Parenteral immunization with a cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) adjuvanted Helicobacter pylori vaccine induces protective immunity against H. pylori infection in mice

References

• Matsumoto H, Shiotani A, Graham DY. Current and future treatment of helicobacter pylori infections. Adv Exp Med Biol. 2019;1149:211–25. doi:10.1007/5584_2019_367.
   PubMed Web of Science ®Google Scholar
• de Brito BB, da Silva FAF, Soares AS, Pereira VA, Santos MLC, Sampaio MM, Neves PHM, de Melo FF. Pathogenesis and clinical management of Helicobacter pylori gastric infection. World J Gastroenterol. 2019;25(37):5578–89. doi:10.3748/wjg.v25.i37.5578.
   PubMed Web of Science ®Google Scholar
• Chmiela M, Karwowska Z, Gonciarz W, Allushi B, Staczek P. Host pathogen interactions in Helicobacter pylori related gastric cancer. World J Gastroenterol. 2017;23(9):1521–40. doi:10.3748/wjg.v23.i9.1521.
   PubMed Web of Science ®Google Scholar
• Johnson KS, Ottemann KM. Colonization, localization, and inflammation: the roles of H. pylori chemotaxis in vivo. Curr Opin Microbiol. 2018;41:51–57. S1369-5274(17)30153-4 [pii]. doi:10.1016/j.mib.2017.11.019.
   PubMed Web of Science ®Google Scholar
• Kanglesiji DYU, Lin Y, Xiaohong MA. Helicobacter pylori infection in the plateau region of China and its relationship with the pathogenesis of gastric cancer. Oncol Prog. 2017;15(5):584–6,603. doi:10.11877/j.1672-1535.2017.15.05.31.
   Google Scholar
• Tacconelli E, Carrara E, Savoldi A, Harbarth S, Mendelson M, Monnet DL, Pulcini C, Kahlmeter G, Kluytmans J, Carmeli Y, et al. Discovery, research, and development of new antibiotics: the WHO priority list of antibiotic-resistant bacteria and tuberculosis. Lancet Infect Dis. 2018;18(3):318–27. S1473-3099(17)30753-3 [pii]. doi:10.1016/S1473-3099(17)30753-3.
   PubMed Web of Science ®Google Scholar
• Mirzaei N, Poursina F, Moghim S, Rashidi N, Ghasemian Safaei H. The study of H. pylori putative candidate factors for single- and multi-component vaccine development. Crit Rev Microbiol. 2017;43(5):631–50. doi:10.1080/1040841X.2017.1291578.
   PubMed Web of Science ®Google Scholar
• Guo L, Yang H, Tang F, Yin R, Liu H, Gong X, Wei J, Zhang Y, Xu G, Liu K. Oral immunization with a multivalent epitope-based vaccine, based on NAP, urease, HSP60, and HpaA, provides therapeutic effect on H. pylori infection in mongolian gerbils. Front Cell Infect Microbiol. 2017;7:349. doi:10.3389/fcimb.2017.00349.
   PubMed Web of Science ®Google Scholar
• Li B, Yuan H, Chen L, Sun H, Hu J, Wei S, Zhao Z, Zou Q, Wu C. The influence of adjuvant on UreB protection against Helicobacter pylori through the diversity of CD4+ T-cell epitope repertoire. Oncotarget. 2017;8(40):68138–52. doi:10.18632/oncotarget.19248.
   PubMedGoogle Scholar
• Yang WC, ChenL, Li HB, Li B, Hu J, Zhang JY, Yang SM, Zou QM, Guo H, Wu C. Identification of two novel immunodominant UreB CD4(+) T cell epitopes in Helicobacter pylori infected subjects. Vaccine. 2013;31(8):1204–09. doi:10.1016/j.vaccine.2012.12.058S0264-410X(12)01845-2.
   PubMed Web of Science ®Google Scholar
• Sjokvist Ottsjo L, Jeverstam F, Yrlid L, Wenzel AU, Walduck AK, Raghavan S. Induction of mucosal immune responses against Helicobacter pylori infection after sublingual and intragastric route of immunization. Immunology. 2017;150(2):172–83. doi:10.1111/imm.12676.
   PubMed Web of Science ®Google Scholar
• Zeng M, Mao XH, Li JX, Tong WD, Wang B, Zhang YJ, Guo G, Zhao ZJ, Li L, Wu DL, et al. Efficacy, safety, and immunogenicity of an oral recombinant Helicobacter pylori vaccine in children in China: a randomised, double-blind, placebo-controlled, phase 3 trial. Lancet. 2015;386(10002):1457–64. doi:10.1016/S0140-6736(15)60310-5S0140-6736(15)60310-5.
   PubMed Web of Science ®Google Scholar
• Zhong YX, Chen J, Liu Y, Tang CF, Wei B, Liu MY. Oral immunization of BALB/c mice with Helicobacter pylori lysate combined with dmLT adjuvant for the induction of mucosal and system immune response. Chin J Microbiol Immunol. 2019;39(4):298–304. doi:10.3760/cma.j.0254-5101.2019.04.009.
   Google Scholar
• Li J, Lee RK, Chen W, Yan H. 2′-Fluoro-c-di-GMP as an oral vaccine adjuvant. RSC Adv. 2019;9(71):41481–89. doi:10.1039/c9ra08310c.
   PubMed Web of Science ®Google Scholar
• Chen J, Zhong YX, Tang CF, Liu Y, Wang XW, Zhang YB, Wang P, Liu MY, Wei B. Cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) enhances the immune responses against Helicobacter pylori in BALB/c mice. Chin J Microbiol Immunol. 2018;38(12):914–21. doi:10.3760/cma.j.0254-5101.2018.12.007.
   Google Scholar
• Chen J, Zhong YX, Liu Y, Tang CF, Zhang YB, Wei B, Liu MY. The preliminary analysis of immune response in BALB/c mice immunized with Cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) and protein antigens from Helicobacter pylori by intramuscular injection. Chin J Biol. 2019;32(10):1074–79. doi:10.13200/j.cnki.cjb.002827.
   Google Scholar
• Kato K, Omura H, Ishitani R, Nureki O. Cyclic GMP-AMP as an endogenous second messenger in innate immune signaling by cytosolic DNA. Annu Rev Biochem. 2017;86:541–66. doi:10.1146/annurev-biochem-061516-044813.
   PubMed Web of Science ®Google Scholar
• Yan Q, Wu X, Zhang Z, Guo F, Yang Q, Yang G. Cyclic guanosine monophosphate-adenosine monophosphate (cGAMP): a novel vaccine adjuvant. Chin J Microbiol Immunol. 2017;37(10):790–94. doi:10.3760/cma.j.0254-5101.2017.10.012.
   Google Scholar
• Chen J, Liu MY, Tang CF, Liu Y, Zhong YX, Tang F, Ma ZJ, Hou JW, Wei B. Cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) enhances humoral immune responses against norovirus (GⅡ. 4) virus-like particles. Chin J Microbiol Immunol. 2017;37(10):761–65. doi:10.3760/cma.j.0254-5101.2017.10.007.
   Google Scholar
• Patel GBZH, Ponce A, Chen W. Mucosal and systemic immune responses by intranasal immunization using archaeal lipid-adjuvanted vaccines. Vaccine. 2007;25(51):8622–36. doi:10.1016/j.vaccine.2007.09.042.
   PubMed Web of Science ®Google Scholar
• Wang G, Yu S, Yu X. Progress of immune mechanism on Helicobacter pylori vaccine. Chin J Cell MoI Immunol. 2017;33(1):128–32. doi:10.13423/j.cnki.cjcmi.008060.
   Google Scholar
• Fan HY, Wu XB, Yu F, Bai Y, Long BG. Oral immunization with recombinant Lactobacillus acidophilus expressing the adhesin Hp0410 of Helicobacter pylori induces mucosal and systemic immune responses. Clin Vaccine Immunol. 2014;21(2):126–32. doi:10.1128/CVI.00434-13CVI.00434-13.
   PubMedGoogle Scholar
• Sun H, Yuan H, Tan R, Li B, Guo G, Zhang J, Jing H, Qin Y, Zhao Z, Zou Q, et al. Immunodominant antigens that induce Th1 and Th17 responses protect mice against Helicobacter pylori infection. Oncotarget. 2018;9(15):12050–63. doi:10.18632/oncotarget.23927.
   PubMedGoogle Scholar
• Akhiani AA. The role of type-specific antibodies in colonization and infection by Helicobacter pylori. Curr Opin Infect Dis2005;18(3):223–27. doi:10.1097/01.qco.0000168382.86024.14.
   PubMed Web of Science ®Google Scholar
• Bagheri N, Salimzadeh L, Shirzad H. The role of T helper 1-cell response in Helicobacter pylori-infection. Microb Pathog. 2018;123:1–8. doi:10.1016/j.micpath.2018.06.033.
   PubMed Web of Science ®Google Scholar