Acute encephalitis after COVID-19 vaccination: A case report and literature review

References

• Halperin JJ. Diagnosis and management of acute encephalitis. Handb Clin Neurol. 2017;140:1–7. doi:10.1016/B978-0-444-63600-3.00018-0.
   Google Scholar
• George BP, Schneider EB, Venkatesan A. Encephalitis hospitalization rates and inpatient mortality in the United States, 2000–2010. Plos One. 2014;9(9):e104169. doi:10.1371/journal.pone.0104169.
   PubMed Web of Science ®Google Scholar
• Vandervorst F, Guldolf K, Peeters I, Vanderhasselt T, Michiels K, Berends KJ, Van Laethem J, Pipeleers L, Vincken S, Seynaeve L, et al. Encephalitis associated with the SARS-CoV-2 virus: a case report. Interdiscip Neurosurg. 2020;22:100821. doi:10.1016/j.inat.2020.100821.
   PubMedGoogle Scholar
• Moriguchi T, Harii N, Goto J, Harada D, Sugawara H, Takamino J, Ueno M, Sakata H, Kondo K, Myose N, et al. A first case of meningitis/encephalitis associated with SARS-Coronavirus-2. Int J Infect Dis. 2020;94:55–58. doi:10.1016/j.ijid.2020.03.062.
   PubMed Web of Science ®Google Scholar
• Manzano GS, McEntire CRS, Martinez-Lage M, Mateen FJ, Hutto SK. Acute disseminated encephalomyelitis and acute hemorrhagic leukoencephalitis following COVID-19: systematic review and meta-synthesis. Neurol Neuroimmunol Neuroinflamm. 2021;8(6):e1080. doi:10.1212/NXI.0000000000001080.
   PubMed Web of Science ®Google Scholar
• Baden LR, El Sahly HM, Essink B, Kotloff K, Frey S, Novak R, Diemert D, Spector SA, Rouphael N, Creech CB, et al. Efficacy and safety of the mRNA-1273 SARS-CoV-2 vaccine. N Engl J Med. 2021 Feb 4;384(5):403–416. doi:10.1056/NEJMoa2035389.
   PubMed Web of Science ®Google Scholar
• Polack FP, Thomas SJ, Kitchin N, Absalon J, Gurtman A, Lockhart S, Perez JL, Pérez Marc G, Moreira ED, Zerbini C, et al. Safety and efficacy of the BNT162b2 mRNA Covid-19 vaccine. N Engl J Med. 2020 Dec 31;383(27):2603–2615. doi:10.1056/NEJMoa2034577.
   PubMed Web of Science ®Google Scholar
• Goss AL, Samudralwar RD, Das RR, Nath A. ANA investigates: neurological complications of COVID-19 vaccines. Ann Neurol. 2021;89(5):856–857. doi:10.1002/ana.26065.
   PubMed Web of Science ®Google Scholar
• Patone M, Handunnetthi L, Saatci D, Pan J, Katikireddi SV, Razvi S, Hunt D, Mei XW, Dixon S, Zaccardi F, et al. Neurological complications after first dose of COVID-19 vaccines and SARS-CoV-2 infection. Nat Med. 2021;27(12):2144–2153. doi:10.1038/s41591-021-01556-7.
   PubMed Web of Science ®Google Scholar
• Zuhorn F, Graf T, Klingebiel R, Schäbitz WR, Rogalewski A. Postvaccinal encephalitis after ChAdox1 nCov-19. Ann Neurol. 2021;90(3):506–511. doi:10.1002/ana.26182.
   PubMed Web of Science ®Google Scholar
• Vogrig A, Janes F, Gigli GL, Curcio F, Negro ID, D’-Agostini S, Fabris M, Valente M. Acute disseminated encephalomyelitis after SARS-CoV-2 vaccination. Clin Neurol Neurosurg. 2021;208:106839. doi:10.1016/j.clineuro.2021.106839.
   PubMed Web of Science ®Google Scholar
• Torrealba-Acosta G, Martin JC, Huttenbach Y, Garcia CR, Sohail MR, Agarwal SK, Wasko C, Bershad EM, Hirzallah MI. Acute encephalitis, myoclonus and sweet syndrome after mRNA-1273 vaccine. BMJ Case Rep. 2021 Jul 26;14(7):e243173. doi:10.1136/bcr-2021-243173.
   PubMedGoogle Scholar
• Kania K, Ambrosius W, Tokarz Kupczyk E, Kozubski W. Acute disseminated encephalomyelitis in a patient vaccinated against SARS-CoV-2. Ann Clin Transl Neurol. 2021;8(10):2000–2003. doi:10.1002/acn3.51447.
   PubMed Web of Science ®Google Scholar
• Garg RK, Paliwal VK. Spectrum of neurological complications following COVID-19 vaccination. Neurol Sci. 2022;43(1):3–40. doi:10.1007/s10072-021-05662-9.
   PubMed Web of Science ®Google Scholar
• Sejvar JJ, Kohl KS, Bilynsky R, Blumberg D, Cvetkovich T, Galama J, Gidudu J, Katikaneni L, Khuri-Bulos N, Oleske J, et al. Encephalitis, myelitis, and acute disseminated encephalomyelitis (ADEM): case definitions and guidelines for collection, analysis, and presentation of immunization safety data. Vaccine. 2007 Aug 1;25(31):5771–5792. doi:10.1016/j.vaccine.2007.04.060.
   PubMed Web of Science ®Google Scholar
• Huynh W, Cordato DJ, Kehdi E, Masters LT, Dedousis C. Post-Vaccination encephalomyelitis: literature review and illustrative case. J Clin Neurosci. 2008;15(12):1315–1322. doi:10.1016/j.jocn.2008.05.002.
   PubMed Web of Science ®Google Scholar
• Venkatesan A, Tunkel AR, Bloch KC, Lauring AS, Sejvar J, Bitnun A, Stahl JP, Mailles A, Drebot M, Rupprecht CE, et al. Case definitions, diagnostic algorithms, and priorities in encephalitis: consensus statement of the international encephalitis consortium. Clin Infect Dis. 2013;57(8):1114–1128. doi:10.1093/cid/cit458.
   PubMed Web of Science ®Google Scholar
• Segal Y, Shoenfeld Y. Vaccine-Induced autoimmunity: the role of molecular mimicry and immune crossreaction. Cell Mol Immunol. 2018;15(6):586–594. doi:10.1038/cmi.2017.151.
   PubMed Web of Science ®Google Scholar
• Vojdani A, Kharrazian D. Potential antigenic cross-reactivity between SARS-CoV-2 and human tissue with a possible link to an increase in autoimmune diseases. Clin Immunol. 2020;217:108480. doi:10.1016/j.clim.2020.108480.
   PubMed Web of Science ®Google Scholar
• Nakayama T. Causal relationship between immunological responses and adverse reactions following vaccination. Vaccine. 2019;37(2):366–371. doi:10.1016/j.vaccine.2018.11.045.
   PubMed Web of Science ®Google Scholar
• Nakayama T. An inflammatory response is essential for the development of adaptive immunity-immunogenicity and immunotoxicity. Vaccine. 2016;34(47):5815–5818. doi:10.1016/j.vaccine.2016.08.051.
   PubMed Web of Science ®Google Scholar
• Zambreanu L, Lightbody S, Bhandari M, Hoskote C, Kandil H, Houlihan CF, Lunn MP. A case of limbic encephalitis associated with asymptomatic COVID-19 infection. J Neurol Neurosurg Psychiatry. 2020;91(11):1229–1230. doi:10.1136/jnnp-2020-323839.
   PubMed Web of Science ®Google Scholar
• Meshref M, Hewila IM, Abdel Mageed S, Morra ME. COVID-19 associated with encephalitis: case report and review of literature. Neurologist. 2021;26(6):268–270. doi:10.1097/NRL.0000000000000347.
   PubMed Web of Science ®Google Scholar
• Valencia Sanchez C, Theel E, Binnicker M, Toledano M, McKeon A. Autoimmune encephalitis after SARS-CoV-2 infection: case frequency, findings, and outcomes. Neurology. 2021;97(23):e2262–e2268. doi:10.1212/WNL.0000000000012931.
   PubMed Web of Science ®Google Scholar
• Correia AO, Feitosa PWG, Moreira JLS, Sár N, Fonseca RB, Nobre MEP. Neurological manifestations of COVID-19 and other coronaviruses: a systematic review. Neurol Psychiatry Brain Res. 2020;37:27–32. doi:10.1016/j.npbr.2020.05.008.
   PubMedGoogle Scholar
• Pilotto A, Masciocchi S, Volonghi I, De Giuli V, Caprioli F, Mariotto S, Ferrari S, Bozzetti S, Imarisio A, Risi B, et al. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) encephalitis is a cytokine release syndrome: evidences from cerebrospinal fluid analyses. Clin Infect Dis. 2021 Nov 2;73(9):e3019–e3026. doi:10.1093/cid/ciaa1933.
   PubMedGoogle Scholar
• Dantzer R. Neuroimmune interactions: from the brain to the immune system and vice versa. Physiol Rev. 2018;98(1):477–504. doi:10.1152/physrev.00039.2016.
   PubMed Web of Science ®Google Scholar