2,691
Views
11
CrossRef citations to date
0
Altmetric
Research Paper

Characterization of the UK anthrax vaccine and human immunogenicity

ORCID Icon, ORCID Icon, , , , ORCID Icon & ORCID Icon show all
Pages 747-758 | Received 16 May 2020, Accepted 17 Jul 2020, Published online: 08 Sep 2020

References

  • Whiting G, Wheeler JX, Rijpkema S. Identification of peptide sequences as a measure of Anthrax vaccine stability during storage. Hum Vaccin Immunother. 2014;10:1669–81. doi:10.4161/hv.28443.
  • Whiting GC, Rijpkema S, Adams T, Corbel MJ. Characterisation of adsorbed anthrax vaccine by two-dimensional gel electrophoresis. Vaccine. 2004;22:4245–51. doi:10.1016/j.vaccine.2004.04.036.
  • Dumas EK, Garman L, Cuthbertson H, Charlton S, Hallis B, Engler RJM, Choudhari S, Picking WD, James JA, Farris AD, et al. Lethal factor antibodies contribute to lethal toxin neutralization in recipients of anthrax vaccine precipitated. Vaccine. 2017;35:3416–22. doi:10.1016/j.vaccine.2017.05.006.
  • Turnbull PC. Anthrax vaccines: past, present and future. Vaccine. 1991;9:533–39. doi:10.1016/0264-410x(91)90237-z.
  • Turnbull PC, Leppla SH, Broster MG, Quinn CP, Melling J. Antibodies to anthrax toxin in humans and guinea pigs and their relevance to protective immunity. Med Microbiol Immunol. 1988;177:293–303. doi:10.1007/BF00189414.
  • Chen L, Schiffer JM, Dalton S, Sabourin CL, Niemuth NA, Plikaytis BD, Quinn CP. Comprehensive analysis and selection of anthrax vaccine adsorbed immune correlates of protection in rhesus macaques. Clin vaccine immunol. 2014;21(11):1512–20. doi:10.1128/CVI.00469-14.
  • Reuveny S, White MD, Adar YY, Kafri Y, Altboum Z, Gozes Y, Kobiler D, Shafferman A, Velan B. Search for correlates of protective immunity conferred by anthrax vaccine. Infect Immun. 2001;69(5):2888–93. doi:10.1128/IAI.69.5.2888-2893.2001.
  • Chen Z, Moayeri M, Crown D, Emerson S, Gorshkova I, Schuck P, Leppla SH, Purcell RH. Novel chimpanzee/human monoclonal antibodies that neutralize anthrax lethal factor: evidence for possible synergy with anti-pa antibody. Infect Immun. 2009;77:3902–08. doi:10.1128/IAI.00200-09.
  • Pezard C, Weber M, Sirard JC, Berche P, Mock M. Protective immunity induced by Bacillus anthracis toxin-deficient strains. Infect Immun. 1995;63:1369–72. doi:10.1128/IAI.63.4.1369-1372.1995.
  • Albrecht MT, Li H, Williamson ED, LeButt CS, Flick-Smith HC, Quinn CP, Westra H, Galloway D, Mateczun A, Goldman S, et al. Human monoclonal antibodies against anthrax lethal factor and protective antigen act independently to protect against Bacillus anthracis infection and enhance endogenous immunity to anthrax. Infect Immun. 2007;75(11):5425–33. doi:10.1128/IAI.00261-07.
  • Staats HF, Alam SM, Scearce RM, Kirwan SM, Zhang JX, Gwinn WM, Haynes BF. In vitro and in vivo characterization of anthrax anti-protective antigen and anti-lethal factor monoclonal antibodies after passive transfer in a mouse lethal toxin challenge model to define correlates of immunity. Infect Immun. 2007;75(11):5443–52. doi:10.1128/IAI.00529-07.
  • Winterroth L, Rivera J, Nakouzi AS, Dadachova E, Casadevall A. Neutralizing monoclonal antibody to edema toxin and its effect on murine anthrax. Infect Immun. 2010;78(6):2890–98. doi:10.1128/IAI.01101-09.
  • Leysath CE, Chen K-H, Moayeri M, Crown D, Fattah R, Chen Z, Das SR, Purcell RH, Leppla SH. Mouse monoclonal antibodies to anthrax edema factor protect against infection. Infect Immun. 2011;79(11):4609–16. doi:10.1128/IAI.05314-11.
  • Dumas EK, Gross T, Larabee J, Pate L, Cuthbertson H, Charlton S, Hallis B, Engler RJ, Collins LC, Spooner CE, et al. Anthrax vaccine precipitated induces edema toxin-neutralizing, edema factor-specific antibodies in human recipients. Clin vaccine immunol. 2017:24. doi:10.1128/CVI.00165-17.
  • Uchida M, Harada T, Enkhtuya J, Kusumoto A, Kobayashi Y, Chiba S, Shyaka A, Kawamoto K. Protective effect of Bacillus anthracis surface protein EA1 against anthrax in mice. Biochem Biophys Res Commun. 2012;421(2):323–28. doi:10.1016/j.bbrc.2012.04.007.
  • Crowe SR, Garman L, Engler RJ, Farris AD, Ballard JD, Harley JB, James JA. Anthrax vaccination induced anti-lethal factor IgG: fine specificity and neutralizing capacity. Vaccine. 2011;29(20):3670–78. doi:10.1016/j.vaccine.2011.03.011.
  • Marrack P, McKee AS, Munks MW. Towards an understanding of the adjuvant action of aluminium. Nat Rev Immunol. 2009;9:287–93. doi:10.1038/nri2510.
  • Wen Y, Shi Y. Alum: an old dog with new tricks. Emerg Microbes Infect. 2016;5:e25. doi:10.1038/emi.2016.40.
  • Glenny ATPC, Waddington H, Wallace U. The antigenic value of toxoid precipitated by potassium alum. J Pathol Bacteriol. 1926;3:8–45.
  • Vessely C, Estey T, Randolph TW, Henderson I, Cooper J, Nayar R, Braun LJ, Carpenter JF. Stability of a trivalent recombinant protein vaccine formulation against botulinum neurotoxin during storage in aqueous solution. J Pharm Sci. 2009;98(9):2970–93. doi:10.1002/jps.21498.
  • Zhu D, Huang S, McClellan H, Dai W, Syed NR, Gebregeorgis E, Mullen GED, Long C, Martin LB, Narum D, et al. Efficient extraction of vaccines formulated in aluminum hydroxide gel by including surfactants in the extraction buffer. Vaccine. 2012;30(2):189–94. doi:10.1016/j.vaccine.2011.11.025.
  • Chittineni SPaM SC. Improved method for Hepatitis B vaccine in-vitro potency. Int J Pharm Sci Invention. 2014;3:39–42.
  • Patel VJ, Thalassinos K, Slade SE, Connolly JB, Crombie A, Murrell JC, Scrivens JH. A comparison of labeling and label-free mass spectrometry-based proteomics approaches. J Proteome Res. 2009;8(7):3752–59. doi:10.1021/pr900080y.
  • Silva JC, Denny R, Dorschel CA, Gorenstein M, Kass IJ, Li G-Z, McKenna T, Nold MJ, Richardson K, Young P, et al. Quantitative proteomic analysis by accurate mass retention time pairs. Anal Chem. 2005;77(7):2187–200. doi:10.1021/ac048455k.
  • Li GZ, Vissers JP, Silva JC, Golick D, Gorenstein MV, Geromanos SJ. Database searching and accounting of multiplexed precursor and product ion spectra from the data independent analysis of simple and complex peptide mixtures. Proteomics. 2009;9:1696–719. doi:10.1002/pmic.200800564.
  • Silva JC, Gorenstein MV, Li GZ, Vissers JP, Geromanos SJ. Absolute quantification of proteins by LCMSE: a virtue of parallel MS acquisition. Mol Cell Proteomics. 2006;5:144–56. doi:10.1074/mcp.M500230-MCP200.
  • Jensen KK, Andreatta M, Marcatili P, Buus S, Greenbaum JA, Yan Z, Sette A, Peters B, Nielsen M. Improved methods for predicting peptide binding affinity to MHC class II molecules. Immunology. 2018;154(3):394–406. doi:10.1111/imm.12889.
  • Wang P, Sidney J, Kim Y, Sette A, Lund O, Nielsen M, Peters B. Peptide binding predictions for HLA DR, DP and DQ molecules. BMC Bioinform. 2010;11(1):568. doi:10.1186/1471-2105-11-568.
  • IEDB.[ Accessed 2017 Jun]. http://wwwiedborg/
  • MegAlign. 2016 Sep. [accessed 2016 Nov 25]. https://www.dnastar.com/t-megalign.aspx
  • NCBI. 2016 Jul. [accessed 2016 Dec 05]. https://www.ncbi.nlm.nih.gov/
  • Kramer G, Woolerton Y, van Straalen JP, Vissers JP, Dekker N, Langridge JI, Beynon RJ, Speijer D, Sturk A, Aerts JMFG, et al. Accuracy and reproducibility in quantification of plasma protein concentrations by mass spectrometry without the use of isotopic standards. PLoS One. 2015;10(10):e0140097. doi:10.1371/journal.pone.0140097.
  • Chevreux G, Tilly N, Bihoreau N. Quantification of proteins by data independent acquisition: performance assessment of the Hi3 methodology. Anal Biochem. 2018;549:184–87. doi:10.1016/j.ab.2018.03.019.
  • Jenkins MK, Moon JJ. The role of naive T cell precursor frequency and recruitment in dictating immune response magnitude. J Immunol. 2012;188:4135–40. doi:10.4049/jimmunol.1102661.
  • Ford ML, Koehn BH, Wagener ME, Jiang W, Gangappa S, Pearson TC, Larsen CP. Antigen-specific precursor frequency impacts T cell proliferation, differentiation, and requirement for costimulation. J Exp Med. 2007;204(2):299–309. doi:10.1084/jem.20062319.
  • Martinez RJ, Andargachew R, Martinez HA, Evavold BD. Low-affinity CD4+ T cells are major responders in the primary immune response. Nat Commun. 2016;7:13848. doi:10.1038/ncomms13848.
  • Edwards LJ, Evavold BD. T cell recognition of weak ligands: roles of signaling, receptor number, and affinity. Immunol Res. 2011;50:39–48. doi:10.1007/s12026-011-8204-3.
  • Musson JA, Walker N, Flick-Smith H, Williamson ED, Robinson JH. Differential processing of CD4 T-cell epitopes from the protective antigen of Bacillus anthracis. J Biol Chem. 2003;278:52425–31. doi:10.1074/jbc.M309034200.
  • Sadegh-Nasseri S, Kim A. Selection of immunodominant epitopes during antigen processing is hierarchical. Mol Immunol. 2018. doi:10.1016/j.molimm.2018.08.011.
  • Fontaine M, Vogel I, Van Eycke YR, Galuppo A, Ajouaou Y, Decaestecker C, Kassiotis G, Moser M, Leo O. Regulatory T cells constrain the TCR repertoire of antigen-stimulated conventional CD 4 T cells. Embo J. 2018;37:398–412. doi:10.15252/embj.201796881.
  • Gfeller D, Bassani-Sternberg M. Predicting antigen presentation-what could we learn from a million peptides? Front Immunol. 2018;9:1716. doi:10.3389/fimmu.2018.01716.
  • Pittman PR, Leitman SF, Oro JG, Norris SL, Marano NM, Ranadive MV, Sink BS, McKee KT. Protective antigen and toxin neutralization antibody patterns in anthrax vaccinees undergoing serial plasmapheresis. Clin Diagn Lab Immunol. 2005;12:713–21. doi:10.1128/CDLI.12.6.713-721.2005.
  • Quinn CP, Sabourin CL, Schiffer JM, Niemuth NA, Semenova VA, Li H, Rudge TL, Brys AM, Mittler RS, Ibegbu CC, et al. Humoral and cell-mediated immune responses to alternate booster schedules of anthrax vaccine adsorbed in humans. Clin vaccine immunol. 2016;23:326–38. doi:10.1128/CVI.00696-15.
  • Ingram RJ, Metan G, Maillere B, Doganay M, Ozkul Y, Kim LU, Baillie L, Dyson H, Williamson ED, Chu KK, et al. Natural exposure to cutaneous anthrax gives long-lasting T cell immunity encompassing infection-specific epitopes. J Immunol. 2010;184:3814–21. doi:10.4049/jimmunol.0901581.
  • Ovsyannikova IG, Pankratz VS, Vierkant RA, Pajewski NM, Quinn CP, Kaslow RA, Jacobson RM, Poland GA. Human leukocyte antigens and cellular immune responses to anthrax vaccine adsorbed. Infect Immun. 2013;81:2584–91. doi:10.1128/IAI.00269-13.
  • Pajewski NM, Parker SD, Poland GA, Ovsyannikova IG, Song W, Zhang K, McKinney BA, Pankratz VS, Edberg JC, Kimberly RP, et al. The role of HLA-DR-DQ haplotypes in variable antibody responses to anthrax vaccine adsorbed. Genes Immun. 2011;12:457–65. doi:10.1038/gene.2011.15.