bergström A , Alm JS , Scheynius A , Van Hage M , Waser M , Braun-Fahrlander C , Schram-Bijkerk D , Huber M , et al. Allergic disease and sensitization in Steiner school children. J Allergy Clin Immunol. 2005;117(1):59–66. doi:10.1016/j.jaci.2005.09.039. PMID:16387585
  • Hansen I , Klimek L , Mösges R , Hörmann K . Mediators of inflammation in the early and the late phase of allergic rhinitis. Curr Opin Allergy Clin Immunol. 2004;4(3):159–63. doi:10.1097/00130832-200406000-00004. PMID:15126935
  • Bacharier LB , Geha RS . Molecular mechanisms of IgE regulation. J Allergy Clin Immunol. 2000;105(2 Pt 2):S547–58. doi:10.1016/S0091-6749(00)90059-9. PMID:10669540
  • Pawankar R , Mori S , Ozu C , Kimura S . Overview on the pathomechanisms of allergic rhinitis. Asia Pac Allergy. 2011;1(3):157–167. doi:10.5415/apallergy.2011.1.3.157. PMID:22053313
  • Burks WA , Calderon MA , Casale T , Cox L , Demoly P , Jutel M , Nelson H , Akdis CA . Update on allergy immunotherapy : American Academy of Allergy, Asthma & Immunology / European Academy of Allergy and Clinical Immunology / PRACTALL consensus report. J Allergy Clin Immunol. 2013;131(5):1288–1296.e3. doi:10.1016/j.jaci.2013.01.049. PMID:23498595
  • Durham SR , Till SJ . Immunologic changes associated with allergen immunotherapy. J Allergy Clin Immunol. 1998;102(2):157–64. doi:10.1016/S0091-6749(98)70079-X. PMID:9723654
  • Bousquet J , Lockey R , Malling H . Allergen immunotherapy : Therapeutic vaccines for allergic diseases. J Allergy Clin Immunol. 1997;102(4):558–62. doi:10.1016/S0091-6749(98)70271-4
  • Makatsori M , Pfaar O , Lleonart R , Calderon MA . Recombinant Allergen Immunotherapy : Clinical Evidence of Efficacy-A Review. Curr Allergy Astma Rep. 2013;13(4):371–80. doi:10.1007/s11882-013-0359-7
  • Durham SR , Emminger W , Kapp A , Colombo G , De JGR , Rak S , Scadding GK , Andersen JS , Riis B , Dahl R . Long-term clinical efficacy in grass pollen – induced rhinoconjunctivitis after treatment with SQ-standardized grass allergy immunotherapy tablet. J Allergy Clin Immunol. 2010;125(1):131-138.e1-7. doi:10.1016/j.jaci.2009.10.035
  • Akdis M , Akdis CA . Therapeutic manipulation of immune tolerance in allergic disease. Nat Reviews Drug Disc. 2009;8:645–660. doi:10.1038/nrd2653
  • Jutel M , Akdis CA . Immunological mechanisms of allergen-specific immunotherapy. Allergy. 2011;66(6):725–32. doi:10.1111/j.1398-9995.2011.02589.x. PMID:21466562
  • Brunetto B , Tinghino R , Braschi MC , Antonicelli L , Pini C , Iacovacci P . Characterization and comparison of commercially available mite extracts for in vivo diagnosis. Allergy. 2010;65(2):184–90. doi:10.1111/j.1398-9995.2009.02150.x. PMID:19796217
  • Curin M , Reininger R , Swoboda I , Focke M , Valenta R , Spitzauer S . Skin prick test extracts for dog allergy diagnosis show considerable variations regarding the content of major and minor dog allergens. Int Arch Allergy Immunol. 2011;154(3):258–63. doi:10.1159/000321113. PMID:20861648
  • Blank S , Seismann H , Michel Y , McIntyre M , Cifuentes L , Braren I , Grunwald T , Darsow U , Ring J , Bredehorst R , et al. Api m 10, a genuine A. mellifera venom allergen, is clinically relevant but underrepresented in therapeutic extracts. Allergy. 2011;66(10):1322–1329. doi:10.1111/j.1398-9995.2011.02667.x. PMID:21658068
  • Focke M , Swoboda I , Marth K , Valenta R . Developments in allergen-specific immunotherapy: From allergen extracts to allergy vaccines bypassing allergen-specific immunoglobulin e and T cell reactivity. Clinical and Experimental Allergy. 2010;40:385–97. doi:10.1111/j.1365-2222.2009.03443.x. PMID:20210812
  • Chapman MD , Smith AM , Vailes LD , Arruda LK , Dhanaraj V , Pomes A . Recombinant allergens for diagnosis and therapy of allergic diseases. J Allergy Clin Immunol. 2000;106(3):409–18. doi:10.1067/mai.2000.109832. PMID:10984358
  • Pauli G , Larsen TH , Rak S , Horak F , Pastorello E , Valenta R , Purohit A , Arvidsson M , Kavina A , Schroeder JW , et al. Efficacy of recombinant birch pollen vaccine for the treatment of birch-allergic rhinoconjunctivitis. J Allergy Clin Immunology. 2008;122(5):951–60. doi:10.1016/j.jaci.2008.09.017
  • Akdis CA , Akdis M . Advances in allergen immunotherapy: Aiming for complete tolerance to allergens. Sci Transl Med. 2015;7(280):280–286. doi:10.1126/scitranslmed.aaa7390
  • Pohlit H , Holger F , Saloga J . Could allergen-specific immunotherapy benefit from the use of nanocarriers? Nanomedicine. 2016;11(11):1329–31. doi:10.2217/nnm-2016-0111. PMID:27221075
  • Witte A , Wanner G , Blasi UDO , Halfmann G , Szostak M , Lubitz W . Endogenous transmembrane tunnel formation mediated by pX174 Lysis protein E. J Bacteriology. 1990;172(7):4109–4114. doi:10.1128/jb.172.7.4109-4114.1990
  • Szostak MP , Hensel A , Eko F , Klein R , Auer T , Mader H , Haslberger A , Bunka S , Wanner G , Lubitz W . Bacterial ghosts : Non-living candidate vaccines. J Biotechnol. 1996;44(1–3):161–170. doi:10.1016/0168-1656(95)00123-9. PMID:8717400
  • Langemann T , Koller VJ , Muhammad A , Kudela P , Mayr UB , Lubitz W . The bacterial ghost platform system Production and applications. Bioeng Bugs. 2010;1(5):326–36. doi:10.4161/bbug.1.5.12540. PMID:21326832
  • Paukner S , Stiedl T , Kudela P , Bizik J , Laham F Al , Lubitz W . Bacterial ghosts as a novel advanced targeting system for drug and DNA delivery. Expert Opin drug Deliv. 2006;3(1):11–22. doi:10.1517/17425247.3.1.11. PMID:16370937
  • Witte A , Wanner G , Sulzner M , Lubitz W . Dynamics of PhiX174 protein E-mediated lysis of Escherichia coli . Arch. Microbiolol. 1992;157(4):381–388. doi:10.1007/BF00248685
  • Fu X , Himes BA , Ke D , Rice WJ , Ning J , Zhang P . Controlled bacterial lysis for electron tomography of native cell membranes. Structure. 2014;22(12):1875–82. doi:10.1016/j.str.2014.09.017. PMID:25456413
  • Macri C , Dumont C , Johnston APR , Mintern JD . Targeting dendritic cells : a promising strategy to improve vaccine effectiveness. Clin Transl Immunol. 2016;5(3):e66–68. doi:10.1038/cti.2016.6
  • Jechlinger W , Haller C , Resch S , Hofmann A , Szostak MP , Lubitz W . Comparative immunogenicity of the Hepatitis B virus core 149 antigen displayed on the inner and outer membrane of bacterial ghosts. Vaccine. 2005;23(27):3609–17. doi:10.1016/j.vaccine.2004.11.078. PMID:15855021
  • Mayr UB , Walcher P , Azimpour C , Riedmann E , Haller C , Lubitz W , Beate U , Walcher P , Azimpour C , Riedmann E , et al. Bacterial ghosts as antigen delivery vehicles. Adv Drug Deliv Rev. 2005;57(9):1381–91. doi:10.1016/j.addr.2005.01.027. PMID:15878634
  • Choi SH , Nam YK , Kim KH . Novel expression system for combined vaccine production in edwardsiella tarda ghost and cadaver cells. Mol Biotechnol. 2010;46(2):127–33. doi:10.1007/s12033-010-9277-2. PMID:20369310
  • Paukner S , Kohl G , Jalava K , Lubitz W . Sealed bacterial ghosts — novel targeting vehicles for advanced drug delivery of water-soluble substances. J Drug Target. 2003;11(3):151–61. PMID:13129825
  • Bottazzi B , Doni A , Garlanda C , Mantovani A . An integrated view of humoral innate immunity: Pentraxins as a Paradigm. Annu Rev Immunol. 2010;28:157–83. doi:10.1146/annurev-immunol-030409-101305. PMID:19968561
  • Charbit A , Boulain JC , Ryterl A , Hofnung M . Probing the topology of a bacterial membrane protein by genetic insertion of a foreign epitope ; expression at the cell surface. EMBO J. 1986;5(11):3029–37. PMID:2431904
  • Freudl R , Maclntyre S , Degen M , Henning U . Cell surface exposure of the outer membrane protein OmpA of escherichia coli K-12. J Mol. 1986;188(3):491–4. doi:10.1016/0022-2836(86)90171-3
  • Matricardi PM , Bjorksten B , Bonini S , Bousquet J , Djukanovic R , Dreborg S , Gereda J , Malling JH , Popov E , Raz E , et al. Microbial products in allergy prevention and therapy. Allergy. 2003;58(6):461–71. doi:10.1034/j.1398-9995.2003.00175.x. PMID:12757444
  • Frick OL , Teuber SS , Buchanan BB , Morigasaki S , Umetsu DT . Allergen immunotherapy with heat-killed Listeria monocytogenes alleviates peanut and food-induced anaphylaxis in dogs. Allergy. 2005;60(2):243–50. doi:10.1111/j.1398-9995.2004.00711.x. PMID:15647048
  • Li X , Srivastava K , Grishin A , Huang CH , Schofield B , Burks W , Sampson HA . Food and drug reactions and anaphylaxis Rapid publication Persistent protective effect of heat- killed Escherichia coli producing “ engineered,” recombinant peanut proteins in a murine model of peanut. J Allergy Clin Immunol. 2003;112(1):159–67. doi:10.1067/mai.2003.1622. PMID:12847493
  • Guimarães JQM , Silva ODA , Alves R , Fukuhara CH , Soares de Amaral VB , Almeida VB , Ynoue LH , Oliveira R , Camargo SM , Rodrigues GSS , et al. Mite-specific immunotherapy using allergen and / or bacterial extracts in atopic patients in Brazil. J Investig Allergol Clin Immunol. 2008;18(2):84–92. PMID:18447136
  • Bohle B , Breitwieser A , Zwölfer B , Jahn-schmid B , Sára M , Sleytr UB , Ebner C . A novel approach to specific allergy treatment: The recombinant fusion protein of a bacterial cell surface (S-Layer) protein and the major birch pollen allergen Bet v 1 (rSbsC-Bet v 1) combines reduced allergenicity with immunomodulating capacity. J Immunol. 2004;172(11):6642–8. doi:10.4049/jimmunol.172.11.6642. PMID:15153479
  • Jahn-schmid B , Messner P , Unger FM , Sleytr UB , Scheiner O , Kraft D . Toward selective elicitation of TH1-controlled vaccination responses: Vaccine applications of bacterial surface layer proteins. J Biotechnol. 1996;44(1–3):225–231. doi:10.1016/0168-1656(95)00124-7. PMID:8717408
  • Jahn-schmid B , Siemann U , Zenker A , Bohle B , Messner P , Unger FM , Sleytr UB , Scheiner O , Kraft D , Ebner C . Bet v 1, the major birch pollen allergen, conjugated to crystalline bacterial cell surface proteins, expands allergen-specific T cells of the T h 1 / T h 0 phenotype in vitro by induction of IL-12. Intl Immunol. 1997;9(12):1867–1874. doi:10.1093/intimm/9.12.1867
  • Haslberger AG , Kohl G , Felnerova D , Mayr UB , Furst-Ladani S , Lubitz W . Activation, stimulation and uptake of bacterial ghosts in antigen presenting cells. J Biotechnol. 2000;83(1–2):57–66. doi:10.1016/S0168-1656(00)00298-4. PMID:11000461
  • Langemann T , Mayr UB , Meitz A , Lubitz W , Herwig C . Multi-parameter flow cytometry as a process analytical technology (PAT) approach for the assessment of bacterial ghost production. Appl Microbiol Biotechnol. 2016;100(1):409–418. doi:10.1007/s00253-015-7089-9. PMID:26521248
  • Haidinger W , Szostak MP , Jechlinger W , Lubitz W . Online Monitoring of Escherichia coli Ghost Production. Appl Environ Microbiol. 2003;69(1):468–474. doi:10.1128/AEM.69.1.468-474.2003. PMID:12514029
  • Kassmannhuber J , Rauscher M , Schöner L , Witte A . Functional display of ice nucleation protein InaZ on the surface of bacterial ghosts. Bioengineered. 2017;1–13. doi:10.1080/21655979.2017.1284712. PMID:28121482
  • Hess J , Gentschevt I , Miko D , Welzel M , Ladel C , Goebelt W , Kaufmann SH . Superior efficacy of secreted over somatic antigen display in recombinant Salmonella vaccine induced protection against listeriosis. Proc Natl Acad Sci USA. 1996;93(4):1458–1463. doi:10.1073/pnas.93.4.1458. PMID:8643654
  • Muralinath M , Kuehn MJ , Roland KL , Curtiss R . Immunization with salmonella enterica serovar typhimurium-derived outer membrane vesicles delivering the pneumococcal protein pspa confers protection against challenge with streptococcus pneumoniae. Infect Immun. 2011;79(2):887–94. doi:10.1128/IAI.00950-10. PMID:21115718
  • Hjelm A , Söderström B , Vikström D , Jong WS , Luirink J , De Gier JW . Autotransporter-based antigen display in bacterial ghosts. Appl Environ Microbiol. 2015;81(2):726–735. doi:10.1128/AEM.02733-14. PMID:25398861
  • Walcher P , Mayr UB , Azimpour-tabrizi C , Eko FO , Jechlinger W , Mayrhofer P , Alefantis T , Mujer CV , DelVecchio VG , Lubitz W . Antigen discovery and delivery of subunit vaccines by nonliving bacterial ghost vectors. Expert Rev Vaccines. 2004;3(6):681–691. doi:10.1586/14760584.3.6.681. PMID:15606353
  • Gangl K , Niederberger V , Valenta R . Multiple grass mixes as opposed to single grasses for allergen immunotherapy in allergic rhinitis. Clin Exp Allergy. 2013;43(11):1202–16. doi:10.1111/cea.12128. PMID:24152153
  • Jutel M , Jaeger L , Suck R , Meyer H , Fiebig H , Cromwell O . Allergen-specific immunotherapy with recombinant grass pollen allergens. J Allergy Clin Immunol. 116(3):608–13. doi:10.1016/j.jaci.2005.06.004. PMID:16159631
  • Moghimi SM. Chemical camouflage of nanospheres with a poorly reactive surface: Towards development of stealth and target-specific nanocarriers. Biochim Biophys Acta. 2002;1590(1–3):131–9. doi:10.1016/S0167-4889(02)00204-5. PMID:12063176
  • Haslberger AG , Mader HJ , Schmalnauer M , Kohl G , Szostak MP , Messner P , Sleytr UB , Wanner G , Furst-Ladani S , Lubitz W . Bacterial cell envelopes (ghosts) and LPS but not bacterial S-layers induce synthesis of immune-mediators in mouse macrophages involving CD14. Innate Immun. 1997;4(6):431–441.
  • Wang T , Li Y , Wang F , Zhou C . Nonadherence to sublingual immunotherapy in allergic rhinitis: a real-life analysis. Int Forum Allergy Rhinol. 2017;7(4):389–92. doi:10.1002/alr.21909. PMID:28151587
  • Huter V , Szostak MP , Gampfer J , Prethaler S , Wanner G , Gabor F , Lubitz W . Bacterial ghosts as drug carrier and targeting vehicles. J Control Release.1999;61(1–2):51–63. doi:10.1016/S0168-3659(99)00099-1. PMID:10469902
  • Lubitz W. Bacterial ghosts as carrier and targeting system. Expert Opin Ther. 2001;1(5):765–71. doi:10.1517/14712598.1.5.765
  • Palffy R , Gardlık R , Hodosy J , Behuliak M , Resko P , Radvansky J , Celec P . Bacteria in gene therapy : bactofection versus alternative gene therapy. 2006;13(2):101–5.
  • Bachmann MF , Jennings GT . Vaccine delivery : A matter of size, geometry, kinetics and molecular patterns. Nat Rev Immunol. 2010;10(11):787–96. doi:10.1038/nri2868. PMID:20948547

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