1,673
Views
7
CrossRef citations to date
0
Altmetric
Commentary

Lessons learned from Zaire ebolavirus to help address urgent needs for vaccines against Sudan ebolavirus and Marburg virus

, &
Pages 2855-2860 | Received 13 Feb 2020, Accepted 07 Mar 2020, Published online: 10 Apr 2020

References

  • Agency EM Ervebo; 2019 Dec 17 [accessed 2019 Dec 20]. https://www.ema.europa.eu/en/medicines/human/EPAR/ervebo.
  • Administration FD First FDA-approved vaccine for the prevention of Ebola virus disease, marking a critical milestone in public health preparedness and response. 2019 [ accessed 2019 Dec 17]. https://www.fda.gov/news-events/press-announcements/first-fda-approved-vaccine-prevention-ebola-virus-disease-marking-critical-milestone-public-health
  • Wolfe DN, Zarrabian AG, Disbrow GL, Espeland EM. Progress towards a vaccine against Ebola to meet emergency medical countermeasure needs. Vaccine. 2017;17:7178–82.
  • Heymann D, Hodgson A, Sall AA, Freedman DO, Staples JE, Althabe F, Baruah K, Mahmud G, Kandun N, Vasconcelos PFC, et al. Zika virus and microencephaly: why is this situation a PHEIC. Lancet. 2016;387(10020):719–21. doi:10.1016/S0140-6736(16)00320-2.
  • Taubengerger J, Morens DM. Pandemic influenza - including a risk assessment of H5N1. Rev Sci Technol. 2009;28(1):187–202. doi:10.20506/rst.28.1.1879.
  • Silva W, Das TK, Izurieta R. Estimating disease burden of a potential A (H7N9) pandemic influenza outbreak in the United States. BMC Public Health. 2017;17(1):898. doi:10.1186/s12889-017-4884-5.
  • Prevention, C.f.D.C.a. Outbreaks chronology: Ebola virus diseae. 2016 [accessed 2017 Jul 1]. http://www.cdc.gov/vhf/ebola/outbreaks/history/chronology.html
  • Prevention, C.f.D.C.a. Chronology of Marburg hemorrhagic fever outbreaks. 2014 [accessed 2017 Jul 1] https://www.cdc.gov/vhf/marburg/resources/outbreak-table.html
  • Goldstein T, Anthony SJ, Gbakima A, Bird BH, Bangura J, Tremeau-Bravard A, Belaganahalli MN, Wells HL, Dhanota JK, Liang E, et al. The discovery of Bombali virus adds further support for bats as hosts of ebolaviruses. Nat Microbiol. 2018;3(10):1084–89. doi:10.1038/s41564-018-0227-2.
  • Wasswa H. Uganda grapples wiht new Marburg disease outbreak. BMJ. 2017;359:5252. doi:10.1136/bmj.j5252.
  • Ledgerwood J, Costner P, Desai N, Holman L, Enama ME, Yamshchikov G, Mulangu S, Hu Z, Andrews CA, Sheets RA, et al. A replication defective recombinant Ad5 vaccine expressing Ebola virus GP is safe and immunogenic in healthy adults. Vaccine. 2010;29(2):304–13. doi:10.1016/j.vaccine.2010.10.037.
  • Martin J, Sullivan NJ, Enama ME, Gordon IJ, Roederer M, Koup RA, Bailer RT, Chakrabarti BK, Bailey MA, Gomez PL, et al. A DNA vaccine for Ebola virus is safe and immunogenic in a Phase 1 clinical trial. Clin Vaccine Immunol. 2006;13(11):1267–77. doi:10.1128/CVI.00162-06.
  • Herbert A, Kuehne AI, Barth JF, Ortiz RA, Nichols DK, Zak SE, Stonier SW, Muhammad MA, Bakken RR, Prugar LI, et al. Venezuelan equine encephalitis virus replicon particle vaccine protects nonhuman primates from intramuscular and aerosol challenge with ebolavirus. J Virol. 2013;87(9):4952–64. doi:10.1128/JVI.03361-12.
  • Martins KAO, Cooper CL, Stronsky SM, Norris SLW, Kwilas SA, Steffens JT, Benko JG, van Tongeren SA, Bavari S. Adjuvant-enhanced CD4 T cell responses are critical to durable vaccine immunity. EBioMedicine. 2015;27(3):67–78.
  • Geisbert T, Feldmann H. Recombinant vesicular stomatitis virus–based vaccines against Ebola and Marburg virus infections. J Infect Dis. 2011;204(Supplement 3):S1075–1081. doi:10.1093/infdis/jir349.
  • Stanley DA, Honko A, Asiedu C, Trefry JC, Lau-Kilby AW, Johnson JC, Hensley L, Ammendola V, Abbate A, Grazioli F, et al. Chimpanzee adenovirus vaccine generates acute and durable protective immunity against ebolavirus challenge. Nat Med. 2014;20(10):1126–29. doi:10.1038/nm.3702.
  • Geisbert T, Bailey M, Hensley L, Asiedu C, Geisbert J, Stanley D, Honko A, Johnson J, Mulangu S, Pau MG, et al. Recombinant adenovirus serotype 26 (Ad26) and Ad35 vaccine vectors bypass immunity to Ad5 and protect nonhuman primates against ebolavirus challenge. J Virol. 2011;85(9):4222–33. doi:10.1128/JVI.02407-10.
  • Cross R, Mire CE, Feldmann H, Geisbert TW. Post-exposure treatments for Ebola and Marburg virus infections. Nat Rev Drug Discov. 2018;22(218):S448–S452.
  • Administration, F.a.D. Product development under the animal rule. Guidance for Industry. C.f.D.E.a.R.C.f.B.E.a. Research, Editor. 2015 [accessed 2019 Dec 12]. https://www.fda.gov/downloads/drugs/guidances/ucm399217.pdf
  • Alfson K, Avena LE, Beadles MW, Staples H, Nunneley JW, Ticer A, Dick EJ, Owston MA, Reed C, Patterson JL, et al. Particle-to-PFU ratio of Ebola virus influences disease course and survival in cynomolgus macaques. J Virol. 2015;89(13):6773–81. doi:10.1128/JVI.00649-15.
  • Geisbert T, Strong JE, Feldmann H. Considerations in the use of nonhuman primate models of Ebola virus and Marburg virus infection. J Infect Dis. 2015;212(Supplement 2):S91–97. doi:10.1093/infdis/jiv284.
  • Marzi A, Feldmann H. Ebola virus vaccines: an overview of current approaches. Expert Rev Vaccines. 2014;13(4):521–31. doi:10.1586/14760584.2014.885841.
  • Mire CE, Miller AD, Carville A, Westmoreland SV, Geisbert JB, Mansfield KG, Feldmann H, Hensley LE, Geisbert TW. Recombinant vesicular stomatitis virus vaccine vectors expressing filovirus glycoproteins lack neurovirulence in nonhuman primates. PLoS Negl Trop Dis. 2012;6(3):1567. doi:10.1371/journal.pntd.0001567.
  • Jones SM, Stroher U, Fernando L, Qiu X, Alimonti J, Melito P, Bray M, Klenk HD, Feldmann H. Assessment of a vesicular stomatitis virus-based vaccine by use of the mouse model of Ebola virus hemorrhagic fever. J Infect Dis. 2007;196:S404–S412. doi:10.1086/525008.
  • Al-Humadi N. Pre-clinical toxicology consideratinos for vaccine development. Vaccine. 2017;35(43):5762–67. doi:10.1016/j.vaccine.2017.09.021.
  • Sullivan N, Martin J, Graham B, Nabel G. Correlates of protective immunity for Ebola vaccines: implications for regulatory approval by the animal rule. Nat Rev Microbiol. 2009;7(4):393–400. doi:10.1038/nrmicro2129.
  • Rudge TL Jr, Sankovich KA, Niemuth NA, Anderson MS, Badorrek CS, Skomrock ND, Cirimotich CM, Sabourin CL. Development, qualification, and validation of the filovirus animal nonclinical group anti-Ebola virus glycoprotein immunoglobulin G enzyme-linked immunosorbent assay for human serum samples. PLoS One. 2019;14(4):e0215457. doi:10.1371/journal.pone.0215457.
  • Kibuuka H, Berkowitz N, Millard M, Enama ME, Tindikahwa A, Sekiziyivu AB, Costner P, Sitar S, Glover D, Hu Z, et al. Safety and immunogenicity of Ebola virus and Marburg virus glycoprotein DNA vaccines assessed separately and concomitantly in healthy Ugandan adults: a phase 1b, randomised, double-blind, placebo-controlled clinical trial. Lancet. 2015;385(9977):1545–54. doi:10.1016/S0140-6736(14)62385-0.
  • Reynolds P, Marzi A. Ebola and Marburg virus vaccines. Virus Genes. 2017;53(4):501–15. doi:10.1007/s11262-017-1455-x.
  • Suschak J, Schmaljohn CS. Vaccines against Ebola virus and Marburg virus: recent advances and promising candidates. Hum Vaccines Immunotherapeutics. 2019;15(10):2359–77. doi:10.1080/21645515.2019.1651140.
  • Hirschberg R, Ward LA, Kilgore N, Kurnat R, Schiltz H, Albrecht MT, Christopher GW, Nuzum E. Challenges, progress, and opportunities: proceedings of the Filovirus medical countermeasures workshop. Viruses. 2014;6(7):2673–97. doi:10.3390/v6072673.
  • Smither SJ, Nelson M, Eastaugh L, Nunez A, Salguero FJ, Lever MS. Experimental respiratory infection of marmosets (Callithrix jacchus) with Ebola virus kikwit. J Infect Dis. 2015;212(Suppl 2):S336–345. doi:10.1093/infdis/jiv371.
  • Kroeker A, He S, de La Vega M, Wong G, Embury-Hyatt C, Qiu X. Characterization of Sudan Ebolavirus infection in ferrets. Oncotarget. 2017;8(28):46262–72. doi:10.18632/oncotarget.17694.
  • Cross RW, Mire CE, Borsevich V, Geisbert JB, Fenton KA, Geisbert TW. The domestic ferret (Mustela putorius furo) as a lethal infection model for 3 species of ebolavirus. J Infect Dis. 2016;214(4):565–69. doi:10.1093/infdis/jiw209.
  • Alfson K, Avena LE, Worwa G, Carrion R, Griffiths A. Development of a lethal intranasal exposure model of Ebola virus in the cynomolgus macaque. Viruses. 2017;9(11):319. doi:10.3390/v9110319.
  • Organization WH, Ebola Virus Disease; Democratic Republic of the Congo External Situation Report 71. 2019: https://www.who.int/emergencies/diseases/ebola/drc-2019/situation-reports.
  • Alliance GTV Gavi Board approves new Ebola vaccine programme. 2019 [ accessed 2019 Dec 6]. https://www.gavi.org/news/media-room/gavi-board-approves-new-ebola-vaccine-programme