IgY antibodies for the immunoprophylaxis and therapy of respiratory infections

References

• Bryce J, Boschi-Pinto C, Shibuya K, Black RE. WHO estimates of the causes of death in children. Lancet (London, England). 2005;365:1147–1152. doi:10.1016/S0140-6736(05)71877-8.
   PubMed Web of Science ®Google Scholar
• Qazi S, Aboubaker S, MacLean R, Fontaine O, Mantel C, Goodman T, Young M, Henderson P, Cherian T. Ending preventable child deaths from pneumonia and diarrhoea by 2025. Development of the integrated global action plan for the prevention and control of pneumonia and diarrhoea. Arch Dis Child. 2015;100(Suppl 1):S23–8. doi:10.1136/archdischild-2013-305429.
   PubMed Web of Science ®Google Scholar
• Ujunwa F, Ezeonu C. Risk factors for acute respiratory tract infections in under-five children in enugu Southeast Nigeria. Ann Med Health Sci Res. 2014;4:95–99. doi:10.4103/2141-9248.126610.
   PubMedGoogle Scholar
• Mogayzel PJ Jr., Naureckas ET, Robinson KA, Brady C, Guill M, Lahiri T, Lubsch L, Matsui J, Oermann CM, Ratjen F, et al. Cystic Fibrosis Foundation pulmonary guideline. pharmacologic approaches to prevention and eradication of initial Pseudomonas aeruginosa infection. Ann Am Thorac Soc. 2014;11:1640–1650. doi:10.1513/AnnalsATS.201404-166OC.
   PubMedGoogle Scholar
• Flume PA, Mogayzel PJ Jr., Robinson KA, Goss CH, Rosenblatt RL, Kuhn RJ, Marshall BC. Cystic fibrosis pulmonary guidelines: treatment of pulmonary exacerbations. Am J Respir Crit Care Med. 2009;180:802–808. doi:10.1164/rccm.200812-1845PP.
   PubMed Web of Science ®Google Scholar
• Griffith DE, Aksamit T, Brown-Elliott BA, Catanzaro A, Daley C, Gordin F, Holland SM, Horsburgh R, Huitt G, Iademarco MF, et al. An official ATS/IDSA statement: diagnosis, treatment, and prevention of nontuberculous mycobacterial diseases. Am J Respir Crit Care Med. 2007;175:367–416. doi:10.1164/rccm.200604-571ST.
   PubMed Web of Science ®Google Scholar
• Mogayzel PJ Jr., Naureckas ET, Robinson KA, Mueller G, Hadjiliadis D, Hoag JB, Lubsch L, Hazle L, Sabadosa K, Marshall B. Cystic fibrosis pulmonary guidelines. Chronic medications for maintenance of lung health. Am J Respir Crit Care Med. 2013;187:680–689.
   PubMed Web of Science ®Google Scholar
• Pasteur MC, Bilton D, At H. British thoracic Soc B. British thoracic society guideline for non-CF bronchiectasis. Thorax. 2010;65:I1–I58. doi:10.1136/thx.2010.136119.
   PubMed Web of Science ®Google Scholar
• McCaskill JL, Ressel S, Alber A, Redford J, Power UF, Schwarze J, Dutia BM, Buck AH. Broad-spectrum inhibition of respiratory virus infection by MicroRNA mimics targeting p38 MAPK signaling. Mol Ther Nucl Acids. 2017;7:256–266. doi:10.1016/j.omtn.2017.03.008.
   Google Scholar
• Corti D, Passini N, Lanzavecchia A, Zambon M. Rapid generation of a human monoclonal antibody to combat Middle East respiratory syndrome. J Infect Public Health. 2016;9:231–235. doi:10.1016/j.jiph.2016.04.003.
   PubMed Web of Science ®Google Scholar
• Sparrow E, Friede M, Sheikh M, Torvaldsen S. Therapeutic antibodies for infectious diseases. Bull World Health Organ. 2017;95:235–237. doi:10.2471/BLT.16.178061.
   PubMed Web of Science ®Google Scholar
• Keller MA, Stiehm ER. Passive immunity in prevention and treatment of infectious diseases. Clin Microbiol Rev. 2000;13:602–614.
   PubMed Web of Science ®Google Scholar
• Graham BS, Ambrosino DM. History of passive antibody administration for prevention and treatment of infectious diseases. Curr Opin HIV AIDS. 2015;10:129–134. doi:10.1097/COH.0000000000000154.
   PubMed Web of Science ®Google Scholar
• Kelley B. Industrialization of mAb production technology: the bioprocessing industry at a crossroads. mAbs. 2009;1:443–452.
   PubMed Web of Science ®Google Scholar
• Casadevall A, Dadachova E, Pirofski LA. Passive antibody therapy for infectious diseases. Nat Rev Microbiol. 2004;2:695–703. doi:10.1038/nrmicro974.
   PubMed Web of Science ®Google Scholar
• Warr GW, Magor KE, Higgins DA. IgY: clues to the origins of modern antibodies. Immunol Today. 1995;16:392–398. doi:10.1016/0167-5699(95)80008-5.
   PubMedGoogle Scholar
• Carlander D, Stalberg J, Larsson A. Chicken antibodies: a clinical chemistry perspective. Ups J Med Sci. 1999;104:179–189.
   PubMed Web of Science ®Google Scholar
• Thomsen K, Christophersen L, Bjarnsholt T, Jensen PO, Moser C, Hoiby N. Anti-Pseudomonas aeruginosa IgY antibodies augment bacterial clearance in a murine pneumonia model. J Cyst Fibr. 2016;15:171–178. doi:10.1016/j.jcf.2015.08.002.
   PubMed Web of Science ®Google Scholar
• Nguyen HH, Tumpey TM, Park HJ, Byun Y-H, Tran LD, Nguyen VD, Kilgore PE, Czerkinsky C, Katz JM, Seong BL, et al. Prophylactic and therapeutic efficacy of avian antibodies against influenza virus H5N1 and H1N1 in mice. PLoS One. 2010;5:e10152. doi:10.1371/journal.pone.0010152.
   PubMed Web of Science ®Google Scholar
• Rahman S, Van Nguyen S, Icatlo FC Jr., Umeda K, Kodama Y. Oral passive IgY-based immunotherapeutics: a novel solution for prevention and treatment of alimentary tract diseases. Hum Vaccin Immunother. 2013;9:1039–1048. doi:10.4161/hv.23383.
   PubMed Web of Science ®Google Scholar
• Vega CG, Bok M, Vlasova AN, Chattha KS, Fernández FM, Wigdorovitz A, Parreño VG, Saif LJ, Salmon H. IgY antibodies protect against human Rotavirus induced diarrhea in the neonatal gnotobiotic piglet disease model. PLoS One. 2012;7:e42788. doi:10.1371/journal.pone.0042788.
   PubMed Web of Science ®Google Scholar
• Torche AM, Le Dimna M, Le Corre P, Mesplede A, Le Gal S, Cariolet R, Le Potier MF. Immune responses after local administration of IgY loaded-PLGA microspheres in gut-associated lymphoid tissue in pigs. Vet Immunol Immunopathol. 2006;109:209–217. doi:10.1016/j.vetimm.2005.08.016.
   PubMed Web of Science ®Google Scholar
• Akita E, Jang C, Kitts D, Nakai S. Evaluation of allergenicity of egg yolk immunoglobulin Y and other egg proteins by passive cutaneous anaphylaxis. Food Agric Immunol. 1999;11:191–201. doi:10.1080/09540109999861.
   Web of Science ®Google Scholar
• Kovacs-Nolan J, Mine Y. Egg yolk antibodies for passive immunity. Annu Rev Food Sci Technol. 2012;3:163–182. doi:10.1146/annurev-food-022811-101137.
   PubMed Web of Science ®Google Scholar
• Xu Y, Li X, Jin L, Zhen Y, Lu Y, Li S, You J, Wang L. Application of chicken egg yolk immunoglobulins in the control of terrestrial and aquatic animal diseases: a review. Biotechnol Adv. 2011;29:860–868. doi:10.1016/j.biotechadv.2011.07.003.
   PubMed Web of Science ®Google Scholar
• Zhang X, Calvert RA, Sutton BJ, Dore KA. IgY: a key isotype in antibody evolution. Biol Rev Camb Philos Soc. 2017;92:2144–2156. doi:10.1111/brv.12325.
   PubMed Web of Science ®Google Scholar
• Muller S, Schubert A, Zajac J, Dyck T, Oelkrug C. IgY antibodies in human nutrition for disease prevention. Nutr J. 2015;14:109. doi:10.1186/s12937-015-0067-3.
   PubMed Web of Science ®Google Scholar
• Gilgunn S, Millan Martin S, Wormald MR, Zapatero-Rodríguez J, Conroy PJ, O’Kennedy RJ, Rudd PM, Saldova R, Mondelli MU. Comprehensive N-Glycan profiling of avian immunoglobulin Y. PLoS One. 2016;11:e0159859. doi:10.1371/journal.pone.0159859.
   PubMed Web of Science ®Google Scholar
• Liu L. Antibody glycosylation and its impact on the pharmacokinetics and pharmacodynamics of monoclonal antibodies and Fc-fusion proteins. J Pharm Sci. 2015;104:1866–1884. doi:10.1002/jps.24444.
   PubMed Web of Science ®Google Scholar
• Casadevall A, Scharff MD. Return to the past: the case for antibody-based therapies in infectious diseases. Clin Infect Dis. 1995;21:150–161.
   PubMed Web of Science ®Google Scholar
• Baxter D. Active and passive immunity, vaccine types, excipients and licensing. Occup Med (Lond). 2007;57:552–556. doi:10.1093/occmed/kqm110.
   PubMed Web of Science ®Google Scholar
• Patterson R, Youngner JS, Weigle WO, Dixon FJ. The metabolism of serum proteins in the hen and chick and secretion of serum proteins by the ovary of the hen. J Gen Physiol. 1962;45:501–513.
   PubMed Web of Science ®Google Scholar
• Rose ME, Orlans E, Buttress N. Immunoglobulin classes in the hen’s egg: their segregation in yolk and white. Eur J Immunol. 1974;4:521–523. doi:10.1002/eji.1830040715.
   PubMed Web of Science ®Google Scholar
• Hamal KR, Burgess SC, Pevzner IY, Erf GF. Maternal antibody transfer from dams to their egg yolks, egg whites, and chicks in meat lines of chickens. Poult Sci. 2006;85:1364–1372. doi:10.1093/ps/85.8.1364.
   PubMed Web of Science ®Google Scholar
• Chalghoumi R, Marcq C, Thewis A, Portetelle D, Beckers Y. Effects of feed supplementation with specific hen egg yolk antibody (immunoglobin Y) on Salmonella species cecal colonization and growth performances of challenged broiler chickens. Poult Sci. 2009;88:2081–2092. doi:10.3382/ps.2009-00173.
   PubMed Web of Science ®Google Scholar
• Gadde U, Rathinam T, Lillehoj HS. Passive immunization with hyperimmune egg-yolk IgY as prophylaxis and therapy for poultry diseases–A review. Animal Health Res Rev. 2015;16:163–176. doi:10.1017/S1466252315000195.
   PubMed Web of Science ®Google Scholar
• Calmette A. The treatment of animals poisoned with snake venom by the injection of antivenomous serum. Br Med J. 1896;2:399–400.
   PubMedGoogle Scholar
• Eibl MM. History of immunoglobulin replacement. Immunol Allergy Clin North Am. 2008;28:737–64, viii. doi:10.1016/j.iac.2008.06.004.
   PubMed Web of Science ®Google Scholar
• Hsu JL, Safdar N. Polyclonal immunoglobulins and hyperimmune globulins in prevention and management of infectious diseases. Infect Dis Clin North Am. 2011;25:773–788. doi:10.1016/j.idc.2011.07.005.
   PubMed Web of Science ®Google Scholar
• Casadevall A, Dadachova E, Pirofski L. Passive antibody therapy for infectious diseases. Nat Rev Microbiol. 2004;2:695–703. doi:10.1038/nrmicro974.
   PubMed Web of Science ®Google Scholar
• Weltzin R, Monath TP. Intranasal antibody prophylaxis for protection against viral disease. Clin Microbiol Rev. 1999;12:383-+.
   PubMed Web of Science ®Google Scholar
• Klemperer F. Ueber natürliche Immunitätund ihre Verwerthung für die immunisirungstherapie. Archiv Für Experimentelle Pathologie Und Pharmakologie. 1893;31:356–382.
   Google Scholar
• Wen JL, Zhao SQ, He DG, Yang YN, Li YM, Zhu SS. Preparation and characterization of egg yolk immunoglobulin Y specific to influenza B virus. Antiviral Res. 2012;93:154–159. doi:10.1016/j.antiviral.2011.11.005.
   PubMed Web of Science ®Google Scholar
• Wallach MG, Webby RJ, Islam F, Walkden-Brown S, Emmoth E, Feinstein R, Gronvik K-O. Cross-protection of chicken immunoglobulin Y antibodies against H5N1 and H1N1 viruses passively administered in mice. Clin Vaccine Immunol. 2011;18:1083–1090. doi:10.1128/CVI.05075-11.
   PubMed Web of Science ®Google Scholar
• Schade R, Hlinak A. Egg yolk antibodies, state of the art and future prospects. Altex. 1996;13:5–9.
   PubMedGoogle Scholar
• Selvan K, Sentila R, Michael A. Generation and characterization of chicken egg yolk antibodies against propionibacterium acnes for the prevention of acne vulgaris. Indian J Dermatol. 2012;57:15–19. doi:10.4103/0019-5154.92669.
   PubMedGoogle Scholar
• Ibrahim El SM, Rahman AK, Isoda R, Umeda K, Van Sa N, Kodama Y. vitro and in vivo effectiveness of egg yolk antibody against Candida albicans (anti-CA IgY). Vaccine. 2008;26:2073–2080. doi:10.1016/j.vaccine.2008.02.046.
   PubMed Web of Science ®Google Scholar
• Nguyen SV, Icatlo FC Jr., Nakano T, Isogai E, Hirose K, Mizugai H, Kobayashi-Sakamoto M, Isogai H, Chiba I. Anti-cell-associated glucosyltransferase immunoglobulin Y suppression of salivary mutans streptococci in healthy young adults. J Am Dent Assoc. 2011;142:943–949.
   PubMed Web of Science ®Google Scholar
• Yokoyama K, Sugano N, Shimada T, Shofiqur RAKM, Ibrahim E-SM, Isoda R, Umeda K, Sa NV, Kodama Y, Ito K. Effects of egg yolk antibody against Porphyromonas gingivalis gingipains in periodontitis patients. J Oral Sci. 2007;49:201–206.
   PubMedGoogle Scholar
• Suzuki H, Nomura S, Masaoka T, Goshima H, Kamata N, Kodama Y, Ishii H, Kitajima M, Nomoto K, Hibi T. Effect of dietary anti-Helicobacter pylori-urease immunoglobulin Y on Helicobacter pylori infection. Aliment Pharmacol Ther. 2004;20(Suppl 1):185–192. doi:10.1111/apt.2004.20.issue-s1.
   PubMed Web of Science ®Google Scholar
• Hong KS, Ki MR, Ullah HMA, Lee E-J, Kim YD, Chung M-J, Elfadl AK, Park J-K, Jeong K-S. Preventive effect of anti-VacA egg yolk immunoglobulin (IgY) on Helicobacter pylori-infected mice. Vaccine. 2018;36:371–380. doi:10.1016/j.vaccine.2017.11.082.
   PubMed Web of Science ®Google Scholar
• Gujral N, Lobenberg R, Suresh M, Sunwoo H. In-vitro and in-vivo binding activity of chicken egg yolk immunoglobulin Y (IgY) against gliadin in food matrix. J Agric Food Chem. 2012;60:3166–3172. doi:10.1021/jf205319s.
   PubMed Web of Science ®Google Scholar
• Hirai K, Arimitsu H, Umeda K, Yokota K, Shen L, Ayada K, Kodama Y, Tsuji T, Hirai Y, Oguma K. Passive oral immunization by egg yolk immunoglobulin (IgY) to Vibrio cholerae effectively prevents cholera. Acta Med Okayama. 2010;64:163–170. doi:10.18926/AMO/40008.
   PubMed Web of Science ®Google Scholar
• Rahman S, Higo-Moriguchi K, Htun KW, Taniguchi K, Icatlo FC, Tsuji T, Kodama Y, Van Nguyen S, Umeda K, Oo HN, et al. Randomized placebo-controlled clinical trial of immunoglobulin Y as adjunct to standard supportive therapy for rotavirus-associated diarrhea among pediatric patients. Vaccine. 2012;30:4661–4669. doi:10.1016/j.vaccine.2012.04.091.
   PubMed Web of Science ®Google Scholar
• Hirose M, Ando T, Shofiqur R, Umeda K, Kodama Y, Nguyen S, Goto T, Shimada M, Nagaoka S. Anti-obesity activity of hen egg anti-lipase immunoglobulin yolk, a novel pancreatic lipase inhibitor. Nutr Metab (Lond). 2013;10:70. doi:10.1186/1743-7075-10-70.
   PubMed Web of Science ®Google Scholar
• Dai YC, Wang YY, Zhang XF, Tan M, Xia M, Wu X-B, Jiang X, Nie J. Evaluation of anti-norovirus IgY from egg yolk of chickens immunized with norovirus P particles. J Virol Methods. 2012;186:126–131. doi:10.1016/j.jviromet.2012.07.002.
   PubMed Web of Science ®Google Scholar
• Lee KE, Han BK, Han JY, Hong JY, Kim MN, Heo WI, Sohn MH, Kim KW, Kim KE. Production of egg yolk antibodies specific to house dust mite proteins. Yonsei Med J. 2014;55:999–1004. doi:10.3349/ymj.2014.55.4.999.
   PubMed Web of Science ®Google Scholar
• Lee CH, Lee YC, Liang MH, Leu S-J, Lin L-T, Chiang J-R, Yang -Y-Y. Antibodies against venom of the snake deinagkistrodon acutus. Appl Environ Microbiol. 2015;82:71–80. doi:10.1128/AEM.02608-15.
   PubMed Web of Science ®Google Scholar
• Attallah AM, Abbas AT, Ismail H, Abdel-Raouf M, El-Dosoky I. Efficacy of passive immunization with IgY antibodies to a 58-kDa H. pylori antigen on severe gastritis in BALB/c mouse model. J Immunoassay Immunochem. 2009;30:359–377. doi:10.1080/15321810903187922.
   PubMed Web of Science ®Google Scholar
• Najdi S, Nikbakht Brujeni G, Sheikhi N, Chakhkar S. Development of anti-Helicobacter pylori immunoglobulins Y (IgYs) in quail. Iranian J Veteri Res. 2016;17:106–110.
   PubMed Web of Science ®Google Scholar
• Thu HM, Myat TW, Win MM, Thant KZ, Rahman S, Umeda K, Nguyen SV, Icatlo FC, Higo-Moriguchi K, Taniguchi K, et al. Chicken egg yolk antibodies (IgY) for prophylaxis and treatment of rotavirus diarrhea in human and animal neonates: a concise review. Korean J Food Sci Animal Res. 2017;37:1–9. doi:10.5851/kosfa.2017.37.1.1.
   PubMed Web of Science ®Google Scholar
• Jin LZ, Baidoo SK, Marquardt RR, Frohlich AA. In vitro inhibition of adhesion of enterotoxigenic Escherichia coli K88 to piglet intestinal mucus by egg-yolk antibodies. FEMS Immunol Med Microbiol. 1998;21:313–321.
   PubMed Web of Science ®Google Scholar
• Lee EN, Sunwoo HH, Menninen K, Sim JS. In vitro studies of chicken egg yolk antibody (IgY) against Salmonella enteritidis and Salmonella typhimurium. Poult Sci. 2002;81:632–641. doi:10.1093/ps/81.5.632.
   PubMed Web of Science ®Google Scholar
• Nie R, Wu D, Hu G, Zhang J, Yang H, Wen Z. Effect of specific egg yolk immunoglobulins on phagocytosis by neutrophils. Chin J Vet Med. 2004;12:23–25.
   Google Scholar
• Zhen YH, Jin LJ, Guo J, Li X-Y, Lu Y-N, Chen J, Xu Y-P. Characterization of specific egg yolk immunoglobulin (IgY) against mastitis-causing Escherichia coli. Vet Microbiol. 2008;130:126–133. doi:10.1016/j.vetmic.2007.12.014.
   PubMed Web of Science ®Google Scholar
• Thomsen K, Christophersen L, Bjarnsholt T, Jensen PO, Moser C, Hoiby N. Anti-pseudomonas aeruginosa IgY antibodies induce specific bacterial aggregation and internalization in human polymorphonuclear neutrophils. Infect Immun. 2015;83:2686–2693. doi:10.1128/IAI.02970-14.
   PubMed Web of Science ®Google Scholar
• Wang LH, Li XY, Jin LJ, You J-S, Zhou Y, Li S-Y, Xu Y-P. Characterization of chicken egg yolk immunoglobulins (IgYs) specific for the most prevalent capsular serotypes of mastitis-causing Staphylococcus aureus. Vet Microbiol. 2011;149:415–421. doi:10.1016/j.vetmic.2010.11.029.
   PubMed Web of Science ®Google Scholar
• Li X, Wang L, Zhen Y, Li S, Xu Y. Chicken egg yolk antibodies (IgY) as non-antibiotic production enhancers for use in swine production: a review. J Anim Sci Biotechnol. 2015;6:40. doi:10.1186/s40104-015-0038-8.
   PubMed Web of Science ®Google Scholar
• Ikemori Y, Peralta RC, Kuroki M, Yokoyama H, Kodama Y. Research note: avidity of chicken yolk antibodies to enterotoxigenic Escherichia coli fimbriae. Poult Sci. 1993;72:2361–2365. doi:10.3382/ps.0722361.
   PubMed Web of Science ®Google Scholar
• Gassmann M, Thommes P, Weiser T, Hubscher U. Efficient production of chicken egg yolk antibodies against a conserved mammalian protein. FASEB J. 1990;4:2528–2532.
   PubMed Web of Science ®Google Scholar
• Jensenius JC, Andersen I, Hau J, Crone M, Koch C. Eggs: conveniently packaged antibodies. Methods for purification of yolk IgG. J Immunol Methods. 1981;46:63–68.
   PubMed Web of Science ®Google Scholar
• Pauly D, Dorner M, Zhang X, Hlinak A, Dorner B, Schade R. Monitoring of laying capacity, immunoglobulin Y concentration, and antibody titer development in chickens immunized with ricin and botulinum toxins over a two-year period. Poult Sci. 2009;88:281–290. doi:10.3382/ps.2008-00323.
   PubMed Web of Science ®Google Scholar
• Sharma JM. Introduction to poultry vaccines and immunity. Adv Vet Med. 1999;41:481–494.
   PubMedGoogle Scholar
• Leslie GA, Clem LW. Phylogen of immunoglobulin structure and function. 3. Immunoglobulins of the chicken. J Exp Med. 1969;130:1337–1352.
   PubMed Web of Science ®Google Scholar
• Shimizu M, Nagashima H, Sano K, Hashimoto K, Ozeki M, Tsuda K, Hatta H. Molecular stability of chicken and rabbit immunoglobulin G. Biosci Biotechnol Biochem. 1992;56:270–274.
   PubMed Web of Science ®Google Scholar
• Nilsson E, Stalberg J, Larsson A. IgY stability in eggs stored at room temperature or at +4 degrees C. Br Poult Sci. 2012;53:42–46. doi:10.1080/00071668.2011.646951.
   PubMed Web of Science ®Google Scholar
• Larsson A, Balow RM, Lindahl TL, Forsberg PO. Chicken antibodies: taking advantage of evolution–a review. Poult Sci. 1993;72:1807–1812. doi:10.3382/ps.0721807.
   PubMed Web of Science ®Google Scholar
• Staak C, Schwarzkopf C, Behn I, Hommel U, Hlinak A, Schade R, Erhard M. Isolation of IgY from Yolk. In: Schade R, Behn I, Erhard M, Hlinak A, Staak C, editors Chicken egg yolk antibodies, production and application: IgY-technology. Berlin (Heidelberg): Springer Berlin Heidelberg; 2001. p. 65–107.
   Google Scholar
• Shimizu M, Fitzsimmons RC, Nakai S. Anti-E. coli lmmunoglobulin Y isolated from egg yolk of immunized chickens as a potential food ingredient. J Food Sci. 1988;53:1360–1368. doi:10.1111/jfds.1988.53.issue-5.
   Web of Science ®Google Scholar
• Fu CY, Huang H, Wang XM, Liu Y-G, Wang Z-G, Cui S-J, Gao H-L, Li Z, Li J-P, Kong X-G. Preparation and evaluation of anti-SARS coronavirus IgY from yolks of immunized SPF chickens. J Virol Methods. 2006;133:112–115. doi:10.1016/j.jviromet.2005.10.027.
   PubMed Web of Science ®Google Scholar
• Yokoyama H, Peralta RC, Diaz R, Sendo S, Ikemori Y, Kodama Y. Passive protective effect of chicken egg yolk immunoglobulins against experimental enterotoxigenic Escherichia coli infection in neonatal piglets. Infect Immun. 1992;60:998–1007.
   PubMed Web of Science ®Google Scholar
• Losch U, Schranner I, Wanke R, Jurgens L. The chicken egg, an antibody source. Zentralblatt Fur Veterinarmedizin Reihe B J Vet Med Series B. 1986;33:609–619.
   PubMedGoogle Scholar
• Hatta H, Tsuda K, Akachi S, Kim M, Yamamoto T. Productivity and some properties of egg yolk antibody (IgY) against human rotavirus compared with rabbit IgG. Biosci Biotechnol Biochem. 1993;57:450–454.
   PubMed Web of Science ®Google Scholar
• Shimizu M, Nagashima H, Hashimoto K. Comparative studies in molecular stability of immunoglobulin G from different species. Comp Biochem Phys B. 1993;106:255–261.
   PubMed Web of Science ®Google Scholar
• Lee KA, Chang SK, Lee YJ, Lee JH, Koo NS. Acid stability of anti-Helicobacter pyroli IgY in aqueous polyol solution. J Biochem Mol Biol. 2002;35:488–493.
   PubMedGoogle Scholar
• Kubickova B, Majerova B, Hadrabova J, Noskova L, Stiborova M, Hodek P. Effect of chicken antibodies on inflammation in human lung epithelial cell lines. Neuro Endocrinol Lett. 2014;35(Suppl 2):99–104.
   PubMedGoogle Scholar
• Nilsson E, Kollberg H, Johannesson M, Wejaker PE, Carlander D, Larsson A. More than 10 years’ continuous oral treatment with specific immunoglobulin Y for the prevention of Pseudomonas aeruginosa infections: a case report. J Med Food. 2007;10:375–378. doi:10.1089/jmf.2006.214.
   PubMed Web of Science ®Google Scholar
• Xie MQ, Meng YX, Li ZH, Li Y-Q, Zhang K-X, Zhao X-M, Xiong G-J, Chen Y-M. [Effect of specific immunoglobulin Y in the treatment of acute and chronic pharyngitis]. Zhonghua Er Bi Yan Hou Ke Za Zhi. 2004;39:112–115.
   PubMedGoogle Scholar
• Lafond KE, Nair H, Rasooly MH, Valente F, Booy R, Rahman M, Kitsutani P, Yu H, Guzman G, Coulibaly D, et al. Global role and burden of influenza in pediatric respiratory hospitalizations, 1982-2012: a systematic analysis. PLoS Med. 2016;13:e1001977. doi:10.1371/journal.pmed.1001977.
   PubMed Web of Science ®Google Scholar
• Vos T, Barber RM, Bell B, Bertozzi-Villa A, Biryukov S, Bolliger I, Charlson F, Davis A, Degenhardt L, Dicker D, et al. Global, regional, and national incidence, prevalence, and years lived with disability for 301 acute and chronic diseases and injuries in 188 countries, 1990-2013: a systematic analysis for the global burden of disease study 2013. Lancet (London, England). 2015;386:743–800. doi:10.1016/S0140-6736(15)60692-4.
   PubMed Web of Science ®Google Scholar
• Bassaganya-Riera J, Song R, Roberts PC, Hontecillas R. PPAR-gamma activation as an anti-inflammatory therapy for respiratory virus infections. Viral Immunol. 2010;23:343–352. doi:10.1089/vim.2010.0016.
   PubMed Web of Science ®Google Scholar
• Quigley E. Influenza therapies: vaccines and antiviral drugs. Drug Discov Today. 2006;11:478–480. doi:10.1016/j.drudis.2006.04.010.
   PubMed Web of Science ®Google Scholar
• Berry CM. Antibody immunoprophylaxis and immunotherapy for influenza virus infection: utilization of monoclonal or polyclonal antibodies?. Hum Vaccin Immunother. 2017;14(3):1–4.
   Web of Science ®Google Scholar
• Yang YE, Wen JL, Zhao SQ, Zhang K, Zhou YL. Prophylaxis and therapy of pandemic H1N1 virus infection using egg yolk antibody. J Virol Methods. 2014;206:19–26. doi:10.1016/j.jviromet.2014.05.016.
   PubMed Web of Science ®Google Scholar
• Tsukamoto M, Hiroi S, Adachi K, Kato H, Inai M, Konishi I, Tanaka M, Yamamoto R, Sawa M, Handharyani E, et al. Antibodies against swine influenza virus neutralize the pandemic influenza virus A/H1N1. Mol Med Rep. 2011;4:209–214. doi:10.3892/mmr.2011.410.
   PubMed Web of Science ®Google Scholar
• Maselli DJ, Keyt H, Restrepo MI. Inhaled antibiotic therapy in chronic respiratory diseases. Int J Mol Sci. 2017;18:1062. doi:10.3390/ijms18051062.
   Web of Science ®Google Scholar
• Emerson J, Rosenfeld M, McNamara S, Ramsey B, Gibson RL. Pseudomonas aeruginosa and other predictors of mortality and morbidity in young children with cystic fibrosis. Pediatr Pulmonol. 2002;34:91–100. doi:10.1002/ppul.10127.
   PubMed Web of Science ®Google Scholar
• Nixon GM, Armstrong DS, Carzino R, Carlin JB, Olinsky A, Robertson CF, Grimwood K. Clinical outcome after early Pseudomonas aeruginosa infection in cystic fibrosis. J Pediatr. 2001;138:699–704. doi:10.1067/mpd.2001.112897.
   PubMed Web of Science ®Google Scholar
• Breidenstein EB, De La Fuente-Nunez C, Hancock RE. Pseudomonas aeruginosa: all roads lead to resistance. Trends Microbiol. 2011;19:419–426. doi:10.1016/j.tim.2011.04.005.
   PubMed Web of Science ®Google Scholar
• Gibson RL, Burns JL, Ramsey BW. Pathophysiology and management of pulmonary infections in cystic fibrosis. Am J Respir Crit Care Med. 2003;168:918–951. doi:10.1164/rccm.200304-505SO.
   PubMed Web of Science ®Google Scholar
• Doring G, Flume P, Heijerman H, Elborn JS. Treatment of lung infection in patients with cystic fibrosis: current and future strategies. J Cyst Fibr. 2012;11:461–479. doi:10.1016/j.jcf.2012.10.004.
   PubMed Web of Science ®Google Scholar
• Nilsson E, Larsson A, Olesen HV, Wejaker PE, Kollberg H. Good effect of IgY against Pseudomonas aeruginosa infections in cystic fibrosis patients. Pediatr Pulmonol. 2008;43:892–899. doi:10.1002/ppul.20875.
   PubMed Web of Science ®Google Scholar
• Quie PG. Lung defense against infection. J Pediatr. 1986;108:813–816.
   PubMed Web of Science ®Google Scholar
• Brett MM, Ghoneim AT, Littlewood JM. Serum IgA antibodies against Pseudomonas aeruginosa in cystic fibrosis. Arch Dis Child. 1990;65:259–263.
   PubMed Web of Science ®Google Scholar
• Thomsen K, Christophersen L, Jensen PO, Bjarnsholt T, Moser C, Hoiby N. Anti-Pseudomonas aeruginosa IgY antibodies promote bacterial opsonization and augment the phagocytic activity of polymorphonuclear neutrophils. Hum Vaccin Immunother. 2016;12:1690–1699.
   PubMed Web of Science ®Google Scholar
• Honko AN, Mizel SB. Effects of flagellin on innate and adaptive immunity. Immunol Res. 2005;33:83–101. doi:10.1385/IR:33:1:083.
   PubMed Web of Science ®Google Scholar
• Prince A. Flagellar activation of epithelial signaling. Am J Respir Cell Mol Biol. 2006;34:548–551. doi:10.1165/rcmb.2006-0022SF.
   PubMed Web of Science ®Google Scholar
• Nilsson E, Amini A, Wretlind B, Larsson A. Pseudomonas aeruginosa infections are prevented in cystic fibrosis patients by avian antibodies binding Pseudomonas aeruginosa flagellin. J Chromatograp B, Anal Technol Biomed Life Sci. 2007;856:75–80. doi:10.1016/j.jchromb.2007.05.029.
   PubMed Web of Science ®Google Scholar
• Kollberg H, Carlander D, Olesen H, Wejaker PE, Johannesson M, Larsson A. Oral administration of specific yolk antibodies (IgY) may prevent Pseudomonas aeruginosa infections in patients with cystic fibrosis: a phase I feasibility study. Pediatr Pulmonol. 2003;35:433–440. doi:10.1002/ppul.10290.
   PubMed Web of Science ®Google Scholar
• Waters V, Smyth A. Cystic fibrosis microbiology: advances in antimicrobial therapy. J Cyst Fibr. 2015;14:551–560. doi:10.1016/j.jcf.2015.02.005.
   PubMed Web of Science ®Google Scholar
• Perlman S, Netland J. Coronaviruses post-SARS: update on replication and pathogenesis. Nat Rev Microbiol. 2009;7:439–450. doi:10.1038/nrmicro2147.
   PubMed Web of Science ®Google Scholar
• Rota PA, Oberste MS, Monroe SS, Nix WA, Campagnoli R, Icenogle JP, Penaranda S, Bankamp B, Maher K, Chen MH, et al. Characterization of a novel coronavirus associated with severe acute respiratory syndrome. Science (New York, NY). 2003;300:1394–1399. doi:10.1126/science.1085952.
   Google Scholar
• Drosten C, Gunther S, Preiser W, Van Der Werf S, Brodt H-R, Becker S, Rabenau H, Panning M, Kolesnikova L, Fouchier RAM, et al. Identification of a novel coronavirus in patients with severe acute respiratory syndrome. N Engl J Med. 2003;348:1967–1976. doi:10.1056/NEJMoa030747.
   PubMed Web of Science ®Google Scholar
• Lechartier B, Rybniker J, Zumla A, Cole ST. Tuberculosis drug discovery in the post-post-genomic era. EMBO Mol Med. 2014;6:158–168. doi:10.1002/emmm.201201772.
   PubMed Web of Science ®Google Scholar
• Bhatt K, Salgame P. Host innate immune response to Mycobacterium tuberculosis. J Clin Immunol. 2007;27:347–362. doi:10.1007/s10875-007-9084-0.
   PubMed Web of Science ®Google Scholar
• World Health Organization. Global Tuberculosis Report, 2016. Geneva, Switzerland: WHO; 2017. Accessed. http://www.who.int/tb/publications/global_report/en/.
   Google Scholar
• Wang XZ, Chen SS, Xu YJ, Zheng HJ, Xiao TY, Li YQ, Chen X, Huang MX, Zhang HF, Fang XJ, et al. Identification and evaluation of the novel immunodominant antigen Rv2351c from Mycobacterium tuberculosis. Emerg Microbes Infect. 2017;6(6):6.
   Web of Science ®Google Scholar
• Sudjarwo SA, Eraiko K, Sudjarwo GW. Koerniasari. The potency of chicken egg yolk immunoglobulin (IgY) specific as immunotherapy to Mycobacterium tuberculosis infection. J Adv Pharm Technol Res. 2017;8:91–96.
   PubMed Web of Science ®Google Scholar
• Stott EJ, Taylor G. Respiratory syncytial virus. Brief Rev Arch Virol. 1985;84:1–52.
   PubMed Web of Science ®Google Scholar
• Nair H, Nokes DJ, Gessner BD, Dherani M, Madhi SA, Singleton RJ, O’Brien KL, Roca A, Wright PF, Bruce N, et al. Global burden of acute lower respiratory infections due to respiratory syncytial virus in young children: a systematic review and meta-analysis. Lancet (London, England). 2010;375:1545–1555. doi:10.1016/S0140-6736(10)60206-1.
   PubMed Web of Science ®Google Scholar
• Taylor G. Animal models of respiratory syncytial virus infection. Vaccine. 2017;35:469–480. doi:10.1016/j.vaccine.2016.11.054.
   PubMed Web of Science ®Google Scholar
• Valarcher JF, Taylor G. Bovine respiratory syncytial virus infection. Vet Res. 2007;38:153–180. doi:10.1051/vetres:2006053.
   PubMed Web of Science ®Google Scholar
• Ferella A, Bellido D, Chacana P, Wigdorovitz A, Santos MJD, Mozgovoj MV. Chicken egg yolk antibodies against bovine respiratory syncytial virus neutralize the virus in vitro. Procedia Vaccinol. 2012;6:33–38. doi:10.1016/j.provac.2012.04.006.
   Google Scholar
• Lipman NS, Jackson LR, Trudel LJ, Weis-Garcia F. Monoclonal versus polyclonal antibodies: distinguishing characteristics, applications, and information resources. ILAR J. 2005;46:258–268.
   PubMed Web of Science ®Google Scholar
• Lee W, Syed Atif A, Tan SC, Leow CH. Insights into the chicken IgY with emphasis on the generation and applications of chicken recombinant monoclonal antibodies. J Immunol Methods. 2017;447:71–85. doi:10.1016/j.jim.2017.05.001.
   PubMed Web of Science ®Google Scholar
• Spillner E, Braren I, Greunke K, Seismann H, Blank S, Du Plessis D. Avian IgY antibodies and their recombinant equivalents in research, diagnostics and therapy. Biol J Int Assoc Biol Standard. 2012;40:313–322. doi:10.1016/j.biologicals.2012.05.003.
   Google Scholar