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Mini-Review

Vaccinia virus-based vector against infectious diseases and tumors

ORCID Icon, , , , &
Pages 1578-1585 | Received 18 May 2020, Accepted 18 Oct 2020, Published online: 19 Feb 2021

References

  • Liu MA. Vaccine developments. Nat Med. 1998;4:515–19. doi:10.1038/nm0598supp-515.
  • Kaufman HL, Kohlhapp FJ, Zloza A. Oncolytic viruses: a new class of immunotherapy drugs. Nat Rev Drug Discov. 2015;14:642–62. doi:10.1038/nrd4663.
  • Koch T, Dahlke C, Fathi A, Kupke A, Krähling V, Okba N, Halwe S, Rohde C, Eickmann M, Volz A, et al. Safety and immunogenicity of a modified vaccinia virus Ankara vector vaccine candidate for Middle East respiratory syndrome: an open-label, phase 1 trial. Lancet Infect Dis. 2020;20:827–38. doi:10.1016/S1473-3099(20)30248-6.
  • Potts KG, Irwin CR, Favis NA, Pink DB, Vincent KM, Lewis JD, Moore RB, Hitt MM, Evans DH. Deletion of F4L (ribonucleotide reductase) in vaccinia virus produces a selective oncolytic virus and promotes anti-tumor immunity with superior safety in bladder cancer models. EMBO Mol Med. 2017;9:638–54. doi:10.15252/emmm.201607296.
  • Scutts SR, Ember SW, Ren H, Ye C, Lovejoy CA, Mazzon M, Veyer DL, Sumner RP, Smith GL. DNA-PK is targeted by multiple vaccinia virus proteins to inhibit DNA sensing. Cell Rep. 2018;25:1953–65. doi:10.1016/j.celrep.2018.10.034.
  • Kleinpeter P, Remy-Ziller C, Winter E, Gantzer M, Nourtier V, Kempf J, Hortelano J, Schmitt D, Schultz H, Geist M, et al. By binding CD80 and CD86, the vaccinia virus M2 protein blocks their interactions with both CD28 and CTLA4 and potentiates CD80 Binding to PD-L1. J Virol. 2019;93. doi:10.1128/JVI.00207-19.
  • Mackett M, Smith GL, Moss B. Vaccinia virus: a selectable eukaryotic cloning and expression vector. Proc Natl Acad Sci U S A. 1982;79:7415–19. doi:10.1073/pnas.79.23.7415.
  • Kennedy RB, Ovsyannikova I, Poland GA. Smallpox vaccines for biodefense. Vaccine. 2009;27(Suppl 4):D73–D79. doi:10.1016/j.vaccine.2009.07.103.
  • Garcia-Arriaza J, Esteban M. Enhancing poxvirus vectors vaccine immunogenicity. Hum Vaccin Immunother. 2014;10:2235–44. doi:10.4161/hv.28974.
  • Nakatake M, Kurosaki H, Kuwano N, Horita K, Ito M, Kono H, Okamura T, Hasegawa K, Yasutomi Y, Nakamura T. Partial deletion of glycoprotein B5R enhances vaccinia virus neutralization escape while preserving oncolytic function. Mol Ther Oncolytics. 2019;14:159–71. doi:10.1016/j.omto.2019.05.003.
  • Gray GE, Huang Y, Grunenberg N, Laher F, Roux S, Andersen-Nissen E, De Rosa SC, Flach B, Randhawa AK, Jensen R, et al. Immune correlates of the Thai RV144 HIV vaccine regimen in South Africa. Sci Transl Med. 2019;11. doi:10.1126/scitranslmed.aax1880.
  • Colby DJ, Sarnecki M, Barouch DH, Tipsuk S, Stieh DJ, Kroon E, Schuetz A, Intasan J, Sacdalan C, Pinyakorn S, et al. Safety and immunogenicity of Ad26 and MVA vaccines in acutely treated HIV and effect on viral rebound after antiretroviral therapy interruption. Nat Med. 2020;26:498–501. doi:10.1038/s41591-020-0774-y.
  • Mega ER. ‘Mosaic’ HIV vaccine to be tested in thousands of people across the world. Nature. 2019;572:165–66. doi:10.1038/d41586-019-02319-8.
  • Herfst S, Schrauwen EJ, Linster M, Chutinimitkul S, de Wit E, Munster VJ, Sorrell EM, Bestebroer TM, Burke DF, Smith DJ, et al. Airborne transmission of influenza A/H5N1 virus between ferrets. Science. 2012;336:1534–41. doi:10.1126/science.1213362.
  • Fouchier RA, Garcia-Sastre A, Kawaoka Y. H5N1 virus: transmission studies resume for avian flu. Nature. 2013;493:609. doi:10.1038/nature11858.
  • Xie X, Zhao C, He Q, Qiu T, Yuan S, Ding L, Liu L, Jiang L, Wang J, Zhang L, et al. Influenza vaccine with consensus internal antigens as immunogens provides cross-group protection against influenza A viruses. Front Microbiol. 2019;10:1630. doi:10.3389/fmicb.2019.01630.
  • Perez P, Lazaro-Frias A, Jimenez DON, Blazquez AB, Escribano-Romero E, Ortego J, Saiz JC, Esteban M, et al. A vaccine based on a modified vaccinia virus ankara vector expressing zika virus structural proteins controls zika virus replication in mice. Sci Rep. 2018;8:17385. doi:10.1038/s41598-018-35724-6.
  • Deng Y, Chuai X, Chen P, Chen H, Wang W, Ruan L, Li W, Tan W. Recombinant vaccinia vector-based vaccine (Tiantan) boosting a novel HBV subunit vaccine induced more robust and lasting immunity in rhesus macaques. Vaccine. 2017;35:3347–53. doi:10.1016/j.vaccine.2017.04.059.
  • Heo J, Reid T, Ruo L, Breitbach CJ, Rose S, Bloomston M, Cho M, Lim HY, Chung HC, Kim CW, et al. Randomized dose-finding clinical trial of oncolytic immunotherapeutic vaccinia JX-594 in liver cancer. Nat Med. 2013;19:329–36. doi:10.1038/nm.3089.
  • Deng L, Fan J, Guo M, Huang B. Oncolytic and immunologic cancer therapy with GM-CSF-armed vaccinia virus of Tian Tan strain Guang9. Cancer Lett. 2016;372:251–57. doi:10.1016/j.canlet.2016.01.025.
  • Downs-Canner S, Guo ZS, Ravindranathan R, Breitbach CJ, O’Malley ME, Jones HL, Moon A, McCart JA, Shuai Y, Zeh HJ, et al. Phase 1 study of intravenous oncolytic poxvirus (vvDD) in patients with advanced solid cancers. Mol Ther. 2016;24:1492–501. doi:10.1038/mt.2016.101.
  • McCart JA, Ward JM, Lee J, Hu Y, Alexander HR, Libutti SK, Moss B, Bartlett DL. Systemic cancer therapy with a tumor-selective vaccinia virus mutant lacking thymidine kinase and vaccinia growth factor genes. Cancer Res. 2001;61:8751–57.
  • Zeh HJ, Downs-Canner S, McCart JA, Guo ZS, Rao UN, Ramalingam L, Thorne SH, Jones HL, Kalinski P, Wieckowski E, et al. First-in-man study of western reserve strain oncolytic vaccinia virus: safety, systemic spread, and antitumor activity. Mol Ther. 2015;23:202–14. doi:10.1038/mt.2014.194.
  • Hermiston TW, Kuhn I. Armed therapeutic viruses: strategies and challenges to arming oncolytic viruses with therapeutic genes. Cancer Gene Ther. 2002;9:1022–35. doi:10.1038/sj.cgt.7700542.
  • Deng L, Yang X, Fan J, Ding Y, Peng Y, Xu D, Huang B, Hu Z. An oncolytic vaccinia virus armed with GM-CSF and IL-24 double genes for cancer targeted therapy. Onco Targets Ther. 2020;13:3535–44. doi:10.2147/OTT.S249816.
  • Pernas S, Tolaney SM. HER2-positive breast cancer: new therapeutic frontiers and overcoming resistance. Ther Adv Med Oncol. 2019;11:432518737. doi:10.1177/1758835919833519.
  • Jochems C, Tucker JA, Vergati M, Boyerinas B, Gulley JL, Schlom J, Tsang KY. Identification and characterization of agonist epitopes of the MUC1-C oncoprotein. Cancer Immunol Immunother. 2014;63:161–74. doi:10.1007/s00262-013-1494-7.
  • Berkeley RA, Steele LP, Mulder AA, van den Wollenberg D, Kottke TJ, Thompson J, Coffey M, Hoeben RC, Vile RG, Melcher A, et al. Antibody-neutralized reovirus is effective in oncolytic virotherapy. Cancer Immunol Res. 2018;6:1161–73. doi:10.1158/2326-6066.CIR-18-0309.
  • Ribas A, Dummer R, Puzanov I, VanderWalde A, Andtbacka R, Michielin O, Olszanski AJ, Malvehy J, Cebon J, Fernandez E, et al. Oncolytic Virotherapy Promotes Intratumoral T Cell Infiltration and Improves Anti-PD-1 Immunotherapy. Cell. 2018;174:1031–32. doi:10.1016/j.cell.2018.07.035.
  • Yang R, Wang L, Sheng J, Huang Q, Pan D, Xu Y, Yan J, Wang X, Dong Z, Yang M. Combinatory effects of vaccinia virus VG9 and the STAT3 inhibitor Stattic on cancer therapy. Arch Virol. 2019;164:1805–14. doi:10.1007/s00705-019-04257-2.

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