Vaccine hesitancy and influenza beliefs among parents of children requiring a second dose of influenza vaccine in a season: An American Academy of Pediatrics (AAP) Pediatric Research in Office Settings (PROS) study

References

• Centers for Disease Control and Prevention (CDC). Estimates of deaths associated with seasonal influenza — United States, 1976-2007. MMWR Morb Mortal Wkly Rep. 2010;59(33):1057–62.
   PubMedGoogle Scholar
• Thompson WW, Shay DK, Weintraub E, Brammer L, Bridges CB, Cox NJ, Fukuda K. Influenza-Associated Hospitalizations in the United States. JAMA. 2004;292(11):1333–40. doi:10.1001/jama.292.11.1333
   Google Scholar
• Molinari N-AM, Ortega-Sanchez IR, Messonnier ML, Thompson WW, Wortley PM, Weintraub E, Bridges CB. The annual impact of seasonal influenza in the US: measuring disease burden and costs. Vaccine. 2007;25(27):5086–96. doi:10.1016/j.vaccine.2007.03.046.
   PubMed Web of Science ®Google Scholar
• Estimated influenza illnesses, medical visits, hospitalizations, and deaths in the United States — 2017–2018 influenza season | CDC. 2019 Mar 26 [accessed 2019 May 13]. https://www.cdc.gov/flu/about/burden/2017-2018.htm.
   Google Scholar
• Louie JK, Schechter R, Honarmand S, Guevara HF, Shoemaker TR, Madrigal NY, Woodfill CJI, Backer HD, Glaser CA. Severe pediatric influenza in California, 2003-2005: implications for immunization recommendations. Pediatrics. 2006;117(4):e610–618. doi:10.1542/peds.2005-1373.
   PubMed Web of Science ®Google Scholar
• Neuzil KM, Zhu Y, Griffin MR, Edwards KM, Thompson JM, Tollefson SJ, Wright PF. Burden of interpandemic influenza in children younger than 5 years: a 25-year prospective study. J Infect Dis. 2002;185(2):147–52. doi:10.1086/338363.
   PubMed Web of Science ®Google Scholar
• Neuzil KM, Mellen BG, Wright PF, Mitchel EF, Griffin MR. The effect of influenza on hospitalizations, outpatient visits, and courses of antibiotics in children. N Engl J Med. 2000;342(4):225–31. doi:10.1056/NEJM200001273420401.
   PubMed Web of Science ®Google Scholar
• Jules A, Grijalva CG, Zhu Y, Talbot HK, Williams JV, Poehling KA, Chaves SS, Edwards KM, Schaffner W, Shay DK, et al. Influenza-related hospitalization and ED visits in children less than 5 years: 2000–2011. Pediatrics. 2015;135(1):e66–74. doi:10.1542/peds.2014-1168..
   Google Scholar
• Zhou H, Thompson WW, Viboud CG, Ringholz CM, Cheng P-Y, Steiner C, Abedi GR, Anderson LJ, Brammer L, Shay DK. Hospitalizations associated with influenza and respiratory syncytial virus in the United States, 1993-2008. Clin Infect Dis. 2012;54(10):1427–36. doi:10.1093/cid/cis211.
   PubMed Web of Science ®Google Scholar
• Newland JG, Laurich VM, Rosenquist AW, Heydon K, Licht DJ, Keren R, Zaoutis TE, Watson B, Hodinka RL, Coffin SE. Neurologic complications in children hospitalized with influenza: characteristics, incidence, and risk factors. J Pediatr. 2007;150(3):306–10.
   Google Scholar
• Mistry RD, Fischer JB, Prasad PA, Coffin SE, Alpern ER. Severe complications in influenza-like illnesses. Pediatrics. 2014;134(3):e684–90.
   Google Scholar
• CDC. Key facts about seasonal flu vaccine. Centers for Disease Control and Prevention. 2018 Sep 6 [accessed 2019 Jun 21]. https://www.cdc.gov/flu/prevent/keyfacts.htm.
   Google Scholar
• Ferdinands JM, Olsho LEW, Agan AA, Bhat N, Sullivan RM, Hall M, Mourani PM, Thompson M, Randolph AG. Effectiveness of influenza vaccine against life-threatening RT-PCR-confirmed influenza illness in US children, 2010–2012. J Infect Dis. 2014;210(5):674–83. doi:10.1093/infdis/jiu185.
   PubMed Web of Science ®Google Scholar
• Flannery B, Reynolds SB, Blanton L, Santibanez TA, O’Halloran A, Lu P-J, Chen J, Foppa IM, Gargiullo P, Bresee J, et al. Influenza vaccine effectiveness against pediatric deaths: 2010–2014. Pediatrics. 2017;139(5):e20164244. doi:10.1542/peds.2016-4244.
   PubMed Web of Science ®Google Scholar
• Grohskopf LA, Sokolow LZ, Broder KR, Walter EB, Bresee JS, Fry AM, Jernigan DB. Prevention and control of seasonal influenza with vaccines: recommendations of the advisory committee on immunization practices — United States, 2017–18 influenza season. MMWR Recomm Rep. 2017;66(2):1–20. doi:10.15585/mmwr.rr6602a1.
   PubMed Web of Science ®Google Scholar
• Grohskopf LA, Sokolow LZ, Broder KR, Walter EB, Fry AM, Jernigan DB. Prevention and control of seasonal influenza with vaccines: recommendations of the advisory committee on immunization practices—United States, 2018–19 influenza season. MMWR Recomm Rep. 2018;67(3):1–20. doi:10.15585/mmwr.rr6703a1
   Google Scholar
• Grohskopf LA, Sokolow LZ, Broder KR, Walter EB, Fry AM, Jernigan DB. Prevention and control of seasonal influenza with vaccines. MMWR Recomm Rep. 2016;65(No. RR-5):1–54. doi:10.15585/mmwr.rr6505a1
   Google Scholar
• Poehling KA, Edwards KM, Griffin MR, Szilagyi PG, Staat MA, Iwane MK, Snively BM, Suerken CK, Hall CB, Weinberg GA et al. The burden of influenza in young children, 2004–2009. Pediatrics. 2013;131(2):207–16.
   Google Scholar
• Neuzil KM, Jackson LA, Nelson J, Klimov A, Cox N, Bridges CB, Dunn J, DeStefano F, Shay D. Immunogenicity and reactogenicity of 1 versus 2 doses of trivalent inactivated influenza vaccine in vaccine-naive 5-8-year-old children. J Infect Dis. 2006;194(8):1032–39. doi:10.1086/jid.2006.194.issue-8.
   PubMed Web of Science ®Google Scholar
• Allison MA, Daley MF, Crane LA, Barrow J, Beaty BL, Allred N, Berman S, Kempe A. Influenza vaccine effectiveness in healthy 6- to 21-month-old children during the 2003-2004 season. J Pediatr. 2006;149(6):755–762.e1. doi:10.1016/j.jpeds.2006.06.036.
   PubMed Web of Science ®Google Scholar
• Hofstetter AM, Natarajan K, Martinez RA, Rabinowitz D, Vawdrey DK, Stockwell MS. Influenza vaccination coverage and timeliness among children requiring two doses, 2004–2009. Prev Med. 2013;56(3):165–70. doi:10.1016/j.ypmed.2012.11.018.
   PubMed Web of Science ®Google Scholar
• Bhatt P, Block SL, Toback SL, Ambrose CS. A prospective observational study of US in-office pediatric influenza vaccination during the 2007 to 2009 influenza seasons: use and factors associated with increased vaccination rates. Clin Pediatr (Phila). 2010;49(10):954. doi:10.1177/0009922810370868.
   PubMed Web of Science ®Google Scholar
• Pabst LJ, Chaves SS, Weinbaum C. Trends in compliance with two-dose influenza vaccine recommendations among children aged 6 months through 8 years. Vaccine. 2013;31(31):3116–20. doi:10.1016/j.vaccine.2013.04.080.
   PubMed Web of Science ®Google Scholar
• Estimates of flu vaccination coverage among children — United States, 2017–18 flu season | fluVaxView | seasonal influenza (Flu) | CDC. 2019 Feb 26 [accessed 2019 May 22]. https://www.cdc.gov/flu/fluvaxview/coverage-1718estimates-children.htm.
   Google Scholar
• Salmon DA, Dudley MZ, Glanz JM, Omer SB. Vaccine hesitancy: causes, consequences, and a call to action. Am J Prev Med. 2015;49(6):S391–S398. doi:10.1016/j.amepre.2015.06.009.
   PubMed Web of Science ®Google Scholar
• Hofstetter AM, Simon TD, Lepere K, Ranade D, Strelitz B, Englund JA, Opel DJ. Parental vaccine hesitancy and declination of influenza vaccination among hospitalized children. Hosp Pediatr. 2018;8(10):628–35. doi:10.1542/hpeds.2018-0025.
   PubMedGoogle Scholar
• Quinn SC, Jamison AM, An J, Hancock GR, Freimuth VS. Measuring vaccine hesitancy, confidence, trust and flu vaccine uptake: results of a national survey of White and African American adults. Vaccine. 2019;37(9):1168–73. doi:10.1016/j.vaccine.2019.01.033.
   PubMed Web of Science ®Google Scholar
• Gust DA, Kennedy A, Shui I, Smith PJ, Nowak G, Pickering LK. Parent attitudes toward immunizations and healthcare providers the role of information. Am J Prev Med. 2005;29(2):105–12. doi:10.1016/j.amepre.2005.04.010.
   PubMed Web of Science ®Google Scholar
• Strelitz B, Gritton J, Klein EJ, Bradford MC, Follmer K, Zerr DM, Englund JA, Opel DJ. Parental vaccine hesitancy and acceptance of seasonal influenza vaccine in the pediatric emergency department. Vaccine. 2015;33(15):1802–07. doi:10.1016/j.vaccine.2015.02.034.
   PubMed Web of Science ®Google Scholar
• Smith PJ, Humiston SG, Marcuse EK, Zhao Z, Dorell CG, Howes C, Hibbs B. Parental delay or refusal of vaccine doses, childhood vaccination coverage at 24 months of age, and the health belief model. Public Health Rep. 2011;126(2_suppl):135–46. doi:10.1177/00333549111260S215.
   PubMed Web of Science ®Google Scholar
• Oladejo O, Allen K, Amin A, Frew PM, Bednarczyk RA, Omer SB. Comparative analysis of the Parent Attitudes about Childhood Vaccines (PACV) short scale and the five categories of vaccine acceptance identified by Gust et al. Vaccine. 2016;34(41):4964–68. doi:10.1016/j.vaccine.2016.08.046.
   PubMed Web of Science ®Google Scholar
• Scott VP, Opel DJ, Reifler J, Rikin S, Pethe K, Barrett A, Stockwell MS. Office-based educational handout for influenza vaccination: a randomized controlled trial. Pediatrics. 2019 Jul 10;144:e20182580. doi:10.1542/peds.2018-2580.
   PubMed Web of Science ®Google Scholar
• Opel DJ, Mangione-Smith R, Taylor JA, Korfiatis C, Wiese C, Catz S, Martin DP. Development of a survey to identify vaccine-hesitant parents. Hum Vaccin. 2011;7(4):419–25. doi:10.4161/hv.7.4.14120.
   PubMed Web of Science ®Google Scholar
• Graubard BI, Korn EL. Predictive margins with survey data. Biometrics. 1999;55(2):652–59. doi:10.1111/j.0006-341X.1999.00652.x.
   PubMed Web of Science ®Google Scholar
• Moving to a World Beyond “p < .05”: The American Statistician: Vol 73, No sup1. [accessed 2019 Jul 31]. doi:10.1080/00031305.2019.1583913.
   Google Scholar
• Allan K, Fallon B, Maguire J, Tran D. 2473 How does acquiring a vaccine-preventable disease impact parental and physician responses to vaccine hesitancy? Open Forum Infect Dis. 2018;5(Suppl 1):S741. doi:10.1093/ofid/ofy210.2126.
   Google Scholar
• Sadaf A, Richards JL, Glanz J, Salmon DA, Omer SB. A systematic review of interventions for reducing parental vaccine refusal and vaccine hesitancy. Vaccine. 2013;31(40):4293–304. doi:10.1016/j.vaccine.2013.07.013.
   PubMed Web of Science ®Google Scholar
• Schmid P, Rauber D, Betsch C, Lidolt G, Denker M-L. Barriers of influenza vaccination intention and behavior – a systematic review of influenza vaccine hesitancy, 2005 – 2016. PLoS One. 2017;12(1):e0170550. doi:10.1371/journal.pone.0170550.
   PubMed Web of Science ®Google Scholar
• Bianco A, Mascaro V, Zucco R, Pavia M. Parent perspectives on childhood vaccination: how to deal with vaccine hesitancy and refusal? Vaccine. 2019;37(7):984–90. doi:10.1016/j.vaccine.2018.12.062.
   PubMed Web of Science ®Google Scholar
• Williams SE, Morgan A, Opel D, Edwards K, Weinberg S, Rothman R. Screening tool predicts future underimmunization among a pediatric practice in tennessee. Clin Pediatr (Phila). 2016;55(6):537–42. doi:10.1177/0009922815615823.
   PubMed Web of Science ®Google Scholar
• Larson HJ, Jarrett C, Eckersberger E, Smith DMD, Paterson P. Understanding vaccine hesitancy around vaccines and vaccination from a global perspective: a systematic review of published literature, 2007–2012. Vaccine. 2014;32(19):2150–59. doi:10.1016/j.vaccine.2014.01.081.
   PubMed Web of Science ®Google Scholar
• Danis K, Georgakopoulou T, Stavrou T, Laggas D, Panagiotopoulos T. Socioeconomic factors play a more important role in childhood vaccination coverage than parental perceptions: a cross-sectional study in Greece. Vaccine. 2010;28(7):1861–69. doi:10.1016/j.vaccine.2009.11.078.
   PubMed Web of Science ®Google Scholar
• Kepka D, Warner EL, Kinney AY, Spigarelli MG, Mooney K. Low human papillomavirus (HPV) vaccine knowledge among Latino parents in Utah. J Immigrant Minority Health. 2015;17(1):125–31. doi:10.1007/s10903-014-0003-1.
   PubMed Web of Science ®Google Scholar
• Peterson P, McNabb P, Ramya Maddali S, Heath J, Santibañez S. Engaging communities to reach immigrant and minority populations: the Minnesota Immunization Networking Initiative (MINI), 2006-2017. Public Health Rep. 2019;134:003335491983457. doi:10.1177/0033354919834579.
   Web of Science ®Google Scholar
• Biasio LR. Vaccine hesitancy and health literacy. Hum Vaccin Immunother. 2016;13(3):701–02. doi:10.1080/21645515.2016.1243633.
   PubMed Web of Science ®Google Scholar
• Humiston SG, Lerner EB, Hepworth E, Blythe T, Goepp JG. Parent opinions about universal influenza vaccination for infants and toddlers. Arch Pediatr Adolesc Med. 2005;159(2):108–12. doi:10.1001/archpedi.159.2.108.
   PubMedGoogle Scholar
• Fitch P, Racine A. Parental beliefs about vaccination among an ethnically diverse inner-city population. J Natl Med Assoc. 2004;96:1047–50.
   PubMed Web of Science ®Google Scholar
• Le Saux N. Dispelling myths held by parents about the influenza vaccine. Paediatr Child Health. 2009;14(9):618–20. doi:10.1093/pch/14.9.618.
   PubMed Web of Science ®Google Scholar
• Lin CJ, Nowalk MP, Zimmerman RK, Ko F-S, Zoffel L, Hoberman A, Kearney DH. Beliefs and attitudes about influenza immunization among parents of children with chronic medical conditions over a two-year period. J Urban Health. 2006;83(5):874–83. doi:10.1007/s11524-006-9084-z.
   PubMed Web of Science ®Google Scholar
• Chau JPC, Lo SHS, Choi KC, Chau MHK, Tong DWK, Kwong TKY, Thompson DR. Factors determining the uptake of influenza vaccination among children with chronic conditions. Pediatr Infect Dis J. 2017;36(7):E197–E202. doi:10.1097/INF.0000000000001550.
   PubMed Web of Science ®Google Scholar
• Keane MT, Walter MV, Patel BI, Moorthy S, Stevens RB, Bradley KM, Buford JF, Anderson EL, Anderson LP, Tibbals K, et al. Confidence in vaccination: a parent model. Vaccine. 2005;23(19):2486–93. doi:10.1016/j.vaccine.2004.10.026.
   PubMed Web of Science ®Google Scholar
• Chen C-H, Chiu P-J, Chih Y-C, Yeh G-L. Determinants of influenza vaccination among young Taiwanese children. Vaccine. 2015;33(16):1993–98. doi:10.1016/j.vaccine.2015.01.032.
   PubMed Web of Science ®Google Scholar
• Ewig CLY, Tang KM, Leung TF, You JHS. Influenza vaccine coverage and predictive factors associated with influenza vaccine uptake among pediatric patients. Am J Infect Control. 2018;46(11):1278–83. doi:10.1016/j.ajic.2018.04.219.
   PubMed Web of Science ®Google Scholar
• Jarrett C, Wilson R, O’Leary M, Eckersberger E, Larson HJ. Strategies for addressing vaccine hesitancy – A systematic review. Vaccine. 2015;33(34):4180–90. (WHO Recommendations Regarding Vaccine Hesitancy). doi:10.1016/j.vaccine.2015.04.040.
   PubMed Web of Science ®Google Scholar
• Eskola J, Duclos P, Schuster M, MacDonald NE. How to deal with vaccine hesitancy? Vaccine. 2015;33(34):4215–17. WHO Recommendations Regarding Vaccine Hesitancy. doi:10.1016/j.vaccine.2015.04.043.
   PubMed Web of Science ®Google Scholar
• Henrikson NB, Opel DJ, Grothaus L, Nelson J, Scrol A, Dunn J, Faubion T, Roberts M, Marcuse EK, Grossman DC. Physician communication training and parental vaccine hesitancy: a randomized trial. Pediatrics. 2015;136(1):70–79. doi:10.1542/peds.2014-3199.
   PubMed Web of Science ®Google Scholar
• Shen S (Cindy), Dubey V. Addressing vaccine hesitancy. Can Family Physician. 2019;65:175–81.
   PubMed Web of Science ®Google Scholar
• Nyhan B, Reifler J. Does correcting myths about the flu vaccine work? An experimental evaluation of the effects of corrective information. Vaccine. 2015;33(3):459–64. doi:10.1016/j.vaccine.2014.11.017.
   PubMed Web of Science ®Google Scholar