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Review

Viral gene delivery vectors: the next generation medicines for immune-related diseases

, & ORCID Icon
Pages 14-21 | Received 31 Jan 2020, Accepted 14 Apr 2020, Published online: 15 May 2020

References

  • Alippe Y, Mbalaviele G. Omnipresence of inflammasome activities in inflammatory bone diseases. Semin Immunopathol. 2019;41(5):607–18. doi:10.1007/s00281-019-00753-4.
  • Attanasio J, Wherry EJ. Costimulatory and Coinhibitory Receptor Pathways in Infectious Disease. Immunity. 2016;44(5):1052–68. doi:10.1016/j.immuni.2016.04.022.
  • Abbas A. Basic Immunology: functions and disorders of the immune system. 6th ed. Elsevier; 2019. p. 1–320.
  • Medzhitov R, Janeway CA. Decoding the Patterns of Self and Nonself by the Innate Immune System. Science. 2002;296:298–300. doi:10.1126/science.1068883.
  • Ramos PS, Shedlock AM, Langefeld CD. Genetics of autoimmune diseases: insights from population genetics. J Hum Genet. 2015;60:657–64. doi:10.1038/jhg.2015.94.
  • Goris A, Liston A. The Immunogenetic Architecture of Autoimmune Disease. Cold Spring Harb Perspect Biol. 2012;4(3):a007260–0. doi:10.1101/cshperspect.a007260.
  • Nathan C, Ding A. Nonresolving Inflammation. Cell. 2010;140(6):871–82. doi:10.1016/j.cell.2010.02.029.
  • de Haan P, Klein HC, ‘T Hart BA. Autoimmune Aspects of Neurodegenerative and Psychiatric Diseases: A Template for Innovative Therapy. Front Psychiatry. 2017;8:158–11. doi:10.3389/fpsyt.2017.00046.
  • Altmann DM. Neuroimmunology and neuroinflammation in autoimmune, neurodegenerative and psychiatric disease. Immunology. 2018;154(2):167–68. doi:10.1111/imm.12943.
  • Sima P, Vannucci L, Vetvicka V. Atherosclerosis as autoimmune disease. Ann Transl Med. 2018;6(7):116–6. doi:10.21037/atm.2018.02.02.
  • Beumer W, Gibney SM, Drexhage RC, Pont-Lezica L, Doorduin J, Klein HC, Steiner J, Connor TJ, Harkin A, Versnel MA, et al. The immune theory of psychiatric diseases: a key role for activated microglia and circulating monocytes. J Leukoc Biol. 2012;92(5):959–75. doi:10.1189/jlb.0212100.
  • Winer S, Winer DA. The adaptive immune system as a fundamental regulator of adipose tissue inflammation and insulin resistance. Immunol and Cell Biol. 2012;90(8):755–62. doi:10.1038/icb.2011.110.
  • Kheradmand F, Shan M, Xu C, Corry DB. Autoimmunity in chronic obstructive pulmonary disease: clinical and experimental evidence. Exp Rev Clin Immunol. 2014;8(3):285–92. doi:10.1586/eci.12.7.
  • Wen Z, Fiocchi C. Inflammatory Bowel Disease: autoimmune or Immune-mediated Pathogenesis? Clin and Devel Immunol. 2004;11(3–4):195–204. doi:10.1080/17402520400004201.
  • Serra P, Santamaria P. Nanoparticle-based approaches to immune tolerance for the treatment of autoimmune diseases. Eur J Immunol. 2018;48(5):751–56. doi:10.1002/eji.201747059.
  • Steinman L, Ho PP, Robinson WH, Utz PJ, Villoslada P. Antigen-specific tolerance to self-antigens in protein replacement therapy, gene therapy and autoimmunity. Curr Opin Immunol. 2019;61:46–53. doi:10.1016/j.coi.2019.07.011.
  • Benvenuto M, Mattera R, Masuelli L, Tresoldi I, Giganti MG, Frajese GV, Manzari V, Modesti A, Bei R. The crossroads between cancer immunity and autoimmunity: antibodies to self-antigens. Front Biosci. 2017;22:1289–329. doi:10.2741/4545.
  • Vossenaar ER, van Venrooij WJ. Citrullinated proteins: sparks that may ignite the fire in rheumatoid arthritis. Arthritis Res Ther. 2004;6:107–11. doi:10.1186/ar1184.
  • Consort RK, Perez CR, Del Rosário Flores RD,CME, Trincani BI, da Silva CL, Eliete B, Guerra MC, Eleonora K. Immunization with plasmids encoding M2 acetylcholine muscarinic receptor epitopes impairs cardiac function in mice and induces autophagy in the myocardium. Autoimmunity. 2018;1–13.
  • Schlüter A, Horstmann M, Diaz-Cano S, Plöhn S, Stähr K, Mattheis S, Oeverhaus M, Lang S, Flögel U, Berchner-Pfannschmidt U, et al. Genetic immunization with mouse thyrotrophin hormone receptor plasmid breaks self-tolerance for a murine model of autoimmune thyroid disease and Graves’ orbitopathy. Clin and Exp Immunol. 2017;191(3):255–67. doi:10.1111/cei.13075.
  • Kawai T, Akira S. Toll-like receptor and RIG-1-like receptor signaling. Ann New York Acad Sci. 2008;1143:1–20.
  • Milone MC, O’Doherty U. Clinical use of lentiviral vectors. Leukemia. 2018;32(7):1529–41. doi:10.1038/s41375-018-0106-0.
  • Li C, Samulski RJ. Engineering adeno-associated virus vectors for gene therapy. Nat Rev Genet. 2020;21(4):255–72. doi:10.1038/s41576-019-0205-4.
  • Thomson AW, Knolle PA. Antigen-presenting cell function in the tolerogenic liver environment. Nature. 2010;10:753–66.
  • LoDuca PA, Hoffman BE, Herzog RW. Hepatic gene transfer as a means of tolerance induction to transgene products. Curr Gene Ther. 2009;9(2):104–14. doi:10.2174/156652309787909490.
  • Keeler GD, Markusic DM, Hoffman BE. Liver Induced Transgene Tolerance with AAV Vectors. Cell Immunol. 2017;342:1–27.
  • Recino A, Gan SU, Sia KC, Sawyer Y, Trendell J, Kay R, Gribble FM, Reimann F, Foale R, Notaridou M, et al. Immunosuppression overcomes insulin- and vector-specific immune responses that limit efficacy of AAV2/8-mediated insulin gene therapy in NOD mice. Gene Ther. 2019;26:1–17.
  • Tengvall S, Eneljung T, Jirholt P, Turesson O, Wing K, Holmdahl R, Kihlberg J, Stern A, Mårtensson I-L, Henningsson L, et al. Gene Therapy Induces Antigen-Specific Tolerance in Experimental Collagen-Induced Arthritis. PLoS ONE. 2016;11:e0154630–21. doi:10.1371/journal.pone.0154630.
  • Keeler GD, Kumar S, Palaschak B, Silverberg EL, Markusic DM, Jones NT, Hoffman BE. Gene Therapy-Induced Antigen-Specific Tregs Inhibit Neuro-inflammation and Reverse Disease in a Mouse Model of Multiple Sclerosis. Mol Ther. 2018;26(1):173–83. doi:10.1016/j.ymthe.2017.09.001.
  • Hoffman BE, Herzog RW. Coaxing the liver into preventing autoimmune disease in the brain. J Clin Invest. 2008;118:1–3.
  • Hüser D, Khalid D, Lutter T, Hammer E-M, Weger S, Heßler M, Kalus U, Tauchmann Y, Hensel-Wiegel K, Lassner D, et al. High Prevalence of Infectious Adeno-associated Virus (AAV) in Human Peripheral Blood Mononuclear Cells Indicative of T Lymphocytes as Sites of AAV Persistence. J Virol. 2017;91:754–13. doi:10.1128/JVI.02137-16.
  • Boutin SS, Monteilhet VV, Veron PP, Leborgne CC, Benveniste OO, Montus MFM, Masurier CC. Prevalence of serum IgG and neutralizing factors against adeno-associated virus (AAV) types 1, 2, 5, 6, 8, and 9 in the healthy population: implications for gene therapy using AAV vectors. Audio, Transactions IRE Prof Group. 2010;21:704–12.
  • Martino AT, Markusic DM. Immune response mechanisms against AAV vectors in animal models. Mol Ther Methods Clin Dev. 2019;17:1–22.
  • Chen L. Tsai. SV40 Hijacks Cellular Transport, Membrane Penetration, and Disassembly Machineries to Promote Infection. Viruses. 2019;11:917–11. doi:10.3390/v11100917.
  • Toscano MG, de Haan P. How Simian Virus 40 Hijacks the Intracellular Protein Trafficking Pathway to Its Own Benefit … and Ours. Front Immunol. 2018;9:1–9. doi:10.3389/fimmu.2018.01160.
  • Toscano MG, van der Velden J, van der Werf S, Odijk M, Roque A, Camacho-Garcia RJ, Herrera-Gomez IG, Mancini I, de Haan P. Generation of a Vero-Based Packaging Cell Line to Produce SV40 Gene Delivery Vectors for Use in Clinical Gene Therapy Studies. Mol Ther Methods Clin Dev. 2017;6:124–34. doi:10.1016/j.omtm.2017.06.007.
  • López-Lázaro M. The stem cell division theory of cancer. Crit Rev Oncol/Hematol. 2018;123:95–113. doi:10.1016/j.critrevonc.2018.01.010.
  • Dashti S, Taherian-Esfahani Z. Cellular immune responses against cancer-germline genes in cancers. Hum Antibodies. 2019;12:1–8.
  • Vigneron N. Human Tumor Antigens and Cancer Immunotherapy. BioMed Res Internatl. 2015;2015:1–17. doi:10.1155/2015/948501.
  • Schumacher TN, Scheper W, Kvistborg P. Cancer Neoantigens. Annu Rev Immunol. 2019;37:173–200. doi:10.1146/annurev-immunol-042617-053402.
  • Achinger-Kawecka J, Valdes-Mora F, Luu P-L, Giles KA, Caldon CE, Qu W, Nair S, Soto S, Locke WJ, Yeo-Teh NS, et al. Epigenetic reprogramming at estrogen-receptor binding sites alters 3D chromatin landscape in endocrine-resistant breast cancer. Nat Commun. 2020;11(1):1–17. doi:10.1038/s41467-019-14098-x.
  • Gonzalez H, Hagerling C, Werb Z. Roles of the immune system in cancer: from tumor initiation to metastatic progression. Genes Dev. 2018;32(19–20):1267–84. doi:10.1101/gad.314617.118.
  • Hemminki K, Liu X, Ji J, Sundquist J, Sundquist K. Effect of autoimmune diseases on risk and survival in histology-specific lung cancer. Eur Respir J. 2012;40(6):1489–95. doi:10.1183/09031936.00222911.
  • Sharma P, Allison JP. The future of immune checkpoint therapy. Science. 2015;348:56–61. doi:10.1126/science.aaa8172.
  • Kim TK, Herbst RS, Defining CL. Understanding Adaptive Resistance in Cancer Immunotherapy. Trends Immunol. 2018;39:624–31. doi:10.1016/j.it.2018.05.001.
  • Restifo NP, Smyth MJ, Snyder A. Acquired resistance to immunotherapy and future challenges. Nat Rev Cancer. 2016;16:121–26. doi:10.1038/nrc.2016.2.
  • Overwijk WW. Cancer vaccines in the era of checkpoint blockade: the magic is in the adjuvant. Curr Opin Immunol. 2017;47:103–09. doi:10.1016/j.coi.2017.07.015.
  • Hollingsworth RE, Jansen K. Turning the corner on therapeutic cancer vaccines. NPJ Vaccines. 2019;4(1):1–10. doi:10.1038/s41541-019-0103-y.
  • Lawler SE, Speranza M-C, Cho C-F, Chiocca EA. Oncolytic Viruses in Cancer Treatment. JAMA Oncol. 2017;3(6):841–49. doi:10.1001/jamaoncol.2016.2064.
  • Peters C, Grandi P, Nigim F. Updates on Oncolytic Virus Immunotherapy for Cancers. Molecular Therapy. Oncolytics. 2019;12:259–62. doi:10.1016/j.omto.2019.01.008.
  • Liu Y, Fang Y, Chen X, Wang Z, Liang X, Zhang T, Liu M, Zhou N, Lv J, Tang K, et al. Gasdermin E-mediated target cell pyroptosis by CAR T cells triggers cytokine release syndrome. Sci Immunol. 2020;5:eaax7969. doi:10.1126/sciimmunol.aax7969.
  • Lane C, Leitch J, Tan X, Hadjati J, Bramson JL, Wan Y. Vaccination-induced autoimmune vitiligo is a consequence of secondary trauma to the skin. Cancer Res. 2004;64:1509–14.
  • Pardoll DM. Inducing autoimmune disease to treat cancer. Proc Natl Acad Sci USA. 1999;96:5340–42. doi:10.1073/pnas.96.10.5340.
  • Rayner JO, Dryga SA, Kamrud KI. Alphavirus vectors and vaccination. Rev Med Virol. 2002;12:279–96. doi:10.1002/rmv.360.
  • Larocca C, Schlom J. Viral Vector-Based Therapeutic Cancer Vaccines. The Cancer J. 2011;17:359–71. doi:10.1097/PPO.0b013e3182325e63.
  • Wold WSM, Toth K. Adenovirus vectors for gene therapy, vaccination and cancer gene therapy. Curr Gene Ther. 2013;13:421–33. doi:10.2174/1566523213666131125095046.
  • Lachmann R. Herpes simplex virus‐based vectors. Int J Exp Pathol. 2004;85:177–90. doi:10.1111/j.0959-9673.2004.00383.x.
  • Guo ZS, Lu B, Guo Z, Giehl E, Feist M, Dai E, Liu W, Storkus WJ, He Y, Liu Z, et al. Vaccinia virus-mediated cancer immunotherapy: cancer vaccines and oncolytics. J Immunother Cancer. 2019;7:1–21. doi:10.1186/s40425-018-0495-7.
  • Lundstrom K. Plasmid DNA-based Alphavirus Vaccines. Vaccines. 2019;7(1):29–10. doi:10.3390/vaccines7010029.
  • Morse MA, Hobeika AC, Osada T, Berglund P, Hubby B, Negri S, Niedzwiecki D, Devi GR, Burnett BK, Clay TM, et al. An alphavirus vector overcomes the presence of neutralizing antibodies and elevated numbers of Tregs to induce immune responses in humans with advanced cancer. J Clin Invest. 2010;120(9):3234–41. doi:10.1172/JCI42672.
  • Slovin SF, Kehoe M, Durso R, Fernandez C, Olson W, Gao JP, Israel R, Scher HI, Morris S. A phase I dose escalation trial of vaccine replicon particles (VRP) expressing prostate-specific membrane antigen (PSMA) in subjects with prostate cancer. Vaccine. 2013;31(6):943–49. doi:10.1016/j.vaccine.2012.11.096.
  • Singh A. An alphavirus-based therapeutic cancer vaccine: from design to clinical trial. Cancer Immunol Immunother. 2019;68:849–59. doi:10.1007/s00262-018-2276-z.
  • de Meijer C, Wouterse B, Polder J, Koopmanschap M. The effect of population aging on health expenditure growth: a critical review. Eur J Ageing. 2013;10:353–61. doi:10.1007/s10433-013-0280-x.