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Immune responses after live attenuated influenza vaccination

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Pages 571-578 | Received 08 Apr 2017, Accepted 03 Sep 2017, Published online: 03 Jan 2018

References

  • WHO. Fact sheet about seasonal influenza. 2017. http://www.who.int/mediacentre/factsheets/fs211/en/
  • Stohr K. Influenza–WHO cares. Lancet Infect Dis. 2002;2:517. doi:10.1016/S1473-3099(02)00366-3. PMID:12206966.
  • Thompson WW, Shay DK, Weintraub E, et al. Influenza-associated hospitalizations in the United States. JAMA. 2004;292:1333-40. doi:10.1001/jama.292.11.1333. PMID:15367555.
  • Molinari NA, Ortega-Sanchez IR, Messonnier ML, et al. The annual impact of seasonal influenza in the US: Measuring disease burden and costs. Vaccine. 2007;25:5086-96. doi:10.1016/j.vaccine.2007.03.046. PMID:17544181.
  • WHO. Vaccines against influenza WHo position paper – November 2012. Weekly Epidemiological Record. 2012;87(47):461-476. PMID:23210147.
  • CDC. People at high risk of developing Flu–Related complications. 2016. https://www.cdc.gov/flu/about/disease/high_risk.htm
  • Rothberg MB, Haessler SD, Brown RB. Complications of viral influenza. Am J Med. 2008;121:258-64. doi:10.1016/j.amjmed.2007.10.040. PMID:18374680.
  • Gaglani MJ, Piedra PA, Riggs M, Herschler G, Fewlass C, Glezen WP. Safety of the intranasal, trivalent, live attenuated influenza vaccine (LAIV) in children with intermittent wheezing in an open-label field trial. Pediatr Infect Dis J. 2008;27:444-52. doi:10.1097/INF.0b013e3181660c2e. PMID:18401289.
  • Miller MA, Viboud C, Olson DR, Grais RF, Rabaa MA, Simonsen L. Prioritization of influenza pandemic vaccination to minimize years of life lost. J Infect Dis. 2008;198:305-11. doi:10.1086/589716. PMID:18558871.
  • Sridhar S, Brokstad KA, Cox RJ. Influenza vaccination strategies: Comparing inactivated and live attenuated influenza vaccines. Vaccines (Basel). 2015;3:373-89. doi:10.3390/vaccines3020373. PMID:26343192.
  • Webster RG, Bean WJ, Gorman OT, Chambers TM, Kawaoka Y. Evolution and ecology of influenza A viruses. Microbiol Rev. 1992;56:152-79. PMID:1579108.
  • CDC. Transmission of avian influenza a viruses between animals and people. 2015. https://www.cdc.gov/flu/avianflu/virus-transmission.htm
  • Turner PJ, Southern J, Andrews NJ, Miller E, Erlewyn-Lajeunesse M, Investigators SS. Safety of live attenuated influenza vaccine in atopic children with egg allergy. J Allergy Clin Immunol. 2015;136:376-81. doi:10.1016/j.jaci.2014.12.1925. PMID:25684279.
  • Toback SL, Levin MJ, Block SL, Belshe RB, Ambrose CS, Falloon J. Quadrivalent Ann Arbor strain live-attenuated influenza vaccine. Expert Rev Vaccines. 2012;11:1293-303. doi:10.1586/erv.12.108. PMID:23151111.
  • Milian E, Kamen AA. Current and emerging cell culture manufacturing technologies for influenza vaccines. Biomed Res Int. 2015;2015:504831. doi:10.1155/2015/504831. PMID:25815321.
  • Russell CA, Jones TC, Barr IG, et al. Influenza vaccine strain selection and recent studies on the global migration of seasonal influenza viruses. Vaccine. 2008;26 Suppl 4:D31-4. doi:10.1016/j.vaccine.2008.07.078. PMID:19230156.
  • WHO. WHO recommendations on pandemic (H1N1) 2009 vaccines. 2009
  • Bridges CB, Kuehnert MJ, Hall CB. Transmission of influenza: Implications for control in health care settings. Clin Infect Dis. 2003;37:1094-101. doi:10.1086/378292. PMID:14523774.
  • Simonsen L, Clarke MJ, Schonberger LB, Arden NH, Cox NJ, Fukuda K. Pandemic versus epidemic influenza mortality: A pattern of changing age distribution. J Infect Dis. 1998;178:53-60. doi:10.1086/515616. PMID:9652423.
  • Jefferson T, Rivetti A, Di Pietrantonj C, Demicheli V, Ferroni E. Vaccines for preventing influenza in healthy children. Cochrane Database Syst Rev. 2012;8:CD004879
  • Pebody R, Green H, Andrews N, et al. Uptake and impact of a new live attenuated influenza vaccine programme in England: Early results of a pilot in primary school-age children, 2013/14 influenza season. Euro Surveill. 2014;19 (22). http://www.eurosurveillance.org/content/10.2807/ese.19.22.20823-en.ES2014.19.22.20823
  • Folkehelseinstituttet. Fakta om influensa. 2016. https://www.fhi.no/en/id/influensa/seasonal-influenza/influenza---fact-sheet-about-season/
  • Allen JE, Gardner SN, Vitalis EA, Slezak TR. Conserved amino acid markers from past influenza pandemic strains. BMC Microbiol. 2009;9:77. doi:10.1186/1471-2180-9-77. PMID:19386124.
  • Salo H, Kilpi T, Sintonen H, Linna M, Peltola V, Heikkinen T. Cost-effectiveness of influenza vaccination of healthy children. Vaccine. 2006;24:4934-41. doi:10.1016/j.vaccine.2006.03.057. PMID:16678945.
  • Dobson J, Whitley RJ, Pocock S, Monto AS. Oseltamivir treatment for influenza in adults: A meta-analysis of randomised controlled trials. Lancet. 2015;385:1729-37. doi:10.1016/S0140-6736(14)62449-1. PMID:25640810.
  • Ampofo K, Gesteland PH, Bender J, et al. Epidemiology, complications, and cost of hospitalization in children with laboratory-confirmed influenza infection. Pediatrics. 2006;118:2409-17. doi:10.1542/peds.2006-1475. PMID:17142526.
  • Morgan OW, Bramley A, Fowlkes A, et al. Morbid obesity as a risk factor for hospitalization and death due to 2009 pandemic influenza A(H1N1) disease. PLoS One. 2010;5:e9694. doi:10.1371/journal.pone.0009694. PMID:20300571.
  • Lee N, Ison MG. Editorial commentary. “Late” treatment with neuraminidase inhibitors for severely ill patients with influenza: Better late than never?. Clin Infect Dis. 2012;55:1205-8. doi:10.1093/cid/cis642. PMID:22843780.
  • Slepushkin AN, Obrosova-Serova NP, Burtseva EI, et al. Comparison of live attenuated and inactivated influenza vaccines in schoolchildren in Russia: I. Safety and efficacy in two Moscow schools, 1987/88. Vaccine. 1993;11:323-8. doi:10.1016/0264-410X(93)90194-3. PMID:8447161.
  • Committee for Medicinal Products for Human Use. Guideline on Influenza Vaccines. Non-clinical and Clinical Module. 2016. EMA/CHMP/VWP/457259/2014. http://www.ema.europa.eu/docs/en_GB/document_library/Scientific_guideline/2016/07/WC500211324.pdf
  • Hoft DF, Babusis E, Worku S, et al. Live and inactivated influenza vaccines induce similar humoral responses, but only live vaccines induce diverse T-cell responses in young children. J Infect Dis. 2011;204:845-53. doi:10.1093/infdis/jir436. PMID:21846636.
  • Mohn KG, Bredholt G, Brokstad KA, et al. Longevity of B-Cell and T-Cell responses after live attenuated influenza vaccination in children. J Infect Dis. 2015;211(10):1541–9. PMID:25425696.
  • Clements ML, Murphy BR. Development and persistence of local and systemic antibody responses in adults given live attenuated or inactivated influenza A virus vaccine. J Clin Microbiol. 1986;23:66-72. PMID:3700610.
  • Wrammert J, Smith K, Miller J, et al. Rapid cloning of high-affinity human monoclonal antibodies against influenza virus. Nature. 2008;453:667-71. doi:10.1038/nature06890. PMID:18449194.
  • Mohn KG, Brokstad KA, Pathirana RD, et al. Live attenuated influenza vaccination in children induces B-cell responses in tonsils. J Infect Dis. 2016;214(5):722–731. doi:10.1093/infdis/jiw230. PMID:27247344.
  • Belshe RB, Edwards KM, Vesikari T, et al. Live attenuated versus inactivated influenza vaccine in infants and young children. N Engl J Med. 2007;356:685-96. doi:10.1056/NEJMoa065368. PMID:17301299.
  • He XS, Holmes TH, Zhang C, et al. Cellular immune responses in children and adults receiving inactivated or live attenuated influenza vaccines. J Virol. 2006;80:11756-66. doi:10.1128/JVI.01460-06. PMID:16971435.
  • Forrest BD, Pride MW, Dunning AJ, et al. Correlation of cellular immune responses with protection against culture-confirmed influenza virus in young children. Clin Vaccine Immunol. 2008;15:1042-53. doi:10.1128/CVI.00397-07. PMID:18448618.
  • Cha TA, Kao K, Zhao J, Fast PE, Mendelman PM, Arvin A. Genotypic stability of cold-adapted influenza virus vaccine in an efficacy clinical trial. J Clin Microbiol. 2000;38:839-45. PMID:10655394.
  • Kiseleva I, Dubrovina I, Bazhenova E, Fedorova E, Larionova N, Rudenko L. Possible outcomes of reassortment in vivo between wild type and live attenuated influenza vaccine strains. Vaccine. 2012;30:7395-9. doi:10.1016/j.vaccine.2012.09.076. PMID:23063833.
  • Stiehm ER, Chin TW, Haas A, Peerless AG. Infectious complications of the primary immunodeficiencies. Clin Immunol Immunopathol. 1986;40:69-86. doi:10.1016/0090-1229(86)90070-X. PMID:3521971.
  • Block SL, Yogev R, Hayden FG, Ambrose CS, Zeng W, Walker RE. Shedding and immunogenicity of live attenuated influenza vaccine virus in subjects 5–49 years of age. Vaccine. 2008;26:4940-6. doi:10.1016/j.vaccine.2008.07.013. PMID:18662737.
  • Ambrose CS, Dubovsky F, Yi T, Belshe RB, Ashkenazi S. The safety and efficacy of live attenuated influenza vaccine in young children with asthma or prior wheezing. Eur J Clin Microbiol Infect Dis. 2012;31:2549-57. doi:10.1007/s10096-012-1595-9. PMID:22410646.
  • Ison MG, Hui DS, Clezy K, et al. A clinical trial of intravenous peramivir compared with oral oseltamivir for the treatment of seasonal influenza in hospitalized adults. Antivir Ther. 2013;18:651-61. doi:10.3851/IMP2442. PMID:23111657.
  • Caspard H, Heikkinen T, Belshe RB, Ambrose CS. A systematic review of the efficacy of live attenuated influenza vaccine upon revaccination of children. Hum Vaccin Immunother. 2016;12(7):1721–7
  • Jefferson T, Rivetti A, Harnden A, Di Pietrantonj C, Demicheli V. Vaccines for preventing influenza in healthy children. Cochrane Database Syst Rev. 2008;16(2):CD004879. PMID:18425905.
  • Jefferson T, Di Pietrantonj C, Rivetti A, Bawazeer GA, Al-Ansary LA, Ferroni E. Vaccines for preventing influenza in healthy adults. Cochrane Database Syst Rev. 2010:CD001269 PMID:20614424.
  • Osterholm MT, Kelley NS, Sommer A, Belongia EA. Efficacy and effectiveness of influenza vaccines: A systematic review and meta-analysis. Lancet Infect Dis. 2012;12:36-44. doi:10.1016/S1473-3099(11)70295-X. PMID:22032844.
  • Coelingh K, Olajide IR, MacDonald P, Yogev R. Efficacy and effectiveness of live attenuated influenza vaccine in school-age children. Expert Rev Vaccines. 2015;14(10):1331–46
  • Ambrose CS, Levin MJ, Belshe RB. The relative efficacy of trivalent live attenuated and inactivated influenza vaccines in children and adults. Influenza Other Respir Viruses. 2011;5:67-75. doi:10.1111/j.1750-2659.2010.00183.x. PMID:21306569.
  • Tam JS, Capeding MR, Lum LC, et al. Efficacy and safety of a live attenuated, cold-adapted influenza vaccine, trivalent against culture-confirmed influenza in young children in Asia. Pediatr Infect Dis J. 2007;26:619-28. doi:10.1097/INF.0b013e31806166f8. PMID:17596805.
  • Belshe RB, Toback SL, Yi T, Ambrose CS. Efficacy of live attenuated influenza vaccine in children 6 months to 17 years of age. Influenza Other Respir Viruses. 2010;4:141-5. doi:10.1111/j.1750-2659.2009.00124.x. PMID:20409210.
  • Rhorer J, Ambrose CS, Dickinson S, et al. Efficacy of live attenuated influenza vaccine in children: A meta-analysis of nine randomized clinical trials. Vaccine. 2009;27:1101-10. doi:10.1016/j.vaccine.2008.11.093. PMID:19095024.
  • Ashkenazi S, Vertruyen A, Aristegui J, et al. Superior relative efficacy of live attenuated influenza vaccine compared with inactivated influenza vaccine in young children with recurrent respiratory tract infections. Pediatr Infect Dis J. 2006;25:870-9. doi:10.1097/01.inf.0000237829.66310.85. PMID:17006279.
  • Fleming DM, Crovari P, Wahn U, et al. Comparison of the efficacy and safety of live attenuated cold-adapted influenza vaccine, trivalent, with trivalent inactivated influenza virus vaccine in children and adolescents with asthma. Pediatr Infect Dis J. 2006;25:860-9. doi:10.1097/01.inf.0000237797.14283.cf. PMID:17006278.
  • Caspard H, Heikkinen T, Belshe RB, Ambrose CS. A systematic review of the efficacy of live attenuated influenza vaccine upon revaccination of children. Hum Vaccin Immunother. 2016;12:1721-7. PMID:26751513.
  • Black S, Nicolay U, Vesikari T, et al. Hemagglutination inhibition antibody titers as a correlate of protection for inactivated influenza vaccines in children. Pediatr Infect Dis J. 2011;30:1081-5. doi:10.1097/INF.0b013e3182367662. PMID:21983214.
  • Bandell A, Woo J, Coelingh K. Protective efficacy of live-attenuated influenza vaccine (multivalent, Ann Arbor strain): A literature review addressing interference. Expert Rev Vaccines. 2011;10:1131-41. doi:10.1586/erv.11.73. PMID:21854309.
  • Wright PF, Hoen AG, Ilyushina NA, et al. Correlates of immunity to influenza as determined by challenge of children with live, Attenuated influenza vaccine. Open Forum Infect Dis. 2016;3:ofw108. doi:10.1093/ofid/ofw108. PMID:27419180.
  • Jegaskanda S, Luke C, Hickman HD, et al. Generation and protective ability of influenza virus-specific antibody-dependent cellular cytotoxicity in humans elicited by vaccination, Natural infection, and Experimental challenge. J Infect Dis. 2016;214:945-52. doi:10.1093/infdis/jiw262. PMID:27354365.
  • Wilkinson TM, Li CK, Chui CS, et al. Preexisting influenza-specific CD4+ T cells correlate with disease protection against influenza challenge in humans. Nat Med. 2012;18:274-80. doi:10.1038/nm.2612. PMID:22286307.
  • Sridhar S, Begom S, Bermingham A, et al. Cellular immune correlates of protection against symptomatic pandemic influenza. Nat Med. 2013;19:1305-12. doi:10.1038/nm.3350. PMID:24056771.
  • Hayward AC, Wang L, Goonetilleke N, et al. Natural T cell mediated protection against seasonal and pandemic influenza: Results of the flu watch cohort study. Am J Respir Crit Care Med. 2015;191(12):1422–31. doi:10.1164/rccm.201411-1988OC.
  • van de Sandt CE, Hillaire ML, Geelhoed-Mieras MM, Osterhaus AD, Fouchier RA, Rimmelzwaan GF. Human influenza a virus-specific CD8+ T-Cell response is long-lived. J Infect Dis. 2015;212:81-5. doi:10.1093/infdis/jiv018. PMID:25583167.
  • Ambrose CS, Yi T, Walker RE, Connor EM. Duration of protection provided by live attenuated influenza vaccine in children. Pediatr Infect Dis J. 2008;27:744-8. doi:10.1097/INF.0b013e318174e0f8. PMID:18600188.
  • Ambrose CS, Wu X, Jones T, Mallory RM. The role of nasal IgA in children vaccinated with live attenuated influenza vaccine. Vaccine. 2012;30:6794-801. doi:10.1016/j.vaccine.2012.09.018. PMID:23000125.
  • Beyer WE, Palache AM, de Jong JC, Osterhaus AD. Cold-adapted live influenza vaccine versus inactivated vaccine: Systemic vaccine reactions, local and systemic antibody response, and vaccine efficacy. A meta-analysis. Vaccine. 2002;20:1340-53. doi:10.1016/S0264-410X(01)00471-6. PMID:11818152.
  • Fry AM. Effectiveness of neuraminidase inhibitors for severe influenza. Lancet Respir Med. 2014;2:346-8. doi:10.1016/S2213-2600(14)70068-2. PMID:24815800.
  • CDC. Prevention and control of influenza with vaccines: Recommendations of the advisory committee on immunization practices, United States, 2015–16 influenza season. Morbidity and Mortality Weekly Report (MMWR). 2015;64(30):818–825
  • Belshe RB, Gruber WC, Mendelman PM, et al. Correlates of immune protection induced by live, attenuated, cold-adapted, trivalent, intranasal influenza virus vaccine. J Infect Dis. 2000;181:1133-7. doi:10.1086/315323. PMID:10720541.
  • Treanor JJ, Kotloff K, Betts RF, et al. Evaluation of trivalent, live, cold-adapted (CAIV-T) and inactivated (TIV) influenza vaccines in prevention of virus infection and illness following challenge of adults with wild-type influenza A (H1N1), A (H3N2), and B viruses. Vaccine. 1999;18:899-906. doi:10.1016/S0264-410X(99)00334-5. PMID:10580204.
  • Park AW, Daly JM, Lewis NS, Smith DJ, Wood JL, Grenfell BT. Quantifying the impact of immune escape on transmission dynamics of influenza. Science. 2009;326:726-8. doi:10.1126/science.1175980. PMID:19900931.
  • Couch RB, Atmar RL, Franco LM, et al. Prior infections with seasonal influenza A/H1N1 virus reduced the illness severity and epidemic intensity of pandemic H1N1 influenza in healthy adults. Clin Infect Dis. 2012;54:311-7. doi:10.1093/cid/cir809. PMID:22075792.
  • Mohn KG, Brokstad KA, Pathirana RD, et al. Live attenuated influenza vaccine in children induces B-Cell responses in tonsils. J Infect Dis. 2016;214:722-31. doi:10.1093/infdis/jiw230. PMID:27247344.
  • Brokstad KA, Cox RJ, Olofsson J, Jonsson R, Haaheim LR. Parenteral influenza vaccination induces a rapid systemic and local immune response. J Infect Dis. 1995;171:198-203. doi:10.1093/infdis/171.1.198. PMID:7798664.
  • CDC. Interim Estimates of 2013–14 seasonal influenza vaccine Effectiveness — United States, February 2014. MMWR Morb Mortal Wkly Rep. 2014;63(7):137–142
  • Dowdle WR. Influenza A virus recycling revisited. Bull World Health Organ. 1999;77:820-8. PMID:10593030.
  • CDC newsroom. Advisory Committee on Immunization . Practices (ACIP) recommends a preference for using the nasal spray flu vaccine. 2014. https://www.cdc.gov/media/releases/2014/s0625-acip.html
  • CDC newsroom. ACIP votes down use of LAIV for 2016-2017 flu season. 2016. https://www.cdc.gov/media/releases/2016/s0622-laiv-flu.html
  • Nohynek H, Baum U, Syrjanen R, Ikonen N, Sundman J, Jokinen J. Effectiveness of the live attenuated and the inactivated influenza vaccine in two-year-olds – a nationwide cohort study Finland, influenza season 2015/16. Euro Surveill. 2016;21 (38):30346. http://www.eurosurveillance.org/content/10.2807/1560-7917.ES.2016.21.38.30346. PMID:27684447.
  • Pebody R, Warburton F, Ellis J, et al. Effectiveness of seasonal influenza vaccine for adults and children in preventing laboratory-confirmed influenza in primary care in the United Kingdom: 2015/16 End-of-season results. Euro Surveill. 2016;21(38):30348. http://www.eurosurveillance.org/content/10.2807/1560-7917.ES.2016.21.38.30348
  • Zimmerman RK, Nowalk MP, Chung J, et al. 2014–2015 influenza vaccine effectiveness in the United States by vaccine type. Clin Infect Dis. 2016;63:1564-1573. doi:10.1093/cid/ciw635. PMID:27702768.
  • Victor JC, Lewis KD, Diallo A, et al. Efficacy of a Russian-backbone live attenuated influenza vaccine among children in Senegal: A randomised, double-blind, placebo-controlled trial. Lancet Glob Health. 2016;4:e955-e965. doi:10.1016/S2214-109X(16)30201-7. PMID:27746224.
  • Brooks WA, Zaman K, Lewis KD, et al. Efficacy of a Russian-backbone live attenuated influenza vaccine among young children in Bangladesh: A randomised, double-blind, placebo-controlled trial. Lancet Glob Health. 2016;4:e946-e954. doi:10.1016/S2214-109X(16)30200-5. PMID:27746226.
  • Pebody R, Sile B, Warburton F, et al. Live attenuated influenza vaccine effectiveness against hospitalisation due to laboratory-confirmed influenza in children two to six years of age in England in the 2015/16 season. Euro Surveill. 2017;22. http://www.eurosurveillance.org/content/10.2807/1560-7917.ES.2017.22.4.30450
  • Chung JR, Flannery B, Thompson MG, et al. Seasonal Effectiveness of Live Attenuated and Inactivated Influenza Vaccine. Pediatrics. 2016;137(2):e20153279. doi:10.1542/peds.2015-3279.
  • Dressel H, Nowak D. [Influenza vaccination for health care workers: Should we strengthen individual responsibility or should it be mandatory?]. Dtsch Med Wochenschr. 2009;134:1649. doi:10.1055/s-0029-1233995. PMID:19650029.
  • Brandtzaeg P. Immunology of tonsils and adenoids: Everything the ENT surgeon needs to know. Int J Pediatr Otorhinolaryngol. 2003;67 Suppl 1:S69-76. doi:10.1016/j.ijporl.2003.08.018. PMID:14662171.
  • Sada-Ovalle I, Talayero A, Chavez-Galan L, et al. Functionality of CD4+ and CD8+ T cells from tonsillar tissue. Clin Exp Immunol. 2012;168:200-6. doi:10.1111/j.1365-2249.2012.04573.x. PMID:22471281.
  • Quiding-Jarbrink M, Granstrom G, Nordstrom I, Holmgren J, Czerkinsky C. Induction of compartmentalized B-cell responses in human tonsils. Infect Immun. 1995;63:853-7. PMID:7868256.
  • Panapasa JA, Cox RJ, Mohn KG, Aqrawi LA, Brokstad KA. The expression of B & T cell activation markers in children's tonsils following live attenuated influenza vaccine. Hum Vaccin Immunother. 2015;11:1663-72. doi:10.1080/21645515.2015.1032486. PMID:26148331.
  • Pizzolla A, Wang Z, Groom JR, et al. Nasal-associated lymphoid tissues (NALTs) support the recall but not priming of influenza virus-specific cytotoxic T cells. Proc Natl Acad Sci U S A. 2017;114:5225-5230. doi:10.1073/pnas.1620194114. PMID:28461487.
  • Kucharski AJ, Gog JR. The role of social contacts and original antigenic sin in shaping the age pattern of immunity to seasonal influenza. PLoS Comput Biol. 2012;8:e1002741. doi:10.1371/journal.pcbi.1002741. PMID:23133346.
  • McMichael AJ, Gotch FM, Noble GR and Beare PA. Cytotoxic T-cell immunity to influenza. N Engl J Med. 1983;309:13-7. doi:10.1056/NEJM198307073090103. PMID:6602294.
  • Francis T. The doctrine of original antigenic sin. Proceedings of the American Philosophical Society 104, 6 (Dec. 15, 1960), pp. 572-578 1960;104:572-578
  • He XS, Holmes TH, Mahmood K, et al. Phenotypic changes in influenza-specific CD8+ T cells after immunization of children and adults with influenza vaccines. J Infect Dis. 2008;197:803-11. doi:10.1086/528804. PMID:18279048.
  • Belshe RB, Gruber WC, Mendelman PM, et al. Efficacy of vaccination with live attenuated, cold-adapted, trivalent, intranasal influenza virus vaccine against a variant (A/Sydney) not contained in the vaccine. J Pediatr. 2000;136:168-75. doi:10.1016/S0022-3476(00)70097-7. PMID:10657821.
  • Cheng X, Zengel JR, Suguitan AL, Jr., et al. Evaluation of the humoral and cellular immune responses elicited by the live attenuated and inactivated influenza vaccines and their roles in heterologous protection in ferrets. J Infect Dis. 2013;208:594-602. doi:10.1093/infdis/jit207. PMID:23656978.
  • Rekstin A, Isakova-Sivak I, Petukhova G, et al. Immunogenicity and cross protection in mice afforded by Pandemic H1N1 live attenuated influenza vaccine containing wild-type nucleoprotein. Biomed Res Int. 2017;2017:9359276. doi:10.1155/2017/9359276. PMID:28210631.
  • Jang YH, Seong BL. Cross-protective immune responses elicited by live attenuated influenza vaccines. Yonsei Med J. 2013;54:271-82. doi:10.3349/ymj.2013.54.2.271. PMID:23364956.
  • Zens KD, Chen JK, Farber DL. Vaccine-generated lung tissue-resident memory T cells provide heterosubtypic protection to influenza infection. JCI Insight. 2016;1(10):e85832. doi:10.1172/jci.insight.85832. PMID:27468427.
  • Bodewes R, Kreijtz JH, Rimmelzwaan GF. Yearly influenza vaccinations: A double-edged sword?. Lancet Infect Dis. 2009;9:784-8. doi:10.1016/S1473-3099(09)70263-4. PMID:19879807.
  • Soema PC, van Riet E, Kersten G, Amorij JP. Development of cross-protective influenza a vaccines based on cellular responses. Front Immunol. 2015;6:237. doi:10.3389/fimmu.2015.00237. PMID:26029218.
  • Dropulic LK, Cohen JI. Severe viral infections and primary immunodeficiencies. Clin Infect Dis. 2011;53:897-909. doi:10.1093/cid/cir610. PMID:21960712.
  • Krammer F, Palese P. Advances in the development of influenza virus vaccines. Nat Rev Drug Discov. 2015;14:167-82. doi:10.1038/nrd4529. PMID:25722244.
  • Quinones-Parra S, Grant E, Loh L, et al. Preexisting CD8+ T-cell immunity to the H7N9 influenza A virus varies across ethnicities. Proc Natl Acad Sci U S A. 2014;111:1049-54. doi:10.1073/pnas.1322229111. PMID:24395804.
  • Krammer F. Emerging influenza viruses and the prospect of a universal influenza virus vaccine. Biotechnol J. 2015;10:690-701. doi:10.1002/biot.201400393. PMID:25728134.
  • Soema PC, Kompier R, Amorij JP, Kersten GF. Current and next generation influenza vaccines: Formulation and production strategies. Eur J Pharm Biopharm. 2015;94:251-63. doi:10.1016/j.ejpb.2015.05.023.
  • Wang TT, Tan GS, Hai R, et al. Broadly protective monoclonal antibodies against H3 influenza viruses following sequential immunization with different hemagglutinins. PLoS Pathog. 2010;6:e1000796. doi:10.1371/journal.ppat.1000796.