Projected impact of a plant-derived vaccine on the burden of seasonal influenza in Canada

References

• Public Health Agency of Canada. Canadian immunization guide chapter on influenza and statement on seasonal influenza vaccine for 2017–2018. 2017 [accessed 2020 Apr 13]. https://www.canada.ca/en/public-health/services/publications/healthy-living/canadian-immunization-guide-statement-seasonal-influenza-vaccine-2017-2018.html .
   Google Scholar
• Schanzer DL, McGeer A, Morris K. Statistical estimates of respiratory admissions attributable to seasonal and pandemic influenza for Canada: influenza hospitalization multipliers. Influenza Other Respir Viruses. 2013;7:799–808. doi:10.1111/irv.12011 .
   PubMed Web of Science ®Google Scholar
• Ng C, Ye L, Noorduyn SG, Hux M, Thommes E, Goeree R, Ambrose A, Andrew MK, Hatchette T, Boivin G, et al. Resource utilization and cost of influenza requiring hospitalization in Canadian adults: a study from the serious outcomes surveillance network of the Canadian Immunization Research Network. Influenza Other Respir Viruses. 2018;12:232–40. doi:10.1111/irv.12521 .
   PubMed Web of Science ®Google Scholar
• Schanzer DL, Sevenhuysen C, Winchester B, Mersereau T, Nishiura H. Estimating influenza deaths in Canada, 1992–2009. PLoS One. 2013;8:e80481. doi:10.1371/journal.pone.0080481 .
   PubMed Web of Science ®Google Scholar
• National Advisory Committee on Immunization (NACI). An Advisory Committee Statement (ACS) National Advisory Committee on Immunization (NACI): Canadian immunization guide chapter on influenza and statement on seasonal influenza vaccine for 2018–2019; 2018.
   Google Scholar
• Belongia EA, Simpson MD, King JP, Sundaram ME, Kelley NS, Osterholm MT, McLean HQ. Variable influenza vaccine effectiveness by subtype: a systematic review and meta-analysis of test-negative design studies. Lancet Infect Dis. 2016;16:942–51. doi:10.1016/S1473-3099(16)00129-8.
   PubMed Web of Science ®Google Scholar
• Lewnard J, Cobey S. Immune history and influenza vaccine effectiveness. Vaccines. 2018;6:28. doi:10.3390/vaccines6020028.
   PubMed Web of Science ®Google Scholar
• Public Health Agency of Canada. FluWatch annual report: 2018–19 influenza season. 2020 [accessed 2020 Apr 13]. https://www.canada.ca/en/public-health/services/publications/diseases-conditions/fluwatch/2018-2019/annual-report.html .
   Google Scholar
• Rolfes MA, Flannery B, Chung JR, O’Halloran A, Garg S, Belongia EA, Gaglani M, Zimmerman RK, Jackson ML, Monto AS, et al. Effects of influenza vaccination in the United States during the 2017–2018 influenza season. Clin Infect Dis. 2019;69:1845–53. doi:10.1093/cid/ciz075.
   PubMed Web of Science ®Google Scholar
• Flannery B, Kondor RJG, Chung JR, Gaglani M, Reis M, Zimmerman RK, Nowalk MP, Jackson ML, Jackson LA, Mono AS, Martin ET, Belongia EA, McLean HQ, Kim SS, Blanton L, Kniss K, Budd AP, Brammer L, Stark TJ, Barnes JR, Wentworth DE, Fry AM, Patel M. Spread of antigenically drifted influenza A(H3N2) viruses and vaccine effectiveness in the United States during the 2018–2019 season. J Infect Dis Jiz. 2019;543. doi:10.1093/infdis/jiz543.
   Google Scholar
• Skowronski DM, Janjua NZ, De Serres G, Sabaiduc S, Eshaghi A, Dickinson JA, Fonseca K, Winter A-L, Gubbay JB, Krajden M, et al. Low 2012–13 influenza vaccine effectiveness associated with mutation in the egg-adapted H3N2 vaccine strain not antigenic drift in circulating viruses. PLoS One. 2014;9:e92153. doi:10.1371/journal.pone.0092153.
   PubMed Web of Science ®Google Scholar
• Wu NC, Zost SJ, Thompson AJ, Oyen D, Nycholat CM, McBride R, Paulson JC, Hensley SE, Wilson IA. A structural explanation for the low effectiveness of the seasonal influenza H3N2 vaccine. PLOS Pathog. 2017;13:e1006682. doi:10.1371/journal.ppat.1006682.
   PubMed Web of Science ®Google Scholar
• Barr IG, Donis RO, Katz JM, McCauley JW, Odagiri T, Trusheim H, Tsai TF, Wentworth DE. Cell culture-derived influenza vaccines in the severe 2017–2018 epidemic season: a step towards improved influenza vaccine effectiveness. Npj Vaccines. 2018;3:44. doi:10.1038/s41541-018-0079-z.
   PubMed Web of Science ®Google Scholar
• D’Aoust M-A, Couture MM-J, Charland N, Trépanier S, Landry N, Ors F, Vézina L-P. The production of hemagglutinin-based virus-like particles in plants: a rapid, efficient and safe response to pandemic influenza: pandemic influenza vaccines from plants. Plant Biotechnol J. 2010;8:607–19. doi:10.1111/j.1467-7652.2009.00496.x.
   PubMed Web of Science ®Google Scholar
• Le Mauff F, Mercier G, Chan P, Burel C, Vaudry D, Bardor M, Vézina L-P, Couture M, Lerouge P, Landry N, et al. Biochemical composition of haemagglutinin-based influenza virus-like particle vaccine produced by transient expression in tobacco plants. Plant Biotechnol J. 2015;13:717–25. doi:10.1111/pbi.12301.
   PubMed Web of Science ®Google Scholar
• Ward BJ, Makarkov A, Séguin A, Pillet S, Trépanier S, Dhaliwall J, Libman MD, Vesikari T, Landry N. Efficacy, immunogenicity, and safety of a plant-derived, quadrivalent, virus-like particle influenza vaccine in adults (18–64 years) and older adults (≥65 years): two multicentre, randomised phase 3 trials. Lancet. 2020;396:1491–503. doi:10.1016/S0140-6736(20)32014-6.
   PubMed Web of Science ®Google Scholar
• Jackson CH, Thompson SG, Sharples LD. Accounting for uncertainty in health economic decision models by using model averaging. J R Stat Soc Ser A Stat Soc. 2009;172:383–404. doi:10.1111/j.1467-985X.2008.00573.x .
   PubMed Web of Science ®Google Scholar
• Statistics Canada. Table 17-10-0005-01 population estimates on July 1st, by age and sex. 2020 [accessed 2020 May 28]. https://www150.statcan.gc.ca/t1/tbl1/en/tv.action?pid=1710000501 .
   Google Scholar
• Bucher HC, Guyatt GH, Griffith LE, Walter SD. The results of direct and indirect treatment comparisons in meta-analysis of randomized controlled trials. J Clin Epidemiol. 1997;50:683–91. doi:10.1016/S0895-4356(97)00049-8 .
   PubMed Web of Science ®Google Scholar
• Newall AT, Chen C, Wood JG, Stockwell MS. Within-season influenza vaccine waning suggests potential net benefits to delayed vaccination in older adults in the United States. Vaccine. 2018;36:5910–15. doi:10.1016/j.vaccine.2018.08.007 .
   PubMed Web of Science ®Google Scholar
• Puig-Barberà J, Mira-Iglesias A, Tortajada-Girbés M, López-Labrador FX, Librero-López J, Díez-Domingo J, Carballido-Fernández M, Carratalá-Munuera C, Correcher-Medina P, Gil-Guillén V, et al. Waning protection of influenza vaccination during four influenza seasons, 2011/2012 to 2014/2015. Vaccine. 2017;35:5799–807. doi:10.1016/j.vaccine.2017.09.035 .
   PubMed Web of Science ®Google Scholar
• PHAC. Influenza weekly reports 2017–18 season. 2018 [accessed 2020 July 13]. https://www.canada.ca/en/public-health/services/diseases/flu-influenza/influenza-surveillance/weekly-reports-2017-2018-season.html .
   Google Scholar
• PHAC. Influenza weekly reports 2018–19 season. 2019 [accessed 2020 July 13]. https://www.canada.ca/en/public-health/services/diseases/flu-influenza/influenza-surveillance/weekly-reports-2018-2019-season.html .
   Google Scholar
• Molinari NAM, Ortega-Sanchez IR, Messonnier ML, Thompson WW, Wortley PM, Weintraub E, Bridges CB. The annual impact of seasonal influenza in the US: measuring disease burden and costs. Vaccine. 2007;25:5086–96. doi:10.1016/j.vaccine.2007.03.046 .
   PubMed Web of Science ®Google Scholar
• Reed C, Chaves SS, Daily Kirley P, Emerson R, Aragon D, Hancock EB, Butler L, Baumbach J, Hollick G, Bennett NM, et al. Estimating influenza disease burden from population-based surveillance data in the United States. PLoS One. 2015;10:e0118369. doi:10.1371/journal.pone.0118369 .
   PubMed Web of Science ®Google Scholar
• Hughes MM, Reed C, Flannery B, Garg S, Singleton JA, Fry AM, Rolfes MA. Projected population benefit of increased effectiveness and coverage of influenza vaccination on influenza burden in the United States. Clin Infect Dis Ciz. 2019;676. doi:10.1093/cid/ciz676 .
   Google Scholar
• Rondy M, El Omeiri N, Thompson MG, Levêque A, Moren A, Sullivan SG. Effectiveness of influenza vaccines in preventing severe influenza illness among adults: a systematic review and meta-analysis of test-negative design case-control studies. J Infect. 2017;75:381–94. doi:10.1016/j.jinf.2017.09.010 .
   PubMed Web of Science ®Google Scholar
• Sah P, Medlock J, Fitzpatrick MC, Singer BH, Galvani AP. Optimizing the impact of low-efficacy influenza vaccines. Proc Natl Acad Sci. 2018;115:5151–56. doi:10.1073/pnas.1802479115 .
   PubMed Web of Science ®Google Scholar
• Skowronski DM, Chambers C, De Serres G, Sabaiduc S, Winter A-L, Dickinson JA, Gubbay JB, Drews SJ, Fonseca K, Charest H, et al. Vaccine effectiveness against lineage-matched and -mismatched influenza B viruses across 8 seasons in Canada, 2010–2011 to 2017–2018. Clin Infect Dis. 2019;68:1754–57. doi:10.1093/cid/ciy876 .
   PubMed Web of Science ®Google Scholar
• DiazGranados CA, Dunning AJ, Kimmel M, Kirby D, Treanor J, Collins A, Pollak R, Christoff J, Earl J, Landolfi V, et al. Efficacy of high-dose versus standard-dose influenza vaccine in older adults. N Engl J Med. 2014;371:635–45. doi:10.1056/NEJMoa1315727 .
   PubMed Web of Science ®Google Scholar
• DiazGranados CA, Robertson CA, Talbot HK, Landolfi V, Dunning AJ, Greenberg DP. Prevention of serious events in adults 65 years of age or older: a comparison between high-dose and standard-dose inactivated influenza vaccines. Vaccine. 2015;33:4988–93. doi:10.1016/j.vaccine.2015.07.006 .
   PubMed Web of Science ®Google Scholar
• Sinilaite A, Gemmill I, Harrison R. Summary of the NACI supplemental statement on mammalian cell culture-based influenza vaccines. Can Commun Dis Rep. 2020;46:324–32. doi:10.14745/ccdr.v46i10a03 .
   PubMedGoogle Scholar
• Fine P, Eames K, Heymann DL. “Herd immunity”: a rough guide. Clin Infect Dis. 2011;52:911–16. doi:10.1093/cid/cir007 .
   PubMed Web of Science ®Google Scholar
• CDC. “CDC Seasonal Flu Vaccine Effectiveness Studies”. 2020 [accessed 17 Jul 2020]. https://www.cdc.gov/flu/vaccines-work/effectiveness-studies.htm .
   Google Scholar