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Mini Review

Evidence and speculations: vaccines and therapeutic options for COVID-19 pandemic

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Pages 1113-1121 | Received 13 May 2020, Accepted 11 Sep 2020, Published online: 16 Oct 2020

References

  • Bonilla-Aldana DK, Quintero-Rada K, Montoya-Posada JP, Ramírez-Ocampo S, Paniz-Mondolfi A, Rabaan AA, Sah R, Rodríguez-Morales AJ. SARS-CoV, MERS-CoV and now the 2019-novel CoV: have we investigated enough about coronaviruses?–A bibliometric analysis. Travel Med Infect Dis. 2020;33:101566. doi:10.1016/j.tmaid.2020.101566.
  • Shereen MA, Khan S, Kazmi A, Bashir N, Siddique R. COVID-19 infection: origin, transmission, and characteristics of human coronaviruses. J Adv Res. 2020;24:91–98. doi:10.1016/j.jare.2020.03.005.
  • Gao H, Yao H, Yang S, Li L. From SARS to MERS: evidence and speculation. Front Med. 2016;10(4):377–82. doi:10.1007/s11684-016-0466-7.
  • Báez-Santos YM, John SES, Mesecar AD. The SARS-coronavirus papain-like protease: structure, function and inhibition by designed antiviral compounds. Antiviral Res. 2015;115:21–38. doi:10.1016/j.antiviral.2014.12.015.
  • Khan M, Shereen MA, Khokhar M, Kamil A, Rahman H A novel effective therapeutic approach for treatment of Leishmania tropica through Miltefosine Loaded Chitosan Nanoparticles. 2020.
  • Rodriguez-Morales AJ, Bonilla-Aldana DK, Tiwari R, Sah R, Rabaan AA, Dhama K. COVID-19, an emerging coronavirus infection: current scenario and recent developments-an overview. J Pure Appl Microbiol. 2020;14(1):6150. doi:10.22207/JPAM.14.1.02.
  • Khan S, Nabi G, Han G, Siddique R, Lian S, Shi H, Bashir N, Ali A, Shereen MA. Novel coronavirus: how things are in Wuhan. Clinical Microbiol Infect. 2020;26(4):399. doi:10.1016/j.cmi.2020.02.005.
  • Zhu N, Zhang D, Wang W, Li X, Yang B, Song J, Zhao X, Huang B, Shi W, Lu R, et al. A novel coronavirus from patients with pneumonia in China, 2019. New England J Med. 2020;382(8):727–33. doi:10.1056/NEJMoa2001017.
  • Phan T. Novel coronavirus: from discovery to clinical diagnostics. Infec Gen Evol. 2020;79:104211. doi:10.1016/j.meegid.2020.104211.
  • Zhang T, Wu Q, Zhang Z. Probable pangolin origin of SARS-CoV-2 associated with the COVID-19 outbreak. Current Biol. 2020;30(7):1346–1351.e2. doi:10.1016/j.cub.2020.03.022.
  • Wan Y, Shang J, Graham R, Baric RS, Li F. Receptor recognition by the novel coronavirus from Wuhan: an analysis based on decade-long structural studies of SARS coronavirus. J Virol. 2020;94(7):e00127-20.
  • Xiong C, Jiang L, Chen Y, Jiang Q. Evolution and variation of 2019-novel coronavirus. Biorxiv. 2020.
  • Gao QY, Chen YX, Fang JY. 2019 novel coronavirus infection and gastrointestinal tract. J Dig Dis. 2020;30(3):1346–1351.e2. doi:10.1111/1751-2980.12851.
  • Chan JF-W, Kok K-H, Zhu Z, Chu H, To KK-W, Yuan S, Yuen K-Y. Genomic characterization of the 2019 novel human-pathogenic coronavirus isolated from a patient with atypical pneumonia after visiting Wuhan. Emerg Micro Infect. 2020;9(1):221–36. doi:10.1080/22221751.2020.1719902.
  • Chen J. Pathogenicity and transmissibility of 2019-nCoV—a quick overview and comparison with other emerging viruses. Microbes Infect. 2020;22(2):69–71. doi:10.1016/j.micinf.2020.01.004.
  • Khailany RA, Safdar M, Ozaslan M. Genomic characterization of a novel SARS-CoV-2. Gene Rep. 2020;19:100682. doi:10.1016/j.genrep.2020.100682.
  • Khan S, Liu J, Xue M. Transmission of SARS-CoV-2, required developments in research and associated public health concerns. Front Med. 2020;7:310.
  • Yu P, Zhu J, Zhang Z, Han Y. A familial cluster of infection associated with the 2019 novel coronavirus indicating possible person-to-person transmission during the incubation period. J Infect Dis. 2020;221(11):1757–61. doi:10.1093/infdis/jiaa077.
  • Nishiura H, Linton NM, Akhmetzhanov AR. Serial interval of novel coronavirus (COVID-19) infections. Inter J Infect Dis. 2020;93:284‒286.
  • Baig AM, Khaleeq A, Ali U, Syeda H. Evidence of the COVID-19 virus targeting the CNS: tissue distribution, host-virus interaction, and proposed neurotropic mechanisms. ACS Chem Neurosci. 2020;11(7):995–98. doi:10.1021/acschemneuro.0c00122.
  • Vetter P, Eckerle I, Kaiser L. Covid-19: a puzzle with many missing pieces. BMJ. 2020:m627. doi:10.1136/bmj.m627.
  • Wu F, Zhao S, Yu B, Chen YM, Wang W, Song ZG, Hu Y, Tao ZW, Tian JH, Pei YY et al. A new coronavirus associated with human respiratory disease in China. Nature. 2020;579:265–69.
  • de Wilde AH, Snijder EJ, Kikkert M, van Hemert MJ. Host factors in coronavirus replication. Roles Host Gene Non Cod RNA Exp Virus Infec Springer. 2017;419:1–42.
  • Millet JK, Whittaker GR. Host cell proteases: critical determinants of coronavirus tropism and pathogenesis. Virus Res. 2015;202:120–34. doi:10.1016/j.virusres.2014.11.021.
  • Wrapp D, Wang N, Corbett KS, Goldsmith JA, Hsieh C-L, Abiona O, Graham BS, McLellan JS. Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation. Science. 2020;367(6483):1260–63. doi:10.1126/science.abb2507.
  • Linton NM, Kobayashi T, Yang Y, Hayashi K, Akhmetzhanov AR, Jung S-M, Yuan B, Kinoshita R, Nishiura H. Incubation period and other epidemiological characteristics of 2019 novel coronavirus infections with right truncation: a statistical analysis of publicly available case data. J Clin Med. 2020;9(2):538. doi:10.3390/jcm9020538.
  • Wang Y, Wang Y, Chen Y, Qin Q. Unique epidemiological and clinical features of the emerging 2019 novel coronavirus pneumonia (COVID‐19) implicate special control measures. J Med Virol. 2020;92(6):568–76. doi:10.1002/jmv.25748.
  • Tian S, Hu N, Lou J, Chen K, Kang X, Xiang Z, Chen H, Wang D, Liu N, Liu D, et al. Characteristics of COVID-19 infection in Beijing. J Infect. 2020;80(4):401–06. doi:10.1016/j.jinf.2020.02.018.
  • Shanmugaraj B, Malla A, Phoolcharoen W. Emergence of novel coronavirus 2019-nCoV: need for rapid vaccine and biologics development. Pathogens. 2020;9(2):148. doi:10.3390/pathogens9020148.
  • Favre G, Pomar L, Musso D, Baud D. 2019-nCoV epidemic: what about pregnancies? Lancet (London, England). 2020;395(10224):e40. doi:10.1016/S0140-6736(20)30311-1.
  • Chen S, Huang B, Luo DJ, Li X, Yang F, Zhao Y, Nei X, Huang BX. Pregnant women with new coronavirus infection: a clinical characteristics and placental pathological analysis of three cases. Zhon Bing Li Xue Za Zhi Chin J Pathol. 2020;49:E005–E.
  • Li Y, Zhao R, Zheng S, Chen X, Wang J, Sheng X, Zhou J, Cai H, Fang Q, Yu F, et al. Lack of vertical transmission of severe acute respiratory syndrome coronavirus. Emerg Infect Dis. 2020;2:1335‒36.(China).
  • Lee SM, Kang WS, Cho A-R, Kim T, Park JK. Psychological impact of the 2015 MERS outbreak on hospital workers and quarantined hemodialysis patients. Compr Psychiatry. 2018;87:123–27. doi:10.1016/j.comppsych.2018.10.003.
  • Chiang JJ, Cole SW, Bower JE, Irwin MR, Taylor SE, Arevalo J, Fuligni AJ. Depressive symptoms and immune transcriptional profiles in late adolescents. Brain Behav Immun. 2019;80:163–69. doi:10.1016/j.bbi.2019.03.004.
  • Liem A, Wang C, Wariyanti Y, Latkin CA, Hall BJ. The neglected health of international migrant workers in the COVID-19 epidemic. Lancet Psych. 2020;7(4):e20. doi:10.1016/S2215-0366(20)30076-6.
  • Zitting K-M, Münch MY, Cain SW, Wang W, Wong A, Ronda JM, Aeschbach D, Czeisler CA, Duffy JF. Young adults are more vulnerable to chronic sleep deficiency and recurrent circadian disruption than older adults. Sci Rep. 2018;8(1):1–14. doi:10.1038/s41598-018-29358-x.
  • Liu S, Yang L, Zhang C, Xiang Y-T, Liu Z, Hu S, Zhang B. Online mental health services in China during the COVID-19 outbreak. Lancet Psych. 2020;7(4):e17–e8. doi:10.1016/S2215-0366(20)30077-8.
  • Dong L, Hu S, Gao J. Discovering drugs to treat coronavirus disease 2019 (COVID-19). Drug Discov Ther. 2020;14(1):58–60. doi:10.5582/ddt.2020.01012.
  • Sheahan TP, Sims AC, Leist SR, Schäfer A, Won J, Brown AJ, Montgomery SA, Hogg A, Babusis D, Clarke MO, et al. Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV. Nat Commun. 2020;11(1):1–14. doi:10.1038/s41467-019-13940-6.
  • Wang M, Cao R, Zhang L, Yang X, Liu J, Xu M, Shi Z, Hu Z, Zhong W, Xiao G, et al. Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro. Cell Res. 2020;30(3):269–71. doi:10.1038/s41422-020-0282-0.
  • Jean -S-S, Lee P-I, Hsueh P-R. Treatment options for COVID-19: the reality and challenges. J Micro Bio Immunol Infec. 2020;53(3):436–43. doi:10.1016/j.jmii.2020.03.034.
  • Agostini ML, Andres EL, Sims AC, Graham RL, Sheahan TP, Lu X, Smith EC, Case JB, Feng JY, Jordan R, et al. Coronavirus susceptibility to the antiviral remdesivir (GS-5734) is mediated by the viral polymerase and the proofreading exoribonuclease. MBio. 2018:9(2).
  • Beigel JH, Tomashek KM, Dodd LE, Mehta AK, Zingman BS, Kalil AC, Hohmann E, Chu HY, Luetkemeyer A, Kline S, et al. Remdesivir for the treatment of Covid-19—preliminary report. New England J Med. 2020. doi:10.1056/NEJMoa2007764.
  • Cai Q, Yang M, Liu D, Chen J, Shu D, Xia J, Liao X, Gu Y, Cai Q, Yang Y, et al. Experimental treatment with favipiravir for COVID-19: an open-label control study. Engineering. 2020. doi:10.1016/j.eng.2020.03.007.
  • Cao B, Wang Y, Wen D, Liu W, Wang J, Fan G, Ruan L, Song B, Cai Y, Wei M, et al. A trial of lopinavir–ritonavir in adults hospitalized with severe Covid-19. New England J Med. 2020;382(19):1787–99. doi:10.1056/NEJMoa2001282.
  • Baden LR, Rubin EJ. Covid-19—the search for effective therapy. N Engl J Med. 2020; 382:1851‒1852
  • Luo H, Tang Q-L, Shang Y-X, Liang S-B, Yang M, Robinson N, Liu JP. Can Chinese medicine be used for prevention of corona virus disease 2019 (COVID-19)? A review of historical classics, research evidence and current prevention programs. Chin J Integr Med. 2020;17:1–8.
  • Klasse PJ, Moore JP. Antibodies to SARS-CoV-2 and their potential for therapeutic passive immunization. Elife. 2020.
  • Derebail VK, Falk RJ. ANCA-associated vasculitis—refining therapy with plasma exchange and glucocorticoids. N Engl J Med 2020; 382:671‒673
  • Shen C, Wang Z, Zhao F, Yang Y, Li J, Yuan J, Wang, March F, Li D, Yang M, et al. Posting date. Treatment of 5 critically ill patients with COVID19 with convalescent plasma. JAMA. 2020;323(16):1582. doi:10.1001/jama.2020.4783.
  • Dhama K, Sharun K, Tiwari R, Dadar M, Malik YS, Singh KP, Chaicumpa W. COVID-19, an emerging coronavirus infection: advances and prospects in designing and developing vaccines, immunotherapeutics, and therapeutics. Hum Vaccin Immunother. 20202;16(6):1232‒1238.
  • Pinto D, Park Y-J, Beltramello M, Walls AC, Tortorici MA, Bianchi S, Jaconi S, Culap K, Zatta F, De Marco A. Cross-neutralization of SARS-CoV-2 by a human monoclonal SARS-CoV antibody. Nature. 2020;18:1–6.
  • Garg AD, Coulie PG, Van den Eynde BJ, Agostinis P. Integrating next-generation dendritic cell vaccines into the current cancer immunotherapy landscape. Trends Immunol. 2020;7:577–93. doi:10.1016/j.it.2017.05.006.
  • Nace G, Evankovich J, Eid R, Tsung A. Dendritic cells and damage-associated molecular patterns: endogenous danger signals linking innate and adaptive immunity. J Innate Immun. 2012;4(1):6–15. doi:10.1159/000334245.
  • Le TT, Andreadakis Z, Kumar A, Roman RG, Tollefsen S, Saville M, Mayhew S. The COVID-19 vaccine development landscape. Nat Rev Drug Discov. 2020;19(5):305–06. doi:10.1038/d41573-020-00073-5.
  • Sherley JL, Prentice D An ethics assessment of COVID-19 vaccine programs.
  • ClinicalTrials.gov. Immunity and safety of Covid-19 synthetic minigene vaccine. 2020.
  • Kruse RL. Therapeutic strategies in an outbreak scenario to treat the novel coronavirus originating in Wuhan, China. F1000Research. 2020;9:72.
  • Somasundaram R, Choraria A, Antonysamy M. An approach towards development of monoclonal IgY antibodies against SARS CoV-2 spike protein (S) using phage display method: A review. Int Immunopharmacol. 2020;85:106654. doi:10.1016/j.intimp.2020.106654.
  • Palaniyappan A, Das D, Kammila S, Suresh MR, Sunwoo HH. Diagnostics of severe acute respiratory syndrome-associated coronavirus (SARS-CoV) nucleocapsid antigen using chicken immunoglobulin Y. Poult Sci. 2012;91:636–42. doi:10.3382/ps.2011-01916.
  • Zost SJ, Gilchuk P, Case JB, Binshtein E, Chen RE, Nkolola JP, Schäfer A, Reidy JX, Trivette A, Nargi RS, et al. Potently neutralizing and protective human antibodies against SARS-CoV-2. Nature. 2020:584:443‒9.
  • de Alwis R, Chen S, Gan ES, Ooi EE. Impact of immune enhancement on Covid-19 polyclonal hyperimmune globulin therapy and vaccine development. EBioMedicine. 2020:102768. doi:10.1016/j.ebiom.2020.102768.
  • He C, Qin M, Sun X. Highly pathogenic coronaviruses: thrusting vaccine development in the spotlight. Acta Pharm Sin B. 2020;10(7):1175–91. doi:10.1016/j.apsb.2020.05.009.
  • Guo Y, Sun S, Wang K, Zhang S, Zhu W, Chen Z. Elicitation of immunity in mice after immunization with the S2 subunit of the severe acute respiratory syndrome coronavirus. DNA Cell Biol. 2005;24:510–15. doi:10.1089/dna.2005.24.510.
  • Li J, Ulitzky L, Silberstein E, Taylor DR, Viscidi R. Immunogenicity and protection efficacy of monomeric and trimeric recombinant SARS coronavirus spike protein subunit vaccine candidates. Viral Immunol. 2013;26:126–32. doi:10.1089/vim.2012.0076.
  • McKay B Drugmakers rush to develop vaccines against china virus. The Wall Street Journal Available online: https://www wsj com/articles/drugmakers-rush-to-develop-vaccines-against-china-virus-11579813026 (accessed on 23 March 2020).
  • Yi C, Yi Y, Li J. mRNA vaccines: possible tools to combat SARS-CoV-2. Virol Sin. 2020;35:259‒62.
  • Smith J CureVac bids to develop first mRNA coronavirus vaccine. 2020.
  • Park A. Inside the company that’s hot-wiring vaccine research in the race to combat the coronavirus. Time. 2020;2020.
  • de Vries APJ, Alwayn IPJ, Hoek RAS, van den Berg AP, Ultee FCW, Vogelaar SM, Haase-Kromwijk BJ, Heemskerk MB, Hemke AC, Nijboer WN. Coronavirus dashboard (COVID-19)-update log. J Am Soc Nephrol. 2020.
  • Inovio IP Inovio selected by cepi to develop vaccine against new coronavirus inovio.
  • Technology P. University of Waterloo to develop nasal vaccine for Covid-19. Pharmaceutical Technology; 2020.
  • Onyeador O Cobra and the KI collaborate to develop COVID-19 vaccine. PRODUCT & INDUSTRY NEWS, 2020.
  • ClinicalTrials.gov. Evaluating the Safety, Tolerability and Immunogenicity of bacTRL-Spike Vaccine for Prevention of COVID-19. 2020.
  • Cheung E China coronavirus: hong Kong researchers have already developed vaccine but need time to test it, expert reveals. 2020.
  • News GR. GeoVax and BravoVax (Wuhan, China) to collaborate on development of coronavirus vaccine. 2020.
  • Biopharmaceuticals C. Clover initiates development of recombinant subunit-trimer vaccine for wuhan coronavirus (2019-nCoV). 2020.
  • Johnson. Our COVID-19 response efforts. 2020.
  • Codagenix I. Codagenix and Serum Institute of India Initiate Co-Development of a Scalable, Live-Attenuated Vaccine Against the 2019 Novel Coronavirus, COVID-19. 2020.
  • Hennessy J. Australia’s been asked to make a coronavirus vaccine at ‘unprecedented speed. Sci Alert. 2020.
  • Vaxart. Vaxart announces initiation of coronavirus vaccine program. 2020.
  • Mukherjee S The first coronavirus drug candidate is set for testing in China. 2020.
  • Radcliffe S Here’s exactly where we are with vaccines and treatments for COVID-19. 2020.
  • Gao Q, Bao L, Mao H, Wang L, Xu K, Yang M, Li Y, Zhu L, Wang N, Lv Z, et al. Rapid development of an inactivated vaccine for SARS-CoV-2. bioRxiv. 2020.
  • Liu A China’s CanSino Bio advances COVID-19 vaccine into phase 2 on preliminary safety data. 2020.
  • Sanofi. Sanofi’s Response in the Fight against COVID-19. SanofiFacts. 2020.
  • Stanton D. Merck betting on ‘swish-and-swallow’ and single administration COVID vaccines. Bioprocess Int. 2020.
  • Technology P. Coronavirus: vir Biotechnology and Novavax announce vaccine plans. 2020.
  • Mestrovic T PiCoVacc vaccine candidate for COVID-19 effective in animal trials. 2020.
  • Lurie N, Saville M, Hatchett R, Halton J. Developing Covid-19 vaccines at pandemic speed. New England J Med. 2020;382:1969–73. doi:10.1056/NEJMp2005630.
  • Rogers J CEPI-funded COVID-19 vaccine candidates progress to clinical trials. 2020.
  • World Health O. DRAFT landscape of COVID-19 candidate vaccines. World; 2020.
  • Gouglas D, Le TT, Henderson K, Kaloudis A, Danielsen T, Hammersland NC, Robinson JM, Heaton PM, Røttingen J-A. Estimating the cost of vaccine development against epidemic infectious diseases: a cost minimisation study. Lancet Global Health. 2018;6:e1386–e96. doi:10.1016/S2214-109X(18)30346-2.
  • Mullard A. COVID-19 vaccine development pipeline gears up. Lancet. 2020;395:1751–52. doi:10.1016/S0140-6736(20)31252-6.
  • Folegatti PM, Ewer KJ, Aley PK, Angus B, Becker S, Belij-Rammerstorfer S, Bellamy D, Bibi S, Bitaye M, Clutterbuck AE, et al. Safety and immunogenicity of the ChAdOx1 nCoV-19 vaccine against SARS-CoV-2: a preliminary report of a phase 1/2, single-blind, randomised controlled trial. Lancet. 2020.

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