Nasal aluminum (oxy)hydroxide enables adsorbed antigens to induce specific systemic and mucosal immune responses

References

• Mbow ML, De Gregorio E, Valiante NM, Rappuoli R. New adjuvants for human vaccines. Curr Opin Immunol. 2010;22:411-6. PMID:20466528
   PubMed Web of Science ®Google Scholar
• Bomford R. The comparative selectivity of adjuvants for humoral and cell-mediated immunity. I. Effect on the antibody response to bovine serum albumin and sheep red blood cells of Freund's incomplete and complete adjuvants, alhydrogel, Corynebacterium parvum, Bordetella pertussis, muramyl dipeptide and saponin. Clin Exp Immunol. 1980;39:426-34. PMID:6248282
   PubMed Web of Science ®Google Scholar
• Harris JR, Soliakov A, Lewis RJ, Depoix F, Watkinson A, Lakey JH. Alhydrogel(R) adjuvant, ultrasonic dispersion and protein binding: a TEM and analytical study. Micron. 2012;43:192-200. PMID:21831642
   PubMed Web of Science ®Google Scholar
• Butler WT, Rossen RD, Wenden RD. Effect of physical state and route of inoculation of diphtheria toxoid on the formation of nasal secretory and serum antibodies in man. J Immunol. 1970;104:1396-400. PMID:5463220
   PubMed Web of Science ®Google Scholar
• Isaka M, Yasuda Y, Kozuka S, Miura Y, Taniguchi T, Matano K, Goto N, Tochikubo K. Systemic and mucosal immune responses of mice to aluminium-adsorbed or aluminium-non-adsorbed tetanus toxoid administered intranasally with recombinant cholera toxin B subunit. Vaccine. 1998;16:1620-6. PMID:9713937
   PubMed Web of Science ®Google Scholar
• Isaka M, Yasuda Y, Taniguchi T, Kozuka S, Matano K, Maeyama J, Morokuma K, Ohkuma K, Goto N, Tochikubo K. Comparison of systemic and mucosal responses of mice to aluminium-adsorbed diphtheria toxoid between intranasal administration and subcutaneous injection. Nagoya Med J. 2001;45:5-15
   Google Scholar
• Stewart-Tull DES. Recommendations for the Assessment of Adjuvants (Immunopotentiators). In: Gregoriadis G, Allison AC, Poste G, eds. Immunological adjuvants and vaccines. Boston, MA: Springer US, 1989:213-26
   Google Scholar
• Stewart-Tull DES. The assessment and use of adjuvants. In: Gregoriadis G, Allison AC, Poste G, eds. Vaccines: Recent trends and progress. Boston, MA: Springer US, 1991:85-92
   Google Scholar
• Casella CR, Mitchell TC. Putting endotoxin to work for us: monophosphoryl lipid A as a safe and effective vaccine adjuvant. Cell Mol Life Sci. 2008;65:3231-40. PMID:18668203
   PubMed Web of Science ®Google Scholar
• Childers NK, Miller KL, Tong G, Llarena JC, Greenway T, Ulrich JT, Michalek SM. Adjuvant activity of monophosphoryl lipid a for nasal and oral immunization with soluble or liposome-associated antigen. Infect Immun. 2000;68:5509-16. PMID:10992447
   PubMed Web of Science ®Google Scholar
• Sasaki S, Hamajima K, Fukushima J, Ihata A, Ishii N, Gorai I, Hirahara F, Mohri H, Okuda K. Comparison of intranasal and intramuscular immunization against human immunodeficiency virus Type 1 with a DNA-Monophosphoryl lipid A adjuvant vaccine. Infect Immun. 1998;66:823-6. PMID:9453648
   PubMed Web of Science ®Google Scholar
• Kamphuis T, Shafique M, Meijerhof T, Stegmann T, Wilschut J, de Haan A. Efficacy and safety of an intranasal virosomal respiratory syncytial virus vaccine adjuvanted with monophosphoryl lipid A in mice and cotton rats. Vaccine. 2013;31:2169-76. doi:10.1016/j.vaccine.2013.02.043. PMID:23499594
   PubMed Web of Science ®Google Scholar
• Baldridge JR, Yorgensen Y, Ward JR, Ulrich JT. Monophosphoryl lipid A enhances mucosal and systemic immunity to vaccine antigens following intranasal administration. Vaccine. 2000;18:2416-25. doi:10.1016/S0264-410X(99)00572-1. PMID:10738099
   PubMed Web of Science ®Google Scholar
• Nathaniel FP, Sacci JB, Alving CR, Richardson EC. Enhancement by lipid A of mucosal immunogenicity of liposome-associated cholera toxin. Rev Infect Dis. 1984;6:563-6. doi:10.1093/clinids/6.4.563. PMID:6474016
   PubMedGoogle Scholar
• Blanco JCG, Boukhvalova MS, Pletneva LM, Shirey KA, Vogel SN. A recombinant anchorless respiratory syncytial virus (RSV) fusion (F) protein/monophosphoryl lipid A (MPL) vaccine protects against RSV-induced replication and lung pathology. Vaccine. 2014;32:1495-500. doi:10.1016/j.vaccine.2013.11.032. PMID:24252693
   PubMed Web of Science ®Google Scholar
• Couch RB, Atmar RL, Cate TR, Quarles JM, Keitel WA, Arden NH, Wells J, Niño D, Wyde PR. Contrasting effects of type I interferon as a mucosal adjuvant for influenza vaccine in mice and humans. Vaccine. 2009;27:5344-8. doi:10.1016/j.vaccine.2009.06.084. PMID:19607949
   PubMed Web of Science ®Google Scholar
• Hirano T, Kodama S, Kawano T, Maeda K, Suzuki M. Monophosphoryl lipid A induced innate immune responses via TLR4 to enhance clearance of nontypeable Haemophilus influenzae and Moraxella catarrhalis from the nasopharynx in mice. FEMS Immunol Med Microbiol. 2011;63:407-17. doi:10.1111/j.1574-695X.2011.00866.x. PMID:22092567
   PubMed Web of Science ®Google Scholar
• Uddowla S, Freytag LC, Clements JD. Effect of adjuvants and route of immunizations on the immune response to recombinant plague antigens. Vaccine. 2007;25:7984-93. doi:10.1016/j.vaccine.2007.09.030. PMID:17933440
   PubMed Web of Science ®Google Scholar
• VanCott TC, Kaminski RW, Mascola JR, Kalyanaraman VS, Wassef NM, Alving CR, Ulrich JT, Lowell GH, Birx DL. HIV-1 neutralizing antibodies in the genital and respiratory tracts of mice intranasally immunized with oligomeric gp160. J. Immunol. 1998;160:2000-12. PMID:9469464
   PubMed Web of Science ®Google Scholar
• Li J, Arevalo MT, Chen Y, Posadas O, Smith JA, Zeng M. Intranasal immunization with influenza antigens conjugated with cholera toxin subunit B stimulates broad spectrum immunity against influenza viruses. Hum Vaccin Immunother. 2014;10:1211-20. doi:10.4161/hv.28407. PMID:24632749
   PubMed Web of Science ®Google Scholar
• Thakkar SG, Cui Z. Methods to Prepare Aluminum Salt-Adjuvanted Vaccines. Methods Mol Biol. 2017;1494:181-99. doi:10.1007/978-1-4939-6445-1_13. PMID:27718194
   PubMedGoogle Scholar
• Drachenberg KJ, Wheeler AW, Stuebner P, Horak F. A well‐tolerated grass pollen‐specific allergy vaccine containing#8232;a novel adjuvant, monophosphoryl lipid A, reduces allergic symptoms after only four preseasonal injections. Allergy. 2001;56:498-505. doi:10.1034/j.1398-9995.2001.056006498.x. PMID:11421893
   PubMed Web of Science ®Google Scholar
• Platts-Mills TA, Schuyler AJ, Erwin EA, Commins SP, Woodfolk JA. IgE in the diagnosis and treatment of allergic disease. J. Allergy Clin Immunol. 2016;137:1662-70. doi:10.1016/j.jaci.2016.04.010. PMID:27264001
   PubMed Web of Science ®Google Scholar
• Eickhoff TC, Myers M. Workshop summary. Aluminum in vaccines. Vaccine. 2002;20(Suppl 3):S1-4. doi:10.1016/S0264-410X(02)00163-9. PMID:12184358
   PubMed Web of Science ®Google Scholar
• Hem SL, Hogenesch H. Relationship between physical and chemical properties of aluminum-containing adjuvants and immunopotentiation. Expert Rev Vaccines. 2007;6:685-98. doi:10.1586/14760584.6.5.685. PMID:17931150
   PubMed Web of Science ®Google Scholar
• Flarend RE, Hem SL, White JL, Elmore D, Suckow MA, Rudy AC, Dandashli EA. In vivo absorption of aluminium-containing vaccine adjuvants using 26Al. Vaccine. 1997;15:1314-8. doi:10.1016/S0264-410X(97)00041-8. PMID:9302736
   PubMed Web of Science ®Google Scholar
• Hem SL. Elimination of aluminum adjuvants. Vaccine. 2002;20(Suppl 3):S40-3. doi:10.1016/S0264-410X(02)00170-6. PMID:12184363
   PubMed Web of Science ®Google Scholar
• Stuart BO. Deposition of inhaled aerosols. Arch Intern Med. 1973;131:60-73. doi:10.1001/archinte.1973.00320070056006. PMID:4569374
   PubMed Web of Science ®Google Scholar
• Hatch TF. Distribution and deposition of inhaled particles in respiratory tract. Bacteriol Rev. 1961;25:237. PMID:13905321
   PubMedGoogle Scholar
• Djupesland PG, Mahmoud RA, Messina JC. Accessing the brain: the nose may know the way. J Cereb Blood Flow Metab. 2013;33:793-4. doi:10.1038/jcbfm.2013.41. PMID:23486291
   PubMed Web of Science ®Google Scholar
• Pauluhn J. Pulmonary toxicity and fate of agglomerated 10 and 40 nm aluminum oxyhydroxides following 4-week inhalation exposure of rats: toxic effects are determined by agglomerated, not primary particle size. Toxicol Sci. 2009;109:152-67. doi:10.1093/toxsci/kfp046. PMID:19251949
   PubMed Web of Science ®Google Scholar
• Perl DP, Good PF. Uptake of aluminium into central nervous system along nasal-olfactory pathways. Lancet. 1987;1:1028. doi:10.1016/S0140-6736(87)92288-4. PMID:2883359
   PubMed Web of Science ®Google Scholar
• Harkema JR, Carey SA, Wagner JG. The nose revisited: A brief review of the comparative structure, function, and toxicologic pathology of the nasal epithelium. Toxicol Pathol. 2006;34:252-69. doi:10.1080/01926230600713475. PMID:16698724
   PubMed Web of Science ®Google Scholar
• Glenny AT, Buttle, AH, Stevens MF. Rate of disappearance of diphtheria toxoid injected into rabbits and guinea pigs:toxoid precipitated with alum. J Pathol Bacteriol. 1931;34:267-75. doi:10.1002/path.1700340214.
   Google Scholar
• Tritto E, Mosca F, De Gregorio E. Mechanism of action of licensed vaccine adjuvants. Vaccine. 2009;27:3331-4. doi:10.1016/j.vaccine.2009.01.084. PMID:19200813
   PubMed Web of Science ®Google Scholar
• Eisenbarth SC, Colegio OR, O'Connor W, Sutterwala FS, Flavell RA. Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants. Nature. 2008;453:1122-6. doi:10.1038/nature06939. PMID:18496530
   PubMed Web of Science ®Google Scholar
• Franchi L, Nunez G. The Nlrp3 inflammasome is critical for aluminium hydroxide-mediated IL-1beta secretion but dispensable for adjuvant activity. Eur J Immunol. 2008;38:2085-9. doi:10.1002/eji.200838549. PMID:18624356
   PubMed Web of Science ®Google Scholar
• Kool M, Petrilli V, De Smedt T, Rolaz A, Hammad H, van Nimwegen M, Bergen IM, Castillo R, Lambrecht BN, Tschopp J. Cutting edge: alum adjuvant stimulates inflammatory dendritic cells through activation of the NALP3 inflammasome. J Immunol. 2008;181:3755-9. doi:10.4049/jimmunol.181.6.3755. PMID:18768827
   PubMed Web of Science ®Google Scholar
• Hornung V, Bauernfeind F, Halle A, Samstad EO, Kono H, Rock KL, Fitzgerald KA, Latz E. Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization. Nat Immunol. 2008;9:847-56. doi:10.1038/ni.1631. PMID:18604214
   PubMed Web of Science ®Google Scholar
• Kool M, Soullie T, van Nimwegen M, Willart MA, Muskens F, Jung S, Hoogsteden HC, Hammad H, Lambrecht BN. Alum adjuvant boosts adaptive immunity by inducing uric acid and activating inflammatory dendritic cells. J Exp Med. 2008;205:869-82. doi:10.1084/jem.20071087. PMID:18362170
   PubMed Web of Science ®Google Scholar
• Tochikubo K, Isaka M, Yasuda Y, Kozuka S, Matano K, Miura Y, Taniguchi T. Recombinant cholera toxin B subunit acts as an adjuvant for the mucosal and systemic responses of mice to mucosally co-administered bovine serum albumin. Vaccine. 1998;16:150-5. doi:10.1016/S0264-410X(97)00194-1. PMID:9607023
   PubMed Web of Science ®Google Scholar
• Stagg AJ, Burke F, Hill S, Knight SC. Isolation of mouse spleen dendritic cells. Dendritic Cell Protocols. 2001;64:9-22. doi:10.1385/1-59259-150-7:9.
   Google Scholar
• Bungener L, Geeraedts F, ter Veer W, Medema J, Wilschut J, Huckriede A. Alum boosts TH2-type antibody responses to whole-inactivated virus influenza vaccine in mice but does not confer superior protection. Vaccine. 2008;26:2350-9. doi:10.1016/j.vaccine.2008.02.063. PMID:18400340
   PubMed Web of Science ®Google Scholar